Dr Kim Bridle
Dr

Kim Bridle

Email: 
Phone: 
+61 7 334 60698

Background

Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.

Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.

Availability

Dr Kim Bridle is:
Available for supervision

Fields of research

Clinical sciences

Qualifications

  • Bachelor of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Kim Bridle’s works on UQ eSpace

139 works between 1995 and 2023
All (139) Journal Article (65) Conference Publication (74)

41 - 60 of 139 works

2017

Journal Article

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

2017

Journal Article

Contribution of liver nonparenchymal cells to hepatic fibrosis: interactions with the local microenvironment

Fausther, Michel, Pritchard, Michele T., Popov, Yury V. and Bridle, Kim (2017). Contribution of liver nonparenchymal cells to hepatic fibrosis: interactions with the local microenvironment. Biomed Research International, 2017 6824762, 6824762-4. doi: 10.1155/2017/6824762

Contribution of liver nonparenchymal cells to hepatic fibrosis: interactions with the local microenvironment

2017

Journal Article

Low-dose lipopolysaccharide causes biliary injury by blood biliary barrier impairment in a rat hepatic ischemia/reperfusion model

Reiling, Janske, Bridle, Kim R., Gijbels, Marion, Schaap, Frank G., Jaskowski, Lesley, Santrampurwala, Nishreen, Britton, Laurence J., Campbell, Catherine M., Olde Damink, Steven W. M., Crawford, Darrell H. G., Dejong, Cornelius H. C. and Fawcett, Jonathan (2017). Low-dose lipopolysaccharide causes biliary injury by blood biliary barrier impairment in a rat hepatic ischemia/reperfusion model. Liver Transplantation, 23 (2), 194-206. doi: 10.1002/lt.24681

Low-dose lipopolysaccharide causes biliary injury by blood biliary barrier impairment in a rat hepatic ischemia/reperfusion model

2017

Conference Publication

Iron blocks the secretion of apolipoprotein E in cultured human adipocytes

Britton, L. J., Bridle, K., Jaskowski, L. A., He, J., Ng, C., Ruelcke, J. E., Reiling, J., Santrampurwala, N., Hill, M. M., Whitehead, J. P., Subramaniam, V. N. and Crawford, D. H. G. (2017). Iron blocks the secretion of apolipoprotein E in cultured human adipocytes. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology , Gold Coast, QLD, Australia, 20–22 August 2017. Hoboken, NJ United States: Wiley-Blackwell Publishing.

Iron blocks the secretion of apolipoprotein E in cultured human adipocytes

2016

Journal Article

Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet

Britton, Laurence, Jaskowski, Lesley, Bridle, Kim, Santrampurwala, Nishreen, Reiling, Janske, Musgrave, Nick, Subramaniam, V. Nathan and Crawford, Darrell (2016). Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet. Physiological Reports, 4 (12) e12837, e12837. doi: 10.14814/phy2.12837

Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet

2016

Conference Publication

Liver disease in Vietnam veterans: a comparison of veterans with and without PTSD

Hlaing, P. M., Bridle, K. R., Jaskowski, L. A., Harvey, W. M. and Crawford, D. H. G. (2016). Liver disease in Vietnam veterans: a comparison of veterans with and without PTSD. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. Hoboken, NJ United States: Wiley-Blackwell Publishing.

Liver disease in Vietnam veterans: a comparison of veterans with and without PTSD

2016

Conference Publication

The application of normothermic machine perfusion to bench-test human donor livers

Reiling, J., Simpson, A., Bridle, K. R., Lockwood, D., Santrampurwala, N., Britton, L., Dejong, C. H. C., Crawford, D. H. G. and Fawcett, J. (2016). The application of normothermic machine perfusion to bench-test human donor livers. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October 2016. Hoboken, NJ United States: Wiley-Blackwell Publishing.

The application of normothermic machine perfusion to bench-test human donor livers

2015

Journal Article

Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2-/- mice

Bridle, Kim R., Sobbe, Amy L., de Guzman, C. Erika, Santrampurwala, Nishreen, Jaskowski, Lesley A., Clouston, Andrew D., Campbell, Catherine M., Nathan Subramaniam, V. and Crawford, Darrell H. G. (2015). Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2-/- mice. Liver International, 35 (4), 1451-1463. doi: 10.1111/liv.12494

Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2-/- mice

2015

Journal Article

Urea production during Normothermic Machine Perfusion: Price of Success?

Reiling, Janske, Lockwood, David S. R., Simpson, Andrew H., Campbell, Catherine M., Bridle, Kim R., Santrampurwala, Nishreen, Britton, Laurence J., Crawford, Darrell Henry G., Dejong, Cornelius H. C. and Fawcett, Jonathan (2015). Urea production during Normothermic Machine Perfusion: Price of Success?. Liver Transplantation, 21 (5), 700-703. doi: 10.1002/lt.24094

Urea production during Normothermic Machine Perfusion: Price of Success?

2015

Journal Article

Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging

Wang, Haolu, Liang, Xiaowen, Mohammed, Yousuf H., Thomas, James A., Bridle, Kim R., Thorling, Camilla A., Grice, Jeffrey E., Xu, Zhi Ping, Liu, Xin, Crawford, Darrell H. G. and Roberts, Michael S. (2015). Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express, 6 (3), 780-792. doi: 10.1364/BOE.6.000780

Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging

2015

Journal Article

Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

Sobbe, Amy, Bridle, Kim R., Jaskowski, Lesley, de Guzman, C. Erika, Santrampurwala, Nishreen, Clouston, Andrew D., Campbell, Catherine M., Subramaniam, V. Nathan and Crawford, Darrell H. G. (2015). Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. Journal of Gastroenterology and Hepatology, 30 (3), 638-645. doi: 10.1111/jgh.12720

Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

2015

Journal Article

Diagnostic imaging and therapeutic application of nanoparticles targeting the liver

Wang, Haolu, Thorling, Camilla A., Liang, Xiaowen, Bridle, Kim R., Grice, Jeffrey E., Zhu, Yian, Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2015). Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. Journal of Materials Chemistry B, 3 (6), 939-958. doi: 10.1039/C4TB01611D

Diagnostic imaging and therapeutic application of nanoparticles targeting the liver

2015

Conference Publication

Serum adipokines in response to venesection in patients with non-alcoholic fatty liver disease

Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Subramaniam, V., Crawford, D. and Adams, L. (2015). Serum adipokines in response to venesection in patients with non-alcoholic fatty liver disease. Gastro 2015 GESA-AGW and WGO International Congress, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13087

Serum adipokines in response to venesection in patients with non-alcoholic fatty liver disease

2015

Conference Publication

Free fatty acid treatment reduces BMP6 signalling in AML12 hepatocytes

Santrampurwala, N., Bridle, K. R., Reiling, J., Britton, L. J., Jaskowski, L. A., Subramaniam, V. N. and Crawford, D. H. G. (2015). Free fatty acid treatment reduces BMP6 signalling in AML12 hepatocytes. Gastro 2015 GESA-AGW and WGO International Congress, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13087

Free fatty acid treatment reduces BMP6 signalling in AML12 hepatocytes

2015

Conference Publication

Pre-treatment with TIMP-3 prevents the development of biliary injury in an LPS enhanced ischaemia-reperfusion animal model

Reiling, J., Bridle, K., Campbell, C., Santrampurwala, N., Britton, L., Cohen, A., Crawford, D., Dejong, C. and Fawcett, J. (2015). Pre-treatment with TIMP-3 prevents the development of biliary injury in an LPS enhanced ischaemia-reperfusion animal model. World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October, 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13087

Pre-treatment with TIMP-3 prevents the development of biliary injury in an LPS enhanced ischaemia-reperfusion animal model

2014

Conference Publication

The potential role of lipopolysaccharides in the development of biliary injury in an animal partial liver ischemia model

Reiling, J., Bridle, K. R., Santrampurwala, N., Britton, L. J., Crawford, D. H. G., Dejong, C. H. C. and Fawcett, J. (2014). The potential role of lipopolysaccharides in the development of biliary injury in an animal partial liver ischemia model. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.12736_8

The potential role of lipopolysaccharides in the development of biliary injury in an animal partial liver ischemia model

2014

Conference Publication

Successful ex-vivo normothermic oxygenated machine perfusion of human donor livers

Reiling, J., Lockwood, D. S. R., Simpson, A. H., Campbell, C. M., Bridle, K. R., Santrampurwala, N., Britton, L. J., Crawford, D. H. G., Dejong, C. H. C. and Fawcett, J. (2014). Successful ex-vivo normothermic oxygenated machine perfusion of human donor livers. 65th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, United States, 7 - 11 November 2014. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.

Successful ex-vivo normothermic oxygenated machine perfusion of human donor livers

2013

Conference Publication

Impaired iron uptake in Mdr2(-/-) mice results in hepatic iron deficiency: implications for patients with cholestatic liver injury

Sobbe, A. L., Frazer, D. M., Bridle, K. R., Jaskowski, L. A., Anderson, G. J., Subramaniam, V. N. and Crawford, D. H. (2013). Impaired iron uptake in Mdr2(-/-) mice results in hepatic iron deficiency: implications for patients with cholestatic liver injury. The Australian Gastroenterology Week 2013, Melbourne, VIC Australia, 7 - 9 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365

Impaired iron uptake in Mdr2(-/-) mice results in hepatic iron deficiency: implications for patients with cholestatic liver injury

2013

Conference Publication

Heterozygous Deletion of the Hfe Gene Contributes to Hepatic Iron Loading But Not Steatosis in Mice Fed a High Fat Diet

Britton, Laurence, Jaskowski, Lesley, Wilkinson, Ashley, Bridle, Kim, Subramaniam, Nathan and Crawford, Darrell (2013). Heterozygous Deletion of the Hfe Gene Contributes to Hepatic Iron Loading But Not Steatosis in Mice Fed a High Fat Diet. 5th Meeting of the International BioIron Society, University College London UK, 14 - 18 May 2013. Hoboken, NJ United States: John Wiley and Sons, Inc. doi: 10.1002/ajh.23453

Heterozygous Deletion of the Hfe Gene Contributes to Hepatic Iron Loading But Not Steatosis in Mice Fed a High Fat Diet

2013

Conference Publication

An iron-deficient diet attenuates diet-induced hepatic steatosis in HFE-associated non-alcoholic fatty liver disease using Hfe(-/-) mice

Wilkinson, A. S., Bridle, K. R., Britton, L. J., Jaskowski, L. A., Fletcher, L. M., Subramaniam, V. N. and Crawford, D. H. G. (2013). An iron-deficient diet attenuates diet-induced hepatic steatosis in HFE-associated non-alcoholic fatty liver disease using Hfe(-/-) mice. The Australian Gastroenterology Week 2013, Melbourne, VIC Australia, 7 - 9 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365

An iron-deficient diet attenuates diet-induced hepatic steatosis in HFE-associated non-alcoholic fatty liver disease using Hfe(-/-) mice

Current funding

  • 2014 - 2024
    Liver Disease Research
    Gallipoli Medical Research Foundation
    Open grant

Past funding

  • 2014 - 2019
    Immunotherapeutic Approaches for Hepatocellular Carcinoma
    Gallipoli Medical Research Foundation
    Open grant
  • 2013
    Targeting Pathophysiology & therapy of liver fibrosis
    Gallipoli Research Foundation
    Open grant
  • 2011 - 2013
    Targeting the Pathophysiology and Therapy of Liver Fibrosis
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Reginald Ferguson Fellowship - Rapamycin as an Antifibrotic Agent in Cholestatic Liver Disease
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2007 - 2010
    The pathogenesis of co-toxic liver disease
    Queensland Health Smart Health Research Grant
    Open grant
  • 2006 - 2008
    Reginald Ferguson Research Fellowship - Primary Sclerosing Cholangitis - A Life Threatening Complication of Inflammatory Bowel Disease: Investigations to Attenuate Disease Progression
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2006 - 2007
    The use of rapamycin to slow scarring of the liver
    Royal Children's Hospital Foundation
    Open grant
  • 2006 - 2009
    Immunosuppressant-Mediated Changes in Extracellular Matrix Balance in Animal Models of Liver Disease
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2005 - 2007
    Does immunosuppression affect the post-transplantation hepatic fibrogenic response?
    NHMRC Project Grant
    Open grant
  • 2005
    The Influence of Immunosuppression on the Hepatic Stellate Cell Fibrogenic Response
    UQ Early Career Researcher
    Open grant
  • 2004 - 2007
    Pathogenic mechanisms underlying iron co-toxicity in chronic liver disease
    Gastroenterological Society of Australia
    Open grant

Availability

Dr Kim Bridle is:
Available for supervision

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Available projects

  • Novel Therapies for Co-toxic Liver Disease

    This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.

Supervision history

Current supervision

Completed supervision

Enquiries

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