Dr Kim Bridle
Dr

Kim Bridle

Email: 
Phone: 
+61 7 334 60698

Background

Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contributions to the understanding of diseases associated with altered iron metabolism and mechanisms of hepatic fibrosis.

Dr Bridle currently serves on the Research and Grants Committee of the Gastroenterological Society of Australia and is a member of the Ramsay Health Care Human Research Ethics Committee. Dr Bridle is a Section Editor for the journal, BioMed Research International.

Availability

Dr Kim Bridle is:
Available for supervision

Fields of research

Clinical sciences

Qualifications

  • Bachelor of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Kim Bridle’s works on UQ eSpace

139 works between 1995 and 2023
All (139) Journal Article (65) Conference Publication (74)

121 - 139 of 139 works

2002

Journal Article

The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease

Lewindon, PJ, Pereira, TN, Hoskins, AC, Bridle, KR, Williamson, RM and Ramm, GA (2002). The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease. American Journal of Pathology, 160 (5), 1705-1715. doi: 10.1016/S0002-9440(10)61117-0

The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease

2001

Journal Article

Role of myofibroblasts in tumour encapsulation of hepatocellular carcinoma in haemochromatosis

Bridle, Kim R., Crawford, Darrell H. G., Powell, Lawrie W. and Ramm, Grant A. (2001). Role of myofibroblasts in tumour encapsulation of hepatocellular carcinoma in haemochromatosis. Liver, 21 (2), 96-104. doi: 10.1034/j.1600-0676.2001.021002096.x

Role of myofibroblasts in tumour encapsulation of hepatocellular carcinoma in haemochromatosis

2001

Journal Article

Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3

Macdonald, G., Bridle, K. R., Ward, P. J., Walker, N. I., Houglum, K., George, D. K., Smith, J. L., Powell, L. W., Crawford, D. and Ramm, G. A. (2001). Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3. Journal of Gastroenterology and Hepatology, 16 (6), 599-606. doi: 10.1046/j.1440-1746.2001.02445.x

Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3

2001

Journal Article

Erratum: Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominantly in acinar zone 3. (Journal of Gastroenterology and Hepatology (2001) 16 (599-606))

Macdonald, G. A., Bridle, K. R. and Ward, P. J. (2001). Erratum: Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominantly in acinar zone 3. (Journal of Gastroenterology and Hepatology (2001) 16 (599-606)). Journal of Gastroenterology and Hepatology (Australia), 16 (8), 953-953. doi: 10.1046/j.1440-1746.2001.01681.x

Erratum: Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominantly in acinar zone 3. (Journal of Gastroenterology and Hepatology (2001) 16 (599-606))

2000

Journal Article

Morphology of liver repair following cholestatic liver injury: Resolution of ductal hyperplasia, matrix deposition and regression of myofibroblasts

Ramm, G. A., Carr, S. C., Bridle, K. R., Li, L., Britton, R. S., Crawford, D. H. G., Vogler, C. A., Bacon, B. R. and Tracy, T. F. (2000). Morphology of liver repair following cholestatic liver injury: Resolution of ductal hyperplasia, matrix deposition and regression of myofibroblasts. Liver, 20 (5), 387-396. doi: 10.1034/j.1600-0676.2000.020005387.x

Morphology of liver repair following cholestatic liver injury: Resolution of ductal hyperplasia, matrix deposition and regression of myofibroblasts

2000

Journal Article

Repetitive acute pancreatic injury in the mouse induces procollagen alpha(1)(I) expression colocalized to pancreatic stellate cells

Neuschwander-Tetri, BA, Bridle, KR, Wells, LD, Marcu, M and Ramm, GA (2000). Repetitive acute pancreatic injury in the mouse induces procollagen alpha(1)(I) expression colocalized to pancreatic stellate cells. Laboratory Investigation, 80 (2), 143-150. doi: 10.1038/labinvest.3780018

Repetitive acute pancreatic injury in the mouse induces procollagen alpha(1)(I) expression colocalized to pancreatic stellate cells

1999

Conference Publication

Hepatic fibrogenesis in cystic fibrosis liver disease

Blanch, N. L., Bridle, K., Greco, S., Lewindon, P., Murphy, T. M., Pereira, T., Ramm, G. A., Shepherd, R. W., Smith, J. L. and Walker, N. I. (1999). Hepatic fibrogenesis in cystic fibrosis liver disease. 50th Annual Meeting and Postgraduate Conference, Dallas, Texas, Nov 1999. USA: Harcourt and Brace (WD Saunders).

Hepatic fibrogenesis in cystic fibrosis liver disease

1999

Conference Publication

Identification and characterisation of a receptor for transferrin on hepatic stellate cells: role in the transformation to myofibroblasts

Bridle, K., Blanch, N. L., Crawford, D. H. and Ramm, G. A. (1999). Identification and characterisation of a receptor for transferrin on hepatic stellate cells: role in the transformation to myofibroblasts. Australian Gastroenterology Week 1999, Brisbane, 4 - 8 Oct, 1999. Carlton, Vic: Blackwell Science Asia.

Identification and characterisation of a receptor for transferrin on hepatic stellate cells: role in the transformation to myofibroblasts

1999

Conference Publication

Identification and characterisation of the hepatic stellate cell transferrin receptor and influence of transferrin on hepatic stellate cell activation

Bridle, K., Stewart, N. L., Crawford, D. H., Anderson, G. and Ramm, G. A. (1999). Identification and characterisation of the hepatic stellate cell transferrin receptor and influence of transferrin on hepatic stellate cell activation. Bioiron'99, Sorrento Palace, Sorrento-Naples, Italy, 23 - 28 May 1999. Italy: SGC.

Identification and characterisation of the hepatic stellate cell transferrin receptor and influence of transferrin on hepatic stellate cell activation

1998

Journal Article

Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia

Ramm, G. A., Nair, V. G., Bridle, K. R., Shepherd, R. W. and Crawford, D. H. G. (1998). Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. American Journal of Pathology, 153 (2), 527-535. doi: 10.1016/S0002-9440(10)65595-2

Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia

1998

Conference Publication

The contribution of inflammatory cells to iron-induced hepatic fibrogenesis in hemochromatosis

Bridle, K. R., Crawford, D. H. G., Smith, J. L., Fletcher, L. M., Walker, N. I. and Ramm, G. A. (1998). The contribution of inflammatory cells to iron-induced hepatic fibrogenesis in hemochromatosis. 49th Annual Meeting of the American Association for the Study of Liver Disease, Chicago, Il, United States, 6-10 November 1998. Hoboken, NJ, United States: John Wiley & Sons.

The contribution of inflammatory cells to iron-induced hepatic fibrogenesis in hemochromatosis

1998

Journal Article

Hepatic iron stores and steatosis are associated with lipid peroxidation and fibrosis

Macdonald, GA, Bridle, KR, Ward, PJ, Walker, NI, Houglum, K, Powell, LW, Crawford, DHG and Ramm, GA (1998). Hepatic iron stores and steatosis are associated with lipid peroxidation and fibrosis. Hepatology, 28 (4, Part 2 Suppl.), 639A-639A.

Hepatic iron stores and steatosis are associated with lipid peroxidation and fibrosis

1997

Journal Article

Evidence that 'myofibroblast-like' cells are the cellular source of capsular collagen in hepatocellular carcinoma

Ooi, L. P. J., Crawford, D. H. G., Gotley, D. C., Clouston, A. D., Strong, R. W., Gobe, G. C., Halliday, J. W., Bridle, K. R. and Ramm, G. A. (1997). Evidence that 'myofibroblast-like' cells are the cellular source of capsular collagen in hepatocellular carcinoma. Journal of Hepatology, 26 (4), 798-807. doi: 10.1016/S0168-8278(97)80245-0

Evidence that 'myofibroblast-like' cells are the cellular source of capsular collagen in hepatocellular carcinoma

1997

Conference Publication

Interferon-gamma but not transforming growth factor-beta gene expression is upregulated in liver tissue of patients with genetic hemochromatosis

Bridle, K.R., Crawford, D.H.G., Fletcher, L.M. and Ramm, G.A. (1997). Interferon-gamma but not transforming growth factor-beta gene expression is upregulated in liver tissue of patients with genetic hemochromatosis. 48th Annual Meeting of the American Association for the Study of Liver Disease, Chicago, Il, United States, 7-11 November 1997. Hoboken, NJ, United States: John Wiley & Sons.

Interferon-gamma but not transforming growth factor-beta gene expression is upregulated in liver tissue of patients with genetic hemochromatosis

1997

Conference Publication

In vivo hepatic activities of matrix metalloproteinases-2, 3 and 9 are increased in prefibrotic animal and human iron overload

George, D.K., Ramm, G.A., Bridle, K.R., Fletcher, L.M. and Crawford, D.H.G. (1997). In vivo hepatic activities of matrix metalloproteinases-2, 3 and 9 are increased in prefibrotic animal and human iron overload. 48th Annual Meeting of the American Association for the Study of Liver Disease, Chicago, Il, United States, 7-11 November 1997. Hoboken, NJ, United States: John Wiley & Sons.

In vivo hepatic activities of matrix metalloproteinases-2, 3 and 9 are increased in prefibrotic animal and human iron overload

1997

Conference Publication

The role of activated hepatic stellate cells in capsule formation in hepatocellular carcinoma and colorectal metastases to the liver

Ramm, G.A., Ooi, L. L. P. J., Gotley, D. C., Clouston, A. D., Bridle, K. R. and Crawford, D. H. G. (1997). The role of activated hepatic stellate cells in capsule formation in hepatocellular carcinoma and colorectal metastases to the liver. 8th International Symposium on the Cells of the Hepatic Sinusoid, Bordeaux, France, 1-5 September 1996. Leiden, Netherlands: Kupffer Cell Foundation.

The role of activated hepatic stellate cells in capsule formation in hepatocellular carcinoma and colorectal metastases to the liver

1996

Conference Publication

Biliary decompression results in rapid reversal of procollagen alpha(1)(I) gene expression in experimental biliary fibrosis

Ramm, G.A., Crawford, D.H.G., Bridle, K.R., Britton, R.S. and Bacon, B.R. (1996). Biliary decompression results in rapid reversal of procollagen alpha(1)(I) gene expression in experimental biliary fibrosis. 47th Annual Meeting of the American Association for the Study of Liver Disease, Chicag, Il, United States, 8-12 November 1996. Hoboken, NJ, United States: John Wiley & Sons.

Biliary decompression results in rapid reversal of procollagen alpha(1)(I) gene expression in experimental biliary fibrosis

1995

Journal Article

Effect of Extracellular-Matrix Proteins On Vascular Smooth-Muscle Cell Phenotype

Hayward, I.P., Bridle, K.R., Campbell, G.R., Underwood, P.A. and Campbell, J.H. (1995). Effect of Extracellular-Matrix Proteins On Vascular Smooth-Muscle Cell Phenotype. Cell Biology International, 19 (10), 839-846. doi: 10.1006/cbir.1995.1019

Effect of Extracellular-Matrix Proteins On Vascular Smooth-Muscle Cell Phenotype

1995

Journal Article

Effect of Extracellular-Matrix Proteins On Vascular Smooth-Muscle Cell Phenotype

Hayward, I.P., Bridle, K.R., Campbell, G.R., Underwood, P.A. and Campbell, J.H. (1995). Effect of Extracellular-Matrix Proteins On Vascular Smooth-Muscle Cell Phenotype. Cell Biology International, 19 (9), 727-734. doi: 10.1006/cbir.1995.1123

Effect of Extracellular-Matrix Proteins On Vascular Smooth-Muscle Cell Phenotype

Current funding

  • 2014 - 2024
    Liver Disease Research
    Gallipoli Medical Research Foundation
    Open grant

Past funding

  • 2014 - 2019
    Immunotherapeutic Approaches for Hepatocellular Carcinoma
    Gallipoli Medical Research Foundation
    Open grant
  • 2013
    Targeting Pathophysiology & therapy of liver fibrosis
    Gallipoli Research Foundation
    Open grant
  • 2011 - 2013
    Targeting the Pathophysiology and Therapy of Liver Fibrosis
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Reginald Ferguson Fellowship - Rapamycin as an Antifibrotic Agent in Cholestatic Liver Disease
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2007 - 2010
    The pathogenesis of co-toxic liver disease
    Queensland Health Smart Health Research Grant
    Open grant
  • 2006 - 2008
    Reginald Ferguson Research Fellowship - Primary Sclerosing Cholangitis - A Life Threatening Complication of Inflammatory Bowel Disease: Investigations to Attenuate Disease Progression
    Ferguson Foundation (Reginald Ferguson)
    Open grant
  • 2006 - 2007
    The use of rapamycin to slow scarring of the liver
    Royal Children's Hospital Foundation
    Open grant
  • 2006 - 2009
    Immunosuppressant-Mediated Changes in Extracellular Matrix Balance in Animal Models of Liver Disease
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2005 - 2007
    Does immunosuppression affect the post-transplantation hepatic fibrogenic response?
    NHMRC Project Grant
    Open grant
  • 2005
    The Influence of Immunosuppression on the Hepatic Stellate Cell Fibrogenic Response
    UQ Early Career Researcher
    Open grant
  • 2004 - 2007
    Pathogenic mechanisms underlying iron co-toxicity in chronic liver disease
    Gastroenterological Society of Australia
    Open grant

Availability

Dr Kim Bridle is:
Available for supervision

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Available projects

  • Novel Therapies for Co-toxic Liver Disease

    This project will examine the pathogenesis of co-toxic liver disease and will study the restoration of iron homeostasis as a potential therapeutic application in liver diseases associated with altered iron metabolism.

Supervision history

Current supervision

Completed supervision

Enquiries

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