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Dr Snehlata Kumari
Dr

Snehlata Kumari

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Overview

Background

Researcher Biography

Dr Snehlata Kumari is the head of skin inflammation and immunity laboratory at the Frazer Institute, the University of Queensland in Brisbane, Australia. She is a board member of the Australasian Society for Dermatology Research (ASDR).

After PhD and post-doctoral training in Germany, she is heading her research group with a focus on elucidating molecular mechanisms and underlying signalling pathways regulating inflammation. She has discovered novel mechanisms by which NF-kappaB, TNF, necroptotic and apoptotic signalling pathways control skin homeostasis and inflammation and published in top-tier journals such as Nature and Immunity.

Her scientific contributions received recognition from the global immunology and dermatology scientific communities including the German National Academy of Sciences, German Research Foundation (SFB), European Society for Dermatological Research, and the 2021 Christina Fleishmann Award for the Young Women Investigator from the International Cytokine and Interferon Society, USA

Overall aims and research focus

- Understanding molecular mechanisms of epithelial and immune cell communication in skin homeostasis and immunity.

- Elucidating signalling pathways and cytokines/chemokine interactions to develop novel drug targets and strategies to treat skin diseases such as Psoriasis, Hidradenitis Suppurative, Atopic Dermatitis.

Availability

Dr Snehlata Kumari is:
Available for supervision
Media expert

Qualifications

  • Bachelor, Patna University
  • Masters (Coursework), University of Pune
  • Doctoral (Research) of Biological Sciences, University of Cologne

Research interests

  • Skin Inflammation and Immunity

    Identifying new regulatory check points to help prevent skin inflammation

  • Skin Cancer

    Development of novel therapeutics for melanoma and non-melanoma cancer

Works

Search Professor Snehlata Kumari’s works on UQ eSpace

27 works between 2010 and 2024

1 - 20 of 27 works

2024

Journal Article

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

Patrick, Ralph, Naval-Sanchez, Marina, Deshpande, Nikita, Huang, Yifei, Zhang, Jingyu, Chen, Xiaoli, Yang, Ying, Tiwari, Kanupriya, Esmaeili, Mohammadhossein, Tran, Minh, Mohamed, Amin R., Wang, Binxu, Xia, Di, Ma, Jun, Bayliss, Jacqueline, Wong, Kahlia, Hun, Michael L., Sun, Xuan, Cao, Benjamin, Cottle, Denny L., Catterall, Tara, Barzilai-Tutsch, Hila, Troskie, Robin-Lee, Chen, Zhian, Wise, Andrea F., Saini, Sheetal, Soe, Ye Mon, Kumari, Snehlata, Sweet, Matthew J. ... Nefzger, Christian M. (2024). The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening. Cell Metabolism, 36 (8), 1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

2024

Journal Article

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Koerner, Lioba, Wachsmuth, Laurens, Kumari, Snehlata, Schwarzer, Robin, Wagner, Theresa, Jiao, Huipeng and Pasparakis, Manolis (2024). ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell Death & Differentiation, 31 (7), 938-953. doi: 10.1038/s41418-024-01321-6

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

2023

Journal Article

Celebrating 100 years of Immunology & Cell Biology – a special focus on the field of tumor immunology in Australia

Kumari, Snehlata, Zemek, Rachael M, Palendira, Umaimainthan and Ebert, Lisa M (2023). Celebrating 100 years of Immunology & Cell Biology – a special focus on the field of tumor immunology in Australia. Immunology and Cell Biology, 101 (9), 783-788. doi: 10.1111/imcb.12690

Celebrating 100 years of Immunology & Cell Biology – a special focus on the field of tumor immunology in Australia

2022

Journal Article

Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseases

Liu, Timothy J., Lin, Lynlee L., McMeniman, Erin, Wu, Jason, Kao, Yung-Ching, Kumari, Snehlata, Boyle, Glen M., Wells, James W., Soyer, H. Peter and Gonzalez-Cruz, Jazmina L. (2022). Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseases. Frontiers in Immunology, 13 1028435, 1-8. doi: 10.3389/fimmu.2022.1028435

Cytokine/Chemokine assessment as a complementary diagnostic tool for inflammatory skin diseases

2022

Journal Article

Macrophages in skin wounds: functions and therapeutic potential

Sim, Seen Ling, Kumari, Snehlata, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Macrophages in skin wounds: functions and therapeutic potential. Biomolecules, 12 (11) 1659, 1-31. doi: 10.3390/biom12111659

Macrophages in skin wounds: functions and therapeutic potential

2022

Journal Article

Methods to identify immune cells in tissues with a focus on skin as a model

Murphy, Peter R., Narayanan, Divyaa and Kumari, Snehlata (2022). Methods to identify immune cells in tissues with a focus on skin as a model. Current Protocols, 2 (7) e485, e485. doi: 10.1002/cpz1.485

Methods to identify immune cells in tissues with a focus on skin as a model

2022

Book Chapter

Hypoxia-induced stress responses in cancer and cancer stem cells

Chipurupalli, Sandhya, Kumari, Snehlata, Desiderio, Vincenzo and Robinson, Nirmal (2022). Hypoxia-induced stress responses in cancer and cancer stem cells. Handbook of oxidative stress in cancer: mechanistic aspects. (pp. 1829-1843) Singapore, Singapore: Springer Nature Singapore. doi: 10.1007/978-981-15-9411-3_121

Hypoxia-induced stress responses in cancer and cancer stem cells

2021

Journal Article

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

Kumari, Snehlata, Van, Trieu-My, Preukschat, Daniela, Schuenke, Hannah, Basic, Marijana, Bleich, André, Klein, Ulf and Pasparakis, Manolis (2021). NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life Science Alliance, 4 (6) e202000956, e202000956. doi: 10.26508/lsa.202000956

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

2020

Journal Article

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Laurien, Lucie, Nagata, Masahiro, Schünke, Hannah, Delanghe, Tom, Wiederstein, Janica L., Kumari, Snehlata, Schwarzer, Robin, Corona, Teresa, Krüger, Marcus, Bertrand, Mathieu J. M., Kondylis, Vangelis and Pasparakis, Manolis (2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nature Communications, 11 (1) 1747, 1747. doi: 10.1038/s41467-020-15466-8

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

2020

Journal Article

Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (Nature, (2020), 580, 7803, (391-395), 10.1038/s41586-020-2129-8)

Jiao, Huipeng, Wachsmuth, Laurens, Kumari, Snehlata, Schwarzer, Robin, Lin, Juan, Eren, Remzi Onur, Fisher, Amanda, Lane, Rebecca, Young, George R., Kassiotis, George, Kaiser, William J. and Pasparakis, Manolis (2020). Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (Nature, (2020), 580, 7803, (391-395), 10.1038/s41586-020-2129-8). Nature, 580 (7804), 391-395. doi: 10.1038/s41586-020-2207-y

Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (Nature, (2020), 580, 7803, (391-395), 10.1038/s41586-020-2129-8)

2020

Journal Article

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Jiao, Huipeng, Wachsmuth, Laurens, Kumari, Snehlata, Schwarzer, Robin, Lin, Juan, Eren, Remzi Onur, Fisher, Amanda, Lane, Rebecca, Young, George R., Kassiotis, George, Kaiser, William J. and Pasparakis, Manolis (2020). Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature, 580 (7803), 391-395+. doi: 10.1038/s41586-020-2129-8

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

2018

Conference Publication

Cell Death and the Regulatory Network of DAMPs in Skin Inflammation

Kumari, S., Lin, J., Kim, S., Van, T-M, Wachsmuth, L., Polykratis, A. and Pasparakis, M. (2018). Cell Death and the Regulatory Network of DAMPs in Skin Inflammation. HOBOKEN: WILEY.

Cell Death and the Regulatory Network of DAMPs in Skin Inflammation

2018

Conference Publication

IKK/NF-kB signaling in keratinocytes controls TNF-dependent necroptosis- and apoptosis-mediated skin inflammation

Kumari, S., Van, T. and Pasparakis, M. (2018). IKK/NF-kB signaling in keratinocytes controls TNF-dependent necroptosis- and apoptosis-mediated skin inflammation. International Investigative Dermatology (IID) Meeting, Orlando Fl, May 16-19, 2018. NEW YORK: ELSEVIER SCIENCE INC.

IKK/NF-kB signaling in keratinocytes controls TNF-dependent necroptosis- and apoptosis-mediated skin inflammation

2017

Journal Article

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

Kondylis, Vangelis, Kumari, Snehlata, Vlantis, Katerina and Pasparakis, Manolis (2017). The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunological Reviews, 277 (1), 113-127. doi: 10.1111/imr.12550

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

2017

Book Chapter

Epithelial cell death and inflammation in skin

Kumari, Snehlata and Pasparakis, Manolis (2017). Epithelial cell death and inflammation in skin. Apoptotic and non-apoptotic cell death. (pp. 77-93) edited by Shigekazu Nagata and Hiroyasu Nakano. Cham, Switzerland: Springer. doi: 10.1007/82_2015_466

Epithelial cell death and inflammation in skin

2016

Journal Article

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Lin, Juan, Kumari, Snehlata, Kim, Chun, Van, Trieu-My, Wachsmuth, Laurens, Polykratis, Apostolos and Pasparakis, Manolis (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540 (7631), 124-128. doi: 10.1038/nature20558

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

2016

Conference Publication

Role of RIP kinase signalling in the development of skin inflammation in mice with keratinocyte-specific IKK deficiency

Kumari, S., Van, T. and Pasparakis, M. (2016). Role of RIP kinase signalling in the development of skin inflammation in mice with keratinocyte-specific IKK deficiency. Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Munich Germany, Sep 07-10, 2016. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.jid.2016.06.354

Role of RIP kinase signalling in the development of skin inflammation in mice with keratinocyte-specific IKK deficiency

2014

Journal Article

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

Kumari, Snehlata, Redouane, Younes, Lopez-Mosqueda, Jaime, Shiraishi, Ryoko, Romanowska, Malgorzata, Lutzmayer, Stefan, Kuiper, Jan, Martinez, Conception, Dikic, Ivan, Pasparakis, Manolis and Ikeda, Fumiyo (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife, 3 e03422. doi: 10.7554/eLife.03422

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

2014

Journal Article

Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin

Kumari, Snehlata, Herzberg, Benjamin, Pofahl, Ruth, Krieg, Thomas and Haase, Ingo (2014). Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin. Journal of Investigative Dermatology, 134 (10), 2541-2550. doi: 10.1038/jid.2014.193

Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin

2014

Journal Article

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Dannappel, Marius, Vlantis, Katerina, Kumari, Snehlata, Polykratis, Apostolos, Kim, Chun, Wachsmuth, Laurens, Eftychi, Christina, Lin, Juan, Corona, Teresa, Hermance, Nicole, Zelic, Matija, Kirsch, Petra, Basic, Marijana, Bleich, Andre, Kelliher, Michelle and Pasparakis, Manolis (2014). RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature, 513 (7516), 90-94. doi: 10.1038/nature13608

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Funding

Past funding

  • 2022 - 2024
    Determining Causative Mechanisms of Hidradenitis Suppurativa (TRI LINC grant led by MSHHS)
    Metro South Hospital and Health Service
    Open grant

Supervision

Availability

Dr Snehlata Kumari is:
Available for supervision

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Supervision history

Current supervision

Media

Enquiries

Contact Dr Snehlata Kumari directly for media enquiries about:

  • Atopic Dermatitis
  • Cytokines
  • Hidradenitis Suppurativa
  • Inflammation
  • Inflammatory Skin Diseases
  • Psoriasis
  • Signalling
  • Skin Inflammation

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