Queensland Alliance for Agriculture and Food Innovation
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Dr. Nguyen is an expert in applying long-read Oxford Nanopore Sequencing Technologies (ONT) in agriculture, particularly livestock and other sectors. Her groundbreaking contributions include being the pioneer in sequencing the genomes of Brahman and Wagyu cattle, developing an innovative epigenetic clock for age prediction in cattle, and successfully implementing ONT portable sequencers for Blockchain traceability systems in Australia.
As a leader in the field, Dr. Nguyen spearheads the use of ONT long-read technology to scaffold genome assemblies in livestock, plants, protists, and insects. Her multidisciplinary expertise in molecular biology, advanced genomics, and animal sciences also empowers her to explore causative markers for commercial SNP arrays and identify significant DNA variants from low-coverage sequencing data sets.
Dr. Nguyen's exceptional achievements and expertise have been acknowledged through the prestigious ARC Industry Fellowship, recognising her as a promising early career researcher. Her work has significantly contributed to advancing genomic research in agriculture and has opened new avenues for utilising ONT sequencing technologies across diverse domains.
Dr Quan Nguyen is a Group Leader at the Institute for Molecular Bioscience (IMB), The University of Queensland. He is leading the Genomics and Machine Learning (GML) lab to study neuroinflammation and cancer-immune cells at single-cell resolution and within spatial morphological tissue context. His research interest is about revealing gene and cell regulators that determine the states of the complex cancer and neuronal ecosystems. Particularly, he is interested in quantifying cellular diversity and the dynamics of cell-cell interactions within the tissues to find ways to improve cancer diagnosis or cell-type specific treatments or the immunoinflammation responses that cause neuronal disease.
Using machine learning and genomic approaches, his group are integrating single-cell spatiotemporal sequencing data with tissue imaging data to find causal links between cellular genotypes, tissue microenvironment, and disease phenotypes. GML lab is also developing experimental technologies that enable large-scale profiling of spatial gene and protein expression (spatial omics) in a range of cancer tissues (focusing on brain and skin cancer) and in mouse brain and spinal cord.
Dr Quan Nguyen completed a PhD in Bioengineering at the University of Queensland in 2013, postdoctoral training in Bioinformatics at RIKEN institute in Japan in 2015, a CSIRO Office of Chief Executive (OCE) Research Fellowship in 2016, an IMB Fellow in 2018, an Australian Research Council DECRA fellowship (2019-2021), and is currently a National Health and Medical Research Council leadership fellow (EL2). He has published in top-tier journals, including Cell, Cell Stem Cell, Nature Methods, Nature Protocols, Nature Communications, Genome Research, Genome Biology and a prize-winning paper in GigaScience. In the past three years, he has contributed to the development of x8 open-source software, x2 web applications, and x4 databases for analysis of single-cell data and spatial transcriptomics. He is looking for enthusiastic research students and research staff to join his group.
Career Summary: 2009: PhD, University of Michigan, USA with training in cardiac physiology, modelling myocardial ischemia in vivo and in vitro, and development of therapeutic approaches for myocardial ischemia; 2009–2015: Postdoctoral Research Fellow, University of Washington, Institute for Stem Cell and Regenerative Medicine, USA with training in stem cell biology, genomics, genome editing, and cell therapeutics for ischemic heart disease; 2015–current: Group Leader, University of Queensland (UQ), Institute for Molecular Bioscience; 2022-current: Associate Professor, UQ; 2018–2021 and 2023-2026: National Heart Foundation Future Leader Fellow. Dr. Palpant’s research team has expertise in human stem cell biology, computational genomics, and cardiac physiology, which enables them to translate outcomes from cell biology and genomics to disease modelling, drug discovery, and preclinical modelling.
I am a molecular virologist and postdoctoral research fellow in Prof. Alexander Khromykh's laboratory, specialising in virus evolution, virus bioinformatics, and reverse genetics.
My research journey began with a Bachelor of Science, First Class Honours in Molecular Biology from The University of Queensland (2015). I then pursued my PhD (2016-2021) at UQ's School of Biology under Prof. Sassan Asgari, where I analysed the virome and microbiome of Aedes aegypti and Aedes albopictus mosquitoes, focusing on their interactions with Wolbachia pipientis infections.
Since 2021, I have been a postdoctoral researcher in Prof. Alexander Khromykh's RNA Virology lab. Here, I contributed to developing the SARS-CoV-2 circular polymerase extension reaction (CPER) reverse-genetics methodology. As a physical containment 3 (PC3) researcher, I examine the virological properties of Flaviviruses and SARS-CoV-2 viruses under stringent PC3 conditions. Recently, with support from Therapeutic Innovation Australia and the Australian Infectious Diseases Research Centre, I have been utilising the Kunjin virus replicon system as a versatile and durable self-replicating RNA platform for vaccine and protein replacement therapy.
Beyond my virology work, I actively provide bioinformatics and phylogenetics support within UQ and internationally. Let's connect if you’re interested in collaborating on differential gene and ncRNA expression analysis, ATAC-sequencing, ancestral state prediction, virus discovery, or microbiome analyses.
I am also on the organising committee of MicroSeq (2023-2024), an Australasian Microbiology conference focused on microbial sequencing promoting PhD students and early career researchers. Additionally, I am an incoming Ex Officio member of the Australian Society for Microbiology (ASM) Queensland branch.
My group's research uses large-scale genomic data to address knowledge gaps in disease, with a particular focus on cardiovascular disease.
Research programme
1. Cardiovascular disease research using big-data and genomics: with the goal of improving prevention and treatment of cardiovascular disease. By focusing on underrepresented groups, including women, my research aims to also address inequity in cardiovascular outcomes. I am the lead of the South Asian Genes and Health in Australia (SAGHA) study, which aims to increase representation of Australian South Asians in cardiovascular and genomics research. See saghaus.org for further details.
2. Drug genomics: I'm interested in using genomic approaches to predict drug effects, including identification of drug repurposing opportunities as well as identifying unknown adverse effects of medication.
3. Liver transplant research: In this collaboration with the QLD Liver Transplant Unit, we are using genomics to understand the effect of normo-thermic perfusion (a new organ storage method) on liver function, with the long-term goal of improving our ability to predict transplant outcomes.
Career summary: I was awarded my PhD from University College London (UK) in cardiovascular genetics. I began my post-doctoral fellowship under the mentorship of Prof Peter Visscher at the Queensland Brain Institute in 2013. Between 2016-2018, I was the lead analyst for the International Heart Failure Genetics Consortium (HERMES). In 2018, I was awarded an NHMRC Early Career Researcher Fellowship to investigate the relationship between cardiovascular and brain-related disorders using large-scale genetic and genomic data, under the mentorship of Prof Naomi Wray. I currently hold a National Heart Foundation Future Leader Fellowship.
Recognition:
2024 Australian Academy of Science Ruth Stephens Gani Medal for outstanding contribution to genetics research
2023 1 of 5 global finalists for the Nature Inspiring Women in Science (Scientific Achievement Award)
2023 Lifesciences QLD Rose-Anne Kelso Award
2023: Named in Australia's Top 25 Women in Science by Newscorp
2022 Queensland Young Tall Poppy Award
2022 UQ Foundation Research Excellence Award
2021/2022 Australian Superstar of STEM,
2020 Genetic Society of Australasia Early Career Award
2020 Women in Technology Rising Star Science Award
Dr Shapter's background was originally in Agricultural Science and higher education which evolved to the completion of her PhD in molecular genetics in 2008. Prior to her current appointments she was the senior researcher on ARC linkage, Australian Flora Foundation and RIRDC research grants looking at the genetic foundations of domestication and adaptation in Australian native grasses. She supervised two HDR students and has a strong publication record in this field. Her research interests centre on identifying and developing practical applications for gene sequencing. Fran is passionate about teaching and has worked as a facilitator commercially and trained early career researchers and PhD candidates in Project Management, IP and commercialisation and Leadership. She was a participant in the 2020 summit and was appointed to the federal advisory Rural R&D Council in 2009. Dr Shapter was also a sitting member of the Office of the Gene Technology Regulator's Ethics and Community Consultative Committee, 2016-2020.
Fran began tutoring at the UQ School of Veterinary Science in 2011, in large animal production, parasitology and microbiology. Since then she has held a variety of teaching, research and professional roles based around project management, curriculum design and blended learning design. She was the project manager for a Scholarship of Teaching and Learning (SoTL) grant which developed 40 vertically and horizontally integrated, online, adaptive tutorials for veterinary science students and was co-author on the manual developed by this project. She assisted with the development of a new flexible delivery laboratory animal science course in 2015 and delivers 5 weeks of online learning units into this course currently. She has been part of the SoTL research and evaluation associated with both these projects and has reported outcomes at University showcases annually since 2016.
In 2017 Fran became the new Student Clinical Skills Hub Coordinator, a purpose-built, state-of-the-art self-directed learning facility for students of veterinary science. Whilst undertaking this role student usage, resource availability and online support for the Hub has increased more than tenfold. Fran's aim is to provide a safe, authentic, self-directed learning environment where students can practice their clinical skills in accordance with individual competences, beyond the scheduled contact hours of their programs and further enhance their capacity for self-directed, lifelong learning whilst acknowledging the vast array of qualifications, previous training, life experience and cultural backgrounds each student brings with them to the Hub.In 2020 Fran recieved a UQ Teaching Excellence Award due to the demonstarted impact of the SVS Student Clinical Skills Hub.
In 2019 Fran was appointed as a Lecturer in Veterinary Science, while continuing her role as the Hub's coordinator. She continues to maintain her teaching roles into the veterinary program in animal handling, animal production, reproduction, microbiology, parasitology and plant identification. Fran has an additional role in the School with regard to asissting with the design, development and integration of blended learning resources, after working with the Science faculties blended learning design team in 2018. However her SoTL portfolio is best showcased by the development of the online learning community and training resources she has developed for the Student Clinical Skills Hub. As of June 2021, Fran has also taken on the role of the School of Veterinary Science Honours Program Coordinator.
RESEARCH INTERESTS Fire Ecology, Ecological Genomics, Wildlife Ecology, Conservation Biology, Invasive Plants
My research group studies fire ecology and conservation biology. Currently, we are working on:
Managing interactions between changing fire regimes and invasive plants
Influence of changing fire regimes on plant-animal interactions
Restoration of native grassland
Biodiversity in agricultural landscapes
Platypus distribution & conservation
We have a special interest in plants and animals living in fire-prone areas because of the fascinating fact that these ecosystems are never static but continually re-shaped by cycles of fire and regeneration. While being grounded in fundamental biology and ecological theory, our research is always aimed at improving knowledge for biodiversity conservation. Our work has applications in fire management, biological invasion and threatened species conservation.
TECHNICAL APPROACHES: POPULATION GENETICS | SPATIAL LANDSCAPE GENETICS | DEMOGRAPHIC SIMULATION MODELLING | STATISTICAL MODELLING OF POPULATIONS & COMMUNITIES | BIOINFORMATICS | SPATIAL ANALYSIS IN R | We also know how to drop a hand-made 1 x 1 m polypipe quadrat on the ground and do good old-fashioned field work.
TEACHING: I teach ecology and wildlife science. At UQ I have coordinated and taught AGRC1032 Elements of Ecology and ANIM3018 Wildlife Technology for four years, among other teaching duties.
EDITORIAL I am Associate Editor for Wildlife Letters (2023–)
I was Associate Editor for Journal of Applied Ecology for four years (2018–2022).
CURRICULUM VITAE
2019 – current Lecturer, University of Queensland
2018 – 2022 Associate Editor, Journal of Applied Ecology
2018 – 2019 Marie Skłodowska-Curie Research Fellow, Trinity College Dublin
2016 – 2017 Post-doctoral Research Fellow, Trinity College Dublin
2015 – 2016 Post-doctoral Research Assistant, University of Melbourne
My research interests are at the intersection of plant developmental genetics, functional genomics, and molecular and systems biology, following my doctoral and postdoctoral training in the USA. The research effort in my group is focused on harnessing transformative genomics technology to understand the genetics of plant development, and to discover regulatory mechanisms coordinating plant growth and development. We utilize a variety of plant species in our research, from the model plant organism Arabidopsis to grain and horticultural crops like wheat, mango, avocado and macadamia. We employ a range of techniques based on high throughout DNA sequencing to explore gene expression, chromatin accessibility and modifications from single cell to whole plant levels, bioinformatics and computational biology tools to infer genetic components of gene regulatory networks, as well as gene editing technology to evaluate phenotipic consequences of perturbations in gene regulatory networks.
I have a keen interest in the evolutionary relationships that underpin symbioses, particularly those involved in plant disease. There are countless examples of how diseases have impacted on different crops throughout history, and this is an ongoing issue that deleteriously impacts food security. My research involves developing a better understanding of the epidemiology of plant diseases and pests, and delivering improved diagnostics and field management. Working with collaborators and international experts, my work involves research on a broad range of plants that are affected by bacteria, fungi, oomycetes and viruses. I have a strong interest in the biotic factors that govern soil health and the methods by which we can promote the development of beneficial microbial communities.
Dr Jian Zeng is a statistical geneticist and NHMRC Emerging Leadership Fellow at the Institute for Molecular Bioscience (IMB) at the University of Queensland (UQ). He received his PhD in animal breeding and genetics at Iowa State University and joined the Program in Complex Trait Genomics (PCTG) at UQ in 2016. His research focuses on the development and application of innovative statistical methods for estimating the genetic architecture and evolutionary signals in complex traits, identifying genetic variants, genes and other molecular intermediates associated with phenotype variation, and predicting trait phenotypes using genome sequence data. In 2019, he was awarded an NHMRC Investigator Emerging Leadership Grant to develop statistical methods and software tools for best predict an individual’s disease risk using genomic and omics data. He was an invited speaker at the prestigious Gordon Research Conference in 2019.
