Overview
Background
Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.
Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.
Availability
- Dr Kim Bridle is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Kim Bridle’s works on UQ eSpace
2020
Journal Article
Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury
Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900
2019
Journal Article
Immune checkpoint blockade therapies for HCC: current status and future implications
Shrestha, Ritu, Bridle, Kim R., Crawford, Darrell H. G. and Jayachandran, Aparna (2019). Immune checkpoint blockade therapies for HCC: current status and future implications. Hepatoma Research, 2019 (5) 32. doi: 10.20517/2394-5079.2019.24
2019
Journal Article
Interleukin-33 / Cyclin D1 imbalance in severe liver steatosis predicts susceptibility to ischemia reperfusion injury
Núñez, Kelley G., Frank, Anderson, Gonzalez-Rosario, Janet, Galliano, Gretchen, Bridle, Kim, Crawford, Darrell, Seal, John, Abbruscato, Frank, Vashistha, Himanshu, Thevenot, Paul T. and Cohen, Ari J. (2019). Interleukin-33 / Cyclin D1 imbalance in severe liver steatosis predicts susceptibility to ischemia reperfusion injury. PLoS One, 14 (4) e0216242, e0216242. doi: 10.1371/journal.pone.0216242
2019
Conference Publication
Tumor necrosis factor-alpha promotes epithelial-to-mesenchymal transition and expression of immune checkpoint molecules in hepatocellular carcinoma
Shrestha, R., Bridle, K., Cao, L., Crawford, D. and Jayachandran, A. (2019). Tumor necrosis factor-alpha promotes epithelial-to-mesenchymal transition and expression of immune checkpoint molecules in hepatocellular carcinoma. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “The Universe Within”, Adelaide Convention Centre, 8-10 September 2019. Richmond, VIC, Australia: Wiley-Blackwell.
2019
Journal Article
Spotlight on Bortezomib: potential in the treatment of hepatocellular carcinoma
Huang, I-Tao, Dhungel, Bijay, Shrestha, Ritu, Bridle, Kim R., Crawford, Darrell H. G., Jayachandran, Aparna and Steel, Jason C (2019). Spotlight on Bortezomib: potential in the treatment of hepatocellular carcinoma. Expert Opinion on Investigational Drugs, 28 (1), 7-18. doi: 10.1080/13543784.2019.1551359
2019
Conference Publication
Enrichment of multiple immune checkpoints in cholangiocarcinoma cancer stem cells
Cao, L., Shrestha, R., Bridle, K., Crawford, D. and Jayachandran, A. (2019). Enrichment of multiple immune checkpoints in cholangiocarcinoma cancer stem cells. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “The Universe Within”, Adelaide Convention Centre, 8-10 September 2019. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/jgh.14797
2019
Conference Publication
Attenuation of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain like pseudokinase (MLKL) blocks the TRIF-RIPK3-MLKL-driven necroptotic cell death in steatotic hepatocytes undergoing ischemic injury
Baidya, R., Jaskowski, L., Gautheron, J., Jayachandran, A., Wang, H., Thevenot, P., Cohen, A., Crawford, D. and Bridle, K. (2019). Attenuation of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain like pseudokinase (MLKL) blocks the TRIF-RIPK3-MLKL-driven necroptotic cell death in steatotic hepatocytes undergoing ischemic injury. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “The Universe Within”, Adelaide Convention Centre, 8-10 September 2019. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/jgh.14798
2018
Journal Article
Exosome-based liquid biopsy in the management of hepatocellular carcinoma
Jayachandran, Aparna, Manda, Sasidhar Venkata, Shrestha, Ritu, Bridle, Kim R., Prithviraj, Prashanth and Crawford, Darrell H. G. (2018). Exosome-based liquid biopsy in the management of hepatocellular carcinoma. Hepatoma Research, 4 (8) 44, 44. doi: 10.20517/2394-5079.2018.59
2018
Journal Article
Monitoring immune checkpoint regulators as predictive biomarkers in hepatocellular carcinoma
Shrestha, Ritu, Prithviraj, Prashanth, Anaka, Matthew, Bridle, Kim R., Crawford, Darrell H. G., Dhungel, Bijay, Steel, Jason C. and Jayachandran, Aparna (2018). Monitoring immune checkpoint regulators as predictive biomarkers in hepatocellular carcinoma. Frontiers in Oncology, 8 (JUL) 269, 269. doi: 10.3389/fonc.2018.00269
2018
Journal Article
Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease
Britton, Laurence, Bridle, Kim, Reiling, Janske, Santrampurwala, Nishreen, Wockner, Leesa, Ching, Helena, Stuart, Katherine, Subramaniam, V Nathan, Jeffrey, Gary, St Pierre, Tim, House, Michael, Gummer, Joel, Trengove, Robert, Olynyk, John, Crawford, Darrell and Adams, Leon (2018). Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease. Hepatology Communications, 2 (6), 644-653. doi: 10.1002/hep4.1190
2018
Journal Article
Ferroportin expression in adipocytes does not contribute to iron homeostasis or metabolic responses to a high calorie diet
Britton, Laurence, Jaskowski, Lesley-Anne, Bridle, Kim, Secondes, Eriza, Wallace, Daniel, Santrampurwala, Nishreen, Reiling, Janske, Miller, Gregory, Mangiafico, Salvatore, Andrikopoulos, Sofianos, Subramaniam, V. Nathan and Crawford, Darrell (2018). Ferroportin expression in adipocytes does not contribute to iron homeostasis or metabolic responses to a high calorie diet. CMGH, 5 (3), 319-331. doi: 10.1016/j.jcmgh.2018.01.005
2018
Journal Article
Iron inhibits the secretion of Apolipoprotein E in cultured human adipocytes
Britton, L. J., Bridle, Kim, Jaskowski, Lesley-Anne, He, Jingjing, Ng, Choaping, Ruelcke, Jayde E., Mohamed, Ahmed, Reiling, Janske, Santrampurwala, Nishreen, Hill, Michelle M., Whitehead, Jonathan P., Subramaniam, V. Nathan and Crawford, Darrell H. G. (2018). Iron inhibits the secretion of Apolipoprotein E in cultured human adipocytes. Cellular and Molecular Gastroenterology and Hepatology, 6 (2), 214-217. doi: 10.1016/j.jcmgh.2018.04.005
2018
Conference Publication
Prognostic Impact of Immune Checkpoint Inhibitor Expression and Its Association with Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma
Shrestha, Ritu, Prithiviraj, Prashanth, Bridle, Kim, Anake, Matthew, Crawford, Darrell H. G. and Jayachandran, Aparna (2018). Prognostic Impact of Immune Checkpoint Inhibitor Expression and Its Association with Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma. Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) / Liver Meeting, San Francisco, CA United States, 9-13 November 2018. Hoboken, NJ United States: Wiley.
2018
Conference Publication
Inflammatory Pathways in Adipocytes Are Activated By Ferritin and Iron
Jaskowski, Lesley, Bridle, Kim, Britton, Laurence J., Jayachandran, Apama, Ramm, Grant A. and Crawford, Darrell H. G. (2018). Inflammatory Pathways in Adipocytes Are Activated By Ferritin and Iron. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, San Francisco, CA, United States, 9-13 November 2018. Hoboken, NJ United States: Wiley.
2018
Conference Publication
Comparable Levels of Inflammatory Mediators in Portal Venous Blood Collected from Organ Donors Donating after Circulatory Death and those Donating after Brain Death
Reiling, Janske, Hohenhaus, Daniel M., Sweet, Matt J., Raj, Ashok S., Campbell, Catherine M., Bridle, Kim R., Santrampurwala, Nishreen, Britton, Laurence J., Crawford, Darrell H. G., Dejong, Cornelis H. C. and Fawcett, Jonathan (2018). Comparable Levels of Inflammatory Mediators in Portal Venous Blood Collected from Organ Donors Donating after Circulatory Death and those Donating after Brain Death. 14th World Congress of the International-Pancreas-and-Islet-Transplant-Association (IPITA), Monterey Ca, 24-27 September 2013. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0000543959.06247.92
2018
Conference Publication
Necroptosis Contributes to Cell Death of Steatotic Hepatocytes Following Ischaemic Injury
Baidya, Raji, Jaskowski, Lesley, Jayachandran, Aparna, Thevenot, Paul, Cohen, Ari J., Crawford, Darrell H.G. and Bridle, Kim (2018). Necroptosis Contributes to Cell Death of Steatotic Hepatocytes Following Ischaemic Injury. Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) / Liver Meeting, San Francisco, California, 9-13 November 2018 . Hoboken, NJ, United States: John Wiley & Sons.
2017
Journal Article
The Implications of the Shift Toward Donation After Circulatory Death in Australia
Reiling, Janske, Forrest, Elizabeth, Bridle, Kim R., Britton, Laurence J., Santrampurwala, Nishreen, Crawford, Darrell H. G., Dejong, Cornelis H. C. and Fawcett, Jonathan (2017). The Implications of the Shift Toward Donation After Circulatory Death in Australia. Transplantation Direct, 3 (12) e226, 1-7. doi: 10.1097/TXD.0000000000000743
2017
Conference Publication
Do macrophages play a role in the development of endotoxin-induced biliary injury in rats?
Reiling, J., Bridle, K. B., Schaap, F. G., Jaskowski, L., Santrampurwala, N., Britton, L. J., Campbell, C. M., Damink, S. W. M. Olde, Crawford, D. H. G., Dejong, C. H. C. and Fawcett, J. (2017). Do macrophages play a role in the development of endotoxin-induced biliary injury in rats?. HOBOKEN: WILEY.
2017
Journal Article
The role of macrophages in the development of biliary injury in a lipopolysaccharide-aggravated hepatic ischaemia-reperfusion model
Reiling, J., Bridle, K. R., Schaap, F. G., Jaskowski, L., Santrampurwala, N., Britton, L. J., Campbell, C. M., Jansen, P. L. M., Damink, S. W. M. O., Crawford, D. H. G., Dejong, C. H. C. and Fawcett, J. (2017). The role of macrophages in the development of biliary injury in a lipopolysaccharide-aggravated hepatic ischaemia-reperfusion model. Biochimica et Biophysica Acta, 1864 (4 Pt B), 1284-1292. doi: 10.1016/j.bbadis.2017.06.028
2017
Journal Article
Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
Heritage, Mandy, Jaskowski, Lesley, Bridle, Kim, Campbell, Catherine, Briskey, David, Britton, Laurence, Fletcher, Linda, Vitetta, Luis, Subramaniam, V. Nathan and Crawford, Darrell (2017). Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice. World Journal of Gastrointestinal Pathophysiology, 8 (2), 67-76. doi: 10.4291/wjgp.v8.i2.67
Funding
Current funding
Supervision
Availability
- Dr Kim Bridle is:
- Available for supervision
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Available projects
-
Novel Therapies for Co-toxic Liver Disease
This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Associate Advisor
Other advisors: Professor Darrell Crawford, Dr Xiaowen Liang
-
Doctor Philosophy
Ferroptosis: a novel layer of regulation for T cell homeostasis and function
Associate Advisor
Other advisors: Dr Joseph Yunis, Dr Zhian Chen, Professor Di Yu
Completed supervision
-
2023
Doctor Philosophy
Attenuation of Liver Injury in Iron-Related Liver Disease
Principal Advisor
Other advisors: Professor Darrell Crawford
-
2021
Doctor Philosophy
Improving Graft Outcomes in Liver Transplantation: Necroptosis in Steatotic Liver Ischaemia Reperfusion Injury
Principal Advisor
Other advisors: Professor Darrell Crawford
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Xiaowen Liang, Dr Haolu Wang
-
2018
Doctor Philosophy
Interactions between iron and fat in non-alcoholic fatty liver disease
Associate Advisor
Other advisors: Professor Darrell Crawford
-
2017
Doctor Philosophy
Optimising outcomes after liver transplantation. Pathophysiology of biliary injury and the application of machine perfusion
Associate Advisor
Other advisors: Professor Darrell Crawford
-
2016
Doctor Philosophy
Hfe-associated Steatohepatitis:Expression Profiling and Identifying the Molecular Basis of Liver Injury
Associate Advisor
Other advisors: Honorary Professor Nathan Subramaniam, Professor Darrell Crawford
-
2014
Doctor Philosophy
Evolution of Fibrosis, Antifibrotic Therapies and Mechanisms of Iron Homeostasis in the Mdr2-/- Mouse Model of Hepatic Fibrogenesis
Associate Advisor
Other advisors: Professor Darrell Crawford, Honorary Professor Nathan Subramaniam
-
2010
Doctor Philosophy
Investigation of hepatic glucose metabolism
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald
Media
Enquiries
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