
Overview
Background
Associate Professor Mitchell Stark is a molecular biologist and Group Leader (Principal Research Fellow) from the Dermatology Research Centre (DRC) based at the Frazer Institute, The University of Queensland (UQ; Brisbane, Australia). He leads the pre-melanoma genomics program at the Frazer Institute and his group has extensive experience in the use of next-generation sequencing, spatial transcriptomics, bioinformatics, and functional analysis for a variety of applications. The Stark Lab’s major research streams include: miRNA biomarkers for melanoma progression and the development a Genomics Atlas of pre-skin cancer lesions, which aim to provide to greater understand melanoma progression from naevi and early invasive melanoma, with a goal to discover novel predictive biomarkers that offer increased precision to the clinical management of patients.
He has been engaged in melanoma and nevus research for 25+ years (with 9-years post PhD) and over this time he has been working towards understanding the aetiology of melanoma, studying gene dysregulation during tumor progression along with predisposition to melanoma in families with high risk for melanoma development. Dr Stark has a total of 97 career publications including 1 book chapter, 83 journal articles, 12 reviews/perspectives and 1 patent (WO/2016/029260) which have been cited a total of 7,053/10,208 times (Scopus/Google; h-index: 38/42) and has published in respected journals such as Nature, Nature Genetics, Cancer Research, and Journal of Investigative Dermatology. He has been awarded a career total of ~$10M as an Investigator (PI/co-PI/co-Investigator) including a prestigious NHMRC Peter Doherty Early Career Research Fellowship (2016-2019) and a recent NHMRC Investigator award (2025-2029), along with several research grants as Principal Investigator (e.g., Advance QLD Innovation Partnership, Department of Defence CDMRP – Melanoma Research Program).
Availability
- Associate Professor Mitchell Stark is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Applied Science, Queensland University of Technology
- Doctor of Philosophy, Queensland University of Technology
Research interests
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MicroRNA Biomarkers
Current projects relate to melanoma progression microRNA biomarkers to aid in increased diagnostic precision of “ambiguous” melanocytic lesions as well as “real-time” monitoring of melanoma disease progression using a “liquid biopsy.”
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Genomics Atlas of pre-skin cancer lesions
Current projects involve using overlapping genomics datasets (e.g. exome, mRNA and miRNA transcriptome, methylation) as well as Spatial Profiling to greater understand the early hallmarks of pre-skin cancer development.
Works
Search Professor Mitchell Stark’s works on UQ eSpace
Featured
2018
Journal Article
Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms
Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms. Journal of Investigative Dermatology, 138 (7), 1636-1644. doi: 10.1016/j.jid.2018.02.012
2025
Conference Publication
Epithelial-mesenchymal transition and immune exclusion underpin the natural history of primary cutaneous melanoma
Tan, S.X., Muller, N., Zhou, C., Vipulaguna, N., Kao, Y., Whiteman, D.C., Soyer, H.P., Stark, M.S., Nguyen, Q. and Khosrotehrani, K. (2025). Epithelial-mesenchymal transition and immune exclusion underpin the natural history of primary cutaneous melanoma. Society for Investigative Dermatology (SID) 2025 Meeting, San Diego, CA United States, 7-10 May 2025. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2025.06.953
2025
Conference Publication
Topical sirolimus prevents cutaneous squamous cell carcinomas by disrupting the balance between differentiation and proliferation
Dousset, L., Zhou, C., Kao, Y., Tan, S., Muller, N., Sormani, L., Cox, C., Soyer, H.P., Stark, M.S., Wong, H., Roy, E. and Khosrotehrani, K. (2025). Topical sirolimus prevents cutaneous squamous cell carcinomas by disrupting the balance between differentiation and proliferation. Society for Investigative Dermatology (SID) 2025 Meeting, San Diego, CA United States, 7-10 May 2025. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2025.06.777
2025
Conference Publication
Spatial transcriptomics reveals molecular determinants of mortality in thin melanoma
Zhou, C., Tan, S.X., Kao, Y., Claeson, M., Brown, S., Lambie, D., Whiteman, D.C., Pandeya, N., Olsen, C.M., Barbour, A., MacGregor, S., Soyer, H.P., Stark, M.S., Hayward, N., Smithers, B.M., Nguyen, Q. and Khosrotehrani, K. (2025). Spatial transcriptomics reveals molecular determinants of mortality in thin melanoma. Society for Investigative Dermatology (SID) 2025 Meeting, San Diego, CA United States, 7-10 May 2025. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2025.06.109
2025
Conference Publication
Spatial transcriptomics profiling of the tumour microenvironment of esophageal adenocarcinoma
Belle, Clemence, Brosda, Sandra, Bonazzi, Vanessa, Kao, Yung-Ching, Brown, Ian, Aoude, Lauren, Stark, Mitchell, Patel, Kalpana, AGITG AGITG DOCTOR Investigators, Atkinson, Victoria and Barbour, Andrew (2025). Spatial transcriptomics profiling of the tumour microenvironment of esophageal adenocarcinoma. 21st ISDE World Congress for Esophageal Diseases, Brisbane, QLD Australia, 18-20 September 2025. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/dote/doaf061.357
2025
Conference Publication
Unravelling melanoma brain metastasis tumor microenvironment characteristics using spatial transcriptomics
Belle, Clemence J., Brosda, Sandra, Bonazzi, Vanessa F., Bulteau, Victor, Stuart, Thomas, Xiong, Zherui, Lambie, Duncan, Johansson, Peter A., Aoude, Lauren G., Patel, Kalpana, Stehbens, Samantha J., Stark, Mitchell S., Haass, Nikolas K., Xu, Wen, Pinkham, Mark B., Foote, Matthew C., Olson, Sarah, Atkinson, Victoria, Kulasinghe, Arutha, Nguyen, Quan H. and Barbour, Andrew (2025). Unravelling melanoma brain metastasis tumor microenvironment characteristics using spatial transcriptomics. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-5076
2025
Journal Article
Prevalence of high-risk melanoma variants in early-onset and/or multiple primary melanoma in an Australian cohort
Maas, Ellie J., Wallingford, Courtney K,, De Bortoli, Emily, Primiero, Clare, Freeman, Ned P., Smit, Darren J., Lee, Katie J., Jagirdar, Kasturee, McMeniman, Erin, Betz-Stablein, Brigid, Stark, Mitchell S., Sturm, Richard A., Soyer, H. Peter and McInerney-Leo, Aideen (2025). Prevalence of high-risk melanoma variants in early-onset and/or multiple primary melanoma in an Australian cohort. Journal of the European Academy of Dermatology and Venereology: JEADV. doi: 10.1111/jdv.20673
2025
Journal Article
Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues
Vo, Tuan, Prakrithi, P., Jones, Kahli, Yoon, Sohye, Lam, Pui Yeng, Kao, Yung-Ching, Ma, Ning, Tan, Samuel X., Jin, Xinnan, Zhou, Chenhao, Crawford, Joanna, Walters, Shaun, Gupta, Ishaan, Soyer, Peter H., Khosrotehrani, Kiarash, Stark, Mitchell S. and Nguyen, Quan (2025). Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues. Journal of Pathology, 265 (3), 274-288. doi: 10.1002/path.6383
2025
Conference Publication
The genomic landscape of matching primary and metastatic melanoma tumours uncovers relevant pathways for the metastatic process
Smit, D.A., Kao, Y.-C., Oey, H., Harris, T., Tom, L.N., Jagirdar, K., Richtig, G., Aigelsreiter, A., Richtig, E., Soyer, H.P. and Stark, M.S. (2025). The genomic landscape of matching primary and metastatic melanoma tumours uncovers relevant pathways for the metastatic process. 21st EADO Congress & 11th World Congress of Melanoma, Athens, Greece, 3-5 April 2025. London, United Kingdom: Elsevier. doi: 10.1016/j.ejcskn.2025.100504
2025
Journal Article
Uncovering molecular mechanisms for amelanotic/hypopigmented primary cutaneous melanoma
Sturm, Richard A., Smit, Darren J., Duffy, David L., McLean, Catriona, Scolyer, Richard A., McArthur, Grant A., Papenfuss, Anthony T., Stark, Mitchell S., Soyer, H. Peter and Mar, Victoria J. (2025). Uncovering molecular mechanisms for amelanotic/hypopigmented primary cutaneous melanoma. British Journal of Dermatology, 192 (1), 55-62. doi: 10.1093/bjd/ljae336
2025
Conference Publication
Genomic landscape of melanoma-prone skin
Lee, K., Kao, Y.-C., Smith, D.J., Oey, H., Saldias Montivero, M.K., Causer, A., Christiansen, B.C., Nguyen, Q., Soyer, H.P. and Stark, M.S. (2025). Genomic landscape of melanoma-prone skin. 21st EADO Congress & 11th World Congress of Melanoma, Athens, Greece, 3-5 April 2025. London, United Kingdom: Elsevier. doi: 10.1016/j.ejcskn.2025.100506
2024
Journal Article
Mitochondrial deletion4977 abundance in melanoma-adjacent skin
Lee, Katie J., Kao, Yung-Ching, Smit, Darren J., Betz-Stablein, Brigid, Huang, Nancy, Kahler, Samuel, Soyer, H. Peter and Stark, Mitchell S. (2024). Mitochondrial deletion4977 abundance in melanoma-adjacent skin. The Journal of Investigative Dermatology, 145 (6), 1-4. doi: 10.1016/j.jid.2024.11.009
2024
Conference Publication
404 Spatial transcriptomic signatures in primary melanomas associated with sentinel node positivity
Muller, N. M., Tan, S. X., Zhou, C., Kao, Y., Stark, M., Nguyen, Q. and Khosrotehrani, K. (2024). 404 Spatial transcriptomic signatures in primary melanomas associated with sentinel node positivity. 53rd Annual ESDR Meeting, 4-7 September 2024, Lisbon, Portugal. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2024.10.414
2024
Journal Article
Challenging the lymph node progression model of melanoma
Kao, Yung-Ching and Stark, Mitchell S (2024). Challenging the lymph node progression model of melanoma. The Journal of Investigative Dermatology, 144 (11), 2344-2346. doi: 10.1016/j.jid.2024.04.021
2024
Journal Article
POT1 and multiple primary melanomas: the dermatological phenotype
Maas, Ellie J., DeBortoli, Emily, Nathan, Vaishnavi, Freeman, Ned P., Mothershaw, Adam, Smit, Darren J., Betz-Stablein, Brigid, Aoude, Lauren G., Stark, Mitchell S., Sturm, Richard A., Soyer, H. Peter and McInerney-Leo, Aideen M. (2024). POT1 and multiple primary melanomas: the dermatological phenotype. Journal of Medical Genetics, 61 (9) jmg-2023-109637, 1-4. doi: 10.1136/jmg-2023-109637
2024
Conference Publication
Assessment of precision melanoma diagnostics: Circulating microrna expression to monitor late-stage treatment
Harris, Teresa, Zaenker, Pauline, McEvoy, Ashleigh C., Soyer, H. Peter, Khattak, Muhammad A., Ziman, Melanie, Millward, Michael, Gray, Elin S. and Stark, Mitchell S. (2024). Assessment of precision melanoma diagnostics: Circulating microrna expression to monitor late-stage treatment. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-7626
2024
Journal Article
MicroRNA expression profiling of cutaneous squamous cell carcinomas and precursor lesions
Hossain, Akbor, Tom, Lisa N., Melati‐Rad, Ala, Yamada, Miko, Hammerlindl, Sabrina, Jagirdar, Kasturee, Prow, Tarl W., Soyer, H. Peter and Stark, Mitchell S. (2024). MicroRNA expression profiling of cutaneous squamous cell carcinomas and precursor lesions. Skin Health and Disease, 4 (3) e360, e360. doi: 10.1002/ski2.360
2024
Journal Article
Terahertz in vivo imaging of human skin: toward detection of abnormal skin pathologies
Qi, X., Bertling, K., Torniainen, J., Kong, F., Gillespie, T., Primiero, C., Stark, M. S., Dean, P., Indjin, D., Li, L. H., Linfield, E. H., Davies, A. G., Brünig, M., Mills, T., Rosendahl, C., Soyer, H. P. and Rakić, A. D. (2024). Terahertz in vivo imaging of human skin: toward detection of abnormal skin pathologies. APL Bioengineering, 8 (1) 016117, 016117. doi: 10.1063/5.0190573
2024
Journal Article
Assessing the genetic risk of nodular melanoma using a candidate gene approach
Stark, Mitchell S., Sturm, Richard A., Pan, Yan, Smit, Darren J., Kommajosyula, Varsha, Lee, Katie J., Jagirdar, Kasturee, McLean, Catriona, Duffy, David L., Soyer, H. Peter and Mar, Victoria J. (2024). Assessing the genetic risk of nodular melanoma using a candidate gene approach. British Journal of Dermatology, 190 (2), 199-206. doi: 10.1093/bjd/ljad365
2023
Journal Article
The skin molecular ecosystem holds the key to nevogenesis and melanomagenesis
Lee, Katie J., Soyer, H. Peter and Stark, Mitchell S. (2023). The skin molecular ecosystem holds the key to nevogenesis and melanomagenesis. The Journal of Investigative Dermatology, 144 (3), 456-465. doi: 10.1016/j.jid.2023.09.271
Funding
Current funding
Supervision
Availability
- Associate Professor Mitchell Stark is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Precision diagnostics for early melanoma detection
Principal Advisor
Other advisors: Dr Quan Nguyen, Professor Peter Soyer, Dr Snehlata Kumari
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Doctor Philosophy
Spatial molecular profiling of melanoma and correlation with dermoscopic patterns
Principal Advisor
Other advisors: Professor Peter Soyer
-
Doctor Philosophy
Predictive and prognostic biomarkers for melanoma progression (BioMEL)
Principal Advisor
Other advisors: Professor Kiarash Khosrotehrani
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Doctor Philosophy
The genomic architecture of suspicious lesions and skin in photodamaged and non-photodamaged areas (PhotoMelanoma)
Principal Advisor
Other advisors: Dr Quan Nguyen, Professor Peter Soyer
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Doctor Philosophy
A nano-map of cytokines in skin: Personalising treatment of skin inflammation by a digital nanotechnology
Associate Advisor
Other advisors: Professor Matt Trau, Dr Alain Wuethrich
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Doctor Philosophy
Harnessing Epigenetic Plasticity to Develop Effective Novel Therapeutic Strategies for Recurrent Melanoma
Associate Advisor
Other advisors: Associate Professor Jason Lee
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Doctor Philosophy
Nanotechnology-Enhanced Sensing Platforms for Early Detection of Cancer Progression
Associate Advisor
Other advisors: Professor Matt Trau, Dr Alain Wuethrich
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Doctor Philosophy
Deep learning analysis of spatial-omics and histopathological images to predict prognosis in gastrointestinal cancer
Associate Advisor
Other advisors: Dr Quan Nguyen
Completed supervision
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2020
Master Philosophy
Identification of clinically useful plasma miRNA as minimally invasive biomarkers for early stage Non-Small Cell Lung Carcinoma (NSCLC)
Principal Advisor
Other advisors: Professor Peter Soyer, Honorary Professor Li Li
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2018
Master Philosophy
Dermoscopic and molecular correlation of melanocytic naevi
Associate Advisor
Other advisors: Professor Peter Soyer
Media
Enquiries
Contact Associate Professor Mitchell Stark directly for media enquiries about:
- Cancer Biomarker
- Early melanoma detection
- Genomics
- Melanoma
- microRNA
- Naevi
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