Overview
Background
Dr. Dalila Iannotta obtained her PhD in Cellular and Molecular Biotechnology in 2022. Her goal is to contribute to nanomedicine by developing new delivery systems that decrease side effects and increase the therapeutic activity of medicines.
She has over eight years of research experience in various areas, such as extracellular vesicles, synthetic nanoparticles, and disease models (wounds and neurological conditions). Her research has resulted in nine publications, including in journals such as the Nature Nanotechnology (IF: 38.1), Journal of Extracellular Vesicles (IF: 21.22) and Nano Today (IF: 18.96).
She has mentored 16 Master’s degree students and five undergraduate students at various institutions, including at The University of Queensland (Australia), Mayo Clinic (USA) (ranked best hospital in the world, Newsweek), D'Annunzio University of Chieti–Pescara (Italy), and University of L’Aquila (Italy). She has also taken an active role in the “Young Scientists” program for high school students.
Main research fields:
- Hybrid delivery systems: design new hybrid nanosystems consisting of synthetic nanoparticles and extracellular vesicles for a best-of-both worlds approach that enables delivery of therapeutic peptides.
- Advanced purification methods for extracellular vesicles: develop improved purification methods for extracellular vesicles derived from biofluids, such as plasma.
Availability
- Dr Dalila Iannotta is:
- Available for supervision
Qualifications
- Masters (Research) of Molecular Biotechnology, unknown
- Doctor of Philosophy of Molecular Biotechnology, unknown
Research impacts
Dr. Iannotta’s research contributes to scientific knowledge and health, through the development of new systems that improve the efficiency and targeting of drugs. Additionally, her research on extracellular vesicles provides valuable contribution to this emerging and exponentially growing field.
Works
Search Professor Dalila Iannotta’s works on UQ eSpace
2023
Journal Article
Entry and exit of extracellular vesicles to and from the blood circulation
Iannotta, Dalila, A, Amruta, Kijas, Amanda W., Rowan, Alan E. and Wolfram, Joy (2023). Entry and exit of extracellular vesicles to and from the blood circulation. Nature Nanotechnology, 19 (1), 137-20. doi: 10.1038/s41565-023-01522-z
2023
Journal Article
Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification
Iannotta, Dalila, Amruta A., Lai, Andrew, Nair, Soumyalekshmi, Koifman, Na'ama, Lappas, Martha, Salomon, Carlos and Wolfram, Joy (2023). Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification. Small, 20 (18) 2307240, 1-14. doi: 10.1002/smll.202307240
2023
Journal Article
Transforming undergraduate laboratory courses with interlinked real-world challenges
Iannotta, Dalila, Goncalves, Jenifer P., Ghebosu, Raluca E., Gopalakrishnan, Aswathi, Cooper-White, Justin and Wolfram, Joy (2023). Transforming undergraduate laboratory courses with interlinked real-world challenges. Trends in Biotechnology, 42 (1), 1-4. doi: 10.1016/j.tibtech.2023.10.006
2023
Journal Article
Vasculature organotropism in drug delivery
Amruta, A., Iannotta, Dalila, Cheetham, Seth W., Lammers, Twan and Wolfram, Joy (2023). Vasculature organotropism in drug delivery. Advanced Drug Delivery Reviews, 201 115054, 1-13. doi: 10.1016/j.addr.2023.115054
2023
Journal Article
Hyaluronic acid: An overlooked extracellular vesicle contaminant
Goncalves, Jenifer P., Ghebosu, Raluca E., Tan, Xuan Ning Sharon, Iannotta, Dalila, Koifman, Na'ama and Wolfram, Joy (2023). Hyaluronic acid: An overlooked extracellular vesicle contaminant. Journal of Extracellular Vesicles, 12 (9) 12362, e12362. doi: 10.1002/jev2.12362
2023
Journal Article
Extracellular vesicle lipids in cancer immunoevasion
Chen, Siyu, Iannotta, Dalila, O'Mara, Megan L., Goncalves, Jenifer Pendiuk and Wolfram, Joy (2023). Extracellular vesicle lipids in cancer immunoevasion. Trends in Cancer, 9 (11), 883-886. doi: 10.1016/j.trecan.2023.08.006
2023
Journal Article
In vitro characterization and real-time label-free assessment of the interaction of chitosan-coated niosomes with intestinal cellular monolayers
Scurti, Elena, Martins, João Pedro, Celia, Christian, Palumbo, Paola, Lombardi, Francesca, Iannotta, Dalila, Di Marzio, Luisa, Santos, Hélder A. and Viitala, Tapani (2023). In vitro characterization and real-time label-free assessment of the interaction of chitosan-coated niosomes with intestinal cellular monolayers. Langmuir, 39 (23), 8255-8266. doi: 10.1021/acs.langmuir.3c00728
2022
Conference Publication
Consideration for extracellular vesicle and lipoprotein interactions in cell culture assays
Iannotta, Dalila, Busatto, Sara, Yang, Yubo, Davidovich, Irina, Talmon, Yeshayahu and Wolfram, Joy (2022). Consideration for extracellular vesicle and lipoprotein interactions in cell culture assays. Australia and New Zealand Society for Extracellular Vesicles Annual Meeting, Gold Coast, QLD, Australia , 9-11 November 2022.
2022
Journal Article
Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays
Busatto, Sara, Yang, Yubo, Iannotta, Dalila, Davidovich, Irina, Talmon, Yeshayahu and Wolfram, Joy (2022). Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays. Journal of Extracellular Vesicles, 11 (4) e12202, e12202. doi: 10.1002/jev2.12202
2022
Journal Article
Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines
Wang, Xinghua, Pham, Anthony, Kang, Lu, Walker, Sierra A., Davidovich, Irina, Iannotta, Dalila, Terkonda, Sarvam P., Shapiro, Shane, Talmon, Yeshayahu, Pham, Si and Wolfram, Joy (2022). Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines. Pharmaceutics, 14 (1) 16, 16. doi: 10.3390/pharmaceutics14010016
2021
Journal Article
Extracellular vesicle therapeutics from plasma and adipose tissue
Iannotta, Dalila, Yang, Man, Celia, Christian, Di Marzio, Luisa and Wolfram, Joy (2021). Extracellular vesicle therapeutics from plasma and adipose tissue. Nano Today, 39 101159, 101159. doi: 10.1016/j.nantod.2021.101159
2021
Journal Article
A simple and quick method for loading proteins in extracellular vesicles
Busatto, Sara, Iannotta, Dalila, Walker, Sierra A., Di Marzio, Luisa and Wolfram, Joy (2021). A simple and quick method for loading proteins in extracellular vesicles. Pharmaceuticals, 14 (4) 356, 356. doi: 10.3390/ph14040356
2021
Journal Article
Conventional nanosized drug delivery systems for cancer applications
Vergallo, Cristian, Hafeez, Muhammad Nadeem, Iannotta, Dalila, Santos, Helder A., D'Avanzo, Nicola, Dini, Luciana, Cilurzo, Felisa, Fresta, Massimo, Di Marzio, Luisa and Christian, Celia (2021). Conventional nanosized drug delivery systems for cancer applications. Bio-Nanomedicine for Cancer Therapy, 1295, 3-27. doi: 10.1007/978-3-030-58174-9_1
2020
Conference Publication
Discoidal nanoparticles: reaction environment-dependent size response
Iannotta, Dalila, Celia, Christian , Wolfram, Joy, Agata, P. and Di Marzio, Luisa (2020). Discoidal nanoparticles: reaction environment-dependent size response. NanoInnovation 2020, Rome, Italy , September 2020.
2020
Journal Article
Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery
Barone, Antonella, Cristiano, Maria Chiara, Cilurzo, Felisa, Locatelli, Marcello, Iannotta, Dalila, Di Marzio, Luisa, Celia, Christian and Paolino, Donatella (2020). Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids and Surfaces B: Biointerfaces, 193 111152, 111152. doi: 10.1016/j.colsurfb.2020.111152
2020
Conference Publication
Hybrid nanocarrier library based biomaterials for therapeutic applications
Iannotta, Dalila, Celia, Christian, Wolfram, Joy, Agata, P. and Di Marzio, Luisa (2020). Hybrid nanocarrier library based biomaterials for therapeutic applications. 1st International Northern Southern Europe Workshop in Nanomedicine, Chieti, Italy, January 2020.
2018
Journal Article
PPARs and energy metabolism adaptation during neurogenesis and neuronal maturation
D'Angelo, Michele, Antonosante, Andrea, Castelli, Vanessa, Catanesi, Mariano, Moorthy, NandhaKumar, Iannotta, Dalila, Cimini, Annamaria and Benedetti, Elisabetta (2018). PPARs and energy metabolism adaptation during neurogenesis and neuronal maturation. International Journal of Molecular Sciences, 19 (7) 1869, 1-16. doi: 10.3390/ijms19071869
2018
Journal Article
The involvement of PPARs in the peculiar energetic metabolism of tumor cells
Antonosante, Andrea, d'Angelo, Michele, Castelli, Vanessa, Catanesi, Mariano, Iannotta, Dalila, Giordano, Antonio, Ippoliti, Rodolfo, Benedetti, Elisabetta and Cimini, Annamaria (2018). The involvement of PPARs in the peculiar energetic metabolism of tumor cells. International Journal of Molecular Sciences, 19 (7) 1907, 1-30. doi: 10.3390/ijms19071907
2018
Journal Article
Probiotic DSF counteracts chemotherapy induced neuropathic pain
Castelli, Vanessa, Palumbo, Paola, d'Angelo, Michele, Moorthy, Nandha Kumar, Antonosante, Andrea, Catanesi, Mariano, Lombardi, Francesca, Iannotta, Dalila, Cinque, Benedetta, Benedetti, Elisabetta, Ippoliti, Rodolfo, Cifone, Maria Grazia and Cimini, Annamaria (2018). Probiotic DSF counteracts chemotherapy induced neuropathic pain. OncoTarget, 9 (46), 27998-28008. doi: 10.18632/oncotarget.25524
Supervision
Availability
- Dr Dalila Iannotta is:
- Available for supervision
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Available projects
-
Development of hybrid nanosystem libraries
Liposomes are self-assembling lipid-based nanoparticles that enclose an aqueous core. An advantage of liposomes is versatility in terms of efficient loading of both hydrophilic and hydrophobic therapeutics. Liposomes represent the largest category of clinically approved nanoparticles, but they have simple surfaces that display limited biointerfacing properties.
In recent years, extracellular vesicles (EVs) have captured considerable interest due to their involvement in multiple physiological and pathological processes. EVs are cell-released nanoparticles that display complex surfaces with organotropic features, making them attractive as drug delivery systems. However, EVs also display disadvantages, such as reduced drug loading efficiency compared to synthetic counterparts.
In this project, a library of hybrid nanosystems with various liposome and EV components will be developed. The hybrid nanosystems will be characterized and assessed in terms of loading efficiency (therapeutic peptides) and organotropism.
Media
Enquiries
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