Overview
Background
Dr María Patricia Hernández Mitre (Patty Mitre) is Postdoctoral Research Fellow in the Antimicrobial Optimisation Group led by Professor Jason Roberts and a member of the CRE-RESPOND (Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal persONalised Dosing) team at the University of Queensland Centre for Clinical Research, located on the Royal Brisbane and Women's Hospital campus at Herston in Brisbane, Queensland, Australia.
She is certified in non-compartmental analysis (NCA) using Phoenix® WinNonlin™ and conducts NCA for Phase 1 clinical trials under NATA ISO 17025-accredited processes, preparing regulatory reports for submission to agencies such as the FDA. In addition, she develops and validates population pharmacokinetic models using Monolix®, Pmetrics™, and NONMEM® to optimise drug therapy and support therapeutic drug monitoring.
Dr Hernández Mitre is leading the individual pharmacokinetic analyses of antifungal therapies from the Screening Anti-Fungal Exposure in Intensive Care Units (SAFE-ICU) study. She also mentors students and clinicians, delivers training in pharmacokinetic modelling, and participates actively in university committees. She is experienced in clinical trial monitoring, regulatory writing, and electronic research data management.
Availability
- Dr Patty Mitre is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Chemistry, Universidad Autónoma de San Luis Potosí
- Masters (Research) of Pharmacy and Biology, Universidad Autónoma de San Luis Potosí
- Doctor of Philosophy of Pharmacy and Biology, Universidad Autónoma de San Luis Potosí
Works
Search Professor Patty Mitre’s works on UQ eSpace
2025
Journal Article
Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study
Roberts, Jason A., Sime, Fekade B., Lipman, Jeffrey, Hernández-Mitre, María Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Ceccarelli, Giancarlo, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2025). Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study. Intensive Care Medicine, 51 (2), 1-16. doi: 10.1007/s00134-025-07793-5
2025
Journal Article
A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE)
Gurunathan, Usha, Medcalf, Robert L., Chiang, Lily, Liu, Zikou, Liu, Xin, Keragala, Charithani B., Hernandez-Mitre, Maria Patricia, Brady, Paul, Wallis, Steven C., Roberts, Jason A., Mullany, Daniel, Nandurkar, Harshal, Eley, Victoria and Parker, Suzanne L. (2025). A pharmacokinetic/pharmacodynamic analysis of intravenous tranexamic acid in adult patients undergoing elective total hip arthroplasty (ORACLE). British Journal of Anaesthesia. doi: 10.1016/j.bja.2024.12.004
2025
Journal Article
Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754, (S1198743X24000557), (10.1016/j.cmi.2024.01.029)]
Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y.C. and Roberts, Jason A. (2025). Erratum to ‘TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate’ [Clin Microbiol Infect (30) (2024) 743–754, (S1198743X24000557), (10.1016/j.cmi.2024.01.029)]. Clinical Microbiology and Infection, 31 (1) 141, 141-141. doi: 10.1016/j.cmi.2024.08.005
2025
Journal Article
Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation
Morales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc
2024
Journal Article
Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study
Novy, Emmanuel, Liu, Xin, Hernandez-Mitre, Maria Patricia, Belveyre, Thibaut, Scala-Bertola, Julien, Roberts, Jason A. and Parker, Suzanne L. (2024). Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study. Anaesthesia Critical Care and Pain Medicine, 43 (3) 101376, 1-8. doi: 10.1016/j.accpm.2024.101376
2024
Journal Article
TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate
Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y. C. and Roberts, Jason A. (2024). TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate. Clinical Microbiology and Infection, 30 (6), 743-754. doi: 10.1016/j.cmi.2024.01.029
2023
Journal Article
A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects
Hernández-Mitre, María Patricia, Wallis, Steven C., Morgan, Elizabeth E., Dudley, Michael N., Loutit, Jeffery S., Griffith, David C. and Roberts, Jason A. (2023). A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects. Antimicrobial Agents and Chemotherapy, 68 (1) e0109923, 1-12. doi: 10.1128/aac.01099-23
2023
Journal Article
Stability of nafamostat in intravenous infusion solutions, human whole blood and extracted plasma: implications for clinical effectiveness studies
Hernández-Mitre, María Patricia, Won, Hayoung, Wallis, Steven C., Parker, Suzanne L. and Roberts, Jason A. (2023). Stability of nafamostat in intravenous infusion solutions, human whole blood and extracted plasma: implications for clinical effectiveness studies. Bioanalysis, 15 (12), 673-681. doi: 10.4155/bio-2023-0040
2023
Journal Article
A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study
Roberts, Jason A., Sime, Fekade, Lipman, Jeffrey, Hernández-Mitre, Maria Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2023). A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study. Critical Care and Resuscitation, 25 (1), 1-5. doi: 10.1016/j.ccrj.2023.04.002
2023
Other Outputs
TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of nafamostat and camostat mesylate randomised clinical trials
Hernández-Mitre, María Patricia, Morpeth, Susan C., Venkatesh, Balasubramanian, Hills, Thomas E., Davis, Joshua, Mahar, Robert K., McPhee, Grace, Jones, Mark, Totterdell, James, Tong, Steven Y. C. and Roberts, Jason A. (2023). TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of nafamostat and camostat mesylate randomised clinical trials. Middletown, DE, United States: INPLASY: International Platform of Registered Systematic Review and Meta-analysis Protocols. doi: 10.37766/inplasy2023.2.0120
2022
Conference Publication
Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections
Zamri, Puteri Juanita, Abdul-Aziz, Mohd-Hafiz, Hernandez-Mitre, Maria Patricia, Hasan, Mohd Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steve, Sumi, Chandra Datta, Sime, Fekade Bruck and Roberts, Jason A (2022). Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier . doi: 10.1016/s2213-7165(22)00339-3
2022
Journal Article
Nafamostat mesylate for treatment of COVID-19 in hospitalised patients: a structured, narrative review
Hernández-Mitre, María Patricia, Tong, Steven Y. C., Denholm, Justin T., Dore, Gregory J., Bowen, Asha C., Lewin, Sharon R., Venkatesh, Balasubramanian, Hills, Thomas E., McQuilten, Zoe, Paterson, David L., Morpeth, Susan C. and Roberts, Jason A. (2022). Nafamostat mesylate for treatment of COVID-19 in hospitalised patients: a structured, narrative review. Clinical Pharmacokinetics, 61 (10), 1331-1343. doi: 10.1007/s40262-022-01170-x
2020
Journal Article
Determination of Levetiracetam in Plasma by a Modified HPLC-UV Method and Its Pharmacokinetic Application
Hernandez-Mitre, Maria P., Medellin-Garibay, Susanna E., Rodríguez-Leyva, Ildefonso, Rodríguez-Pinal, Cristian J., Zarazúa, Sergio, Jung-Cook, Helgi H., Parker, Suzanne L., Romano-Moreno, Silvia and del C. Milán-Segovia, Rosa (2020). Determination of Levetiracetam in Plasma by a Modified HPLC-UV Method and Its Pharmacokinetic Application. Mathews Journal of Pharmaceutical Science, 4 (1). doi: 10.30654/mjps.10004
2020
Journal Article
Population pharmacokinetics and dosing recommendations of levetiracetam in adult and elderly patients with epilepsy
Hernández-Mitre, María Patricia, Medellín-Garibay, Susanna Edith, Rodríguez-Leyva, Ildefonso, Rodríguez-Pinal, Cristian Jazmín, Zarazúa, Sergio, Jung-Cook, Helgi Helene, Roberts, Jason A., Romano-Moreno, Silvia and Milán-Segovia, Rosa del Carmen (2020). Population pharmacokinetics and dosing recommendations of levetiracetam in adult and elderly patients with epilepsy. Journal of Pharmaceutical Sciences, 109 (6), 2070-2078. doi: 10.1016/j.xphs.2020.02.018
2020
Conference Publication
Population Pharmacokinetics Of Levetiracetam In Mexican Adult Patients With Epilepsy
Hernandez-Mitre, Maria Patricia, Medellin-Garibay, Susanna Edith, Rodriguez-Leyva, Ildefonso, Castillo-Ibarra, Herlinda, Rodríguez-Pinal, Cristian Jasmin, Zarazua-Guzman, Sergio, Jung-Cook, Helgi Helene, Romano-Moreno, Silvia and del Carlmen Milan-Segovia, Rosa (2020). Population Pharmacokinetics Of Levetiracetam In Mexican Adult Patients With Epilepsy. 2020 AAN Science Highlights, Online, 14 April 2020. Philadelphia, PA United States: Wolters Kluwer. doi: 10.1212/wnl.94.15_supplement.4643
Funding
Current funding
Supervision
Availability
- Dr Patty Mitre is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Associate Advisor
Other advisors: Professor Jeffrey Lipman, Dr Xin Liu, Professor Jason Roberts
Media
Enquiries
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