Dr Kim Bridle
Dr

Kim Bridle

Email: 
Phone: 
+61 7 334 60698

Background

Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.

Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.

Availability

Dr Kim Bridle is:
Available for supervision

Fields of research

Clinical sciences

Qualifications

  • Bachelor of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Kim Bridle’s works on UQ eSpace

141 works between 1995 and 2025
All (141) Journal Article (65) Conference Publication (76)

101 - 120 of 141 works

2006

Conference Publication

Very low dose rapamycin : In vitro evidence for its use as an antifibrotic agent

Morgan, M. L., Bridle, K. R., Fletcher, L. M. and Crawford, D. H. G. (2006). Very low dose rapamycin : In vitro evidence for its use as an antifibrotic agent. Australian Gastroenterology Week, Adelaide, SA, Australia, 11-14 October 2006. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x

Very low dose rapamycin : In vitro evidence for its use as an antifibrotic agent

2006

Conference Publication

Serum adiponectin is increased in HFE-/- mice fed alcohol

Bridle, K. R., Murphy, T. L., Anderson, G. J., Macdonald, G. A., Crawford, D. H. G. and Fletcher, L. M. (2006). Serum adiponectin is increased in HFE-/- mice fed alcohol. Australian Gastroenterology Week 2006, Adelaide, South Australia, 11-14 October, 2006. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x

Serum adiponectin is increased in HFE-/- mice fed alcohol

2006

Conference Publication

Very low dose rapamycin: in vitro evidence for its use as an antifibrotic agent

Morgan, M. L., Bridle, K. R., Fletcher, L. M. and Crawford, D. H. G. (2006). Very low dose rapamycin: in vitro evidence for its use as an antifibrotic agent. Australian Gastroenterology Week 2006, Adelaide, South Australia, 11-14 October, 2006. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x

Very low dose rapamycin: in vitro evidence for its use as an antifibrotic agent

2005

Conference Publication

Rapamycin, but not cyclosporine A or tacrolimus, reduces hepatic stellate cell activation: implications for post-transplant fibrogenesis

Bridle, K. R., Robinson, M. W., Fletcher, L. M. and Crawford, D. H. (2005). Rapamycin, but not cyclosporine A or tacrolimus, reduces hepatic stellate cell activation: implications for post-transplant fibrogenesis. Australian Gastroenterology Week 2005, Brisbane, Qld, Australia, 19-22 October, 2005. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2005.04091_4.x

Rapamycin, but not cyclosporine A or tacrolimus, reduces hepatic stellate cell activation: implications for post-transplant fibrogenesis

2005

Conference Publication

Optimising conditions for assessing glucose output from isolated rat hepatocytes in response to insulin

Stephenson, M. D., Bridle, K. R., Whitehead, J. P. and Macdonald, G. A. (2005). Optimising conditions for assessing glucose output from isolated rat hepatocytes in response to insulin. Australian Gastroenterology Week 2005, Brisbane, Qld, Australia, 19-22 October, 2005. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2005.04091_4.x

Optimising conditions for assessing glucose output from isolated rat hepatocytes in response to insulin

2005

Journal Article

Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver

Chang, P., Hung, D. Y., Siebert, G. A., Bridle, K. and Roberts, M. S. (2005). Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver. Digestive Diseases And Sciences, 50 (4), 745-752. doi: 10.1007/s10620-005-2567-z

Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver

2005

Conference Publication

Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease

Anderson, Greg, Frazer, David M., Bridle, Kim R., Macdonald, Graeme A., Smith, Jeffrey L., Turlin, Bruno, Subramaniam, Nathan, Crawford, Darrell H., Powell, Lawrie W. and Ramm, Grant A. (2005). Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease. 47th Annual Meeting of the American Society of Hematology, Atlanta, Georgia, USA, 10-13 December, 2005. Washington, D.C., USA: American Society of Hematology.

Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease

2004

Journal Article

Reply

Anderson, Gregory J., Frazer, David M., Bridle, Kim R., Crawford, Darell H. G., Subramaniam, V. Nathan, Powell, Lawrie W. and Ramm, Grant A. (2004). Reply. Gastroenterology, 126 (2), 616-616. doi: 10.1053/j.gastro.2003.12.054

Reply

2004

Conference Publication

Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress

Bridle, Kim, Crawford, Darrell, Fletcher, Linda, Murphy, Therese and Walters, Margaret (2004). Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress. The Liver Meeting 2004: 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, U.S.A., 29 October-2 November 2004. Hoboken, NJ, U.S.A: John Wiley & Sons. doi: 10.1002/hep.1840400508

Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress

2004

Conference Publication

Alcohol-induced down-regulation of hepcidin mRNA expression is mediated by oxidative stress

Bridle, K. R., Murphy, T., Walters, M., Crawford, D. H. G. and Fletcher, L. M. (2004). Alcohol-induced down-regulation of hepcidin mRNA expression is mediated by oxidative stress. Australian Gastroenterology Week 2004, Brisbane Convention Centre, Brisbane Qld, Australia, 4-8 October, 2004. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2004.3615_3..x

Alcohol-induced down-regulation of hepcidin mRNA expression is mediated by oxidative stress

2004

Conference Publication

Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress

Bridle, K., Murphy, T., Walters, M., Crawford, D. and Fletcher, L. (2004). Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress. 55th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston MA, United States, Oct 29 - Nov 02 2004. Hoboken, NJ United States: John Wiley & Sons.

Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress

2004

Conference Publication

Factors affecting the gene expression of hepcidin in chronic viral hepatitis C

Bridle, K. R., Fletcher, L. M., Jonsson, J. R., Richardson, M. M., Clouston, A. D., Powell, E. E. and Crawford, D. H. G. (2004). Factors affecting the gene expression of hepcidin in chronic viral hepatitis C. Australian Gastroenterology Week 2004, Brisbane Convention Centre, Brisbane, Qld Australia, 4-8 October, 2004. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2004.3615_3..x

Factors affecting the gene expression of hepcidin in chronic viral hepatitis C

2003

Journal Article

Identification and characterization of the hepatic stellate cell transferrin receptor

Bridle, Kim R., Crawford, Darrell H. G. and Ramm, Grant A. (2003). Identification and characterization of the hepatic stellate cell transferrin receptor. American Journal of Pathology, 162 (5), 1661-1667. doi: 10.1016/S0002-9440(10)64300-3

Identification and characterization of the hepatic stellate cell transferrin receptor

2003

Journal Article

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H. G., Subramaniam, V. N, Powell, L. W., Anderson, G. J. and Ramm, G. A. (2003). Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet, 361 (9358), 669-673. doi: 10.1016/S0140-6736(03)12602-5

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

2003

Journal Article

Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis

Bridle, K. R., Crawford, D. H. G., Fletcher, L. M., Smith, J. L., Powell, L. W. and Ramm, G. A. (2003). Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis. Journal of Hepatology, 38 (4), 426-433. doi: 10.1016/S0168-8278(02)00444-0

Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis

2003

Conference Publication

A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of haemolytic anemia

Bridle, K. R., Fletcher, L. M., Murphy, T., Walters, M., Hung, D., Chang, P., Siebert, G., Roberts, M. and Crawford, D. H. G. (2003). A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of haemolytic anemia. 54th Annual Meeting of the American Association for the Study of Liver Disease, Boston, Massachusetts, USA, 24-28 October 2003. Carlton South, Vic.: Blackwell Publishing Asia. doi: 10.1046/j.1440-1746.18.s2.5.x

A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of haemolytic anemia

2003

Conference Publication

Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis

Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Millard, K. N., Crawford, D. H. G., Subramaniam, V. N., Powell, L. W., Anderson, G. J. and Ramm , G. A. (2003). Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis. Australian Gastroenterology Week, Cairns, Australia, 7-10 October 2003. Carlton South, Vic., Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1746.18.s2.5.x

Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis

2003

Conference Publication

Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis

Cheung, T. K., Fletcher, L., Bridle, K., Murphy, T. and Crawford, D. (2003). Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis. 54th Annual Meeting of the American-Association-for-the-Study-of-Liver-Disease, Boston MA, United States, Oct 24-28, 2003. Hoboken, NJ United States: John Wiley & Sons.

Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis

2003

Conference Publication

A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of hemolytic anemia

Fletcher,Linda, Bridle, Kim, Murphy, Therese, Walters, Margaret, Hung, Daniel, Chang, Ping, Siebert, Gerhard, Roberts, Michael and Crawford, Darrell (2003). A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of hemolytic anemia. 54th Annual Meeting of the American Association for the Study of Liver Disease, Boston, Massachusetts, USA, 24 - 28 October, 2003. Hoboken, NJ, U.S.A: Wiley Interscience. doi: 10.1002/hep.1840380508

A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of hemolytic anemia

2003

Conference Publication

Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.

Bridle, Kim, Cheung, Ting Kin, Crawford, Darrell, Fletcher, Linda and Murphy, Therese (2003). Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.. The Liver Meeting 2003: 54th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, U.S.A., 25-28 October 2003. 0270-9139 (print); 1527-3350 (electronic): John Wiley & Sons. doi: 10.1002/hep.1840380508

Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.

Current funding

  • 2014 - 2025
    Liver Disease Research
    Gallipoli Medical Research Foundation
    Open grant

Past funding

  • 2014 - 2019
    Immunotherapeutic Approaches for Hepatocellular Carcinoma
    Gallipoli Medical Research Foundation
    Open grant
  • 2013
    Targeting Pathophysiology & therapy of liver fibrosis
    Gallipoli Research Foundation
    Open grant
  • 2011 - 2013
    Targeting the Pathophysiology and Therapy of Liver Fibrosis
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Reginald Ferguson Fellowship - Rapamycin as an Antifibrotic Agent in Cholestatic Liver Disease
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2007 - 2010
    The pathogenesis of co-toxic liver disease
    Queensland Health Smart Health Research Grant
    Open grant
  • 2006 - 2008
    Reginald Ferguson Research Fellowship - Primary Sclerosing Cholangitis - A Life Threatening Complication of Inflammatory Bowel Disease: Investigations to Attenuate Disease Progression
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2006 - 2007
    The use of rapamycin to slow scarring of the liver
    Royal Children's Hospital Foundation
    Open grant
  • 2006 - 2009
    Immunosuppressant-Mediated Changes in Extracellular Matrix Balance in Animal Models of Liver Disease
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2005 - 2007
    Does immunosuppression affect the post-transplantation hepatic fibrogenic response?
    NHMRC Project Grant
    Open grant
  • 2005
    The Influence of Immunosuppression on the Hepatic Stellate Cell Fibrogenic Response
    UQ Early Career Researcher
    Open grant
  • 2004 - 2007
    Pathogenic mechanisms underlying iron co-toxicity in chronic liver disease
    Gastroenterological Society of Australia
    Open grant

Availability

Dr Kim Bridle is:
Available for supervision

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Available projects

  • Novel Therapies for Co-toxic Liver Disease

    This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.

Supervision history

Current supervision

Completed supervision

Enquiries

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