Professor Darrell Crawford
Professor

Darrell Crawford

Email: 
Phone: 
+61 7 334 65115

Background

Profile

Professor Darrell Crawford is a clinical academic Hepatologist with a strong international reputation in the field of liver disease.

He has held leadership positions within national and international professional societies relevant to his discipline and within The University of Queensland, including the Head, School of Medicine, and President Asian Pacific Association for Study of the Liver. He was honoured by election as a Foundation Fellow of the American Association for the Study of Liver Disease and received a Distinguished Service Award for service to the Gastroenterological Society of Australia. He has a strong research profile with > 200 publications and book chapters mostly related to disorders of iron metabolism including co-toxic injury with alcohol and fat, mechanisms and therapy of hepatic fibrosis, and treatment of chronic viral hepatitis.

He has played a key role in reshaping the medical program and medical faculty at The University of Queensland in his roles as Head of School, Acting Deputy Executive Dean and Head of the School of Clinical Medicine. He is committed to improving the quality of medical education, ensuring a contemporary curriculum enhancing the student experience and engaging with all staff who contribute to medical teaching at the University of Queensland.

Online Academic Profile:

http://researchers.uq.edu.au/researcher/678

Availability

Professor Darrell Crawford is:
Available for supervision

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians

Search Professor Darrell Crawford’s works on UQ eSpace

386 works between 1989 and 2024
All (386) Journal Article (204) Book Chapter (1) Conference Publication (181)

1 - 20 of 386 works

2024

Journal Article

Identification and characterization of TM4SF1+ tumor self-seeded cells

Yang, Haotian, Wang, Haolu, He, Yaowu, Yang, Yang, Thompson, Erik W., Xia, Di, Burke, Leslie J., Cao, Lu, Hooper, John D., Roberts, Michael S., Crawford, Darrell H.G. and Liang, Xiaowen (2024). Identification and characterization of TM4SF1+ tumor self-seeded cells. Cell Reports, 43 (7) 114512, 114512. doi: 10.1016/j.celrep.2024.114512

Identification and characterization of TM4SF1+ tumor self-seeded cells

2024

Journal Article

Molecular epidemiology of hepatitis B among Indigenous Australians in Queensland and the Torres Strait Islands

Littlejohn, Margaret, Jaskowski, Lesley-Anne, Edwards, Ros, Jackson, Kathy, Yuen, Lilly, Crawford, Darrel, Locarnini, Stephen A. and Cooksley, Graham (2024). Molecular epidemiology of hepatitis B among Indigenous Australians in Queensland and the Torres Strait Islands. Internal Medicine Journal, 54 (1), 129-138. doi: 10.1111/imj.16166

Molecular epidemiology of hepatitis B among Indigenous Australians in Queensland and the Torres Strait Islands

2023

Journal Article

A salivary biomarker panel to detect liver cirrhosis

Trevisan França de Lima, Lucas, Crawford, Darrell H. G., Broszczak, Daniel A., Zhang, Xi, Bridle, Kim R. and Punyadeera, Chamindie (2023). A salivary biomarker panel to detect liver cirrhosis. iScience, 26 (7) 107015, 107015. doi: 10.1016/j.isci.2023.107015

A salivary biomarker panel to detect liver cirrhosis

2023

Conference Publication

Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer

Ruan, Qi, Cao, Lu, Yang, Haotian, Burke, Leslie, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2023). Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer. EASL Congress 2023, Vienna, Austria, 21 - 24 June 2023. Amsterdam, Netherlands: Elsevier.

Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer

2023

Journal Article

The impact of posttraumatic stress disorder on upper gastrointestinal investigations in Australian Defence Force veterans: a retrospective review

Crawford, Darrell H. G., Mellor, Rebecca, Duenow, Patrick and Connelly, Luke B. (2023). The impact of posttraumatic stress disorder on upper gastrointestinal investigations in Australian Defence Force veterans: a retrospective review. Internal Medicine Journal, 53 (5), 841-844. doi: 10.1111/imj.16088

The impact of posttraumatic stress disorder on upper gastrointestinal investigations in Australian Defence Force veterans: a retrospective review

2023

Journal Article

Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver

Crawford, Darrell H. G., Ramm, Grant A., Bridle, Kim R., Nicoll, Amanda J., Delatycki, Martin B. and Olynyk, John K. (2023). Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver. Hepatology International, 17 (3), 522-541. doi: 10.1007/s12072-023-10510-3

Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver

2022

Journal Article

Remembering Lawrie Powell 1934-2022

Farrell, Geoff, Crawford, Darrell and Anderson, Greg (2022). Remembering Lawrie Powell 1934-2022. Journal of Gastroenterology and Hepatology, 37 (11), 2193-2194. doi: 10.1111/jgh.16031

Remembering Lawrie Powell 1934-2022

2022

Journal Article

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

2022

Journal Article

Polypharmacy in Australian veterans with post-traumatic stress disorder upon admission to a mental health facility: A retrospective chart review

Mellor, Rebecca, Khoo, Andrew, Saunders-Dow, Elise, Raguz, Ella, Taing, Meng-Wong, Hanjani, Leila Shafiee, Freeman, Chris and Crawford, Darrell (2022). Polypharmacy in Australian veterans with post-traumatic stress disorder upon admission to a mental health facility: A retrospective chart review. Drugs - Real World Outcomes, 9 (3), 347-357. doi: 10.1007/s40801-022-00298-3

Polypharmacy in Australian veterans with post-traumatic stress disorder upon admission to a mental health facility: A retrospective chart review

2022

Journal Article

Post‐traumatic stress disorder is associated with a higher rate of polypectomy independent of an increased frequency of colonoscopy in Australian veterans – a retrospective review

Crawford, Darrell H.G., Mellor, Rebecca, Teo, Andrew, Duenow, Patrick and Connelly, Luke B (2022). Post‐traumatic stress disorder is associated with a higher rate of polypectomy independent of an increased frequency of colonoscopy in Australian veterans – a retrospective review. Internal Medicine Journal, 53 (8), 1423-1428. doi: 10.1111/imj.15818

Post‐traumatic stress disorder is associated with a higher rate of polypectomy independent of an increased frequency of colonoscopy in Australian veterans – a retrospective review

2022

Journal Article

Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis

Butcher, Daniel A., Brandis, Kelli J., Wang, Haolu, Spannenburg, Liam, Bridle, Kim R., Crawford, Darrell HG. and Liang, Xiaowen (2022). Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis. European Journal of Surgical Oncology, 48 (3), 621-631. doi: 10.1016/j.ejso.2021.09.017

Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis

2022

Journal Article

APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis

You, Hong, Ma, Xiong, Efe, Cumali, Wang, Guiqiang, Jeong, Sook-Hyang, Abe, Kazumichi, Duan, Weijia, Chen, Sha, Kong, Yuanyuan, Zhang, Dong, Wei, Lai, Wang, Fu-Sheng, Lin, Han-Chieh, Yang, Jin Mo, Tanwandee, Tawesak, Gani, Rino A., Payawal, Diana A., Sharma, Barjesh C., Hou, Jinlin, Yokosuka, Osamu, Dokmeci, A. Kadir, Crawford, Darrell, Kao, Jia-Horng, Piratvisuth, Teerha, Suh, Dong Jin, Lesmana, Laurentius A., Sollano, Jose, Lau, George, Sarin, Shiv K. ... Jia, Jidong (2022). APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis. Hepatology International, 16 (1), 1-23. doi: 10.1007/s12072-021-10276-6

APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis

2022

Journal Article

CD73 and PD-L1 as potential therapeutic targets in gallbladder cancer

Cao, Lu, Bridle, Kim R., Shrestha, Ritu, Prithviraj, Prashanth, Crawford, Darrell H. G. and Jayachandran, Aparna (2022). CD73 and PD-L1 as potential therapeutic targets in gallbladder cancer. International Journal of Molecular Sciences, 23 (3) 1565, 1565. doi: 10.3390/ijms23031565

CD73 and PD-L1 as potential therapeutic targets in gallbladder cancer

2021

Journal Article

Investigation of C reactive Protein and AIM2 Methylation as a marker for PTSD in Australian Vietnam veterans

McD Young, Ross, Lawford, Bruce, Mellor, Rebecca, Morris, Charles P, Voisey, Joanne, on behalf of the PTSD Initiative, McLeay, Sarah, Harvey, Wendy, Romaniuk, Madeline, Crawford, Darrell, Colquhoun, David, McD Young, Ross, Dwyer, Miriam, Gibson, John, O'Sullivan, Robyn, Cooksley, Graham, Strakosch, Christopher, Thomson, Rachel, Voisey, Joanne and Lawford, Bruce (2021). Investigation of C reactive Protein and AIM2 Methylation as a marker for PTSD in Australian Vietnam veterans. Gene, 803 145898, 1-6. doi: 10.1016/j.gene.2021.145898

Investigation of C reactive Protein and AIM2 Methylation as a marker for PTSD in Australian Vietnam veterans

2021

Journal Article

Gene expression analysis in three posttraumatic stress disorder cohorts implicates inflammation and innate immunity pathways and uncovers shared genetic risk with major depressive disorder

Garrett, Melanie E., Qin, Xue Jun, Mehta, Divya, Dennis, Michelle F., Marx, Christine E., Grant, Gerald A., Stein, Murray B., Kimbrel, Nathan A., Beckham, Jean C., Hauser, Michael A., Ashley-Koch, Allison E., Brancu, Mira, Calhoun, Patrick S., Dedert, Eric, Elbogen, Eric B., Fairbank, John A., Hurley, Robin A., Kilts, Jason D., Kirby, Angela, Martindale, Sara, McDonald, Scott D., Moore, Scott D., Morey, Rajendra A., Naylor, Jennifer C., Rowland, Jared, Shura, Robert, Swinkels, Cindy, Szabo, Steven T., Taber, Katherine H. ... Lawford, Bruce (2021). Gene expression analysis in three posttraumatic stress disorder cohorts implicates inflammation and innate immunity pathways and uncovers shared genetic risk with major depressive disorder. Frontiers in Neuroscience, 15 678548. doi: 10.3389/fnins.2021.678548

Gene expression analysis in three posttraumatic stress disorder cohorts implicates inflammation and innate immunity pathways and uncovers shared genetic risk with major depressive disorder

2021

Journal Article

Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways

Crawford, Darrell H.G., Ross, Diana G.F., Jaskowski, Lesley-Anne, Burke, Leslie J., Britton, Laurence J., Musgrave, Nick, Briskey, David, Rishi, Gautam, Bridle, Kim R. and Subramaniam, V. Nathan (2021). Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1867 (7) 166142, 166142. doi: 10.1016/j.bbadis.2021.166142

Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways

2021

Journal Article

Liver organoid as a 3D in vitro model for drug validation and toxicity assessment

Brooks, Anastasia, Liang, Xiaowen, Zhang, Yonglong, Zhao, Chun-Xia, Roberts, Michael S., Wang, Haolu, Zhang, Lei and Crawford, Darrell H.G. (2021). Liver organoid as a 3D in vitro model for drug validation and toxicity assessment. Pharmacological Research, 169 105608, 105608. doi: 10.1016/j.phrs.2021.105608

Liver organoid as a 3D in vitro model for drug validation and toxicity assessment

2021

Journal Article

Self-reported liver disorders in Australian Vietnam War veterans

Wang, H., Liang, X., Bridle, K. and Crawford, D. (2021). Self-reported liver disorders in Australian Vietnam War veterans. Journal of Military and Veterans Health, 29 (3), 43-51.

Self-reported liver disorders in Australian Vietnam War veterans

2021

Journal Article

Dual targeting of sorafenib-resistant HCC-derived cancer stem cells

Shrestha, Ritu, Bridle, Kim R., Cao, Lu, Crawford, Darrell H. G. and Jayachandran, Aparna (2021). Dual targeting of sorafenib-resistant HCC-derived cancer stem cells. Current Oncology, 28 (3), 2150-2172. doi: 10.3390/curroncol28030200

Dual targeting of sorafenib-resistant HCC-derived cancer stem cells

2021

Journal Article

Australian recommendations for the management of hepatocellular carcinoma: a consensus statement

Lubel, John S., Roberts, Stuart K., Strasser, Simone I., Thompson, Alexander J., Philip, Jennifer, Goodwin, Mark, Clarke, Stephen, Crawford, Darrell H. G., Levy, Miriam T. and Shackel, Nick (2021). Australian recommendations for the management of hepatocellular carcinoma: a consensus statement. Medical Journal of Australia, 214 (10), 475-483. doi: 10.5694/mja2.50885

Australian recommendations for the management of hepatocellular carcinoma: a consensus statement

Current funding

  • 2023 - 2025
    A novel proinflammatory mechanism reveals an nnovative therapeutic strategy to treat hepatic inflammation in chronic liver disease (NHRMC Ideas Grant administered by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2021 - 2025
    The IC3 Trial: Identifying Cirrhosis and Liver Cancer in Primary Care (MRFF EPCDR Low Survival Cancers grant led by University of Western Australia)
    University of Western Australia
    Open grant
  • 2014 - 2025
    Liver Disease Research
    Gallipoli Medical Research Foundation
    Open grant

Past funding

  • 2018 - 2020
    Tissue ferritin is a damage-associated molecular pattern (DAMP) in inflammasome-induced inflammation associated with hepatic stellate cell activation and ... (NHMRC Project Grant led by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2017 - 2021
    Physiologically-based pharmacokinetics and pharmacodynamics of therapeutic stem cells for liver disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2020
    SARA: Delineating its Association with the Onset and Development of Liver Fibrosis (NHMRC Project Grant led by Queensland University of Technology)
    Queensland University of Technology
    Open grant
  • 2014 - 2019
    Immunotherapeutic Approaches for Hepatocellular Carcinoma
    Gallipoli Medical Research Foundation
    Open grant
  • 2014 - 2017
    Immunotherapeutic Approaches for Hepatocellular Carcinoma
    Gallipoli Medical Research Foundation
    Open grant
  • 2014
    The role of tumor necrosis factor-alpha in biliary structure formation in vivo
    UQ-Ochsner Seed Fund for Collaborative Research - DVCR funds
    Open grant
  • 2013 - 2016
    Advanced imaging to define hepatic & intestinal drug disposition in aging & liver diseases
    NHMRC Project Grant
    Open grant
  • 2013
    Targeting Pathophysiology & therapy of liver fibrosis
    Gallipoli Research Foundation
    Open grant
  • 2013
    Advanced imaging to define hepatic & intestinal drug disposition in aging & liver diseases (NHMRC Project Grant administered by UniSA)
    University of South Australia
    Open grant
  • 2012 - 2014
    HFE-associated Steatohepatitis: Mechanisms and Therapies
    NHMRC Project Grant
    Open grant
  • 2012 - 2014
    Venesection or expectant management for moderate iron overload in HFE related hereditary haemochromatosis (NHMRC Project Grant administered by Murdoch Childrens Research Institute)
    Murdoch Childrens Research Institute
    Open grant
  • 2011 - 2013
    Targeting the Pathophysiology and Therapy of Liver Fibrosis
    NHMRC Project Grant
    Open grant
  • 2010 - 2017
    Professorial Chair of Military Surgery
    Commonwealth Department of Defence
    Open grant
  • 2009 - 2012
    Mayne Bequest Fund Research Support Award: Factors influencing the efficacy of antifibrotic agents in chronic liver disease
    Mayne Bequest Fund
    Open grant
  • 2007 - 2010
    The pathogenesis of co-toxic liver disease
    Queensland Health Smart Health Research Grant
    Open grant
  • 2006 - 2008
    Reginald Ferguson Research Fellowship - Primary Sclerosing Cholangitis - A Life Threatening Complication of Inflammatory Bowel Disease: Investigations to Attenuate Disease Progression
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2006 - 2007
    The use of rapamycin to slow scarring of the liver
    Royal Children's Hospital Foundation
    Open grant
  • 2006 - 2008
    Altered hepatic pharmacokinetics as a consequence of drug- and disease-induced changes in hepatic vascularity
    NHMRC Project Grant
    Open grant
  • 2006 - 2009
    Immunosuppressant-Mediated Changes in Extracellular Matrix Balance in Animal Models of Liver Disease
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2006
    The Pathogenesis of Co-toxic Liver Disease
    UQ External Support Enabling Grant
    Open grant
  • 2005 - 2007
    Does immunosuppression affect the post-transplantation hepatic fibrogenic response?
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Effect Of Liver Pathophysiology On Hepatic Pharmacokinetics
    NHMRC Project Grant
    Open grant
  • 1996 - 1999
    Milk folate binding protein: enhancement of nutritional bioavailability of folate vitamins
    Dairy Research & Development Corporation
    Open grant

Availability

Professor Darrell Crawford is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma

    Associate Advisor

    Other advisors: Dr Kim Bridle, Dr Xiaowen Liang

  • Doctor Philosophy

    Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver

    Associate Advisor

    Other advisors: Dr Xiaowen Liang, Professor Di Yu

Completed supervision

Enquiries

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