Overview
Background
My research focuses on liver biology and pharmacology and I am a research team leader of the joint liver cancer research program of Frazer Institute and Gallipoli Medical Research Foundation from 2019. My long-term goal is to direct a research group exploring strategies to improve liver cancer outcomes in patients, working closely with clinicians to enable bench-to-bedside translation.
Availability
- Dr Xiaowen Liang is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
I developed an intravital imaging platform for visualising and characterising the spatial distribution of activated hepatic stellate cells and metabolic status in liver cancer. This imaging platform and physiologically based kinetics modelling was applied for the first time to investigate the sub-organ disposition and clearance of therapeutic agents in the liver. By expanding the initial work, I further led studies on assessment and monitoring of cellular oxidative stress, microcirculation, and drug response in the specific liver microenvironment for early prediction of treatment efficacy in liver diseases.
Works
Search Professor Xiaowen Liang’s works on UQ eSpace
2017
Journal Article
Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway
Zhou, Ling-ling, Zhou, Cong, Liang, Xiao-wen, Feng, Zhe, Liu, Zhang-pu, Wang, Hao-lu and Zhou, Xue-ping (2017). Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway. Chinese Journal of Integrative Medicine, 23 (12), 929-936. doi: 10.1007/s11655-017-2546-6
2017
Journal Article
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT
Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. OncoTarget, 8 (29), 47052-47063. doi: 10.18632/oncotarget.16789
2017
Journal Article
Multiphoton imaging for assessing renal disposition in acute kidney injury
Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964
2017
Journal Article
Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy
Li, Xinxing, Lu, Hao, Xu, Kai, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy. BMC Cancer, 17 (1) 227, 227. doi: 10.1186/s12885-017-3222-8
2017
Journal Article
Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury
Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374
2017
Journal Article
The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy
Li, Xinxing, Zhang, Weigang, Zhang, Xianwen, Wang, Haolu, Xu, Kai, Yao, Houshan, Yao, Jun, Liang, Xiaowen and Hu, Zhiqian (2017). The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy. Oncotarget, 8 (29), 46946-46954. doi: 10.18632/oncotarget.14943
2017
Journal Article
A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury
Zhang, Feiyue, Liang, Xiaowen, Zhang, Wenzhu, Wang, Yong-Lei, Wang, Haolu, Mohammed, Yousuf H., Song, Bo, Zhang, Run and Yuan, Jingli (2017). A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors and Bioelectronics, 87, 1005-1011. doi: 10.1016/j.bios.2016.09.067
2017
Conference Publication
Quantitative optical imaging of paracetamol-induced metabolism changes in the liver
Liang, Xiaowen, Wang, Haolu, Liu, Xin and Roberts, Michael (2017). Quantitative optical imaging of paracetamol-induced metabolism changes in the liver. SPIE BioPhotonics Australasia, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242962
2017
Book Chapter
Related topic: Safety evaluation of nanomaterials
Liang, Xiaowen, Wang, Haolu, Liu, Xin, Grice, Jeffrey, Xu, Zhi Ping and Roberts, Michael S. (2017). Related topic: Safety evaluation of nanomaterials. Skin permeation and disposition of therapeutic and cosmeceutical compounds. (pp. 313-322) edited by Kenji Sugibayashi. Tokyo, Japan: Springer Japan. doi: 10.1007/978-4-431-56526-0_28
2017
Book Chapter
Hepatic metabolism in liver health and disease
Liu, X., Wang, H., Liang, X. and Roberts, M. S. (2017). Hepatic metabolism in liver health and disease. Liver Pathophysiology: Therapies and Antioxidants. (pp. 391-400) edited by Pablo Muriel. Cambridge, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-804274-8.00030-8
2017
Journal Article
Exploration of the optimal lymph node count retrieved for patients with node-negative colonic mucinous cancer
Teng, Shifeng, Xu, Kai, Yao, Jun, Zhang, Xianwen, Li, Mingming, Zhang, Yanyan, Zhang, Weigang, Wang, Haolu, Liang, Xiaowen, Li, Xinxing and Hu, Zhiqian (2017). Exploration of the optimal lymph node count retrieved for patients with node-negative colonic mucinous cancer. International Journal of Clinical and Experimental Medicine, 10 (12), 16625-16631.
2017
Conference Publication
Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis
Wang, H., Liang, X., Weijs, L., Brooks, A., Liu, X., Roberts, M. S. and Crawford, D. H. G. (2017). Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, Queensland, 20–22 Aug 2017. Hoboken, NJ United States: Wiley.
2017
Conference Publication
In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe
Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978
2017
Conference Publication
Non-invasive assessment of the liver using imaging
Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883
2017
Conference Publication
Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity
Liang, X., Wang, H., Liu, X., Touraud, M., Chouane, J. B., Tse, B. and Roberts, M. S. (2017). Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, , Gold Coast, Queensland, Australia, 20–22 Aug 2017. Richmond, VIC Australia: Wiley.
2016
Journal Article
MDCT assessment of resectability in hilar cholangiocarcinoma
Ni, Qihong, Wang, Haolu, Zhang, Yunhe, Qian, Lijun, Chi, Jiachang, Liang, Xiaowen, Chen, Tao and Wang, Jian (2016). MDCT assessment of resectability in hilar cholangiocarcinoma. Abdominal Radiology, 42 (3), 1-10. doi: 10.1007/s00261-016-0943-0
2016
Journal Article
Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation
Li, Xinxing, Wang, Haolu, Wang, Juan, Chen, Yuying, Yin, Xiaobin, Shi, Guiying, Li, Hui, Hu, Zhiqian and Liang, Xiaowen (2016). Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. Bmc Cancer, 16 (1) 578, 578. doi: 10.1186/s12885-016-2640-3
2016
Journal Article
Allosteric regulation of fibronectin/α5 β1 interaction by fibronectin-binding MSCRAMMs
Liang, Xiaowen, Garcia, Brandon L., Visai, Livia, Prabhakaran, Sabitha, Meenan, Nicola A. G., Potts, Jennifer R., Humphries, Martin J. and Höök, Magnus (2016). Allosteric regulation of fibronectin/α5 β1 interaction by fibronectin-binding MSCRAMMs. PLoS ONE, 11 (7) e0159118, e0159118. doi: 10.1371/journal.pone.0159118
2016
Journal Article
Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy
Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083
2016
Journal Article
Successful parenchyma-sparing anatomical surgery by 3-dimensional reconstruction of hilar cholangiocarcinoma combined with anatomic variation
Ni, Qihong, Wang, Haolu, Liang, Xiaowen, Zhang, Yunhe, Chen, Wei and Wang, Jian (2016). Successful parenchyma-sparing anatomical surgery by 3-dimensional reconstruction of hilar cholangiocarcinoma combined with anatomic variation. Journal of the College of Physicians and Surgeons Pakistan, 26 (S1), S13-S15.
Funding
Current funding
Past funding
Supervision
Availability
- Dr Xiaowen Liang is:
- Available for supervision
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Available projects
-
Therapeutic modulation of chemotherapy-mediated hepatic stellate cell activation in liver cancer
This project will investigate the molecular mechanism underlying the chemotherapy mediated HSC activation and explore the potential molecular inhibitors to target the key signaling parthway and regulate HSC activation, which will guide the development of effective therapy for liver cancer.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Principal Advisor
Other advisors: Professor Darrell Crawford, Dr Kim Bridle
-
Doctor Philosophy
Ferroptosis-mediated regulation of lymphocyte homeostasis and function in the liver
Associate Advisor
Other advisors: Professor Darrell Crawford, Professor Di Yu
Completed supervision
-
2022
Doctor Philosophy
The Characterisation of Tumour Self-Seeded Cells in Liver Cancer
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Haolu Wang
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Kim Bridle, Dr Haolu Wang
-
2022
Doctor Philosophy
Pharmacotherapy consideration in hospitalized older diabetic and cardiovascular disease patients aged 75 years and above with polypharmacy
Associate Advisor
Other advisors: Dr Xin Liu, Emeritus Professor Michael Roberts
Media
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