I am a comparative and environmental physiologist based at the University of Queensland. My research focuses primarily how the environment constrains the physiology of invertebrates, fish, amphibians and reptiles. I have a highly diverse research program that incorporates fundamental, curiosity-driven research and increasingly, a more applied research agenda in the emerging field of conservation physiology. Conservation physiology explores the responses of organisms to anthropogenic threats and attempts to determine the ecophysiological constraints dictated by current conditions and future environmental change. My research interests encompass the general areas of osmo- and ion-regulation, digestive and thermal physiology, environmental drivers of physiological function (specifically immune function and disease susceptibility) and animal performance in anthropogenically modified environments.
A life-long fascination in sciences provided me with the inspiration to graduate in exercise physiology (University of Sherbrooke, Canada, 2004), complete a PhD in physiology/biophysics (University of Sherbrooke, 2009) and continue in my current role as a postdoctoral researcher at the School of Biomedical Sciences (SBMS) of The University of Queensland. I am a physiologist first and foremost with a particular interest in understanding how skeletal muscle cell normally functions so as to try and elucidate what changes or factors contribute to various forms of muscle weakness with ageing, inactivity or various chronic diseases.
During my previous postdoctoral appointment at La Trobe University (Melbourne, 2010-2017), I have gained considerable experience using the "mechanically skinned muscle fibre" technique in animal muscle. Importantly, I have developed this technique for the first time in human muscle which allows the exciting opportunity to investigate cellular mechanisms of muscle weakness in different clinical population. This is vitally important since most of our existing knowledge on muscle function comes from studies on muscles obtained from animal models. This technical breakthrough has been recognized by editorials of different leading scientific journals in the field of Physiology. I’m now a world recognized expert of this technique which has immense potential for examining any number of physiological questions and even allows for biochemical analyses of any protein of interest in the same cell.
Faculty of Engineering, Architecture and Information Technology
Availability:
Available for supervision
Dr T. Thang Vo-Doan is a Lecturer of the School of Mechanical and Mining Engineering at the University of Queensland. He was a postdoctoral researcher at the Institute of Biology I, University of Freiburg, Germany (2019-2023). He was also a Research Fellow at Nanyang Technological University (NTU), Singapore (2016-2018). He was awarded his PhD in Mechanical Engineering from the School of Mechanical & Aerospace Engineering, NTU in 2016. He received his M.Eng. degree in Manufacturing Engineering and B.Eng. degree in Mechanical Engineering from Ho Chi Minh City University of Technology, Vietnam in 2010 and 2008 respectively. He was awarded the prestigious Human Frontier Science Program Cross-disciplinary Fellowship (2019-2022).
He directs the UQ Biorobotics lab after joining in the University of Queensland. Current research activities of the lab focus on insect-machine hybrid robots, bio-inspired robotics, insect structures and functions, biomechanics, fast lock-on tracking, and brain imaging in untethered insects.
Dr Melanie White heads the Dynamics of Morphogenesis Lab at the Institute for Molecular Bioscience (IMB), University of Queensland and is an ARC Future Fellow. She completed a PhD in Neuroscience at University College London followed by postdoctoral research at The University of Edinburgh. During this time Mel engineered viruses to modulate gene expression in the brain to investigate neuronal function and as a therapeutic approach for neurodegenerative disease. Her work was published in Neuron and PNAS, featured in Nature Reviews Neuroscience and received extensive international media coverage (including the BBC and The Guardian).
In 2012 Mel switched fields to apply quantitative imaging in developmental biology. Her work revealed key mechanisms driving the earliest morphogenetic events in mammalian embryogenesis and was published in Cell, Science, Nature Cell Biology, Developmental Cell and Nature Protocols. Her research was featured on the cover of multiple journals including Cell and she was awarded the inaugural American Society for Cell Biology Porter Prize for Research Excellence (2018).
In 2020, Mel joined the IMB where she will combine her passion for neuroscience and developmental biology to investigate the dynamics of neural tube morphogenesis.
Research overview
The brain and the spinal cord control most of the functions of the body and the mind, yet the dynamics of how they first form is poorly understood. Both structures arise from a common precursor, the neural tube, which forms very early in embryonic development. To generate the forces that sculpt and shape the neural tube, changes in cellular architecture must be tightly coordinated in space and time. These morphological rearrangements occur concurrently with biochemical signalling pathways that specify early neural cell fates.
Our research aims to understand how cellular properties and transcriptional regulators interact with mechanical forces in real time to direct vertebrate neural tube formation and neural cell fate specification. We study the dynamics of neural tube formation by applying advanced imaging technologies in transgenic avian models and human stem cell models.
