Overview
Background
Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.
Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.
Availability
- Dr Kim Bridle is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Kim Bridle’s works on UQ eSpace
2009
Journal Article
Fibrogenesis in Pediatric Cholestatic Liver Disease: Role of Taurocholate and Hepatocyte-Derived Monocyte Chemotaxis Protein-1 in Hepatic Stellate Cell Recruitment
Ramm, GA, Shepherd, RW, Hoskins, AC, Greco, SA, Ney, AD, Pereira, TN, Bridle, Kim R., Doecke, JD, Meikle, PJ, Turlin, B and Lewindon, PJ (2009). Fibrogenesis in Pediatric Cholestatic Liver Disease: Role of Taurocholate and Hepatocyte-Derived Monocyte Chemotaxis Protein-1 in Hepatic Stellate Cell Recruitment. Hepatology, 49 (2), 533-544. doi: 10.1002/hep.22637
2009
Conference Publication
Expression of fibrogenic genes does not differentiate patients with rapid and non-rapid progression post liver transplant for hepatitis C
Sobbe, A.L., Bridle, K.R., Morgan, M.L., Lipka, G., Fletcher, L. and Crawford, D.H.G. (2009). Expression of fibrogenic genes does not differentiate patients with rapid and non-rapid progression post liver transplant for hepatitis C. Australia & New Zealand Medical & Surgical Gastrointestinal Week 2009, Sydney Convention & Exhibition Centre, Sydney, NSW, Australia, 21-24 October 2009. Carlton South, Vic.: Blackwell Publishing Asia.
2009
Journal Article
Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: Evidence for an alcohol-induced hypoxic response
Heritage, Mandy L., Murphy, Therese L., Bridle, Kim R., Anderson, Gregory J., Crawford, Darrell H. G. and Fletcher, Linda M. (2009). Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: Evidence for an alcohol-induced hypoxic response. Alcoholism, Clinical and Experimental Research, 33 (8), 1391-1400. doi: 10.1111/j.1530-0277.2009.00969.x
2009
Conference Publication
The antifibrotic effect of low dose rapamycin is diminished in Mdr2-/- when administered to animals with advanced hepatic fibrosis
Sobbe, AL, Bridle, KR and Crawford, DHG (2009). The antifibrotic effect of low dose rapamycin is diminished in Mdr2-/- when administered to animals with advanced hepatic fibrosis. Australia & New Zealand Medical & Surgical Gastrointestinal Week 2009, Sydney, Australia, 21-24 October 2009. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
2008
Conference Publication
Hepcidin regulation in wild-type and HFE-/mice in response to alcohol consumption: Evidence for an alcohol-induced hypoxic response
Fletcher, L. M., Heritage, M. L., Murphy, T. L., Bridle, K. R., Anderson, G. J. and Crawford, D. H. (2008). Hepcidin regulation in wild-type and HFE-/mice in response to alcohol consumption: Evidence for an alcohol-induced hypoxic response. 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy, 23-27 April, 2008. Copenhagen, Denmark: Elsevier. doi: 10.1016/S0168-8278(08)60888-0
2008
Conference Publication
Hepcidin regulation in response to alcohol consumption: evidence for an alcohol-induced hypoxic response
Heritage, M. L., Jaskowski, L. A., Bridle, K. R., Murphy, T. L., Anderson, G. J., Crawford, D. H. and Fletcher, L. M. (2008). Hepcidin regulation in response to alcohol consumption: evidence for an alcohol-induced hypoxic response. Australian Gastroenterology Week, Brisbane, Qld, Australia, 22-25 October, 2008. Carlton South, Vic, Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2008.05613.x
2008
Conference Publication
Hepcidin regulation in wild-type and Hfe(-/-) mice in response to alcohol consumption: Evidence for an alcohol-induced hypoxic response
FletcherLM, Heritage, ML, MurphyTL, BridleKR, AndersonGJ and CrawfordDH (2008). Hepcidin regulation in wild-type and Hfe(-/-) mice in response to alcohol consumption: Evidence for an alcohol-induced hypoxic response. 43rd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Milan ITALY, APR 23-27, 2008. doi: 10.1016/S0168-8278(08)60888-0
2008
Conference Publication
Rapamycin as an inhibitor of hepatic fibrosis: relevance to whole blood levels
Popa, C., Bridle, K. R., Morgan, M. L., Clouston, A. D., Fletcher, L. M. and Crawford, D. H. G. (2008). Rapamycin as an inhibitor of hepatic fibrosis: relevance to whole blood levels. 43rd Annual Meeting of the European Association for the Study of the Liver, Milan, Italy, 23-27 April, 2008. Ireland: Elsevier. doi: 10.1016/S0168-8278(08)60467-5
2008
Conference Publication
Multiple pathways to hepatic fibrosis are inhibited by rapamycin
Bridle, K. R., Sobbe, A. L., Fletcher, L. M., Clouston, A. D. and Crawford, D. H. G. (2008). Multiple pathways to hepatic fibrosis are inhibited by rapamycin. Australian Gastroenterology Week 2008, Brisbane, Qld, Australia, 22-25 October 2008. Carlton South, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2008.05613.x
2007
Conference Publication
Alcohol consumption further modulates hepcidin gene expression in an animal model of hemochromatosis
Heritage, M. L., Murphy, T. L., Popa, C., Bridle, K. R., Anderson, G. J., Crawford, D. H. G. and Fletcher, L. M. (2007). Alcohol consumption further modulates hepcidin gene expression in an animal model of hemochromatosis. Australian Gastroenterology Week 2007, Perth, Australia, 24–27 October 2007. Melbourne, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2007.05161.x
2007
Conference Publication
Alcohol consumption further modulates hepcidin gene expression in an animal model of hemochromatosis
Fletcher, L. M., Heritage, M. L., Murphy, T. L., Popa, C., Bridle, K. R., Anderson, G. J. and Crawford, D. H. (2007). Alcohol consumption further modulates hepcidin gene expression in an animal model of hemochromatosis. 58th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, Massachusetts, U.S.A., 1-6 November 2007. U.S.A.: Wiley InterScience. doi: 10.1002/hep.22022
2007
Conference Publication
Hepciden gene expression is further suppressed in Hfe-/- mice following chronic ethanol consumption
Fletcher, L. M., Heritage, M. L., Murphy, T. L., Bridle, K. R., Anderson, G. J. and Crawford, D. H. G. (2007). Hepciden gene expression is further suppressed in Hfe-/- mice following chronic ethanol consumption. 2007 International BioIron Society Meeting, Kyoto, Japan, 1-6 April, 2007. New York: Wiley-LISS. doi: 10.1002/ajh.20964
2007
Conference Publication
Rapamycin as an anti-fibrotic agent
Popa, C., Bridle, K. R., Morgan, M. L., Robinson, M. W., Fletcher, L. M. and Crawford, D. H. (2007). Rapamycin as an anti-fibrotic agent. Australian Gastroenterology Week, Perth, Australia, 24-27 October 2007. Australia. doi: 10.1111/j.1440-1746.2007.05161.x
2007
Journal Article
Hepcidin gene expression is further suppressed in HFE-/-mice following chronic ethanol consumption
Fletcher, LM, Heritage, ML, Bridle, KR, Murphy, TL, Anderson, GJ and Crawford, DH (2007). Hepcidin gene expression is further suppressed in HFE-/-mice following chronic ethanol consumption. American Journal of Hematology, 82 (6), 528-529.
2007
Journal Article
Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells
Kobayashi, Yoshimasa, Bridle, Kim R., Ramm, Grant A., O'Neill, Rosemary, Britton, Robert S. and Bacon, Bruce R. (2007). Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells. Liver International, 27 (8), 1066-1075. doi: 10.1111/j.1478-3231.2007.01573.x
2006
Conference Publication
Serum adiponectin is increased in HFE-/- mice fed alcohol
Bridle, K. R., Murphy, T. L., Anderson, G. J., Macdonald, G. A., Crawford, D. H. G. and Fletcher, L. M. (2006). Serum adiponectin is increased in HFE-/- mice fed alcohol. Australian Gastroenterology Week 2006, Adelaide, South Australia, 11-14 October, 2006. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x
2006
Conference Publication
Very low dose rapamycin: in vitro evidence for its use as an antifibrotic agent
Morgan, M. L., Bridle, K. R., Fletcher, L. M. and Crawford, D. H. G. (2006). Very low dose rapamycin: in vitro evidence for its use as an antifibrotic agent. Australian Gastroenterology Week 2006, Adelaide, South Australia, 11-14 October, 2006. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x
2006
Conference Publication
Von Willebrand factor expression in relation to cirrhosis development in a rat model of fibrogenesis
Bridle, K. R., Patella, S., Tchongue, J., Fletcher, L. M., Sievert, W. and Crawford, D. H. G. (2006). Von Willebrand factor expression in relation to cirrhosis development in a rat model of fibrogenesis. Australian Gastroenterology Week 2006, Adelaide, South Australia, 11-14 October, 2006. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x
2006
Conference Publication
Von Willebrand factor expression in relation to cirrhosis development in a rat model of fibrogenesis
Bridle, K. R., Patella, S., Tchongue, J., Fletcher, L. M., Sievert, W. and Crawford, D. H. G. (2006). Von Willebrand factor expression in relation to cirrhosis development in a rat model of fibrogenesis. Australian Gastroenterology Week, Adelaide, Australia, 11–14 October 2006. Oxford United Kingdom: Wiley.
2006
Journal Article
Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells
Bridle, K. R., Li, L., O'Neill, R., Britton, R. S. and Bacon, B. R. (2006). Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells. The Journal of Laboratory and Clinical Medicine, 147 (5), 234-241. doi: 10.1016/j.lab.2005.12.009
Funding
Current funding
Supervision
Availability
- Dr Kim Bridle is:
- Available for supervision
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Available projects
-
Novel Therapies for Co-toxic Liver Disease
This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.
Supervision history
Current supervision
-
Doctor Philosophy
Ferroptosis: A Novel Layer of Regulation for T Cell Homeostasis and Function
Associate Advisor
Other advisors: Dr Joseph Yunis, Dr Zhian Chen, Professor Di Yu
-
Doctor Philosophy
Therapeutic Modulators of Hepatic Stellate Cells for Hepatocellular Carcinoma
Associate Advisor
Other advisors: Dr Xiaowen Liang
-
Doctor Philosophy
Ferroptosis: a novel layer of regulation for T cell homeostasis and function
Associate Advisor
Other advisors: Dr Joseph Yunis, Dr Zhian Chen, Professor Di Yu
Completed supervision
-
-
2021
Doctor Philosophy
Improving Graft Outcomes in Liver Transplantation: Necroptosis in Steatotic Liver Ischaemia Reperfusion Injury
Principal Advisor
-
2025
Doctor Philosophy
Ferroptosis: A Novel Layer of Regulation for T Cell Homeostasis and Function
Associate Advisor
Other advisors: Dr Joseph Yunis, Dr Zhian Chen, Professor Di Yu
-
2024
Doctor Philosophy
Therapeutic modulation of chemotherapy-induced hepatic stellate cell activation in primary liver cancer
Associate Advisor
Other advisors: Dr Xiaowen Liang
-
2023
Doctor Philosophy
Human mesenchymal stem cell-derived liver-on-a-chip for the study of cell migration
Associate Advisor
Other advisors: Emeritus Professor Michael Roberts, Dr Xiaowen Liang, Dr Haolu Wang
-
2018
Doctor Philosophy
Interactions between iron and fat in non-alcoholic fatty liver disease
Associate Advisor
-
2017
Doctor Philosophy
Optimising outcomes after liver transplantation. Pathophysiology of biliary injury and the application of machine perfusion
Associate Advisor
-
2016
Doctor Philosophy
Hfe-associated Steatohepatitis:Expression Profiling and Identifying the Molecular Basis of Liver Injury
Associate Advisor
Other advisors: Honorary Professor Nathan Subramaniam
-
2014
Doctor Philosophy
Evolution of Fibrosis, Antifibrotic Therapies and Mechanisms of Iron Homeostasis in the Mdr2-/- Mouse Model of Hepatic Fibrogenesis
Associate Advisor
Other advisors: Honorary Professor Nathan Subramaniam
-
2010
Doctor Philosophy
Investigation of hepatic glucose metabolism
Associate Advisor
Other advisors: Associate Professor Graeme Macdonald
Media
Enquiries
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