Overview
Background
My research focuses on liver biology and pharmacology and I am a research team leader of the joint liver cancer research program of Frazer Institute and Gallipoli Medical Research Foundation from 2019. My long-term goal is to direct a research group exploring strategies to improve liver cancer outcomes in patients, working closely with clinicians to enable bench-to-bedside translation.
Availability
- Dr Xiaowen Liang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
I developed an intravital imaging platform for visualising and characterising the spatial distribution of activated hepatic stellate cells and metabolic status in liver cancer. This imaging platform and physiologically based kinetics modelling was applied for the first time to investigate the sub-organ disposition and clearance of therapeutic agents in the liver. By expanding the initial work, I further led studies on assessment and monitoring of cellular oxidative stress, microcirculation, and drug response in the specific liver microenvironment for early prediction of treatment efficacy in liver diseases.
Works
Search Professor Xiaowen Liang’s works on UQ eSpace
2016
Journal Article
Allosteric regulation of fibronectin/α5 β1 interaction by fibronectin-binding MSCRAMMs
Liang, Xiaowen, Garcia, Brandon L., Visai, Livia, Prabhakaran, Sabitha, Meenan, Nicola A. G., Potts, Jennifer R., Humphries, Martin J. and Höök, Magnus (2016). Allosteric regulation of fibronectin/α5 β1 interaction by fibronectin-binding MSCRAMMs. PLoS ONE, 11 (7) e0159118, e0159118. doi: 10.1371/journal.pone.0159118
2016
Journal Article
Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy
Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083
2016
Journal Article
Successful parenchyma-sparing anatomical surgery by 3-dimensional reconstruction of hilar cholangiocarcinoma combined with anatomic variation
Ni, Qihong, Wang, Haolu, Liang, Xiaowen, Zhang, Yunhe, Chen, Wei and Wang, Jian (2016). Successful parenchyma-sparing anatomical surgery by 3-dimensional reconstruction of hilar cholangiocarcinoma combined with anatomic variation. Journal of the College of Physicians and Surgeons Pakistan, 26 (S1), S13-S15.
2016
Journal Article
A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells
Wang, Haolu, Liang, Xiaowen, Xu, Zhi Ping, Crawford, Darrell H. G, Liu, Xin and Roberts, Michael S. (2016). A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports, 6 (1) 22293, e22293.1-e22293.12. doi: 10.1038/srep22293
2016
Journal Article
Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles
Liang, Xiaowen, Wang, Haolu, Grice, Jeffrey E., Li, Li, Liu, Xin, Xu, Zhi Ping and Roberts, Michael S. (2016). Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles. Nano Letters, 16 (2), 939-945. doi: 10.1021/acs.nanolett.5b03854
2016
Journal Article
Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney
Liang, Xiaowen, Wang, Haolu, Zhu, Yian, Zhang, Run, Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Grice, Jeffrey E. and Roberts, Michael S. (2016). Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney. Acs Nano, 10 (1), 387-395. doi: 10.1021/acsnano.5b05066
2016
Book Chapter
Multiphoton and fluorescence lifetime imaging microscopy in studying nanoparticle pharmacokinetics in skin and liver
Thorling, Camilla A., Holmes, Amy, Studier, Hauke, Liu, David, Liang, Xiaowen and Roberts, Michael S. (2016). Multiphoton and fluorescence lifetime imaging microscopy in studying nanoparticle pharmacokinetics in skin and liver. Multiphoton and fluorescence lifetime imaging microscopy in studying nanoparticle pharmacokinetics in skin and liver. (pp. 107-123) edited by Stefan G. Stanciu. Rijeka, Croatia: InTech. doi: 10.5772/63452
2015
Journal Article
Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects
Jin, Yue, Wang, Haolu, Ma, Xiaowei, Liang, Xiaowen, Liu, Xin and Wang, Yu (2015). Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects. PLoS ONE, 10 (5) e0127229, e0127229. doi: 10.1371/journal.pone.0127229
2015
Other Outputs
Biodistribution of newly developed water-dispersible CdTe/CdS quantum dots for in vivo imaging
Liang, Xiaowen (2015). Biodistribution of newly developed water-dispersible CdTe/CdS quantum dots for in vivo imaging. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2015.503
2015
Journal Article
Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging
Wang, Haolu, Liang, Xiaowen, Mohammed, Yousuf H., Thomas, James A., Bridle, Kim R., Thorling, Camilla A., Grice, Jeffrey E., Xu, Zhi Ping, Liu, Xin, Crawford, Darrell H. G. and Roberts, Michael S. (2015). Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express, 6 (3), 780-792. doi: 10.1364/BOE.6.000780
2015
Journal Article
Diagnostic imaging and therapeutic application of nanoparticles targeting the liver
Wang, Haolu, Thorling, Camilla A., Liang, Xiaowen, Bridle, Kim R., Grice, Jeffrey E., Zhu, Yian, Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2015). Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. Journal of Materials Chemistry B, 3 (6), 939-958. doi: 10.1039/C4TB01611D
2015
Conference Publication
A physiologically based kinetic model to characterize and predict the biological fate of circulating tumor cells in vivo
Wang, H., Liang, X., Thorling, C., Xu, Z. P., Crawford, D., Liu, X. and Roberts, M. (2015). A physiologically based kinetic model to characterize and predict the biological fate of circulating tumor cells in vivo. European Cancer Congress, Vienna, Austria, 2015. Hoboken, NJ United States: Wiley. doi: 10.1016/S0959-8049(15)30013-7
2015
Conference Publication
A blood-flow limited physiologically based kinetic model to characterize and predict the biological fate of mesenchymal stem cells in vivo
Wang, H., Liang, X., Endo-Munoz, L., Weijs, L., Liu, X., Crawford, D. and Roberts, M. (2015). A blood-flow limited physiologically based kinetic model to characterize and predict the biological fate of mesenchymal stem cells in vivo. Gastro 2015 GESA‐AGW And WGO International Congress, Gastroenterological Society Of Australia Australian Gastroenterology Week 2015 - World Congress Of Gastroenterology, , Brisbane, Queensland, Australia, 28 September‐2 October 2015. Richmond, VIC Australia: Wiley.
2015
Conference Publication
Early diagnosis of hepatocellular carcinoma by in vivo imaging
Liang, X., Wang, H., Zhu, Y., Grice, J., Liu, X., Xu, Z. and Roberts, M. (2015). Early diagnosis of hepatocellular carcinoma by in vivo imaging. European Cancer Congress, Vienna, Austria, 2015. Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(16)30378-1
2014
Journal Article
Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis
Jin, Yue, Wang, Haolu, Liang, Xiaowen, Ma, Jun and Wang, Yu (2014). Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis. Tumor Biology, 35 (8), 8149-8159. doi: 10.1007/s13277-014-2059-x
2014
Journal Article
Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma
Wang, Hui, Wang, Haolu, Chen, Tao, Liang, Xiaowen, Song, Yanyan and Wang, Jian (2014). Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma. World Journal of Surgical Oncology, 12 (1) 191. doi: 10.1186/1477-7819-12-191
2014
Journal Article
Bacteria in hernia sac: an important risk fact for surgical site infection after incarcerated hernia repair
Yang, L., Wang, H., Liang, X., Chen, T., Chen, W., Song, Y. and Wang, J. (2014). Bacteria in hernia sac: an important risk fact for surgical site infection after incarcerated hernia repair. Hernia, 19 (2), 279-283. doi: 10.1007/s10029-014-1275-z
2014
Journal Article
Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells
Liang X., Grice J.E., Zhu Y., Liu D., Sanchez W.Y., Li Z., Crawford D.H.G., Le Couteur D.G., Cogger V.C., Liu X., Xu Z.P. and Roberts M.S. (2014). Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small, 11 (14), 1711-1720. doi: 10.1002/smll.201402698
2013
Journal Article
Penetration of Nanoparticles into Human Skin
Liang, Xiao Wen, Xu, Zhi Ping, Grice, Jeffrey, Zvyagin, Andrei V., Roberts, Michael S. and Liu, Xin (2013). Penetration of Nanoparticles into Human Skin. Current Pharmaceutical Design, 19 (35), 6353-6366. doi: 10.2174/1381612811319350011
Funding
Current funding
Supervision
Availability
- Dr Xiaowen Liang is:
- Available for supervision
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Available projects
-
Therapeutic modulation of chemotherapy-mediated hepatic stellate cell activation in liver cancer
This project will investigate the molecular mechanism underlying the chemotherapy mediated HSC activation and explore the potential molecular inhibitors to target the key signaling parthway and regulate HSC activation, which will guide the development of effective therapy for liver cancer.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Principal Advisor
Other advisors: Dr Kim Bridle
-
Doctor Philosophy
Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver
Associate Advisor
Other advisors: Professor Di Yu
Completed supervision
-
2024
Doctor Philosophy
Therapeutic modulation of chemotherapy-induced hepatic stellate cell activation in primary liver cancer
Principal Advisor
Other advisors: Dr Kim Bridle
-
2022
Doctor Philosophy
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Haolu Wang
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Kim Bridle, Dr Haolu Wang
-
2022
Doctor Philosophy
Pharmacotherapy consideration in hospitalized older diabetic and cardiovascular disease patients aged 75 years and above with polypharmacy
Associate Advisor
Other advisors: Dr Xin Liu, Emeritus Professor Michael Roberts
Media
Enquiries
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