Overview
Background
My research focuses on liver biology and pharmacology and I am a research team leader of the joint liver cancer research program of Frazer Institute and Gallipoli Medical Research Foundation from 2019. My long-term goal is to direct a research group exploring strategies to improve liver cancer outcomes in patients, working closely with clinicians to enable bench-to-bedside translation.
Availability
- Dr Xiaowen Liang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
I developed an intravital imaging platform for visualising and characterising the spatial distribution of activated hepatic stellate cells and metabolic status in liver cancer. This imaging platform and physiologically based kinetics modelling was applied for the first time to investigate the sub-organ disposition and clearance of therapeutic agents in the liver. By expanding the initial work, I further led studies on assessment and monitoring of cellular oxidative stress, microcirculation, and drug response in the specific liver microenvironment for early prediction of treatment efficacy in liver diseases.
Works
Search Professor Xiaowen Liang’s works on UQ eSpace
2018
Journal Article
The role of cellular reactive oxygen species in cancer chemotherapy
Yang, Haotian, Villani, Rehan M., Wang, Haolu, Simpson, Matthew J., Roberts, Michael S., Tang, Min and Liang, Xiaowen (2018). The role of cellular reactive oxygen species in cancer chemotherapy. Journal of Experimental and Clinical Cancer Research, 37 (1) 266, 266. doi: 10.1186/s13046-018-0909-x
2018
Journal Article
A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications
He, Haihong, Liu, Yuxin, Zhou, Zhongneng, Guo, Chunlei, Wang, Hong-Yin, Wang, Zhuang, Wang, Xueli, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications. Free Radical Biology and Medicine, 123, 1-7. doi: 10.1016/j.freeradbiomed.2018.04.563
2018
Journal Article
Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells
Luo, Xiao, Yang, Haotian, Wang, Haolu, Ye, Zhiwei, Zhou, Zhongneng, Gu, Luyan, Chen, Jinquan, Xiao, Yi, Liang, Xiaowen, Qian, Xuhong and Yang, Youjun (2018). Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells. Analytical Chemistry, 90 (9), 5803-5809. doi: 10.1021/acs.analchem.8b00218
2018
Journal Article
A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
He, Haihong, Xia, Yang, Qi, Yingxue, Wang, Hong-Yin, Wang, Zhuang, Bao, Jianming, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry, 29 (4), 1194-1198. doi: 10.1021/acs.bioconjchem.7b00821
2018
Book Chapter
Revealing interaction of dyes and nanomaterials by multiphoton imaging
Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020
2018
Journal Article
Indocyanine green-incorporating nanoparticles for cancer theranostics
Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872
2018
Journal Article
Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice
Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072
2017
Journal Article
The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery
Lu, Hao, Guo, Rong, Yang, Haotian, Wang, Haolu, Liang, Xiaowen, Hu, Zhiqian and Li, Xinxing (2017). The prognostic value of negative lymph node count for patients with cervical cancer after radical surgery. Oncotarget, 9 (2), 2810-2818. doi: 10.18632/oncotarget.23596
2017
Journal Article
Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells
Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209
2017
Journal Article
Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells
Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39
2017
Journal Article
Age-specific impact on the survival of gastric cancer patients with distant metastasis: an analysis of SEER database
Li, Xinxing, Wang, Weijun, Ruan, Canping, Wang, Yi, Wang, Haolu, Liang, Xiaowen, Sun, Yanping and Hu, Zhiqian (2017). Age-specific impact on the survival of gastric cancer patients with distant metastasis: an analysis of SEER database. Oncotarget, 8 (57), 97090-97100. doi: 10.18632/oncotarget.21350
2017
Journal Article
The influence of marital status on survival of gallbladder cancer patients: a population-based study
Li, Xinxing, Liu, Ye, Wang, Yi, Ruan, Canping, Wang, Haolu, Liang, Xiaowen, Sun, Yanping and Hu, Zhiqian (2017). The influence of marital status on survival of gallbladder cancer patients: a population-based study. Scientific Reports, 7 (1) 5322, 5322. doi: 10.1038/s41598-017-05545-0
2017
Journal Article
Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway
Zhou, Ling-ling, Zhou, Cong, Liang, Xiao-wen, Feng, Zhe, Liu, Zhang-pu, Wang, Hao-lu and Zhou, Xue-ping (2017). Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway. Chinese Journal of Integrative Medicine, 23 (12), 929-936. doi: 10.1007/s11655-017-2546-6
2017
Journal Article
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT
Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. OncoTarget, 8 (29), 47052-47063. doi: 10.18632/oncotarget.16789
2017
Journal Article
Multiphoton imaging for assessing renal disposition in acute kidney injury
Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964
2017
Journal Article
Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy
Li, Xinxing, Lu, Hao, Xu, Kai, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy. BMC Cancer, 17 (1) 227, 227. doi: 10.1186/s12885-017-3222-8
2017
Journal Article
Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374
2017
Journal Article
The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy
Li, Xinxing, Zhang, Weigang, Zhang, Xianwen, Wang, Haolu, Xu, Kai, Yao, Houshan, Yao, Jun, Liang, Xiaowen and Hu, Zhiqian (2017). The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy. Oncotarget, 8 (29), 46946-46954. doi: 10.18632/oncotarget.14943
2017
Journal Article
A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury
Zhang, Feiyue, Liang, Xiaowen, Zhang, Wenzhu, Wang, Yong-Lei, Wang, Haolu, Mohammed, Yousuf H., Song, Bo, Zhang, Run and Yuan, Jingli (2017). A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors and Bioelectronics, 87, 1005-1011. doi: 10.1016/j.bios.2016.09.067
2017
Conference Publication
Non-invasive assessment of the liver using imaging
Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883
Funding
Current funding
Supervision
Availability
- Dr Xiaowen Liang is:
- Available for supervision
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Available projects
-
Therapeutic modulation of chemotherapy-mediated hepatic stellate cell activation in liver cancer
This project will investigate the molecular mechanism underlying the chemotherapy mediated HSC activation and explore the potential molecular inhibitors to target the key signaling parthway and regulate HSC activation, which will guide the development of effective therapy for liver cancer.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic regulation of cancer-associated fibroblast subpopulations in liver cancer treatment
Principal Advisor
Other advisors: Dr Yang Yang, Dr Janin Chandra
-
Doctor Philosophy
The physiological regulation of T cells by ferroptosis
Associate Advisor
Other advisors: Dr Naiqi Wang, Professor Di Yu
Completed supervision
-
2024
Doctor Philosophy
Therapeutic modulation of chemotherapy-induced hepatic stellate cell activation in primary liver cancer
Principal Advisor
Other advisors: Dr Kim Bridle
-
2022
Doctor Philosophy
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Haolu Wang
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Kim Bridle, Dr Haolu Wang
-
2022
Doctor Philosophy
Pharmacotherapy consideration in hospitalized older diabetic and cardiovascular disease patients aged 75 years and above with polypharmacy
Associate Advisor
Other advisors: Dr Xin Liu, Emeritus Professor Michael Roberts
Media
Enquiries
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