Overview
Background
My research focuses on liver biology and pharmacology and I am a research team leader of the joint liver cancer research program of Frazer Institute and Gallipoli Medical Research Foundation from 2019. My long-term goal is to direct a research group exploring strategies to improve liver cancer outcomes in patients, working closely with clinicians to enable bench-to-bedside translation.
Availability
- Dr Xiaowen Liang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
I developed an intravital imaging platform for visualising and characterising the spatial distribution of activated hepatic stellate cells and metabolic status in liver cancer. This imaging platform and physiologically based kinetics modelling was applied for the first time to investigate the sub-organ disposition and clearance of therapeutic agents in the liver. By expanding the initial work, I further led studies on assessment and monitoring of cellular oxidative stress, microcirculation, and drug response in the specific liver microenvironment for early prediction of treatment efficacy in liver diseases.
Works
Search Professor Xiaowen Liang’s works on UQ eSpace
2024
Journal Article
STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines
Jia, Wencong, Chandra, Janin, Teoh, Siok Min, Tolley, Lynn, Yang, Haotian, Tse, Brian W. C., Sokolowski, Kamil A., Liang, Xiaowen, Crawford, Darrell H. G., Steel, Jason C., Yu, Chengzhong, Roberts, Michael S., Frazer, Ian H., Chen, Yu, Wang, Haolu and Yu, Meihua (2024). STING nanoagonist boosts antitumor immunity of therapeutic DNA vaccines. Nano Letters, 24 (49), 1-10. doi: 10.1021/acs.nanolett.4c03846
2024
Conference Publication
Therapeutic targeting of a-specific PI3K improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer
Ruan, Qi, Cao, Lu, Yang, Haotian, Burke, Leslie, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2024). Therapeutic targeting of a-specific PI3K improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.
2024
Journal Article
Identification and characterization of TM4SF1+ tumor self-seeded cells
Yang, Haotian, Wang, Haolu, He, Yaowu, Yang, Yang, Thompson, Erik W., Xia, Di, Burke, Leslie J., Cao, Lu, Hooper, John D., Roberts, Michael S., Crawford, Darrell H.G. and Liang, Xiaowen (2024). Identification and characterization of TM4SF1+ tumor self-seeded cells. Cell Reports, 43 (7) 114512. doi: 10.1016/j.celrep.2024.114512
2022
Journal Article
Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis
Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163
2022
Journal Article
Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis
Butcher, Daniel A., Brandis, Kelli J., Wang, Haolu, Spannenburg, Liam, Bridle, Kim R., Crawford, Darrell HG. and Liang, Xiaowen (2022). Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: a systematic review and meta-analysis. European Journal of Surgical Oncology, 48 (3), 621-631. doi: 10.1016/j.ejso.2021.09.017
2022
Book Chapter
Theranostic nanoparticles for imaging and targeted drug delivery to the liver
Wang, Haolu, Yang, Haotian, Ruan, Qi, Roberts, Michael S. and Liang, Xiaowen (2022). Theranostic nanoparticles for imaging and targeted drug delivery to the liver. Fundamentals of drug delivery. (pp. 311-328) edited by Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams and Xiaowen Liang. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119769644.ch12
2021
Journal Article
A monochromophoric approach to succinct ratiometric fluorescent probes without probe-product crosstalk
Xin, Kai, Li, Xinxing, Guo, Yinghua, Zhong, Youhuan, Wang, Jungang, Yang, Haotian, Zhao, Jie, Guo, Chunlei, Huang, Yunxia, Lei, Zuhai, Ying, Yi-Lun, Luo, Xiao, Wang, Haolu, Qian, Xuhong, Yang, Wen, Liang, Xiaowen and Yang, Youjun (2021). A monochromophoric approach to succinct ratiometric fluorescent probes without probe-product crosstalk. CCS Chemistry, 3 (8), 2307-2315. doi: 10.31635/ccschem.020.202000480
2021
Journal Article
Liver organoid as a 3D in vitro model for drug validation and toxicity assessment
Brooks, Anastasia, Liang, Xiaowen, Zhang, Yonglong, Zhao, Chun-Xia, Roberts, Michael S., Wang, Haolu, Zhang, Lei and Crawford, Darrell H.G. (2021). Liver organoid as a 3D in vitro model for drug validation and toxicity assessment. Pharmacological Research, 169 105608, 105608. doi: 10.1016/j.phrs.2021.105608
2021
Journal Article
C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation
Zhang, Yonglong, Wang, Hui, Chen, Tao, Wang, Haolu, Liang, Xiaowen, Zhang, Yuchen, Duan, Jinlin, Qian, Shenjiao, Qiao, Ke, Zhang, Lei, Liu, Yanfeng and Wang, Jian (2021). C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation. Hepatology, 73 (2), 692-712. doi: 10.1002/hep.31304
2021
Journal Article
Preface
Benson, Heather A. E., Roberts, Michael S., Williams, Adrian C. and Liang, Xiaowen (2021). Preface. Fundamentals of Drug Delivery, xvii-xviii. doi: 10.1002/9781119769644.fmatter
2021
Book
Fundamentals of Drug Delivery
Benson, Heather A. E., Roberts, Michael S., Williams, Adrian C. and Liang, Xiaowen eds. (2021). Fundamentals of Drug Delivery. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/9781119769644
2021
Journal Article
Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions
Deng, Zheng, Xuan, Yan, Li, Xinxing, Crawford, William J., Yuan, Zhiqing, Chen, Zhoukan, Brooks, Anastasia, Song, Yanyan, Wang, Haolu, Liang, Xiaowen and Chen, Tao (2021). Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions. Journal of Cancer, 12 (5), 1531-1537. doi: 10.7150/JCA.54617
2020
Journal Article
Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse
Yang, Jingxing, Hou, Mengfei, Sun, Wenshe, Wu, Qinghe, Xu, Jia, Xiong, Liqin, Chai, Yimin, Liu, Yuxin, Yu, Meihua, Wang, Haolu, Xu, Zhi Ping, Liang, Xiaowen and Zhang, Chunfu (2020). Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse. Advanced Science, 7 (16) 2001088, 2001088. doi: 10.1002/advs.202001088
2020
Journal Article
Using in vivo multiphoton fluorescence lifetime imaging to unravel disease-specific changes in the liver redox state
Barkauskas, Deborah S., Medley, Gregory, Liang, Xiaowen, Mohammed, Yousuf H., Thorling, Camilla A., Wang, Haolu and Roberts, Michael S. (2020). Using in vivo multiphoton fluorescence lifetime imaging to unravel disease-specific changes in the liver redox state. Methods and Applications in Fluorescence, 8 (3) 034003, 034003. doi: 10.1088/2050-6120/ab93de
2020
Conference Publication
Synthesis And Edition Of Ultrasound Images Via Sketch Guided Progressive Growing Gans
Liang, Jiamin, Yang, Xin, Li, Haoming, Wang, Yi, Manh The Van,, Dou, Haoran, Chen, Chaoyu, Fang, Jinghui, Liang, Xiaowen, Mai, Zixin, Zhu, Guowen, Chen, Zhiyi and Ni, Dong (2020). Synthesis And Edition Of Ultrasound Images Via Sketch Guided Progressive Growing Gans. IEEE 17th International Symposium on Biomedical Imaging (ISBI), Iowa, IA United States, 3-7 April 2020. Piscataway, NJ United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/isbi45749.2020.9098384
2020
Journal Article
Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials
Spannenburg, Liam J., Sanchez Gonzalez, Mariana, Brooks, Anastasia, Wei, Shujun, Li, Xinxing, Liang, Xiaowen, Gao, Wenchao and Wang, Haolu (2020). Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials. European Journal of Surgical Oncology, 46 (8), 1404-1414. doi: 10.1016/j.ejso.2020.04.052
2020
Journal Article
Computer-aided diagnosis of gallbladder polyps based on high resolution ultrasonography
Chen, Tao, Tu, Shaoxiong, Wang, Haolu, Liu, Xuesong, Li, Fenghua, Jin, Wang, Liang, Xiaowen, Zhang, Xiaoqun and Wang, Jian (2020). Computer-aided diagnosis of gallbladder polyps based on high resolution ultrasonography. Computer Methods and Programs in Biomedicine, 185 105118, 105118. doi: 10.1016/j.cmpb.2019.105118
2020
Journal Article
Hepatic artery classification based on three-dimensional CT
Yan, J., Feng, H., Wang, H., Yuan, F., Yang, C., Liang, X., Chen, W. and Wang, J. (2020). Hepatic artery classification based on three-dimensional CT. British Journal of Surgery, 107 (7), 906-916. doi: 10.1002/bjs.11458
2020
Journal Article
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Ruan, Qi, Wang, Haolu, Burke, Leslie J., Bridle, Kim R., Li, Xinxing, Zhao, Chun-Xia, Crawford, Darrell H. G., Roberts, Michael S. and Liang, Xiaowen (2020). Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma. International Journal of Cancer, 147 (6) ijc.32899, 1519-1527. doi: 10.1002/ijc.32899
2020
Journal Article
Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury
Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900
Funding
Current funding
Supervision
Availability
- Dr Xiaowen Liang is:
- Available for supervision
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Available projects
-
Therapeutic modulation of chemotherapy-mediated hepatic stellate cell activation in liver cancer
This project will investigate the molecular mechanism underlying the chemotherapy mediated HSC activation and explore the potential molecular inhibitors to target the key signaling parthway and regulate HSC activation, which will guide the development of effective therapy for liver cancer.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Principal Advisor
Other advisors: Dr Kim Bridle
-
Doctor Philosophy
Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver
Associate Advisor
Other advisors: Professor Di Yu
Completed supervision
-
2024
Doctor Philosophy
Therapeutic modulation of chemotherapy-induced hepatic stellate cell activation in primary liver cancer
Principal Advisor
Other advisors: Dr Kim Bridle
-
2022
Doctor Philosophy
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Haolu Wang
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Kim Bridle, Dr Haolu Wang
-
2022
Doctor Philosophy
Pharmacotherapy consideration in hospitalized older diabetic and cardiovascular disease patients aged 75 years and above with polypharmacy
Associate Advisor
Other advisors: Dr Xin Liu, Emeritus Professor Michael Roberts
Media
Enquiries
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