Dr Xin Liu
Dr

Xin Liu

Email: 
Phone: 
+61 7 344 38031

Background

Dr Liu is a research fellow at Frazer Institute specialising in pharmacometrics, using mathematic models to understand how medicine behave in the model and to support evidence-based dosing decisions. Her research focuses on population pharmacokinetic (popPK) and physiologically-based pharmacokinetic (PBPK) modelling, dose optimisation, and model-informed precision dosing.

Her work combine clinical data, pharmacology, and quantitative mdoelling to better understand variability in drug exposure and response across different patient populations. This helps inform dosing strategies and supports the development of safer and more effective treatments.

She provides pharmacometric support across a range of research projects, designing and applying PopPK/PBPK models to characterise drug disposition and predict treatment outcomes under different dosing scenarios. Through simulation and quantitative analysis, she helps research teams evaluate dosing regimens, understand patient variability, and generate evidence to support clinical and regulatory decision-making.

Availability

Dr Xin Liu is:
Available for supervision

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Doctor of Philosophy, National University of Singapore

Search Professor Xin Liu’s works on UQ eSpace

113 works between 2003 and 2026
All (113) Journal Article (96) Conference Publication (13) Book Chapter (4)

21 - 40 of 113 works

2025

Journal Article

Population pharmacokinetics and optimized prophylaxis dosing of cefazolin during transcatheter aortic valve implantation

Robson, C., Liu, X., Al-Mukhtar, O., Wallis, S. C., Won, H., Ordonez, J., Gooley, R., Stuart, R. L., Nicholls, S. J., Roberts, J. A. and Rogers, B. A. (2025). Population pharmacokinetics and optimized prophylaxis dosing of cefazolin during transcatheter aortic valve implantation. Journal of Antimicrobial Chemotherapy, 80 (6) dkaf108, 1604-1612. doi: 10.1093/jac/dkaf108

Population pharmacokinetics and optimized prophylaxis dosing of cefazolin during transcatheter aortic valve implantation

2025

Journal Article

Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study

Ngougni Pokem, Perrin, Stéphenne, Xavier, Liu, Xin, Parker, Suzanne L., Van der Linden, Dimitri, Godet, Marie-Laura, Wijnant, Gert-Jan, Chatzis, Olga, Houtekie, Laurent, Haenecour, Astrid, Sokal, Etienne, Roberts, Jason A., Elens, Laure and Van Bambeke, Françoise (2025). Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study. Clinical Microbiology and Infection, 31 (3), 408-416. doi: 10.1016/j.cmi.2024.12.015

Population pharmacokinetics and dosing simulations of temocillin in liver-transplanted paediatric patients: a prospective, open-label, non-randomized study

2025

Journal Article

Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

Abdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2025). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 69 (2) e0143524, 1-15. doi: 10.1128/aac.01435-24

Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study

2024

Journal Article

Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients

Kumta, Nilesh, Heffernan, Aaron J., Cotta, Menino Osbert, Liu, Xin, Parker, Suzanne, Wallis, Steven, Livermore, Amelia, Starr, Therese, Wong, Wai Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2024). Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients. Antimicrobial Agents and Chemotherapy, 69 (2), e0060124. doi: 10.1128/aac.00601-24

Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients

2024

Journal Article

Continuous infusion of piperacillin/tazobactam optimizes intraoperative antibiotic exposure in patients undergoing elective pelvic exenteration surgery

Jackson, Dwane, Ulldemolins, Marta, Liu, Xin, Harris, Craig, Tognolini, Angela, Wallis, Steven C., Sumi, Chandra, Parker, Suzanne L., Eley, Victoria and Roberts, Jason A. (2024). Continuous infusion of piperacillin/tazobactam optimizes intraoperative antibiotic exposure in patients undergoing elective pelvic exenteration surgery. Antimicrobial Agents and Chemotherapy, 68 (12) e0111624, e0111624. doi: 10.1128/aac.01116-24

Continuous infusion of piperacillin/tazobactam optimizes intraoperative antibiotic exposure in patients undergoing elective pelvic exenteration surgery

2024

Journal Article

Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study

Novy, Emmanuel, Liu, Xin, Hernandez-Mitre, Maria Patricia, Belveyre, Thibaut, Scala-Bertola, Julien, Roberts, Jason A. and Parker, Suzanne L. (2024). Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study. Anaesthesia Critical Care and Pain Medicine, 43 (3) 101376, 1-8. doi: 10.1016/j.accpm.2024.101376

Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study

2024

Journal Article

Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis

Ngougni Pokem, Perrin, Liu, Xin, Parker, Suzanne L., Verroken, Alexia, Collienne, Christine, Finet, Patrice, Wijnant, Gert-Jan, Laterre, Pierre-François, Roberts, Jason A., Van Bambeke, Françoise and Wittebole, Xavier (2024). Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis. Journal of Antimicrobial Chemotherapy, 79 (2), 429-442. doi: 10.1093/jac/dkad398

Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis

2022

Journal Article

Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions

Zou, Da, Wu, Zeming, Yi, Xin, Hui, Yue, Yang, Guangze, Liu, Yun, Tengjisi,, Wang, Haofei, Brooks, Anastasia, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S., Gao, Huajian and Zhao, Chun-Xia (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences, 120 (1) e2214757120, e2214757120. doi: 10.1073/pnas.2214757120

Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions

2022

Journal Article

Percutaneous absorption of steroids from finite doses: predicting urinary excretion from in vitro skin permeation testing

Liu, Xin, Cheruvu, Hanumanth S., Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Ghosh, Priyanka, Grice, Jeffrey E. and Roberts, Michael S. (2022). Percutaneous absorption of steroids from finite doses: predicting urinary excretion from in vitro skin permeation testing. International Journal of Pharmaceutics, 625 122095, 1-16. doi: 10.1016/j.ijpharm.2022.122095

Percutaneous absorption of steroids from finite doses: predicting urinary excretion from in vitro skin permeation testing

2022

Journal Article

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

2022

Journal Article

An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions

Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E and Roberts, Michael S. (2022). An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions. Data in Brief, 42 108242, 1-9. doi: 10.1016/j.dib.2022.108242

An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions

2021

Journal Article

Artificial cells for the treatment of liver diseases

Zou, Da, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S. and Zhao, Chun-Xia (2021). Artificial cells for the treatment of liver diseases. Acta Biomaterialia, 130, 98-114. doi: 10.1016/j.actbio.2021.06.012

Artificial cells for the treatment of liver diseases

2021

Journal Article

Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models

Liu, Xin, Anissimov, Yuri G., Grice, Jeffrey E., Cheruvu, Hanumanth Srikanth, Ghosh, Priyanka, Raney, Sam G., Maibach, Howard and Roberts, Michael S. (2021). Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models. Journal of Controlled Release, 334, 37-51. doi: 10.1016/j.jconrel.2021.04.010

Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models

2020

Journal Article

Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose

Liu, Xin, Yousef, Shereen, Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose. European Journal of Pharmaceutics and Biopharmaceutics, 149, 30-44. doi: 10.1016/j.ejpb.2020.01.018

Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose

2020

Conference Publication

Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes

Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058

Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes

2020

Journal Article

Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury

Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900

Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury

2020

Journal Article

Modeling percutaneous absorption for successful drug discovery and development

Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery, 15 (10), 1-18. doi: 10.1080/17460441.2020.1781085

Modeling percutaneous absorption for successful drug discovery and development

2018

Journal Article

Anionic long-circulating quantum dots for long-term intravital vascular imaging

Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244

Anionic long-circulating quantum dots for long-term intravital vascular imaging

2018

Journal Article

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8

Wu, Chao, Kan, Hongwei, Hu, Min, Liu, Xin, Boye, Alex, Jiang, Yufeng, Wu, Jiajun, Wang, Jiyu, Yang, Xiaochuan and Yang, Yan (2018). Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8. Experimental and Therapeutic Medicine, 16 (2), 1052-1060. doi: 10.3892/etm.2018.6292

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8

2018

Book Chapter

Revealing interaction of dyes and nanomaterials by multiphoton imaging

Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020

Revealing interaction of dyes and nanomaterials by multiphoton imaging

Current funding

  • 2025 - 2026
    Quality Medication Care Research UQ Centre for Clinical Research
    Quality Medication Care Pty Ltd
    Open grant

Past funding

  • 2021
    A novel CD14-targeting approach for the treatment of primary sclerosing cholangitis
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2020 - 2021
    Mechanistic and comparative toxicity of commercial essential oils
    Agrifutures Australia
    Open grant
  • 2018 - 2021
    Formulation drug product quality attributes in dermal physiologically-based pharmacokinetic models for topical dermatological drug products and transdermal delivery systems
    United States Food and Drug Administration
    Open grant
  • 2018 - 2021
    Improving oesophageal adenocarcinoma outcomes through understanding genomics and treatment toxicity (NHMRC Project Grant led by The Council of the Queensland Institute of Medical Research)
    Queensland Institute of Medical Research
    Open grant
  • 2017 - 2018
    Dr Xin Liu - Maternity Funding (Advance Queensland Women's Academic Fund)
    Queensland Government Advance Queensland Women's Academic Fund
    Open grant
  • 2017 - 2018
    Optimising the N-acetylcysteine dose regimen for managing paracetamol overdose using mechanistic biomarkers (TACT Pilot Grant awarded under NHMRC Program Grant APP1055176 administered by Uni Sydney)
    University of Sydney
    Open grant
  • 2017 - 2021
    Physiologically-based pharmacokinetics and pharmacodynamics of therapeutic stem cells for liver disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Optimizing the Treatment of Paracetamol Toxicity by Mechanistic Modelling Based on Advanced Imaging - Toxicology (TACT Pilot grant awarded under NHMRC Program grant APP1055176 admin by Uni of Syd)
    University of Sydney
    Open grant

Availability

Dr Xin Liu is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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