Overview
Background
My research focuses on liver biology and pharmacology and I am a research team leader of the joint liver cancer research program of Frazer Institute and Gallipoli Medical Research Foundation from 2019. My long-term goal is to direct a research group exploring strategies to improve liver cancer outcomes in patients, working closely with clinicians to enable bench-to-bedside translation.
Availability
- Dr Xiaowen Liang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
I developed an intravital imaging platform for visualising and characterising the spatial distribution of activated hepatic stellate cells and metabolic status in liver cancer. This imaging platform and physiologically based kinetics modelling was applied for the first time to investigate the sub-organ disposition and clearance of therapeutic agents in the liver. By expanding the initial work, I further led studies on assessment and monitoring of cellular oxidative stress, microcirculation, and drug response in the specific liver microenvironment for early prediction of treatment efficacy in liver diseases.
Works
Search Professor Xiaowen Liang’s works on UQ eSpace
2020
Conference Publication
Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes
Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058
2019
Journal Article
Erratum: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT (Oncotarget (2017) 8 (47052–47063) DOI: 10.18632/oncotarget.16789)
Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2019). Erratum: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT (Oncotarget (2017) 8 (47052–47063) DOI: 10.18632/oncotarget.16789). OncoTarget, 10 (60), 6540-6540. doi: 10.18632/oncotarget.27299
2019
Journal Article
Identification of hub genes and construction of transcriptional regulatory network for the progression of colon adenocarcinoma hub genes and TF regulatory network of colon adenocarcinoma
Wei, Shuxun, Chen, Jinshui, Huang, Yu, Sun, Qiang, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2019). Identification of hub genes and construction of transcriptional regulatory network for the progression of colon adenocarcinoma hub genes and TF regulatory network of colon adenocarcinoma. Journal of Cellular Physiology, 235 (3) jcp.29067, 2037-2048. doi: 10.1002/jcp.29067
2019
Journal Article
Evaluation of quantum dot skin penetration in porcine skin: effect of age and anatomical site of topical application
Nastiti, Christofori M.R.R., Mohammed, Yousuf, Telaprolu, Krishna C., Liang, Xiaowen, Grice, Jeffrey E., Roberts, Michael S. and Benson, Heather A.E. (2019). Evaluation of quantum dot skin penetration in porcine skin: effect of age and anatomical site of topical application. Skin Pharmacology and Physiology, 32 (4), 1-10. doi: 10.1159/000499435
2019
Journal Article
GE11-PDA-Pt@USPIOs nano-formulation for relief of tumor hypoxia and MRI/PAI-guided tumor radio-chemotherapy
Yang, Chengcheng, Mi, Xuan, Su, Huilan, Yang, Jingxing, Gu, Yiyun, Zhang, Lu, Sun, Wenshe, Liang, Xiaowen and Zhang, Chunfu (2019). GE11-PDA-Pt@USPIOs nano-formulation for relief of tumor hypoxia and MRI/PAI-guided tumor radio-chemotherapy. Biomaterials Science, 7 (5), 2076-2090. doi: 10.1039/c8bm01492b
2019
Journal Article
Tumor chemo-radiotherapy with rod-shaped and spherical gold nano probes: shape and active targeting both matter
Zhang, Lu, Su, Huilan, Wang, Haolu, Li, Qian, Li, Xiao, Zhou, Chuanqing, Xu, Jia, Chai, Yimin, Liang, Xiaowen, Xiong, Liqin and Zhang, Chunfu (2019). Tumor chemo-radiotherapy with rod-shaped and spherical gold nano probes: shape and active targeting both matter. Theranostics, 9 (7), 1893-1908. doi: 10.7150/thno.30523
2019
Journal Article
Impact of Tumor Site on Lymph Node Status and Survival in Colon Cancer
Xie, Yayun, Huang, Yu, Ruan, Qi, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2019). Impact of Tumor Site on Lymph Node Status and Survival in Colon Cancer. Journal of Cancer, 10 (11), 2376-2383. doi: 10.7150/jca.32038
2019
Journal Article
Impact of age on risk of lymph node positivity in patients with colon cancer
Wang, Haolu, Lu, Hao, Yang, Haotian, Zhang, Xianwen, Thompson, Erik W., Roberts, Michael S., Hu, Zhigian, Liang, Xiaowen and Li, Xinxing (2019). Impact of age on risk of lymph node positivity in patients with colon cancer. Journal of Cancer, 10 (9), 2102-2108. doi: 10.7150/jca.28377
2019
Journal Article
Designer artificial membrane binding proteins to direct stem cells to the myocardium
Xiao, Wenjin, Green, Thomas I. P., Liang, Xiaowen, Delint, Rosalia Cuahtecontzi, Perry, Guillaume, Roberts, Michael S., Le Vay, Kristian, Back, Catherine R., Ascione, Raimomdo, Wang, Haolu, Race, Paul R. and Perriman, Adam W. (2019). Designer artificial membrane binding proteins to direct stem cells to the myocardium. Chemical Science, 10 (32), 7610-7618. doi: 10.1039/c9sc02650a
2018
Journal Article
Anionic long-circulating quantum dots for long-term intravital vascular imaging
Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244
2018
Journal Article
The role of cellular reactive oxygen species in cancer chemotherapy
Yang, Haotian, Villani, Rehan M., Wang, Haolu, Simpson, Matthew J., Roberts, Michael S., Tang, Min and Liang, Xiaowen (2018). The role of cellular reactive oxygen species in cancer chemotherapy. Journal of Experimental and Clinical Cancer Research, 37 (1) 266, 266. doi: 10.1186/s13046-018-0909-x
2018
Journal Article
A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications
He, Haihong, Liu, Yuxin, Zhou, Zhongneng, Guo, Chunlei, Wang, Hong-Yin, Wang, Zhuang, Wang, Xueli, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications. Free Radical Biology and Medicine, 123, 1-7. doi: 10.1016/j.freeradbiomed.2018.04.563
2018
Journal Article
Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells
Luo, Xiao, Yang, Haotian, Wang, Haolu, Ye, Zhiwei, Zhou, Zhongneng, Gu, Luyan, Chen, Jinquan, Xiao, Yi, Liang, Xiaowen, Qian, Xuhong and Yang, Youjun (2018). Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells. Analytical Chemistry, 90 (9), 5803-5809. doi: 10.1021/acs.analchem.8b00218
2018
Journal Article
A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
He, Haihong, Xia, Yang, Qi, Yingxue, Wang, Hong-Yin, Wang, Zhuang, Bao, Jianming, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry, 29 (4), 1194-1198. doi: 10.1021/acs.bioconjchem.7b00821
2018
Journal Article
Indocyanine green-incorporating nanoparticles for cancer theranostics
Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872
2018
Journal Article
Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice
Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072
2018
Book Chapter
Revealing interaction of dyes and nanomaterials by multiphoton imaging
Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020
2017
Journal Article
The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery
Lu, Hao, Guo, Rong, Yang, Haotian, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2017). The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery. Oncotarget, 9 (2), 2810-2818. doi: 10.18632/oncotarget.23596
2017
Journal Article
Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells
Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209
2017
Journal Article
Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells
Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39
Funding
Current funding
Supervision
Availability
- Dr Xiaowen Liang is:
- Available for supervision
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Available projects
-
Therapeutic modulation of chemotherapy-mediated hepatic stellate cell activation in liver cancer
This project will investigate the molecular mechanism underlying the chemotherapy mediated HSC activation and explore the potential molecular inhibitors to target the key signaling parthway and regulate HSC activation, which will guide the development of effective therapy for liver cancer.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Principal Advisor
Other advisors: Dr Kim Bridle
-
Doctor Philosophy
Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver
Associate Advisor
Other advisors: Professor Di Yu
Completed supervision
-
2024
Doctor Philosophy
Therapeutic modulation of chemotherapy-induced hepatic stellate cell activation in primary liver cancer
Principal Advisor
Other advisors: Dr Kim Bridle
-
2022
Doctor Philosophy
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Haolu Wang
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Kim Bridle, Dr Haolu Wang
-
2022
Doctor Philosophy
Pharmacotherapy consideration in hospitalized older diabetic and cardiovascular disease patients aged 75 years and above with polypharmacy
Associate Advisor
Other advisors: Dr Xin Liu, Emeritus Professor Michael Roberts
Media
Enquiries
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