2020 Conference Publication The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutationFernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014 |
2019 Journal Article The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipaDutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Åsa, Brust, Andreas, Dekan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2019). The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports, 9 (1) 17841, 17841. doi: 10.1038/s41598-019-54186-y |
2019 Journal Article Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptorsRagnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2019). Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors. Science Signaling, 12 (572) eaas9485, eaas9485. doi: 10.1126/scisignal.aas9485 |
2019 Journal Article Insight into T-type calcium channel structure, function and modulationWang, Dan, Ragnarsson, Lotten and Lewis, Richard J. (2019). Insight into T-type calcium channel structure, function and modulation. Current medicinal chemistry, 27 (19), 3098-3122. doi: 10.2174/0929867325666181001112821 |
2018 Journal Article Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel BlockersWang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert J. and Lewis, Richard J. (2018). Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Marine Drugs, 16 (12) 475, 475. doi: 10.3390/md16120475 |
2018 Journal Article Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptidesSousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4 |
2017 Journal Article Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across speciesMuttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398 |
2017 Journal Article Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingiSousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848 |
2017 Journal Article Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptorAbraham, Nikita, Healy, Michael, Ragnarsson, Lotten, Brust, Andreas, Alewood, Paul F. and Lewis, Richard J. (2017). Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports, 7 (1) 45466, 45466. doi: 10.1038/srep45466 |
2017 Journal Article Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responsesWan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407 |
2017 Conference Publication High-throughput cell-based assays for screening Cav3.2 modulators from venomsWang, D., Herzig, V., Dekan, Z., Ragnarsson, Lotten K. N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). High-throughput cell-based assays for screening Cav3.2 modulators from venoms. Venom to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017. |
2017 Conference Publication Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin bindingHassan, Mahadhi, Abraham, Nikita, Ragnarsson, Lotten K.N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017. |
2016 Journal Article Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs)Abraham, Nikita, Paul, Blessy, Ragnarsson, Lotten and Lewis, Richard J. (2016). Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs). PLoS One, 11 (6) e0157363, e0157363. doi: 10.1371/journal.pone.0157363 |
2016 Journal Article Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive propertiesBrust, Andreas, Croker, Daniel, Colless, Barbara, Ragnarsson, Lotten K. N., Andersson, Asa, Jain, Kapil, Garcia-Caraballo, Sonia, Castro, Joel, Brierley, Stuart M., Alewood, Paul F. and Lewis, Richard J. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59 (6), 2381-2395. doi: 10.1021/acs.jmedchem.5b00911 |
2016 Conference Publication Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and DiseaseMuttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley. |
2015 Book Chapter Research methodsFry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press. |
2015 Journal Article Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functionsRagnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2015). Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functions. Molecular Pharmacology, 87 (1), 121-129. doi: 10.1124/mol.114.094557 |
2014 Book Chapter Role of ionotropic glutamate receptors in neurodegenerative and other disordersRagnarsson, Lotten, Dodd, Peter R. and Hynd, Matthew R. (2014). Role of ionotropic glutamate receptors in neurodegenerative and other disorders. Handbook of neurotoxicity. (pp. 1039-1070) New York, NY, United States: Springer Science+Business Media. doi: 10.1007/978-1-4614-5836-4_144 |
2013 Journal Article Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cellsSousa, Silmara R., Vetter, Irina, Ragnarsson, Lotten and Lewis, Richard J. (2013). Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cells. PloS One, 8 (3) e59293, e59293. doi: 10.1371/journal.pone.0059293 |
2013 Journal Article Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptorRagnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Asa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2013). Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor. Journal of Biological Chemistry, 288 (3), 1814-1827. doi: 10.1074/jbc.M112.430785 |