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Dr Xin Liu
Dr

Xin Liu

Email: 
Phone: 
+61 7 344 38031

Overview

Background

Dr Liu is a research fellow at Frazer Institute specialising in pharmacometrics, using mathematic models to understand how medicine behave in the model and to support evidence-based dosing decisions. Her research focuses on population pharmacokinetic (popPK) and physiologically-based pharmacokinetic (PBPK) modelling, dose optimisation, and model-informed precision dosing.

Her work combine clinical data, pharmacology, and quantitative mdoelling to better understand variability in drug exposure and response across different patient populations. This helps inform dosing strategies and supports the development of safer and more effective treatments.

She provides pharmacometric support across a range of research projects, designing and applying PopPK/PBPK models to characterise drug disposition and predict treatment outcomes under different dosing scenarios. Through simulation and quantitative analysis, she helps research teams evaluate dosing regimens, understand patient variability, and generate evidence to support clinical and regulatory decision-making.

Availability

Dr Xin Liu is:
Available for supervision

Qualifications

  • Doctor of Philosophy, National University of Singapore

Works

Search Professor Xin Liu’s works on UQ eSpace

102 works between 2003 and 2026

21 - 40 of 102 works

2022

Journal Article

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

2022

Journal Article

An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions

Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E and Roberts, Michael S. (2022). An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions. Data in Brief, 42 108242, 1-9. doi: 10.1016/j.dib.2022.108242

An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions

2021

Journal Article

Artificial cells for the treatment of liver diseases

Zou, Da, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S. and Zhao, Chun-Xia (2021). Artificial cells for the treatment of liver diseases. Acta Biomaterialia, 130, 98-114. doi: 10.1016/j.actbio.2021.06.012

Artificial cells for the treatment of liver diseases

2021

Journal Article

Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models

Liu, Xin, Anissimov, Yuri G., Grice, Jeffrey E., Cheruvu, Hanumanth Srikanth, Ghosh, Priyanka, Raney, Sam G., Maibach, Howard and Roberts, Michael S. (2021). Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models. Journal of Controlled Release, 334, 37-51. doi: 10.1016/j.jconrel.2021.04.010

Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models

2020

Journal Article

Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose

Liu, Xin, Yousef, Shereen, Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose. European Journal of Pharmaceutics and Biopharmaceutics, 149, 30-44. doi: 10.1016/j.ejpb.2020.01.018

Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose

2020

Journal Article

Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury

Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900

Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury

2020

Journal Article

Modeling percutaneous absorption for successful drug discovery and development

Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery, 15 (10), 1-18. doi: 10.1080/17460441.2020.1781085

Modeling percutaneous absorption for successful drug discovery and development

2020

Conference Publication

Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes

Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058

Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes

2018

Journal Article

Anionic long-circulating quantum dots for long-term intravital vascular imaging

Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244

Anionic long-circulating quantum dots for long-term intravital vascular imaging

2018

Journal Article

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8

Wu, Chao, Kan, Hongwei, Hu, Min, Liu, Xin, Boye, Alex, Jiang, Yufeng, Wu, Jiajun, Wang, Jiyu, Yang, Xiaochuan and Yang, Yan (2018). Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8. Experimental and Therapeutic Medicine, 16 (2), 1052-1060. doi: 10.3892/etm.2018.6292

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8

2018

Journal Article

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

2018

Journal Article

Indocyanine green-incorporating nanoparticles for cancer theranostics

Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872

Indocyanine green-incorporating nanoparticles for cancer theranostics

2018

Book Chapter

Revealing interaction of dyes and nanomaterials by multiphoton imaging

Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020

Revealing interaction of dyes and nanomaterials by multiphoton imaging

2017

Journal Article

Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells

Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209

Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells

2017

Journal Article

Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39

Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

2017

Journal Article

Multiphoton imaging for assessing renal disposition in acute kidney injury

Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964

Multiphoton imaging for assessing renal disposition in acute kidney injury

2017

Journal Article

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

2017

Conference Publication

Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity

Liang, X., Wang, H., Liu, X., Touraud, M., Chouane, J. B., Tse, B. and Roberts, M. S. (2017). Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, , Gold Coast, Queensland, Australia, 20–22 Aug 2017. Richmond, VIC Australia: Wiley.

Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity

2017

Conference Publication

Non-invasive assessment of the liver using imaging

Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883

Non-invasive assessment of the liver using imaging

2017

Book Chapter

Related topic: Safety evaluation of nanomaterials

Liang, Xiaowen, Wang, Haolu, Liu, Xin, Grice, Jeffrey, Xu, Zhi Ping and Roberts, Michael S. (2017). Related topic: Safety evaluation of nanomaterials. Skin permeation and disposition of therapeutic and cosmeceutical compounds. (pp. 313-322) edited by Kenji Sugibayashi. Tokyo, Japan: Springer Japan. doi: 10.1007/978-4-431-56526-0_28

Related topic: Safety evaluation of nanomaterials

Funding

Past funding

  • 2025 - 2026
    Quality Medication Care Research UQ Centre for Clinical Research
    Quality Medication Care Pty Ltd
    Open grant
  • 2021
    A novel CD14-targeting approach for the treatment of primary sclerosing cholangitis
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2020 - 2021
    Mechanistic and comparative toxicity of commercial essential oils
    Agrifutures Australia
    Open grant
  • 2018 - 2021
    Formulation drug product quality attributes in dermal physiologically-based pharmacokinetic models for topical dermatological drug products and transdermal delivery systems
    United States Food and Drug Administration
    Open grant
  • 2018 - 2021
    Improving oesophageal adenocarcinoma outcomes through understanding genomics and treatment toxicity (NHMRC Project Grant led by The Council of the Queensland Institute of Medical Research)
    Queensland Institute of Medical Research
    Open grant
  • 2017 - 2018
    Dr Xin Liu - Maternity Funding (Advance Queensland Women's Academic Fund)
    Queensland Government Advance Queensland Women's Academic Fund
    Open grant
  • 2017 - 2018
    Optimising the N-acetylcysteine dose regimen for managing paracetamol overdose using mechanistic biomarkers (TACT Pilot Grant awarded under NHMRC Program Grant APP1055176 administered by Uni Sydney)
    University of Sydney
    Open grant
  • 2017 - 2021
    Physiologically-based pharmacokinetics and pharmacodynamics of therapeutic stem cells for liver disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Optimizing the Treatment of Paracetamol Toxicity by Mechanistic Modelling Based on Advanced Imaging - Toxicology (TACT Pilot grant awarded under NHMRC Program grant APP1055176 admin by Uni of Syd)
    University of Sydney
    Open grant

Supervision

Availability

Dr Xin Liu is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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communications@uq.edu.au