Overview
Background
Professor Grant Montgomery FAHMS FSRB Hon FRSNZ
Professor Montgomery was born in New Zealand, completed PhD studies in Animal Science at Massey University and post-doctoral research in France. In 1987, he co-founded the New Zealand Sheep Genomics Program in the Biochemistry Department at the University of Otago and pioneered the introduction of genome mapping methods in farm animals. He moved to Australia in 1999 and joined the Queensland Institute of Medical Research where he ran a successful genome mapping program for human complex disease. In 2016, he moved to the University of Queensland and holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI). He is a National Health and Medical Research Council Leadership Fellow and Director of the UQ Genome Innovation Hub. He was elected a Fellow the Society for Reproductive Biology in 2012, Fellow of the Australian Academy of Health and Medical Sciences in 2015, and Honorary Fellow of the Royal Society of New Zealand in 2016. His research focusses on discovery of critical genes and pathways increasing risk for common diseases especially reproductive diseases including endometriosis.
Availability
- Professor Grant Montgomery is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Massey University
Research impacts
Professor Montgomery has made substantial contributions to the worldwide effort to map genomic regions contributing to risk for complex traits and diseases, including endometriosis, age at menarche and menopause, cancers of the reproductive tract, melanoma and inflammatory bowel disease. He is conducting systems genetics and functional studies to identify the genes and pathways affected by these genetic risk factors. His work has identified possible target genes and functional consequences of genetic risk factors in genomic regions associated with endometriosis providing novel insights into the causes of this important disease. He lead a consortium of leading endometriosis clinicians and researchers in Australia awarded a MRFF Frontiers in Health and Medical Science to develop earlier diagnosis and personalised treatments for endometriosis. He is co-leader of International Endometriois Genetics Consortium, Patron of the Endometriosis Association (QLD) Inc (QENDO) and has worked closely with QENDO, other patient groups, clinicians and politicians to help develop the National Action Plan for Endometriosis. He is on the Executive Committee of the National Endometriosis Clinical and Scientific Trials (NECST) Network. He is also Director of the UQ Genome Innovation Hub developing novel methods and pipelines for genomics in health and agriculature that can be widely applied in programs across The University of Queensland.
Works
Search Professor Grant Montgomery’s works on UQ eSpace
2022
Conference Publication
Comparison of Organoids from Menstrual Fluid and Endometrium from Women Taking Hormonal Medication: Potential for Modelling Endometriosis
Filby, Caitlin E., Wyatt, Katherine A., Mortlock, Sally, Cousins, Fiona L., McKinnon, Brett, Tyson, Kate, Montgomery, Grant W. and Gargett, Caroline E. (2022). Comparison of Organoids from Menstrual Fluid and Endometrium from Women Taking Hormonal Medication: Potential for Modelling Endometriosis. 69th Annual Meeting of the Society for Reproductive Investigation SRI 2022, Denver, CO United States, 15-19 March 2022. Heidelberg, Germany: Springer.
2022
Journal Article
Body mass index and the diagnosis of endometriosis: findings from a national data linkage cohort study
Rowlands, Ingrid J., Hockey, Richard, Abbott, Jason A., Montgomery, Grant W. and Mishra, Gita D. (2022). Body mass index and the diagnosis of endometriosis: findings from a national data linkage cohort study. Obesity Research and Clinical Practice, 16 (3), 235-241. doi: 10.1016/j.orcp.2022.04.002
2021
Journal Article
Comparison of organoids from menstrual fluid and hormone-treated endometrium: novel tools for gynecological research
Filby, Caitlin E., Wyatt, Katherine A., Mortlock, Sally, Cousins, Fiona L., McKinnon, Brett, Tyson, Kate E., Montgomery, Grant W. and Gargett, Caroline E. (2021). Comparison of organoids from menstrual fluid and hormone-treated endometrium: novel tools for gynecological research. Journal of Personalized Medicine, 11 (12) 1314, 1314. doi: 10.3390/jpm11121314
2021
Journal Article
Educational attainment of same-sex and opposite-sex dizygotic twins: an individual-level pooled study of 19 twin cohorts
Silventoinen, Karri, Bogl, Leonie H., Jelenkovic, Aline, Vuoksimaa, Eero, Latvala, Antti, Li, Weilong, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E.M., Rebato, Esther, Corley, Robin P., Huibregtse, Brooke M., Hopper, John L., Tyler, Jessica, Duncan, Glen E., Buchwald, Dedra, Silberg, Judy L., Maes, Hermine H., Kandler, Christian, Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Nelson, Tracy L. ... Kaprio, Jaakko (2021). Educational attainment of same-sex and opposite-sex dizygotic twins: an individual-level pooled study of 19 twin cohorts. Hormones and Behavior, 136 105054, 1-6. doi: 10.1016/j.yhbeh.2021.105054
2021
Journal Article
Identical twins carry a persistent epigenetic signature of early genome programming
van Dongen, Jenny, Gordon, Scott D., McRae, Allan F., Odintsova, Veronika V., Mbarek, Hamdi, Breeze, Charles E., Sugden, Karen, Lundgren, Sara, Castillo-Fernandez, Juan E., Hannon, Eilis, Moffitt, Terrie E., Hagenbeek, Fiona A., van Beijsterveldt, Catharina E. M., Jan Hottenga, Jouke, Tsai, Pei-Chien, van Dongen, Jenny, Hottenga, Jouke-Jan, McRae, Allan F., Sugden, Karen, Castillo-Fernandez, Juan E., Hannon, Eilis, Moffitt, Terrie E., Hottenga, Jouke-Jan, de Geus, Eco J. C., Spector, Timothy D., Min, Josine L., Hemani, Gibran, Ehli, Erik A., Paul, Franziska ... Genetics of DNA Methylation Consortium (2021). Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications, 12 (1) 5618, 5618. doi: 10.1038/s41467-021-25583-7
2021
Journal Article
Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality
Adewuyi, Emmanuel O., Mehta, Divya, Sapkota, Yadav, Auta, Asa, Yoshihara, Kosuke, Nyegaard, Mette, Griffiths, Lyn R., Montgomery, Grant W., Chasman, Daniel I. and Nyholt, Dale R. (2021). Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality. Human Genetics, 140 (3), 529-552. doi: 10.1007/s00439-020-02223-6
2021
Journal Article
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Võsa, Urmo, Claringbould, Annique, Westra, Harm-Jan, Bonder, Marc Jan, Deelen, Patrick, Zeng, Biao, Kirsten, Holger, Saha, Ashis, Kreuzhuber, Roman, Yazar, Seyhan, Brugge, Harm, Oelen, Roy, de Vries, Dylan H., van der Wijst, Monique G. P., Kasela, Silva, Pervjakova, Natalia, Alves, Isabel, Favé, Marie-Julie, Agbessi, Mawussé, Christiansen, Mark W., Jansen, Rick, Seppälä, Ilkka, Tong, Lin, Teumer, Alexander, Schramm, Katharina, Hemani, Gibran, Verlouw, Joost, Yaghootkar, Hanieh, Sönmez Flitman, Reyhan ... i2QTL Consortium (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics, 53 (9), 1300-1310. doi: 10.1038/s41588-021-00913-z
2021
Journal Article
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Min, Josine L., Hemani, Gibran, Hannon, Eilis, Dekkers, Koen F., Castillo-Fernandez, Juan, Luijk, René, Carnero-Montoro, Elena, Lawson, Daniel J., Burrows, Kimberley, Suderman, Matthew, Bretherick, Andrew D., Richardson, Tom G., Klughammer, Johanna, Iotchkova, Valentina, Sharp, Gemma, Al Khleifat, Ahmad, Shatunov, Aleksey, Iacoangeli, Alfredo, McArdle, Wendy L., Ho, Karen M., Kumar, Ashish, Söderhäll, Cilla, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Kazmi, Nabila, Mason, Dan, McRae, Allan F., Corcoran, David L., Sugden, Karen ... BIOS Consortium (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics, 53 (9), 1311-1321. doi: 10.1038/s41588-021-00923-x
2021
Journal Article
Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus
Kho, Pik Fang, Mortlock, Sally, Endometrial Cancer Association Consortium , International Endometriosis Genetics Consortium, Rogers, Peter A. W., Nyholt, Dale R., Montgomery, Grant W., Spurdle, Amanda B., Glubb, Dylan M. and O'Mara, Tracy A. (2021). Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus. Human Genetics, 140 (9), 1353-1365. doi: 10.1007/s00439-021-02312-0
2021
Journal Article
Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
Tapmeier, Thomas T., Rahmioglu, Nilufer, Lin, Jianghai, De Leo, Bianca, Obendorf, Maik, Raveendran, Muthuswamy, Fischer, Oliver M., Bafligil, Cemsel, Guo, Manman, Harris, Ronald Alan, Hess-Stumpp, Holger, Laux-Biehlmann, Alexis, Lowy, Ernesto, Lunter, Gerton, Malzahn, Jessica, Martin, Nicholas G., Martinez, Fernando O., Manek, Sanjiv, Mesch, Stefanie, Montgomery, Grant W., Morris, Andrew P., Nagel, Jens, Simmons, Heather A., Brocklebank, Denise, Shang, Catherine, Treloar, Susan, Wells, Graham, Becker, Christian M., Oppermann, Udo ... Zondervan, Krina T. (2021). Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. Science Translational Medicine, 13 (608) eabd6469, 1-12. doi: 10.1126/scitranslmed.abd6469
2021
Journal Article
Phantom epistasis between unlinked loci
Hemani, Gibran, Powell, Joseph E., Wang, Huanwei, Shakhbazov, Konstantin, Westra, Harm-Jan, Esko, Tonu, Henders, Anjali K., McRae, Allan F., Martin, Nicholas G., Metspalu, Andres, Franke, Lude, Montgomery, Grant W., Goddard, Michael E., Gibson, Greg, Yang, Jian and Visscher, Peter M. (2021). Phantom epistasis between unlinked loci. Nature, 596 (7871), E1-E3. doi: 10.1038/s41586-021-03765-z
2021
Journal Article
Protocol for a case-control study investigating the clinical phenotypes and genetic regulation of endometriosis in Indian women: The ECGRI study
Gajbhiye, Rahul K., Montgomery, Grant, Pai, Murlidhar V, Phukan, Pranay, Shekhar, Shashank, Padte, Kedar, Dasmahapatra, Pramathes, John, Bimal M., Shembekar, Chaitanya, Bhurke, Aishwarya V., Bagde, Nilajkumar, Kulkarni, Ketki, Sardeshpande, Nagendra, Humane, Anil, Mahobia, Swati, Shah, Millind, Singh, Uma, Srivastava, Aarti, Mishra, Gita, Warty, Neeta, Chandra, Sunita and Mahale, Smita D. (2021). Protocol for a case-control study investigating the clinical phenotypes and genetic regulation of endometriosis in Indian women: The ECGRI study. BMJ Open, 11 (8) e050844, e050844. doi: 10.1136/bmjopen-2021-050844
2021
Journal Article
Genetic insights into biological mechanisms governing human ovarian ageing
Ruth, Katherine S., Day, Felix R., Hussain, Jazib, Martínez-Marchal, Ana, Aiken, Catherine E., Azad, Ajuna, Thompson, Deborah J., Knoblochova, Lucie, Abe, Hironori, Tarry-Adkins, Jane L., Gonzalez, Javier Martin, Fontanillas, Pierre, Claringbould, Annique, Bakker, Olivier B., Sulem, Patrick, Walters, Robin G., Terao, Chikashi, Turon, Sandra, Horikoshi, Momoko, Lin, Kuang, Onland-Moret, N. Charlotte, Sankar, Aditya, Hertz, Emil Peter Thrane, Timshel, Pascal N., Shukla, Vallari, Borup, Rehannah, Olsen, Kristina W., Aguilera, Paula, Ferrer-Roda, Mònica ... Perry, John R. B. (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature, 596 (7872), 393-397. doi: 10.1038/s41586-021-03779-7
2021
Journal Article
Genetic Relationship Between Endometriosis and Melanoma
Yang, Fei, Mortlock, Sally, MacGregor, Stuart, Iles, Mark M., Landi, Maria Teresa, Shi, Jianxin, Law, Matthew H., Montgomery, Grant W. and on behalf of The International Endometriosis Genetics Consortium (2021). Genetic Relationship Between Endometriosis and Melanoma. Frontiers in Reproductive Health, 3 711123, 1-10. doi: 10.3389/frph.2021.711123
2021
Journal Article
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Mullins, Niamh, Forstner, Andreas J., O'Connell, Kevin S., Coombes, Brandon, Coleman, Jonathan R I, Qiao, Zhen, Als, Thomas D., Bigdeli, Tim B., Børte, Sigrid, Bryois, Julien, Charney, Alexander W., Drange, Ole Kristian, Gandal, Michael J., Hagenaars, Saskia P., Ikeda, Masashi, Kamitaki, Nolan, Kim, Minsoo, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Steinberg, Stacy, Trubetskoy, Vassily, Winsvold, Bendik S., Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Agerbo, Esben, Al Eissa, Mariam ... Andreassen, Ole A. (2021). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature genetics, 53 (6), 817-829. doi: 10.1038/s41588-021-00857-4
2021
Journal Article
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Nabais, Marta F., Laws, Simon M., Lin, Tian, Vallerga, Costanza L., Armstrong, Nicola J., Blair, Ian P., Kwok, John B., Mather, Karen A., Mellick, George D., Sachdev, Perminder S., Wallace, Leanne, Henders, Anjali K., Zwamborn, Ramona A. J., Hop, Paul J., Lunnon, Katie, Pishva, Ehsan, Roubroeks, Janou A. Y., Soininen, Hilkka, Tsolaki, Magda, Mecocci, Patrizia, Lovestone, Simon, Kloszewska, Iwona, Vellas, Bruno, Furlong, Sarah, Garton, Fleur C., Henderson, Robert D., Mathers, Susan, McCombe, Pamela A., Needham, Merrilee ... McRae, Allan F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22 (1) 90, 1-30. doi: 10.1186/s13059-021-02275-5
2021
Journal Article
Genetic regulation of physiological reproductive lifespan and female fertility
McGrath, Isabelle M., Mortlock, Sally and Montgomery, Grant W. (2021). Genetic regulation of physiological reproductive lifespan and female fertility. International Journal of Molecular Sciences, 22 (5) 2556, 1-13. doi: 10.3390/ijms22052556
2021
Journal Article
Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study
Rowlands, I. J., Abbott, J. A., Montgomery, G. W., Hockey, R., Rogers, P. and Mishra, G. D. (2021). Prevalence and incidence of endometriosis in Australian women: a data linkage cohort study. BJOG, 128 (4) 1471-0528.16447, 657-665. doi: 10.1111/1471-0528.16447
2021
Journal Article
Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis
Holdsworth-Carson, Sarah J., Churchill, Molly, Donoghue, Jacqueline F., Mortlock, Sally, Fung, Jenny N., Sloggett, Clare, Chung, Jessica, Cann, Leonie, Teh, Wan Tinn, Campbell, Katie-Rose, Luwor, Rodney, Healey, Martin, Montgomery, Grant, Girling, Jane E. and Rogers, Peter A. W. (2021). Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis. Molecular Human Reproduction, 27 (3) gaab010. doi: 10.1093/molehr/gaab010
2021
Journal Article
Comparison of Familial, Polygenic and Biochemical Predictors of Mortality
Whitfield, John B., Colodro-Conde, Lucía, Timmers, Paul R. H. J., Joshi, Peter K., Montgomery, Grant W. and Martin, Nicholas G. (2021). Comparison of Familial, Polygenic and Biochemical Predictors of Mortality. Twin Research and Human Genetics, 23 (6), 307-315. doi: 10.1017/thg.2020.89
Funding
Current funding
Supervision
Availability
- Professor Grant Montgomery is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Investigating the relationship between Endometriosis and Cancer risk.
Associate Advisor
Other advisors: Dr Sally Mortlock
-
Doctor Philosophy
Exploring the role of clinical, lifestyle, environmental and molecular factors in endometriosis risk
Associate Advisor
Other advisors: Dr Allan McRae, Dr Sally Mortlock
-
Doctor Philosophy
Regulation of the endocannabinoid system in the endometrium across menstrual cycle and implications in endometriosis
Associate Advisor
Other advisors: Dr Brett McKinnon, Dr Akwasi Amoako
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Master Philosophy
Spatial resolved analysis of endometrial tissue
Associate Advisor
Other advisors: Dr Brett McKinnon
Completed supervision
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2023
Doctor Philosophy
Regulation of transcription in human endometrium and endometriosis
Principal Advisor
Other advisors: Dr Sally Mortlock
-
2023
Doctor Philosophy
Investigation of both epidemiological and genetic risk factors for endometriosis: novel insights and important clinical implications
Principal Advisor
Other advisors: Dr Sally Mortlock
-
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2016
Doctor Philosophy
Complex trait genetics: mapping, correlation and causation
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
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2012
Doctor Philosophy
Various approaches to identify breast cancer susceptibility genes.
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna
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2008
Doctor Philosophy
The Aetiology of Obsesity in Australian Families
Associate Advisor
Other advisors: Professor Nick Martin
Media
Enquiries
Contact Professor Grant Montgomery directly for media enquiries about:
- Endometriosis
- Genetics
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