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Dr Xin Liu
Dr

Xin Liu

Email: 
Phone: 
+61 7 344 38031

Overview

Background

Dr Liu is a research fellow at Frazer Institute specialising in pharmacometrics, using mathematic models to understand how medicine behave in the model and to support evidence-based dosing decisions. Her research focuses on population pharmacokinetic (popPK) and physiologically-based pharmacokinetic (PBPK) modelling, dose optimisation, and model-informed precision dosing.

Her work combine clinical data, pharmacology, and quantitative mdoelling to better understand variability in drug exposure and response across different patient populations. This helps inform dosing strategies and supports the development of safer and more effective treatments.

She provides pharmacometric support across a range of research projects, designing and applying PopPK/PBPK models to characterise drug disposition and predict treatment outcomes under different dosing scenarios. Through simulation and quantitative analysis, she helps research teams evaluate dosing regimens, understand patient variability, and generate evidence to support clinical and regulatory decision-making.

Availability

Dr Xin Liu is:
Available for supervision

Qualifications

  • Doctor of Philosophy, National University of Singapore

Works

Search Professor Xin Liu’s works on UQ eSpace

111 works between 2003 and 2026

1 - 20 of 111 works

2026

Journal Article

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Ulldemolins, Marta, Lipman, Jeffrey, Liu, Xin, Abdul-Aziz, Mohd-Hafiz, Baptista, João P., Bilgrami, Irma, Bitker, Laurent, Boidin, Clement, Brinkmann, Alexander, Cheng, Vesa, Choi, Gordon, Cole, C. Louise, De Waele, Jan J., Deans, Renae, Eastwood, Glenn M., Escobar, Leslie, Frey, Otto R., Garreau, Romain, Goutelle, Sylvain, Gresham, Rebecca, Hernandez-Mitre, Maria Patricia, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kielstein, Jan T., Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa ... and the ESCMID PK/PD of Anti-Infectives Study Group (EPASG) (2026). Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy. Critical Care. doi: 10.1186/s13054-026-06226-z

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

2026

Journal Article

Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function

Brooks, Anastasia, Yang, Haotian, Barkauskas, Deborah S., Ranaweera, Supun, Zou, Da, Goh, Sally, Ruan, Qi, Bridle, Kim, Crawford, Darrell H.G., Liu, Xin, Roberts, Michael S., Doran, Michael R., Liang, Xiaowen, Zhao, Chun-Xia and Wang, Haolu (2026). Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function. Cell Reports Methods 101545, 101545-101545. doi: 10.1016/j.crmeth.2026.101545

Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function

2026

Journal Article

Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients

Setiawan, Eko, Gonzalez, Alvaro, Wölky, Saskia A., Cotta, Menino Osbert, Liu, Xin, Sosilya, Hernycane, Maresco-Pennisi, Diane, Novy, Emmanuel, Ordonez, Jenny, Lukas, Dwi Lily, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients. International Journal of Antimicrobial Agents, 67 (8) 107817, 1-11. doi: 10.1016/j.ijantimicag.2026.107817

Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients

2026

Journal Article

Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers

Legg, Amy, Boast, Alison, Piera, Kim, Liu, Xin, Wallis, Steven C., McCarthy, James, Davis, Joshua S., Tong, Steven Y. C., Gwee, Amanda and Roberts, Jason A. (2026). Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers. British Journal of Clinical Pharmacology bcp.70663. doi: 10.1002/bcp.70663

Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers

2026

Journal Article

A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shock

Sulaiman, Helmi, Wölky, Saskia A., Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Hernandez-Mitre, Maria Patricia, Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shock. The Journal of Antimicrobial Chemotherapy, 81 (7) dkag199. doi: 10.1093/jac/dkag199

A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shock

2026

Journal Article

Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections

Zamri, Puteri Juanita, Wölky, Saskia A., Hernandez-Mitre, Maria P., Liu, Xin, Hasan, M. Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steven C., Sumi, Chandra Datta, Parker, Suzanne L., Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2026). Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections. International Journal of Antimicrobial Agents, 67 (7) 107816, 1-11. doi: 10.1016/j.ijantimicag.2026.107816

Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections

2026

Journal Article

Optimising therapeutic target attainment in vancomycin therapy for patients requiring intermittent haemodialysis

Tsai, Danny, Hernández-Mitre, María Patricia, Legg, Amy, Martin, Jacqueline, Sajiv, Cherian, Kodgire, Sachin, Naughton, William, Janson, Sonja, Hughes, Jaquelyne T., Liu, Xin and Roberts, Jason A. (2026). Optimising Therapeutic Target Attainment in Vancomycin Therapy for Patients Requiring Intermittent Haemodialysis. Nephrology, 31 (7) e70239, e70239-e70239. doi: 10.1111/nep.70239

Optimising therapeutic target attainment in vancomycin therapy for patients requiring intermittent haemodialysis

2026

Journal Article

A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients

Briquet, Caroline, Ngougni Pokem, Perrin, Liu, Xin, Wijnant, Gert-Jan, Cornu, Olivier, Yildiz, Halil, Verroken, Alexia, Roberts, Jason A., Yombi, Jean Cyr and Van Bambeke, Françoise (2026). A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients. Antimicrobial Agents and Chemotherapy, 70 (7) e00372-26, e0037226-e0037226. doi: 10.1128/aac.00372-26

A novel meropenem dosing strategy for Outpatient Parenteral Antimicrobial Therapy (OPAT): a pilot pharmacokinetic/pharmacodynamic study in non-critically ill patients

2026

Journal Article

Plasma levels and postpartum breastmilk concentrations of sugammadex: a pharmacokinetic study in women undergoing general anaesthesia for caesarean delivery

Hodge, A. T., Tognolini, A. R., Liu, X., Won, H., Roberts, J. A., Wallis, S. C., Woods, C. A. and Eley, V. A. (2026). Plasma levels and postpartum breastmilk concentrations of sugammadex: a pharmacokinetic study in women undergoing general anaesthesia for caesarean delivery. International Journal of Obstetric Anesthesia, 66 104874, 1-7. doi: 10.1016/j.ijoa.2026.104874

Plasma levels and postpartum breastmilk concentrations of sugammadex: a pharmacokinetic study in women undergoing general anaesthesia for caesarean delivery

2026

Journal Article

Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery

Cheng, Vesa, Suna, Jessica, Liu, Xin, Moloney, Gregory, Marathe, Supreet P., Parker, Suzanne, Ungerer, Jacobus P. J., McWhinney, Brett, Venugopal, Prem, Alphonso, Nelson and Roberts, Jason A. (2026). Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery. Anaesthesia, Critical Care and Pain Medicine, 45 (3) 101653, 1-8. doi: 10.1016/j.accpm.2025.101653

Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery

2026

Journal Article

A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)

Gurunathan, Usha, Medcalf, Robert L., Chiang, Lily, Liu, Zikou, Liu, Xin, Keragala, Charithani B., Hernandez-Mitre, Maria Patricia, Brady, Paul, Wallis, Steven C., Roberts, Jason A., Mullany, Daniel, Nandurkar, Harshal, Eley, Victoria and Parker, Suzanne L. (2026). A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE). British Journal of Anaesthesia, 136 (4), 1157-1165. doi: 10.1016/j.bja.2024.12.004

A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)

2026

Journal Article

Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study

Abdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, Liu, Xin, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2026). Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study. Journal of Antimicrobial Chemotherapy, 81 (4) dkag090, 1-12. doi: 10.1093/jac/dkag090

Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study

2025

Journal Article

A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantation

Cairns, Kelly A., Hernandez-Mitre, Maria Patricia, Peel, Trisha N., Abbott, Iain J., Kaye, David M., Marasco, Silvana, Daly, David, Warner, Victoria, Coldham, Anna, Pope, Jeffrey D., Schneider, Hans G, Dooley, Michael J., Liu, Xin, Roberts, Jason A. and Udy, Andrew A. (2025). A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantation. Clinical Pharmacokinetics, 65 (3), 395-404. doi: 10.1007/s40262-025-01607-z

A pharmacokinetic analysis of intravenous fluconazole in adult patients undergoing mechanical circulatory support device implantation

2025

Journal Article

Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment

Sulaiman, Helmi, Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Jamal, Janattul A., Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Othman-Jailani, Mohamad Irfan, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment. Scientific Reports, 15 (1) 37781, 1-12. doi: 10.1038/s41598-025-20630-5

Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment

2025

Journal Article

Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy

Roberts, Jason A., Ulldemolins, Marta, Liu, Xin, Baptista, João P., Bilgrami, Irma, Boidin, Clement, Brinkmann, Alexander, Castro, Pedro, Choi, Gordon, Cole, Louise, De Waele, Jan J., Deans, Renae, Donnellan, Sine, Eastwood, Glenn M., Frey, Otto R., Goutelle, Sylvain, Gresham, Rebecca, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa, Laterre, Pierre-Francois, Lee, Anna, Lefrant, Jean-Yves, Lei, Katie, Leung, Patricia ... Young, Helen (2025). Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy. Intensive Care Medicine, 51 (9), 1628-1640. doi: 10.1007/s00134-025-08067-w

Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy

2025

Journal Article

Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis

Tognolini, Angela R., Liu, Xin, Pandey, Saurabh, Roberts, Jason A., Wallis, Steven C., Jackson, Dwane and Eley, Victoria A. (2025). Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis. Anaesthesia, 80 (5), 511-521. doi: 10.1111/anae.16531

Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis

2025

Journal Article

Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients

Kumta, Nilesh, Heffernan, Aaron J., Liu, Xin, Parker, Suzanne L., Cotta, Menino Osbert, Wallis, Steven C., Livermore, Amelia, Starr, Therese, Wai, Wong Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2025). Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients. International Journal of Antimicrobial Agents, 65 (5) 107461, 107461. doi: 10.1016/j.ijantimicag.2025.107461

Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients

2025

Journal Article

Population pharmacokinetic modelling of remdesivir and its metabolite GS-441524 in hospitalised patients with COVID-19

Roberts, Darren M., Liu, Xin, Parker, Suzanne L., Burke, Andrew, Peek, Jenny, Carland, Jane E., Murnion, Bridin, Seah, Vincent, Wallis, Steven C., Sumi, Chandra D., Pandey, Saurabh, Buscher, Hergen, Byrne, Anthony, Sandaradura, Indy, Bowen, David, Holz, Simon, Stewart, Adam G., Hajkowicz, Krispin M. and Roberts, Jason A. (2025). Population pharmacokinetic modelling of remdesivir and its metabolite GS-441524 in hospitalised patients with COVID-19. Clinical Pharmacokinetics, 64 (5) e0022222, 743-756. doi: 10.1007/s40262-025-01496-2

Population pharmacokinetic modelling of remdesivir and its metabolite GS-441524 in hospitalised patients with COVID-19

2025

Journal Article

Population pharmacokinetics and optimized prophylaxis dosing of cefazolin during transcatheter aortic valve implantation

Robson, C., Liu, X., Al-Mukhtar, O., Wallis, S. C., Won, H., Ordonez, J., Gooley, R., Stuart, R. L., Nicholls, S. J., Roberts, J. A. and Rogers, B. A. (2025). Population pharmacokinetics and optimized prophylaxis dosing of cefazolin during transcatheter aortic valve implantation. Journal of Antimicrobial Chemotherapy, 80 (6) dkaf108, 1604-1612. doi: 10.1093/jac/dkaf108

Population pharmacokinetics and optimized prophylaxis dosing of cefazolin during transcatheter aortic valve implantation

2025

Journal Article

Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study

Ngougni Pokem, Perrin, Stéphenne, Xavier, Liu, Xin, Parker, Suzanne L., Van der Linden, Dimitri, Godet, Marie-Laura, Wijnant, Gert-Jan, Chatzis, Olga, Houtekie, Laurent, Haenecour, Astrid, Sokal, Etienne, Roberts, Jason A., Elens, Laure and Van Bambeke, Françoise (2025). Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study. Clinical Microbiology and Infection, 31 (3), 408-416. doi: 10.1016/j.cmi.2024.12.015

Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study

Funding

Current funding

  • 2025 - 2026
    Quality Medication Care Research UQ Centre for Clinical Research
    Quality Medication Care Pty Ltd
    Open grant

Past funding

  • 2021
    A novel CD14-targeting approach for the treatment of primary sclerosing cholangitis
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2020 - 2021
    Mechanistic and comparative toxicity of commercial essential oils
    Agrifutures Australia
    Open grant
  • 2018 - 2021
    Formulation drug product quality attributes in dermal physiologically-based pharmacokinetic models for topical dermatological drug products and transdermal delivery systems
    United States Food and Drug Administration
    Open grant
  • 2018 - 2021
    Improving oesophageal adenocarcinoma outcomes through understanding genomics and treatment toxicity (NHMRC Project Grant led by The Council of the Queensland Institute of Medical Research)
    Queensland Institute of Medical Research
    Open grant
  • 2017 - 2018
    Dr Xin Liu - Maternity Funding (Advance Queensland Women's Academic Fund)
    Queensland Government Advance Queensland Women's Academic Fund
    Open grant
  • 2017 - 2018
    Optimising the N-acetylcysteine dose regimen for managing paracetamol overdose using mechanistic biomarkers (TACT Pilot Grant awarded under NHMRC Program Grant APP1055176 administered by Uni Sydney)
    University of Sydney
    Open grant
  • 2017 - 2021
    Physiologically-based pharmacokinetics and pharmacodynamics of therapeutic stem cells for liver disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Optimizing the Treatment of Paracetamol Toxicity by Mechanistic Modelling Based on Advanced Imaging - Toxicology (TACT Pilot grant awarded under NHMRC Program grant APP1055176 admin by Uni of Syd)
    University of Sydney
    Open grant

Supervision

Availability

Dr Xin Liu is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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