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Dr Mitchell Stark
Dr

Mitchell Stark

Email: 
Phone: 
+61 7 344 38027

Overview

Background

Dr Mitchell Stark is a molecular biologist and Group Leader/Senior Research Fellow from the Dermatology Research Centre (DRC) based at the Frazer Institute. His group has extensive experience in microRNA biology and biomarker discovery, next-generation sequencing, bioinformatics, and functional analysis for a variety of applications. The Stark Lab’s major research streams include: miRNA biomarkers for melanoma progression and the development a Genomics Atlas of pre-skin cancer lesions, which aim to provide insight into the early progression of melanoma and keratinocyte cancer, to aid in preventing invasive skin cancer formation and offer increased precision to the clinical management of patients.

Dr Stark completed his PhD (2015) in melanoma microRNA biomarkers at The Queensland University of Technology based at the QIMR Berghofer (QIMRB) Medical Research Institute. Prior to commencing his PhD, he worked as Senior Research Assistant (since 1999) and was trained and mentored in the Hayward lab (QIMRB) where he contributed to and led some seminal findings in the melanoma genetics/genomics field. Dr Stark joined the DRC in 2015 and in 2016 he was awarded a prestigious NHMRC Peter Doherty Early Career Fellowship to lead a pre-melanoma genomics program. Dr Stark has a career total of 80+ publications (h-index 35) including 1 patent and has published in respected journals such as Nature, Nature Genetics, Cancer Research, and Journal of Investigative Dermatology.

Availability

Dr Mitchell Stark is:
Available for supervision
Media expert

Fields of research

Qualifications

  • Bachelor (Honours) of Applied Science, Queensland University of Technology
  • Doctor of Philosophy, Queensland University of Technology

Research interests

  • MicroRNA Biomarkers

    Current projects relate to melanoma progression microRNA biomarkers to aid in increased diagnostic precision of “ambiguous” melanocytic lesions as well as “real-time” monitoring of melanoma disease progression using a “liquid biopsy.”

  • Genomics Atlas of pre-skin cancer lesions

    Current projects involve using overlapping genomics datasets (e.g. exome, mRNA and miRNA transcriptome, methylation) as well as Spatial Profiling to greater understand the early hallmarks of pre-skin cancer development.

Works

Search Professor Mitchell Stark’s works on UQ eSpace

108 works between 2001 and 2024

1 - 20 of 108 works

Featured

2018

Journal Article

Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms

Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms. Journal of Investigative Dermatology, 138 (7), 1636-1644. doi: 10.1016/j.jid.2018.02.012

Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms

2024

Journal Article

Uncovering molecular mechanisms for amelanotic/hypopigmented primary cutaneous melanoma

Sturm, Richard A., Smit, Darren J., Duffy, David L., McLean, Catriona, Scolyer, Richard A., McArthur, Grant A., Papenfuss, Anthony T., Stark, Mitchell S., Soyer, H. Peter and Mar, Victoria J. (2024). Uncovering molecular mechanisms for amelanotic/hypopigmented primary cutaneous melanoma. British Journal of Dermatology ljae336. doi: 10.1093/bjd/ljae336

Uncovering molecular mechanisms for amelanotic/hypopigmented primary cutaneous melanoma

2024

Journal Article

Challenging the lymph node progression model of melanoma

Kao, Yung-Ching and Stark, Mitchell S (2024). Challenging the lymph node progression model of melanoma. The Journal of Investigative Dermatology, 144 (11), 2344-2346. doi: 10.1016/j.jid.2024.04.021

Challenging the lymph node progression model of melanoma

2024

Journal Article

POT1 and multiple primary melanomas: the dermatological phenotype

Maas, Ellie J., DeBortoli, Emily, Nathan, Vaishnavi, Freeman, Ned P., Mothershaw, Adam, Smit, Darren J., Betz-Stablein, Brigid, Aoude, Lauren G., Stark, Mitchell S., Sturm, Richard A., Soyer, H. Peter and McInerney-Leo, Aideen M. (2024). POT1 and multiple primary melanomas: the dermatological phenotype. Journal of Medical Genetics, 61 (9) jmg-2023-109637, 1-4. doi: 10.1136/jmg-2023-109637

POT1 and multiple primary melanomas: the dermatological phenotype

2024

Conference Publication

Assessment of precision melanoma diagnostics: Circulating microrna expression to monitor late-stage treatment

Harris, Teresa, Zaenker, Pauline, McEvoy, Ashleigh C., Soyer, H. Peter, Khattak, Muhammad A., Ziman, Melanie, Millward, Michael, Gray, Elin S. and Stark, Mitchell S. (2024). Assessment of precision melanoma diagnostics: Circulating microrna expression to monitor late-stage treatment. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-7626

Assessment of precision melanoma diagnostics: Circulating microrna expression to monitor late-stage treatment

2024

Journal Article

MicroRNA expression profiling of cutaneous squamous cell carcinomas and precursor lesions

Hossain, Akbor, Tom, Lisa N., Melati‐Rad, Ala, Yamada, Miko, Hammerlindl, Sabrina, Jagirdar, Kasturee, Prow, Tarl W., Soyer, H. Peter and Stark, Mitchell S. (2024). MicroRNA expression profiling of cutaneous squamous cell carcinomas and precursor lesions. Skin Health and Disease, 4 (3) e360, e360. doi: 10.1002/ski2.360

MicroRNA expression profiling of cutaneous squamous cell carcinomas and precursor lesions

2024

Journal Article

Terahertz in vivo imaging of human skin: toward detection of abnormal skin pathologies

Qi, X., Bertling, K., Torniainen, J., Kong, F., Gillespie, T., Primiero, C., Stark, M. S., Dean, P., Indjin, D., Li, L. H., Linfield, E. H., Davies, A. G., Brünig, M., Mills, T., Rosendahl, C., Soyer, H. P. and Rakić, A. D. (2024). Terahertz in vivo imaging of human skin: toward detection of abnormal skin pathologies. APL Bioengineering, 8 (1) 016117, 016117. doi: 10.1063/5.0190573

Terahertz in vivo imaging of human skin: toward detection of abnormal skin pathologies

2024

Journal Article

Assessing the genetic risk of nodular melanoma using a candidate gene approach

Stark, Mitchell S., Sturm, Richard A., Pan, Yan, Smit, Darren J., Kommajosyula, Varsha, Lee, Katie J., Jagirdar, Kasturee, McLean, Catriona, Duffy, David L., Soyer, H. Peter and Mar, Victoria J. (2024). Assessing the genetic risk of nodular melanoma using a candidate gene approach. British Journal of Dermatology, 190 (2), 199-206. doi: 10.1093/bjd/ljad365

Assessing the genetic risk of nodular melanoma using a candidate gene approach

2023

Journal Article

The skin molecular ecosystem holds the key to nevogenesis and melanomagenesis

Lee, Katie J., Soyer, H. Peter and Stark, Mitchell S. (2023). The skin molecular ecosystem holds the key to nevogenesis and melanomagenesis. The Journal of Investigative Dermatology, 144 (3), 456-465. doi: 10.1016/j.jid.2023.09.271

The skin molecular ecosystem holds the key to nevogenesis and melanomagenesis

2023

Journal Article

BRAF variant allele fraction-A predictor of response to targeted therapy?

Stark, Mitchell S., Harris, Teresa, Grossman, Douglas and Judson-Torres, Robert (2023). BRAF variant allele fraction-A predictor of response to targeted therapy?. Journal of the European Academy of Dermatology and Venereology., 37 (10), 1945-1946. doi: 10.1111/jdv.19389

BRAF variant allele fraction-A predictor of response to targeted therapy?

2023

Journal Article

One step closer to improving melanoma diagnosis and prognosis with liquid biopsies

Vergara, Ismael A. and Stark, Mitchell S. (2023). One step closer to improving melanoma diagnosis and prognosis with liquid biopsies. British Journal of Dermatology, 189 (3) ARTN ljad185, 255-256. doi: 10.1093/bjd/ljad185

One step closer to improving melanoma diagnosis and prognosis with liquid biopsies

2023

Journal Article

GOLM1: expanding our understanding of melanoma susceptibility

Maas, Ellie J., Wallingford, Courtney K., DeBortoli, Emily, Smit, Darren J., Betz-Stablein, Brigid, Aoude, Lauren G., Stark, Mitchell S., Sturm, Richard A., Soyer, H. Peter and McInerney-Leo, Aideen M. (2023). GOLM1: expanding our understanding of melanoma susceptibility. Journal of Medical Genetics, 60 (9) jmg-2023-109348, 1-3. doi: 10.1136/jmg-2023-109348

GOLM1: expanding our understanding of melanoma susceptibility

2023

Journal Article

Spatial Randomness in the distribution of acquired melanocytic naevi of the back in a population-based sample

Jayasinghe, Dilki, Betz-Stablein, Brigid, Stark, Mitchell S., Soyer, H. Peter and Janda, Monika (2023). Spatial Randomness in the distribution of acquired melanocytic naevi of the back in a population-based sample. The Journal of Investigative Dermatology, 143 (6), 1108-1111.e3. doi: 10.1016/j.jid.2022.11.013

Spatial Randomness in the distribution of acquired melanocytic naevi of the back in a population-based sample

2023

Conference Publication

275 Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival

Zhou, C., Tan, S. X., Kao, Y., Claeson, M., Brown, S., Lambie, D., Whiteman, D., Soyer, H., Stark, M., Nguyen, Q. and Khosrotehrani, K. (2023). 275 Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival. 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.279

275 Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival

2023

Conference Publication

203 Automated skin surface phenotype for melanoma risk assessment

Betz-Stablein, B. D., Rutjes, C., Kahler, S., Mothershaw, A., Jayasinghe, D., Stark, M., Janda, M. and Soyer, H. (2023). 203 Automated skin surface phenotype for melanoma risk assessment. 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.205

203 Automated skin surface phenotype for melanoma risk assessment

2023

Conference Publication

Automated photodamage assessment from 3D total body photography for an objective assessment of melanoma risk

Kahler, Sam, Rutjes, Chantal, Yan, Siyuan, Mothershaw, Adam, Yu, Zhen, Jayasinghe, Dilki, Ge, Zongyuan, Stark, Mitchell, Janda, Monika, Soyer, Peter and Betz-Stablein, Brigid (2023). Automated photodamage assessment from 3D total body photography for an objective assessment of melanoma risk. Australasian College of Dermatologists 55th Annual Scientific Meeting, Engage, Enhance, Elevate, Virtual, 27-29 May 2023. Richmond, VIC Australia: John Wiley & Sons.

Automated photodamage assessment from 3D total body photography for an objective assessment of melanoma risk

2023

Conference Publication

Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi

Muse, Meghan E., Schaider, Helmut, Oey, Harald, Soyer, H. Peter, Christensen, Brock C. and Stark, Mitchell S. (2023). Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi. 114th Annual Meeting of the American Association for Cancer Research (AACR), Orlando Fl, Apr 14-19, 2023. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2023-6000

Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi

2023

Journal Article

Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi

Muse, Meghan E., Schaider, Helmut, Oey, Harald, Soyer, H. Peter, Christensen, Brock C. and Stark, Mitchell S. (2023). Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi. Journal of Investigative Dermatology, 143 (9), 1830-1834. doi: 10.1016/j.jid.2023.03.1653

Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi

2023

Journal Article

Terahertz imaging of human skin pathologies using laser feedback interferometry with quantum cascade lasers

Qi, Xiaoqiong, Bertling, Karl, Stark, Mitchell S., Taimre, Thomas, Kao, Yung-Ching, Lim, Yah Leng, Han, She, O'Brien, Blake, Collins, Angus, Walsh, Michael, Torniainen, Jari, Gillespie, Timothy, Donose, Bogdan C., Dean, Paul, Li, Lian He, Linfield, Edmund H., Davies, A. Giles, Indjin, Dragan, Soyer, H. Peter and Rakic, Aleksandar D. (2023). Terahertz imaging of human skin pathologies using laser feedback interferometry with quantum cascade lasers. Biomedical Optics Express, 14 (4) ARTN 480615, 1393-1410. doi: 10.1364/boe.480615

Terahertz imaging of human skin pathologies using laser feedback interferometry with quantum cascade lasers

2023

Journal Article

Deficiencies in mismatch DNA repair: providing the soil for large-to-giant congenital melanocytic naevus development

Stark, Mitchell S. (2023). Deficiencies in mismatch DNA repair: providing the soil for large-to-giant congenital melanocytic naevus development. The British journal of dermatology, 188 (1) ARTN ljac037, 5-5. doi: 10.1093/bjd/ljac037

Deficiencies in mismatch DNA repair: providing the soil for large-to-giant congenital melanocytic naevus development

Funding

Current funding

  • 2025 - 2029
    Exploration of the skin molecular ecosystem and early melanoma development
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2025
    Terahertz Quantum Technology for Melanoma Detection and Progression
    Critical Technologies Challenge Program: Round 1 - Stage 1 Feasibility
    Open grant
  • 2022 - 2025
    PREDICT: PREcision DIagnostiCs for early melanoma detection using spaTial biology and AI-guided image analysis
    United States Congressionally Directed Medical Research Programs - Melanoma Research Program
    Open grant
  • 2021 - 2024
    Advanced technological approach to predicting survival in patients diagnosed with locally invasive cutaneous melanoma
    Cancer Council Queensland
    Open grant

Past funding

  • 2022 - 2023
    Laser capture microdissection to empower cancer discoveries, improve diagnosis, treatment and outcomes in amyloidosis patients
    IPF Healthy - Medical Research
    Open grant
  • 2022 - 2023
    Whole exome and transcriptome profiling of patients with advanced cutaneous squamous cell carcinoma exposed to immunotherapy: C-Seq STUDY (Research Support Scheme Project Grant led by Metro South HHS)
    Metro South Hospital and Health Service
    Open grant
  • 2018 - 2022
    Improving outcomes for patients with melanoma brain metastases using novel personalised and response-adapted treatment strategies (PARF Translation Research Innovation Award administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2017 - 2021
    Assessment of precision melanoma diagnostics
    Queensland Government Advance Queensland Innovation Partnerships
    Open grant
  • 2016 - 2018
    MicroRNA expression profiling of SCCs and precursor lesions: The identification of a distinct microRNA expression signature from actinic keratosis, intraepidermal carcinoma, and invasive squamous...
    Australasian College of Dermatologists Scientific Research Fund
    Open grant
  • 2016 - 2019
    Identification of the molecular hallmarks of naevi progressing to melanoma
    NHMRC Early Career Fellowships
    Open grant

Supervision

Availability

Dr Mitchell Stark is:
Available for supervision

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Available projects

  • PhD projects available

    Australian domestic or on-shore International student applicants only.

    The Stark Lab is seeking talented and highly motivated PhD student(s) to join their team at The Dermatology Research Centre, The University of Queensland Diamantina Institute. Various projects are available relating to 2 major research streams: microRNA biomarkers for melanoma progression and the development a Genomics Atlas of pre-skin cancer lesions.

    If you are interested to hear more about the projects, please send your current CV, Academic Transcript, and Cover Letter to m.stark@uq.edu.au

    Living stipend scholarships and Tuition Scholarships are available for application from the UQ Graduate School which are currently a Base Stipend of $28,854 per annum tax free (2022 rate), indexed annually, Overseas Student Health Cover (OSHC). Top-up Scholarships (tax-free) may also be available.

    Applications for scholarships close 17 July 2022 (International) and 25 September (Domestic) for commencement in RQ1 and RQ2 2023.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Dr Mitchell Stark directly for media enquiries about:

  • Cancer Biomarker
  • Early melanoma detection
  • Genomics
  • Melanoma
  • microRNA
  • Naevi

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au