Overview
Background
Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.
Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.
Availability
- Dr Kim Bridle is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Kim Bridle’s works on UQ eSpace
2006
Conference Publication
Very low dose rapamycin : In vitro evidence for its use as an antifibrotic agent
Morgan, M. L., Bridle, K. R., Fletcher, L. M. and Crawford, D. H. G. (2006). Very low dose rapamycin : In vitro evidence for its use as an antifibrotic agent. Australian Gastroenterology Week, Adelaide, SA, Australia, 11-14 October 2006. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x
2005
Conference Publication
Optimising conditions for assessing glucose output from isolated rat hepatocytes in response to insulin
Stephenson, M. D., Bridle, K. R., Whitehead, J. P. and Macdonald, G. A. (2005). Optimising conditions for assessing glucose output from isolated rat hepatocytes in response to insulin. Australian Gastroenterology Week 2005, Brisbane, Qld, Australia, 19-22 October, 2005. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2005.04091_4.x
2005
Journal Article
Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver
Chang, P., Hung, D. Y., Siebert, G. A., Bridle, K. and Roberts, M. S. (2005). Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver. Digestive Diseases And Sciences, 50 (4), 745-752. doi: 10.1007/s10620-005-2567-z
2005
Conference Publication
Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease
Anderson, Greg, Frazer, David M., Bridle, Kim R., Macdonald, Graeme A., Smith, Jeffrey L., Turlin, Bruno, Subramaniam, Nathan, Crawford, Darrell H., Powell, Lawrie W. and Ramm, Grant A. (2005). Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease. 47th Annual Meeting of the American Society of Hematology, Atlanta, Georgia, USA, 10-13 December, 2005. Washington, D.C., USA: American Society of Hematology.
2005
Conference Publication
Rapamycin, but not cyclosporine A or tacrolimus, reduces hepatic stellate cell activation: implications for post-transplant fibrogenesis
Bridle, K. R., Robinson, M. W., Fletcher, L. M. and Crawford, D. H. (2005). Rapamycin, but not cyclosporine A or tacrolimus, reduces hepatic stellate cell activation: implications for post-transplant fibrogenesis. Australian Gastroenterology Week 2005, Brisbane, Qld, Australia, 19-22 October, 2005. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2005.04091_4.x
2004
Journal Article
Reply
Anderson, Gregory J., Frazer, David M., Bridle, Kim R., Crawford, Darell H. G., Subramaniam, V. Nathan, Powell, Lawrie W. and Ramm, Grant A. (2004). Reply. Gastroenterology, 126 (2), 616-616. doi: 10.1053/j.gastro.2003.12.054
2004
Conference Publication
Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress
Bridle, K., Murphy, T., Walters, M., Crawford, D. and Fletcher, L. (2004). Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress. 55th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Boston MA, United States, Oct 29 - Nov 02 2004. Hoboken, NJ United States: John Wiley & Sons.
2004
Conference Publication
Factors affecting the gene expression of hepcidin in chronic viral hepatitis C
Bridle, K. R., Fletcher, L. M., Jonsson, J. R., Richardson, M. M., Clouston, A. D., Powell, E. E. and Crawford, D. H. G. (2004). Factors affecting the gene expression of hepcidin in chronic viral hepatitis C. Australian Gastroenterology Week 2004, Brisbane Convention Centre, Brisbane, Qld Australia, 4-8 October, 2004. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2004.3615_3..x
2004
Conference Publication
Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress
Bridle, Kim, Crawford, Darrell, Fletcher, Linda, Murphy, Therese and Walters, Margaret (2004). Alcohol-induced downregulation of hepcidin mRNA expression is mediated by oxidative stress. The Liver Meeting 2004: 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, U.S.A., 29 October-2 November 2004. Hoboken, NJ, U.S.A: John Wiley & Sons. doi: 10.1002/hep.1840400508
2004
Conference Publication
Alcohol-induced down-regulation of hepcidin mRNA expression is mediated by oxidative stress
Bridle, K. R., Murphy, T., Walters, M., Crawford, D. H. G. and Fletcher, L. M. (2004). Alcohol-induced down-regulation of hepcidin mRNA expression is mediated by oxidative stress. Australian Gastroenterology Week 2004, Brisbane Convention Centre, Brisbane Qld, Australia, 4-8 October, 2004. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2004.3615_3..x
2003
Journal Article
Identification and characterization of the hepatic stellate cell transferrin receptor
Bridle, Kim R., Crawford, Darrell H. G. and Ramm, Grant A. (2003). Identification and characterization of the hepatic stellate cell transferrin receptor. American Journal of Pathology, 162 (5), 1661-1667. doi: 10.1016/S0002-9440(10)64300-3
2003
Journal Article
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H. G., Subramaniam, V. N, Powell, L. W., Anderson, G. J. and Ramm, G. A. (2003). Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet, 361 (9358), 669-673. doi: 10.1016/S0140-6736(03)12602-5
2003
Conference Publication
Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.
Bridle, Kim, Cheung, Ting Kin, Crawford, Darrell, Fletcher, Linda and Murphy, Therese (2003). Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.. The Liver Meeting 2003: 54th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, U.S.A., 25-28 October 2003. 0270-9139 (print); 1527-3350 (electronic): John Wiley & Sons. doi: 10.1002/hep.1840380508
2003
Conference Publication
Reduced hepcidin expression in alcohol-fed rats may be a contributing factor in alcoholic hepatic siderosis
Cheung, T. K., Fletcher, L. M., Bridle, K. R., Murphy, T. L. and Crawford, D. H. G. (2003). Reduced hepcidin expression in alcohol-fed rats may be a contributing factor in alcoholic hepatic siderosis. Australian Gastroenterology Week 2003, Cairns, QLD, Australia, 7-10 Ocrober, 2003. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1746.18.s2.5.x
2003
Journal Article
Effect of alcohol on iron storage diseases of the liver
Fletcher, LM, Bridle, KR and Crawford, DHG (2003). Effect of alcohol on iron storage diseases of the liver. Best Practice & Research In Clinical Gastroenterology, 17 (4), 663-677. doi: 10.1053/ybega.2003.378
2003
Journal Article
Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis
Bridle, K. R., Crawford, D. H. G., Fletcher, L. M., Smith, J. L., Powell, L. W. and Ramm, G. A. (2003). Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis. Journal of Hepatology, 38 (4), 426-433. doi: 10.1016/S0168-8278(02)00444-0
2003
Conference Publication
A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of haemolytic anemia
Bridle, K. R., Fletcher, L. M., Murphy, T., Walters, M., Hung, D., Chang, P., Siebert, G., Roberts, M. and Crawford, D. H. G. (2003). A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of haemolytic anemia. 54th Annual Meeting of the American Association for the Study of Liver Disease, Boston, Massachusetts, USA, 24-28 October 2003. Carlton South, Vic.: Blackwell Publishing Asia. doi: 10.1046/j.1440-1746.18.s2.5.x
2003
Conference Publication
Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis
Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Millard, K. N., Crawford, D. H. G., Subramaniam, V. N., Powell, L. W., Anderson, G. J. and Ramm , G. A. (2003). Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis. Australian Gastroenterology Week, Cairns, Australia, 7-10 October 2003. Carlton South, Vic., Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1746.18.s2.5.x
2003
Conference Publication
Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis
Cheung, T. K., Fletcher, L., Bridle, K., Murphy, T. and Crawford, D. (2003). Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis. 54th Annual Meeting of the American-Association-for-the-Study-of-Liver-Disease, Boston MA, United States, Oct 24-28, 2003. Hoboken, NJ United States: John Wiley & Sons.
2003
Conference Publication
A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of hemolytic anemia
Fletcher,Linda, Bridle, Kim, Murphy, Therese, Walters, Margaret, Hung, Daniel, Chang, Ping, Siebert, Gerhard, Roberts, Michael and Crawford, Darrell (2003). A comparison of the hepatic extraction of transferrin-bound and non-transferrin bound iron in an animal model of hemolytic anemia. 54th Annual Meeting of the American Association for the Study of Liver Disease, Boston, Massachusetts, USA, 24 - 28 October, 2003. Hoboken, NJ, U.S.A: Wiley Interscience. doi: 10.1002/hep.1840380508
Funding
Current funding
Supervision
Availability
- Dr Kim Bridle is:
- Available for supervision
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Available projects
-
Novel Therapies for Co-toxic Liver Disease
This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.
Supervision history
Current supervision
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Associate Advisor
Other advisors: Professor Darrell Crawford, Dr Xiaowen Liang
-
Doctor Philosophy
Ferroptosis: a novel layer of regulation for T cell homeostasis and function
Associate Advisor
Other advisors: Dr Joseph Yunis, Dr Zhian Chen, Professor Di Yu
Completed supervision
-
2023
Doctor Philosophy
Attenuation of Liver Injury in Iron-Related Liver Disease
Principal Advisor
Other advisors: Professor Darrell Crawford
-
2021
Doctor Philosophy
Improving Graft Outcomes in Liver Transplantation: Necroptosis in Steatotic Liver Ischaemia Reperfusion Injury
Principal Advisor
Other advisors: Professor Darrell Crawford
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Xiaowen Liang, Dr Haolu Wang
-
2018
Doctor Philosophy
Interactions between iron and fat in non-alcoholic fatty liver disease
Associate Advisor
Other advisors: Professor Darrell Crawford
-
2017
Doctor Philosophy
Optimising outcomes after liver transplantation. Pathophysiology of biliary injury and the application of machine perfusion
Associate Advisor
Other advisors: Professor Darrell Crawford
-
2016
Doctor Philosophy
Hfe-associated Steatohepatitis:Expression Profiling and Identifying the Molecular Basis of Liver Injury
Associate Advisor
Other advisors: Honorary Professor Nathan Subramaniam, Professor Darrell Crawford
-
2014
Doctor Philosophy
Evolution of Fibrosis, Antifibrotic Therapies and Mechanisms of Iron Homeostasis in the Mdr2-/- Mouse Model of Hepatic Fibrogenesis
Associate Advisor
Other advisors: Professor Darrell Crawford, Honorary Professor Nathan Subramaniam
-
2010
Doctor Philosophy
Investigation of hepatic glucose metabolism
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald
Media
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