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Stephen is a physiologist with expertise in endocrinology and student learning. In laboratory research Stephen investigates the hormonal control of metabolism, growth, appetite, and reproduction - unravelling how hormones regulate physiological mechanisms in healthy individuals versus the dysfunction that occurs in disease states. Stephen also has a scholarly interest in self-regulation of learning and metacognition.

Stephen has taught physiology at UQ to about 40,000 students in biomedical science, animal and veterinary sciences, health science, exercise science, human movement and nutrition science, dentistry, pharmacy, speech pathology, physiotherapy, occupational therapy, and medical doctor programs. He has been the recipient of numerous teaching excellence awards, including a national ALTC Citation for Outstaning Contribution to Student Learning in 2009.

From 2019 to 2024 Stephen was Director of Teaching and Learning in the School of Biomedical Sciences, and during his tenure received a UQ commendation for Service Excellence for leading his School's teaching response to the COVID pandemic, and was recognised as Academic Leader of the Year in 2020 within the UQ Faculty of Medicine.

Dr Cuffe is a systems physiologist focused on understanding the complex changes to maternal physiology that occur during pregnancy and the impact of pregnancy dysfunction of programmed cardiovascular, metabolic and renal disease in offspring. Dr Cuffe has a particular focus on understanding the role of the placenta and its hormones in mediating both maternal and offspring disease. He is most recognised for his research investigating how maternal stress, thyroid dysfunction, hypoxia or altered nutrition affect placental development and program disease in the mother after pregnancy as well as her offspring. Dr Cuffe has an exceptional track record and is excited to take new honours and PhD students into his research laboratory.