Overview
Background
Dr Haolu Wang currently is a Medical Registrar and Basic Physician Trainee with the Royal Australasian College of Physicians - The Prince Charles Hospital and Redcliffe Hospital (Northside) Rotation. He is also an Honorary Research Fellow in the joint liver cancer research program of Frazer Institute, The University of Queensland and Gallipoli Medical Research Foundation. Dr Wang received his Bachelor of Medicine and Master of Surgery qualifications from Shanghai Jiao Tong University School of Medicine. He was awarded his PhD in Clinical Medicine from The University of Queensland. Dr Wang has worked as a Medical Officer at Renji Hospital, Shanghai Jiao Tong University School of Medicine and as a Researcher Officer at Frazer Institute, The University of Queensland.
Dr Wang has authored over 30 publications of clinical and translational research in liver diseases, including Hepatology, Theranostics, Int J Cancer, J Exp Clin Cancer Res and Pharmacol Ther. His standing in this field is reflected by awards from Australian National Health and Medical Research Council, United European Gastroenterology, European Microscopy Congress, The University of Queensland, Frazer Family Foundation and Shanghai Jiao Tong University.
Availability
- Dr Haolu Wang is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Clinical Medicine, Shanghai Jiao Tong University
- Masters (Research) of Clinical Surgery, Shanghai Jiao Tong University
- Doctor of Philosophy of Medicine (Research), The University of Queensland
Research impacts
As a translational researcher, Dr Wang has made contributions to curative efficacy evaluation in liver diseases. He real-time imaged hepatic vascular integrity and revealed the underlying molecular mechanism to predict treatment outcomes in drug-induced liver injury (Sci Rep. 2017, Theranostics. 2020). Using this real-time imaging platform, he was the first to develop modelling approaches to optimise dosing regimens of therapeutic stem cells against liver diseases (Curr Protoc Stem Cell Biol. 2017; Sci Rep. 2016).
As a clinical researcher, he evaluated current treatment efficacy of liver cancer (Eur J Surg Oncol. 2022) and primary sclerosing cholangitis (Pharmacol Ther. 2022), which has been cited by 2023 Practice Guidance of American Association for the Study of Liver Diseases.
Works
Search Professor Haolu Wang’s works on UQ eSpace
2023
Journal Article
Three-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification
Zhang, Jun-Zhe, Yang, Chuan-Xin, Gao, Si, Bu, Jun-Feng, Li, Qin-Qin, Wang, Hao-Lu, Yang, Kai-Ni, Tong, Shan-Shi, Qian, Li-Jun, Zhang, Jin, Hua, Rong, Sun, Yong-Wei, Yan, Jia-Yan and Chen, Wei (2023). Three-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification. World Journal of Surgical Oncology, 21 (1) 239. doi: 10.1186/s12957-023-03126-2
2022
Book Chapter
Theranostic nanoparticles for imaging and targeted drug delivery to the liver
Wang, Haolu, Yang, Haotian, Ruan, Qi, Roberts, Michael S. and Liang, Xiaowen (2022). Theranostic nanoparticles for imaging and targeted drug delivery to the liver. Fundamentals of drug delivery. (pp. 311-328) edited by Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams and Xiaowen Liang. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119769644.ch12
2021
Journal Article
Artificial cells for the treatment of liver diseases
Zou, Da, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S. and Zhao, Chun-Xia (2021). Artificial cells for the treatment of liver diseases. Acta Biomaterialia, 130, 98-114. doi: 10.1016/j.actbio.2021.06.012
2021
Journal Article
C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation
Zhang, Yonglong, Wang, Hui, Chen, Tao, Wang, Haolu, Liang, Xiaowen, Zhang, Yuchen, Duan, Jinlin, Qian, Shenjiao, Qiao, Ke, Zhang, Lei, Liu, Yanfeng and Wang, Jian (2021). C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation. Hepatology, 73 (2), 692-712. doi: 10.1002/hep.31304
2020
Journal Article
Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse
Yang, Jingxing, Hou, Mengfei, Sun, Wenshe, Wu, Qinghe, Xu, Jia, Xiong, Liqin, Chai, Yimin, Liu, Yuxin, Yu, Meihua, Wang, Haolu, Xu, Zhi Ping, Liang, Xiaowen and Zhang, Chunfu (2020). Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse. Advanced Science, 7 (16) 2001088, 2001088. doi: 10.1002/advs.202001088
2020
Journal Article
Hepatic artery classification based on three-dimensional CT
Yan, J., Feng, H., Wang, H., Yuan, F., Yang, C., Liang, X., Chen, W. and Wang, J. (2020). Hepatic artery classification based on three-dimensional CT. British Journal of Surgery, 107 (7), 906-916. doi: 10.1002/bjs.11458
2020
Journal Article
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Ruan, Qi, Wang, Haolu, Burke, Leslie J., Bridle, Kim R., Li, Xinxing, Zhao, Chun-Xia, Crawford, Darrell H. G., Roberts, Michael S. and Liang, Xiaowen (2020). Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma. International Journal of Cancer, 147 (6) ijc.32899, 1519-1527. doi: 10.1002/ijc.32899
2020
Conference Publication
Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes
Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058
2018
Journal Article
A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications
He, Haihong, Liu, Yuxin, Zhou, Zhongneng, Guo, Chunlei, Wang, Hong-Yin, Wang, Zhuang, Wang, Xueli, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications. Free Radical Biology and Medicine, 123, 1-7. doi: 10.1016/j.freeradbiomed.2018.04.563
2018
Journal Article
Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells
Luo, Xiao, Yang, Haotian, Wang, Haolu, Ye, Zhiwei, Zhou, Zhongneng, Gu, Luyan, Chen, Jinquan, Xiao, Yi, Liang, Xiaowen, Qian, Xuhong and Yang, Youjun (2018). Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells. Analytical Chemistry, 90 (9), 5803-5809. doi: 10.1021/acs.analchem.8b00218
2018
Journal Article
A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
He, Haihong, Xia, Yang, Qi, Yingxue, Wang, Hong-Yin, Wang, Zhuang, Bao, Jianming, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry, 29 (4), 1194-1198. doi: 10.1021/acs.bioconjchem.7b00821
2018
Book Chapter
Revealing interaction of dyes and nanomaterials by multiphoton imaging
Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020
2018
Journal Article
Indocyanine green-incorporating nanoparticles for cancer theranostics
Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872
2017
Journal Article
Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells
Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39
2017
Other Outputs
Real-time optical imaging of the liver: diagnosis and prediction of treatment response
Wang, Haolu (2017). Real-time optical imaging of the liver: diagnosis and prediction of treatment response. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2017.646
2017
Journal Article
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT
Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. OncoTarget, 8 (29), 47052-47063. doi: 10.18632/oncotarget.16789
2017
Journal Article
Multiphoton imaging for assessing renal disposition in acute kidney injury
Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964
2017
Journal Article
Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374
2017
Journal Article
A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury
Zhang, Feiyue, Liang, Xiaowen, Zhang, Wenzhu, Wang, Yong-Lei, Wang, Haolu, Mohammed, Yousuf H., Song, Bo, Zhang, Run and Yuan, Jingli (2017). A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors and Bioelectronics, 87, 1005-1011. doi: 10.1016/j.bios.2016.09.067
2017
Conference Publication
In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe
Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978
Funding
Past funding
Supervision
Availability
- Dr Haolu Wang is:
- Available for supervision
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Supervision history
Completed supervision
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Kim Bridle, Dr Xiaowen Liang
-
2023
Doctor Philosophy
Development of artificial mesenchymal stem cells for hepatocellular carcinoma drug delivery
Associate Advisor
Other advisors: Dr Xin Liu, Emeritus Professor Michael Roberts
-
2022
Doctor Philosophy
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Xiaowen Liang
Media
Enquiries
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