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Dr Xin Liu
Dr

Xin Liu

Email: 
Phone: 
+61 7 344 38031

Overview

Background

Dr Liu is a research fellow at Frazer Institute specialising in pharmacometrics, using mathematic models to understand how medicine behave in the model and to support evidence-based dosing decisions. Her research focuses on population pharmacokinetic (popPK) and physiologically-based pharmacokinetic (PBPK) modelling, dose optimisation, and model-informed precision dosing.

Her work combine clinical data, pharmacology, and quantitative mdoelling to better understand variability in drug exposure and response across different patient populations. This helps inform dosing strategies and supports the development of safer and more effective treatments.

She provides pharmacometric support across a range of research projects, designing and applying PopPK/PBPK models to characterise drug disposition and predict treatment outcomes under different dosing scenarios. Through simulation and quantitative analysis, she helps research teams evaluate dosing regimens, understand patient variability, and generate evidence to support clinical and regulatory decision-making.

Availability

Dr Xin Liu is:
Available for supervision

Qualifications

  • Doctor of Philosophy, National University of Singapore

Works

Search Professor Xin Liu’s works on UQ eSpace

113 works between 2003 and 2026

41 - 60 of 113 works

2018

Journal Article

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

2018

Journal Article

Indocyanine green-incorporating nanoparticles for cancer theranostics

Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872

Indocyanine green-incorporating nanoparticles for cancer theranostics

2017

Journal Article

Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells

Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209

Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells

2017

Journal Article

Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39

Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

2017

Journal Article

Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome

Chan, Betty S., Becker, Therese, Chiew, Angela L., Abdalla, Ahmed M., Robertson, Tom A., Liu, Xin, Roberts, Michael S. and Buckley, Nicholas A. (2017). Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome. Journal of Medical Toxicology, 14 (1), 100-103. doi: 10.1007/s13181-017-0637-1

Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome

2017

Journal Article

A novel LC-MS-MS method with an effective antioxidant for the determination of edaravone, a free-radical scavenger in dog plasma and its application to a pharmacokinetic study

Shao, Feng, Hu, Xiao-ling, Liu, Xin and Shan, Mang-ting (2017). A novel LC-MS-MS method with an effective antioxidant for the determination of edaravone, a free-radical scavenger in dog plasma and its application to a pharmacokinetic study. Journal of Chromatographic Science, 55 (6), 595-602. doi: 10.1093/chromsci/bmx012

A novel LC-MS-MS method with an effective antioxidant for the determination of edaravone, a free-radical scavenger in dog plasma and its application to a pharmacokinetic study

2017

Journal Article

Multiphoton imaging for assessing renal disposition in acute kidney injury

Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964

Multiphoton imaging for assessing renal disposition in acute kidney injury

2017

Journal Article

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

2017

Conference Publication

Quantitative optical imaging of paracetamol-induced metabolism changes in the liver

Liang, Xiaowen, Wang, Haolu, Liu, Xin and Roberts, Michael (2017). Quantitative optical imaging of paracetamol-induced metabolism changes in the liver. SPIE BioPhotonics Australasia, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242962

Quantitative optical imaging of paracetamol-induced metabolism changes in the liver

2017

Book Chapter

Hepatic metabolism in liver health and disease

Liu, X., Wang, H., Liang, X. and Roberts, M. S. (2017). Hepatic metabolism in liver health and disease. Liver Pathophysiology: Therapies and Antioxidants. (pp. 391-400) edited by Pablo Muriel. Cambridge, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-804274-8.00030-8

Hepatic metabolism in liver health and disease

2017

Conference Publication

Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis

Wang, H., Liang, X., Weijs, L., Brooks, A., Liu, X., Roberts, M. S. and Crawford, D. H. G. (2017). Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, Queensland, 20–22 Aug 2017. Hoboken, NJ United States: Wiley.

Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis

2017

Conference Publication

In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe

Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978

In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe

2017

Conference Publication

Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity

Liang, X., Wang, H., Liu, X., Touraud, M., Chouane, J. B., Tse, B. and Roberts, M. S. (2017). Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, , Gold Coast, Queensland, Australia, 20–22 Aug 2017. Richmond, VIC Australia: Wiley.

Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity

2017

Conference Publication

Non-invasive assessment of the liver using imaging

Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883

Non-invasive assessment of the liver using imaging

2017

Book Chapter

Related topic: Safety evaluation of nanomaterials

Liang, Xiaowen, Wang, Haolu, Liu, Xin, Grice, Jeffrey, Xu, Zhi Ping and Roberts, Michael S. (2017). Related topic: Safety evaluation of nanomaterials. Skin permeation and disposition of therapeutic and cosmeceutical compounds. (pp. 313-322) edited by Kenji Sugibayashi. Tokyo, Japan: Springer Japan. doi: 10.1007/978-4-431-56526-0_28

Related topic: Safety evaluation of nanomaterials

2016

Journal Article

Estimating maximal in vitro skin permeation flux from studies using non-sink receptor phase conditions

Yousef, Shereen, Liu, Xin, Mostafa, Ahmed, Mohammed, Yousuf, Grice, Jeffrey E., Anissimov, Yuri G., Sakran, Wedad and Roberts, Michael S. (2016). Estimating maximal in vitro skin permeation flux from studies using non-sink receptor phase conditions. Pharmaceutical Research, 33 (9), 2180-2194. doi: 10.1007/s11095-016-1955-8

Estimating maximal in vitro skin permeation flux from studies using non-sink receptor phase conditions

2016

Journal Article

Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy

Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083

Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy

2016

Journal Article

A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells

Wang, Haolu, Liang, Xiaowen, Xu, Zhi Ping, Crawford, Darrell H. G, Liu, Xin and Roberts, Michael S. (2016). A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports, 6 (1) 22293, e22293.1-e22293.12. doi: 10.1038/srep22293

A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells

2016

Journal Article

Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles

Liang, Xiaowen, Wang, Haolu, Grice, Jeffrey E., Li, Li, Liu, Xin, Xu, Zhi Ping and Roberts, Michael S. (2016). Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles. Nano Letters, 16 (2), 939-945. doi: 10.1021/acs.nanolett.5b03854

Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles

2016

Journal Article

Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney

Liang, Xiaowen, Wang, Haolu, Zhu, Yian, Zhang, Run, Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Grice, Jeffrey E. and Roberts, Michael S. (2016). Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney. Acs Nano, 10 (1), 387-395. doi: 10.1021/acsnano.5b05066

Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney

Funding

Current funding

  • 2025 - 2026
    Quality Medication Care Research UQ Centre for Clinical Research
    Quality Medication Care Pty Ltd
    Open grant

Past funding

  • 2021
    A novel CD14-targeting approach for the treatment of primary sclerosing cholangitis
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2020 - 2021
    Mechanistic and comparative toxicity of commercial essential oils
    Agrifutures Australia
    Open grant
  • 2018 - 2021
    Formulation drug product quality attributes in dermal physiologically-based pharmacokinetic models for topical dermatological drug products and transdermal delivery systems
    United States Food and Drug Administration
    Open grant
  • 2018 - 2021
    Improving oesophageal adenocarcinoma outcomes through understanding genomics and treatment toxicity (NHMRC Project Grant led by The Council of the Queensland Institute of Medical Research)
    Queensland Institute of Medical Research
    Open grant
  • 2017 - 2018
    Dr Xin Liu - Maternity Funding (Advance Queensland Women's Academic Fund)
    Queensland Government Advance Queensland Women's Academic Fund
    Open grant
  • 2017 - 2018
    Optimising the N-acetylcysteine dose regimen for managing paracetamol overdose using mechanistic biomarkers (TACT Pilot Grant awarded under NHMRC Program Grant APP1055176 administered by Uni Sydney)
    University of Sydney
    Open grant
  • 2017 - 2021
    Physiologically-based pharmacokinetics and pharmacodynamics of therapeutic stem cells for liver disease
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Optimizing the Treatment of Paracetamol Toxicity by Mechanistic Modelling Based on Advanced Imaging - Toxicology (TACT Pilot grant awarded under NHMRC Program grant APP1055176 admin by Uni of Syd)
    University of Sydney
    Open grant

Supervision

Availability

Dr Xin Liu is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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communications@uq.edu.au