Overview
Background
Our work on human pigmentation genetics has allowed understanding of normal variation in this physical trait and the associated genotypic risk for skin cancer. The genes that determine an individual's skin phototype and the cellular mechanisms that result in the tanning response of melanocytes after UV-exposure of the skin are actively being investigated.
Assoc. Prof Rick Sturm is group leader in the Dermatology Research Centre within the Frazer Institue.
Availability
- Associate Professor Rick Sturm is:
- Available for supervision
- Media expert
Fields of research
Research interests
-
Skin, hair, eye colour and cancer � MC1R/OCA2, the genetic links
Pigmentary traits such as red hair and fair skin, moles, eye colour, lack of tanning ability and propensity to freckle have been identified as genetic risk factors for skin cancer when combined with the environmental risk factor of high ultraviolet exposure. The major areas of investigation are the role of the OCA2 gene in directing eye colour, and the role of human melanocortin-1 receptor (MC1R) gene variants in directing skin phototype and response to UV-induced ligand binding and receptor activation. The MC1R coding sequence is highly polymorphic in human populations and we have examined MC1R variant allele frequencies in the general community as well as a collection of adolescent dizygotic and monozygotic twins with defined pigmentation characteristics. Subscription required to access this paper Variant allele frequencies have also been determined in several case-control studies of sporadic melanoma, basal cell carcinoma and squamous cell carcinoma, and in familial melanoma kindreds collected within Australia. These studies have shown that three MC1R alleles � Arg151Cys, Arg160Trp and Asp294His � were associated with increased risk in all forms of skin cancer and with penetrance and age of onset in familial melanoma in CDKN2A mutation carriers. There is a significant MC1R variant allele heterozygote carrier effect on skin phototype and skin cancer risk, which indicates that these alleles do not behave in a strictly recessive manner.
-
Characterisation of melanoblast stem cell differentiation
The process of development and differentiation of the melanocytic cell lineage is being investigated using primary melanoblast and melanocyte cells cultured in vitro from human skin. This will provide information to allow the genes and processes involved in melanoma tumour formation and metastasis to be examined. These studies focus on the identification and molecular characterisation of the genes involved in melanocyte function.
-
Mechanisms of melanoma metastasis
Expression of the �3 integrin gene in melanoma in situ has been found to be the single most important marker of metastasis yet discovered. Experiments to investigate the effects of this expression has involved the use of Adenoviral gene transduction of the �3 integrin subunit into radial growth phase (RGP) melanoma cell lines and differential gene screening. A skin reconstruction model was used to assay the invasivness of RGP melanoma cells after ectopic �3 integrin expression and these studies have discovered induction of the anti-adhesive protein osteonectin is required for melanoma metastasis.
Works
Search Professor Rick Sturm’s works on UQ eSpace
2018
Conference Publication
Whole-exome sequencing of acquired nevi identifies novel mechanisms for development and maintenance of benign neoplasms
Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies novel mechanisms for development and maintenance of benign neoplasms. Annual Meeting of the American Association for Cancer Research (AACR), Chicago, Illinois, 14-18 April 2018. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2018-5376
2018
Journal Article
Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells
Chhabra, Yash, Yong, Hilary X. L., Fane, Mitchell E., Soogrim, Arish, Lim, Wen, Mahiuddin, Dayana Nur, Kim, Reuben S. Q., Ashcroft, Melinda, Beatson, Scott A., Ainger, Stephen A., Smit, Darren J., Jagirdar, Kasturee, Walker, Graeme J., Sturm, Richard A. and Smith, Aaron G. (2018). Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells. Pigment Cell & Melanoma Research, 31 (1), 51-63. doi: 10.1111/pcmr.12620
2018
Conference Publication
Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi-resistant melanoma
Menon, D. Ravindran, Hammerlindl, H., Emran, A., Torrano, J., Hammerlindl, S., Zhang, G., Krause, L., Somasundaram, R., Sturm, R., Haass, N. K., Flaherty, K., Herlyn, M. and Schaider, H. (2018). Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi-resistant melanoma. International Investigative Dermatology (IID) Meeting, Orlando, Fl, United States, 16-19 May 2018. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2018.03.1252
2018
Conference Publication
Phenotypic and genotypic analysis of amelanotic melanoma patients drawn from a Queensland case-control study
Rayner, J., Duffy, D., McMeniman, E. K., Jagirdar, K., Lee, K., Soyer, H. P. and Sturm, R. A. (2018). Phenotypic and genotypic analysis of amelanotic melanoma patients drawn from a Queensland case-control study. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, Australia, 19–22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/ajd.10_12815
2018
Conference Publication
Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi resistant melanoma
Menon, Dinoop Ravindran, Hammerlindl, Heinz, Al Emran, Abdullah, Torrano, Joachim, Hammerlindl, Sabrina, Zhang, Gao, Somasundaram, Rajasekharan, Sturm, Richard A., Haass, Nikolas K., Flaherty, Keith, Herlyn, Meenhard and Schaider, Helmut (2018). Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi resistant melanoma. Annual Meeting of the American Association for Cancer Research (AACR), Chicago, IL United States, 14-18 April 2018. Philadelphia, PA United States: American Association of Cancer Research. doi: 10.1158/1538-7445.AM2018-5833
2018
Conference Publication
Overview of melanoma genetics for dermatologists and results of a genetic analysis of multiple primary melanoma patients
MoMeniman, E., Sturm, R., Duffy, D., Jagirdar, K., Lee, K., Finnane, A., De'Ambrosis, B., Smithers, M. and Soyer, H. P. (2018). Overview of melanoma genetics for dermatologists and results of a genetic analysis of multiple primary melanoma patients. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, Australia, 19–22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/ajd.14_12815
2017
Journal Article
Distinct histone modifications denote early stress-induced drug tolerance in cancer
Emran, Abdullah Al, Marzese, Diego M., Menon, Dinoop Ravindran, Stark, Mitchell S., Torrano, Joachim, Hammerlindl, Heinz, Zhang, Gao, Brafford, Patricia, Salomon, Matthew P., Nelson, Nellie, Hammerlindl, Sabrina, Gupta, Deepesh, Mills, Gordon B., Lu, Yiling, Sturm, Richard A., Flaherty, Keith, Hoon, Dave S. B., Gabrielli, Brian, Herlyn, Meenhard and Schaider, Helmut (2017). Distinct histone modifications denote early stress-induced drug tolerance in cancer. Oncotarget, 9 (9), 8206-8222. doi: 10.18632/oncotarget.23654
2017
Journal Article
Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: A cross-sectional study
Li, Xiaohong, Lee, Katie J., Duffy, David L., Xu, Dandan, Rao Basude, Madhur Eshwar, Hu, Ying, Zhang, Hang, Jagirdar, Kasturee, Soyer, H. Peter, Dong, Huiting and Sturm, Richard A. (2017). Acquired melanocytic naevus phenotypes and MC1R genotypes in Han Chinese: A cross-sectional study. PeerJ, 5 (12) e4168, e4168. doi: 10.7717/peerj.4168
2017
Journal Article
The evolving universe of BRAF mutations in melanoma
Schaider, H and Sturm, R A (2017). The evolving universe of BRAF mutations in melanoma. The British Journal of Dermatology, 177 (4), 893-893. doi: 10.1111/bjd.15829
2017
Journal Article
Classifying dermoscopic patterns of naevi in a case-control study of melanoma
McWhirter, Seamus R, Duffy, David L, Lee, Katie J, Wimberley, Glen, McClenahan, Philip, Ling, Natalie, Ardigo, Marco, Schaider, Helmut, Soyer, H Peter and Sturm, Richard A (2017). Classifying dermoscopic patterns of naevi in a case-control study of melanoma. PloS One, 12 (10) e0186647, 1-10. doi: 10.1371/journal.pone.0186647
2017
Journal Article
MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression
Heppt, Markus V., Wang, Joshua X., Hristova, Denitsa M., Wei, Zhi, Li, Ling, Evans, Brianna, Beqiri, Marilda, Zaman, Samir, Zhang, Jie, Irmler, Martin, Berking, Carola, Besch, Robert, Beckers, Johannes, Rauscher, Frank J., Sturm, Rick A., Fisher, David E., Herlyn, Meenhard and Fukunaga-Kalabis, Mizuho (2017). MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression. The Journal of Investigative Dermatology, 138 (1), 141-149. doi: 10.1016/j.jid.2017.05.038
2017
Journal Article
Genome-Wide Association shows that pigmentation genes play a role in skin aging
Law, Matthew H., Medland, Sarah E., Zhu, Gu, Yazar, Seyhan, Vinuela, Ana, Wallace, Leanne, Shekar, Sri Niranjan, Duffy, David L., Bataille, Veronique, Glass, Dan, Spector, Tim D., Wood, Diane, MuTHER Consortium, Gordon, Scott D., Barbour, Julie M., Henders, Anjali K., Hewitt, Alex W., Montgomery, Grant W., Sturm, Richard A., Mackey, David A., Green, Adele C., Martin, Nicholas G. and MacGregor, Stuart (2017). Genome-Wide Association shows that pigmentation genes play a role in skin aging. Journal of Investigative Dermatology, 137 (9), 1887-1894. doi: 10.1016/j.jid.2017.04.026
2017
Journal Article
NR4A2 Promotes DNA double-strand break repair upon exposure to UVR
Yin, Kelvin, Chhabra, Yash, Tropee, Romain, Lim, Yi Chieh, Fane, Mitchell, Dray, Eloise, Sturm, Richard A. and Smith, Aaron G. (2017). NR4A2 Promotes DNA double-strand break repair upon exposure to UVR. Molecular Cancer Research, 15 (9), 1184-1196. doi: 10.1158/1541-7786.MCR-17-0002
2017
Journal Article
Testing of viable human skin cell dilution cultures as an approach to validating microsampling
Ainger, Stephen A., Yong, X. L. Hilary, Soyer, H. Peter and Sturm, Richard A. (2017). Testing of viable human skin cell dilution cultures as an approach to validating microsampling. Archives of Dermatological Research, 309 (4), 305-310. doi: 10.1007/s00403-017-1726-3
2017
Journal Article
Skin pigmentation genetics for the clinic
Ainger, Stephen A. , Jagirdar, Kasturee, Lee, Katie J. , Soyer, H. Peter and Sturm, Richard A. (2017). Skin pigmentation genetics for the clinic. Dermatology, 233 (1), 1-15. doi: 10.1159/000468538
2017
Journal Article
GSTP1 does not modify MC1R effects on melanoma risk
Daley, G. M., Duffy, D. L., Pflugfelder, A., Jagirdar, K., Lee, K. J., Yong, X. L., Eigentler, T. K., Weide, B., Smithers, B. M., Martin, N. G., Garbe, C., Soyer, H. P. and Sturm, R. A. (2017). GSTP1 does not modify MC1R effects on melanoma risk. Experimental Dermatology, 26 (8), 730-733. doi: 10.1111/exd.13114
2017
Journal Article
NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF
Fane, Mitchell E., Chhabra, Yash, Hollingsworth, David E. J., Simmons, Jacinta L., Spoerri, Loredana, Oh, Tae Gyu, Chauhan, Jagat, Chin, Toby, Harris, Lachlan, Harvey, Tracey J., Muscat, George E. O., Goding, Colin R., Sturm, Richard A., Haass, Nikolas K., Boyle, Glen M., Piper, Michael and Smith, Aaron G. (2017). NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF. EBioMedicine, 16, 63-75. doi: 10.1016/j.ebiom.2017.01.013
2017
Conference Publication
The prevalence of BRAF and NRAS in dermoscopic subtypes of acquired naevi
Tan, J-M., Tom, L., Jagirdar, K., Lambie, D., Sturm, R., Soyer, P. and Stark, M. (2017). The prevalence of BRAF and NRAS in dermoscopic subtypes of acquired naevi. Australasian College of Dermatologists 50th Annual Scientific Meeting, Darling Harbour, New South Wales, Australia, 6–9 May 2017. Richmond, VIC., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.21_12652
2017
Conference Publication
Iris freckling as a marker of melanoma risk
Laino, A., Berry, E., Jagirdar, K., Lee, K., Duffy, D., Soyer, P. and Sturm, R. (2017). Iris freckling as a marker of melanoma risk. Australasian College of Dermatologists 50th Annual Scientific Meeting, Darling Harbour, New South Wales, Australia, 6–9 May 2017. Richmond, VIC., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.20_12652
2016
Conference Publication
Phenotypic and genotypic risk factors for naevi and melanoma
Sturm, R. (2016). Phenotypic and genotypic risk factors for naevi and melanoma. HOBOKEN: WILEY-BLACKWELL.
Funding
Past funding
Supervision
Availability
- Associate Professor Rick Sturm is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Completed supervision
-
-
2009
Doctor Philosophy
The molecular mechanism of MC1R association with skin cancer risk phenotypes
Principal Advisor
Other advisors: Professor Jennifer Stow
-
2008
Doctor Philosophy
A Melanocyte-Keratinocyte Coculture Model to Study MC1R Dependent Pigmentation Responses
Principal Advisor
-
2006
Doctor Philosophy
MOLECULAR CHANGES DEFINING THE TRANSITION FROM RADIAL TO VERTICAL GROWTH PHASE IN MELANOMA
Principal Advisor
Other advisors: Professor Jennifer Stow
-
2004
Doctor Philosophy
MODELS OF HUMAN NEURAL CREST CELL DIFFERENTIATION IN VITRO
Principal Advisor
-
2020
Master Philosophy
Gene Polymorphisms Associated with Amelanotic/Hypopigmented and Nodular Melanoma
Associate Advisor
Other advisors: Professor Peter Soyer
-
2020
Master Philosophy
The role of SETDB1/2-mediated H3K9me3 in drug-tolerant cancer
Associate Advisor
Other advisors: Associate Professor Helmut Schaider
-
2020
Doctor Philosophy
Genotypic and phenotypic correlations in a cohort of patients with multiple primary melanoma
Associate Advisor
Other advisors: Professor Peter Soyer
-
2018
Master Philosophy
The correlation of skin colour, skin reflectance, freckling, MC1R, TYR, IRF-4 and TPCN2 genotypes with naevus pattern within a case-control study of melanoma
Associate Advisor
Other advisors: Associate Professor Helmut Schaider
-
2018
Master Philosophy
Dermoscopic and molecular correlation of melanocytic naevi
Associate Advisor
Other advisors: Dr Mitchell Stark, Professor Peter Soyer
-
2018
Doctor Philosophy
Phenotypes and Genotypes of Melanoma Patients
Associate Advisor
Other advisors: Professor Peter Soyer
-
2017
Doctor Philosophy
Investigating the role of the MITF-BRN2 expression axis in metastatic melanoma
Associate Advisor
-
2016
Doctor Philosophy
Investigating the role of NR4A genes in response to cellular stress
Associate Advisor
-
-
2014
Doctor Philosophy
Role of IRF6 in epithelial cell-mediated host defence and inflammation
Associate Advisor
Other advisors: Professor Matt Sweet
-
2004
Doctor Philosophy
STRUCTURE-FUNCTION ANALYSIS OF NUCLEAR HORMONE RECEPTORS NUR77 AND NOR I: EVIDENCE FOR A ROLE IN MUSCLE
Associate Advisor
Media
Enquiries
Contact Associate Professor Rick Sturm directly for media enquiries about:
- Basal cell carcinoma
- Carcinoma
- Eye colour
- Genetics
- Hair colour
- Human pigmentation
- Melanoma
- Pigmentation - human skin
- Skin cancer
- Skin colour
- Skin tanning
- Squamous cell carcinoma
- Sun cancer
- Sun damage
- Sun exposure
- Tanning - of skin
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: