Dr

Sara Thygesen

Email: 
Phone: 
+61 7 336 59769

Availability

Dr Sara Thygesen is:
Available for supervision

Qualifications

  • Bachelor, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Sara Thygesen’s works on UQ eSpace

18 works between 2013 and 2024
All (18) Journal Article (13) Book Chapter (1) Conference Publication (3) Other Outputs (1)

1 - 18 of 18 works

2024

Journal Article

Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

Li, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210

Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

2024

Journal Article

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

2024

Journal Article

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

Thygesen, Sara J, Burgener, Sabrina S, Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

2023

Journal Article

Kinetics of severe dengue virus infection and development of gut pathology in mice

Pliego Zamora, Adriana, Kim, Jaehyeon, Vajjhala, Parimala R., Thygesen, Sara J., Watterson, Daniel, Modhiran, Naphak, Bielefeldt-Ohmann, Helle and Stacey, Katryn J. (2023). Kinetics of severe dengue virus infection and development of gut pathology in mice. Journal of Virology, 97 (11) ARTN e0125123, e0125123. doi: 10.1128/jvi.01251-23

Kinetics of severe dengue virus infection and development of gut pathology in mice

2021

Journal Article

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

2020

Journal Article

Manipulation of epithelial cell death pathways by Shigella

Thygesen, Sara J., Pliego‐Zamora, Adriana and Stacey, Katryn J. (2020). Manipulation of epithelial cell death pathways by Shigella. The EMBO Journal, 39 (17), e106202. doi: 10.15252/embj.2020106202

Manipulation of epithelial cell death pathways by Shigella

2019

Journal Article

IRF 1 and IRF 2 regulate the non‐canonical inflammasome

Thygesen, Sara J. and Stacey, Katryn J. (2019). IRF 1 and IRF 2 regulate the non‐canonical inflammasome. EMBO reports, 20 (9) e48891, e48891. doi: 10.15252/embr.201948891

IRF 1 and IRF 2 regulate the non‐canonical inflammasome

2019

Journal Article

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

Thygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

2018

Other Outputs

Inflammasomes and autoimmunity

Thygesen, Sara (2018). Inflammasomes and autoimmunity. PhD Thesis, School of Chemistry & Molecular Biosciences, The University of Queensland. doi: 10.14264/uql.2018.424

Inflammasomes and autoimmunity

2017

Conference Publication

NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

Thygesen, Sara Judith, Sester, David P. and Stacey, Katryn J. (2017). NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa, Japan, 29 October - 2 November 2017. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2017.09.010

NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

2016

Journal Article

Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides

Thygesen, Sara J., Sester, David P., Cridland, Simon O., Wilton, Steve D. and Stacey, Katryn J. (2016). Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides. Immunology and Cell Biology, 94 (5), 520-524. doi: 10.1038/icb.2016.3

Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides

2016

Conference Publication

Cytosolic DNA, HIN-200 proteins and inflammasome activation

Stacey, K. J., Vajjhala, P. R., Sagulenko, V, Thygesen, S., Vitak, N. and Sester, D. P. (2016). Cytosolic DNA, HIN-200 proteins and inflammasome activation. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Cytosolic DNA, HIN-200 proteins and inflammasome activation

2016

Book Chapter

Assessment of inflammasome formation by flow cytometry

Sester, David P., Zamoshnikova, Alina, Thygesen, Sara J., Vajjhala, Parimala R., Cridland, Simon O., Schroder, Kate and Stacey, Katryn J. (2016). Assessment of inflammasome formation by flow cytometry. Current protocols in immunology. (pp. 14.40.1-14.40.29) edited by Coligan, John E., Bierer, Barbara, Margulies, David H., Shevach, Ethan M. and Strober, Warren. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/cpim.13

Assessment of inflammasome formation by flow cytometry

2016

Conference Publication

Inflammasome function in autoimmunity

Thygesen, S. J., Sester, D. P., Sagulenko, V. and Stacey, K. J. (2016). Inflammasome function in autoimmunity. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley-Blackwell.

Inflammasome function in autoimmunity

2015

Journal Article

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.

Sester, David P., Sagulenko, Vitaliya, Thygesen, Sara J., Cridland, Jasmyn A., Loi, Yen Siew, Cridland, Simon O., Masters, Seth L., Genske, Ulrich, Hornung, Veit, Andoniou, Christopher E., Sweet, Matthew J., Degli-Esposti, Mariapia A., Schroder, Kate and Stacey, Katryn J. (2015). Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.. Journal of Immunology, 195 (3), 1233-1241. doi: 10.4049/jimmunol.1402859

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.

2015

Journal Article

A novel flow cytometric method to assess inflammasome formation

Sester, David P., Thygesen, Sara J., Sagulenko, Vitaliya, Vajjhala, Parimala R., Cridland, Jasmyn A., Vitak, Nazarii, Chen, Kaiwen W., Osborne, Geoffrey W., Schroder, Kate and Katryn J. Stacey (2015). A novel flow cytometric method to assess inflammasome formation. The Journal of Immunology, 194 (1), 455-462. doi: 10.4049/jimmunol.1401110

A novel flow cytometric method to assess inflammasome formation

2013

Journal Article

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T., Schroder, K., Vince, J. E., Hill, J. M., Silke, J. and Stacey, K. J. (2013). AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation, 20 (9), 1149-1160. doi: 10.1038/cdd.2013.37

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

2013

Journal Article

Molecular mechanism for p202-mediated specific inhibition of aim2 inflammasome activation

Yin, Qian, Sester, David P., Tian, Yuan, Hsiao, Yu-Shan, Lu, Alvin, Cridland, Jasmyn A., Sagulenko, Vitaliya, Thygesen, Sara J., Choubey, Divaker, Hornung, Veit, Walz, Thomas, Stacey, Katryn J. and Wu, Hao (2013). Molecular mechanism for p202-mediated specific inhibition of aim2 inflammasome activation. Cell Reports, 4 (2), 327-339. doi: 10.1016/j.celrep.2013.06.024

Molecular mechanism for p202-mediated specific inhibition of aim2 inflammasome activation

Availability

Dr Sara Thygesen is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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