Overview
Background
Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.
Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.
Availability
- Dr Kim Bridle is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Kim Bridle’s works on UQ eSpace
2023
Journal Article
Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers
Balaji, Arunpandian, Bell, Craig A., Houston, Zachary H., Bridle, Kim R., Genz, Berit, Fletcher, Nicholas L., Ramm, Grant A. and Thurecht, Kristofer J. (2023). Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers. Biomaterials, 302 122318, 1-18. doi: 10.1016/j.biomaterials.2023.122318
2023
Journal Article
A salivary biomarker panel to detect liver cirrhosis
Trevisan França de Lima, Lucas, Crawford, Darrell H. G., Broszczak, Daniel A., Zhang, Xi, Bridle, Kim R. and Punyadeera, Chamindie (2023). A salivary biomarker panel to detect liver cirrhosis. iScience, 26 (7) 107015, 107015. doi: 10.1016/j.isci.2023.107015
2023
Conference Publication
Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer
Ruan, Qi, Cao, Lu, Yang, Haotian, Burke, Leslie, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2023). Reactive oxygen species-mediated hepatic stellate cell activation via PI3K in liver cancer. EASL Congress 2023, Vienna, Austria, 21 - 24 June 2023. Amsterdam, Netherlands: Elsevier.
2023
Journal Article
Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver
Crawford, Darrell H. G., Ramm, Grant A., Bridle, Kim R., Nicoll, Amanda J., Delatycki, Martin B. and Olynyk, John K. (2023). Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver. Hepatology International, 17 (3), 522-541. doi: 10.1007/s12072-023-10510-3
2022
Journal Article
Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis
Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163
2022
Journal Article
Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis
Butcher, Daniel A., Brandis, Kelli J., Wang, Haolu, Spannenburg, Liam, Bridle, Kim R., Crawford, Darrell HG. and Liang, Xiaowen (2022). Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis. European Journal of Surgical Oncology, 48 (3), 621-631. doi: 10.1016/j.ejso.2021.09.017
2022
Journal Article
CD73 and PD-L1 as potential therapeutic targets in gallbladder cancer
Cao, Lu, Bridle, Kim R., Shrestha, Ritu, Prithviraj, Prashanth, Crawford, Darrell H. G. and Jayachandran, Aparna (2022). CD73 and PD-L1 as potential therapeutic targets in gallbladder cancer. International Journal of Molecular Sciences, 23 (3) 1565, 1565. doi: 10.3390/ijms23031565
2021
Journal Article
Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways
Crawford, Darrell H.G., Ross, Diana G.F., Jaskowski, Lesley-Anne, Burke, Leslie J., Britton, Laurence J., Musgrave, Nick, Briskey, David, Rishi, Gautam, Bridle, Kim R. and Subramaniam, V. Nathan (2021). Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1867 (7) 166142, 166142. doi: 10.1016/j.bbadis.2021.166142
2021
Journal Article
Self-reported liver disorders in Australian Vietnam War veterans
Wang, H., Liang, X., Bridle, K. and Crawford, D. (2021). Self-reported liver disorders in Australian Vietnam War veterans. Journal of Military and Veterans Health, 29 (3), 43-51.
2021
Journal Article
Dual targeting of sorafenib-resistant HCC-derived cancer stem cells
Shrestha, Ritu, Bridle, Kim R., Cao, Lu, Crawford, Darrell H. G. and Jayachandran, Aparna (2021). Dual targeting of sorafenib-resistant HCC-derived cancer stem cells. Current Oncology, 28 (3), 2150-2172. doi: 10.3390/curroncol28030200
2021
Journal Article
Prognostic role of immune checkpoint regulators in cholangiocarcinoma: a pilot study
Cao, Lu, Prithviraj, Prashanth, Shrestha, Ritu, Sharma, Revati, Anaka, Matthew, Bridle, Kim R., Kannourakis, George, Crawford, Darrell H.G. and Jayachandran, Aparna (2021). Prognostic role of immune checkpoint regulators in cholangiocarcinoma: a pilot study. Journal of Clinical Medicine, 10 (10) 2191, 2191. doi: 10.3390/jcm10102191
2021
Journal Article
Combined inhibition of TGF-β1-induced EMT and PD-L1 silencing re-sensitizes hepatocellular carcinoma to sorafenib treatment
Shrestha, Ritu, Prithviraj, Prashanth, Bridle, Kim R., Crawford, Darrell H. G. and Jayachandran, Aparna (2021). Combined inhibition of TGF-β1-induced EMT and PD-L1 silencing re-sensitizes hepatocellular carcinoma to sorafenib treatment. Journal of Clinical Medicine, 10 (9) 1889, 1889. doi: 10.3390/jcm10091889
2021
Journal Article
Inhibition of MLKL attenuates necroptotic cell death in a murine cell model of ischaemia injury
Baidya, Raji, Gautheron, Jérémie, Crawford, Darrell H. G., Wang, Haolu and Bridle, Kim R. (2021). Inhibition of MLKL attenuates necroptotic cell death in a murine cell model of ischaemia injury. Journal of Clinical Medicine, 10 (2) 212, 1-18. doi: 10.3390/jcm10020212
2021
Journal Article
Immune checkpoint molecules are regulated by transforming growth factor (Tgf)-β1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma
Shrestha, Ritu, Bridle, Kim R., Crawford, Darrell H. G. and Jayachandran, Aparna (2021). Immune checkpoint molecules are regulated by transforming growth factor (Tgf)-β1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma. International Journal of Medical Sciences, 18 (12), 2466-2479. doi: 10.7150/ijms.54239
2020
Journal Article
Assessment and transplantation of orphan donor livers: a back-to-base approach to normothermic machine perfusion
Reiling, Janske, Butler, Nick, Simpson, Andrew, Hodgkinson, Peter, Campbell, Catherine, Lockwood, David, Bridle, Kim, Santrampurwala, Nishreen, Britton, Laurence, Crawford, Darrell, Dejong, Cornelius H. C. and Fawcett, Jonathan (2020). Assessment and transplantation of orphan donor livers: a back-to-base approach to normothermic machine perfusion. Liver Transplantation, 26 (12), 1618-1628. doi: 10.1002/lt.25850
2020
Journal Article
The use of minimally invasive biomarkers for the diagnosis and prognosis of hepatocellular carcinoma
Trevisan França de Lima, Lucas, Broszczak, Daniel, Zhang, Xi, Bridle, Kim, Crawford, Darrell and Punyadeera, Chamindie (2020). The use of minimally invasive biomarkers for the diagnosis and prognosis of hepatocellular carcinoma. Biochimica et Biophysica Acta - Reviews on Cancer, 1874 (2) 188451, 188451. doi: 10.1016/j.bbcan.2020.188451
2020
Journal Article
Necroptosis in hepatosteatotic ischaemia-reperfusion injury
Baidya, Raji, Crawford, Darrell H. G., Gautheron, Jérémie, Wang, Haolu and Bridle, Kim R. (2020). Necroptosis in hepatosteatotic ischaemia-reperfusion injury. International Journal of Molecular Sciences, 21 (16) 5931, 1-29. doi: 10.3390/ijms21165931
2020
Journal Article
TNF-α-mediated epithelial-to-mesenchymal transition regulates expression of immune checkpoint molecules in hepatocellular carcinoma
Shrestha, Ritu, Bridle, Kim R., Crawford, Darrell H.G. and Jayachandran, Aparna (2020). TNF-α-mediated epithelial-to-mesenchymal transition regulates expression of immune checkpoint molecules in hepatocellular carcinoma. Molecular Medicine Reports, 21 (4), 1849-1860. doi: 10.3892/mmr.2020.10991
2020
Journal Article
Association between hereditary hemochromatosis and hepatocellular carcinoma: a comprehensive review
Jayachandran, Aparna, Shrestha, Ritu, Bridle, Kim R. and Crawford, Darrell H. G. (2020). Association between hereditary hemochromatosis and hepatocellular carcinoma: a comprehensive review. Hepatoma Research, 6 8. doi: 10.20517/2394-5079.2019.35
2020
Journal Article
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Ruan, Qi, Wang, Haolu, Burke, Leslie J., Bridle, Kim R., Li, Xinxing, Zhao, Chun-Xia, Crawford, Darrell H. G., Roberts, Michael S. and Liang, Xiaowen (2020). Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma. International Journal of Cancer, 147 (6) ijc.32899, 1519-1527. doi: 10.1002/ijc.32899
Funding
Current funding
Supervision
Availability
- Dr Kim Bridle is:
- Available for supervision
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Available projects
-
Novel Therapies for Co-toxic Liver Disease
This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.
Supervision history
Current supervision
-
Doctor Philosophy
Ferroptosis: a novel layer of regulation for T cell homeostasis and function
Associate Advisor
Other advisors: Dr Joseph Yunis, Dr Zhian Chen, Professor Di Yu
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Associate Advisor
Other advisors: Professor Darrell Crawford, Dr Xiaowen Liang
Completed supervision
-
2023
Doctor Philosophy
Attenuation of Liver Injury in Iron-Related Liver Disease
Principal Advisor
Other advisors: Professor Darrell Crawford
-
2021
Doctor Philosophy
Improving Graft Outcomes in Liver Transplantation: Necroptosis in Steatotic Liver Ischaemia Reperfusion Injury
Principal Advisor
Other advisors: Professor Darrell Crawford
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Xiaowen Liang, Dr Haolu Wang
-
2018
Doctor Philosophy
Interactions between iron and fat in non-alcoholic fatty liver disease
Associate Advisor
Other advisors: Professor Darrell Crawford
-
2017
Doctor Philosophy
Optimising outcomes after liver transplantation. Pathophysiology of biliary injury and the application of machine perfusion
Associate Advisor
Other advisors: Professor Darrell Crawford
-
2016
Doctor Philosophy
Hfe-associated Steatohepatitis:Expression Profiling and Identifying the Molecular Basis of Liver Injury
Associate Advisor
Other advisors: Honorary Professor Nathan Subramaniam, Professor Darrell Crawford
-
2014
Doctor Philosophy
Evolution of Fibrosis, Antifibrotic Therapies and Mechanisms of Iron Homeostasis in the Mdr2-/- Mouse Model of Hepatic Fibrogenesis
Associate Advisor
Other advisors: Professor Darrell Crawford, Honorary Professor Nathan Subramaniam
-
2010
Doctor Philosophy
Investigation of hepatic glucose metabolism
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald
Media
Enquiries
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