Overview
Background
Researcher Biography
Dr Snehlata Kumari is the head of skin inflammation and immunity laboratory at the Frazer Institute, the University of Queensland in Brisbane, Australia. She is a board member of the Australasian Society for Dermatology Research (ASDR).
After PhD and post-doctoral training in Germany, she is heading her research group with a focus on elucidating molecular mechanisms and underlying signalling pathways regulating inflammation. She has discovered novel mechanisms by which NF-kappaB, TNF, necroptotic and apoptotic signalling pathways control skin homeostasis and inflammation and published in top-tier journals such as Nature and Immunity.
Her scientific contributions received recognition from the global immunology and dermatology scientific communities including the German National Academy of Sciences, German Research Foundation (SFB), European Society for Dermatological Research, and the 2021 Christina Fleishmann Award for the Young Women Investigator from the International Cytokine and Interferon Society, USA
Overall aims and research focus
- Understanding molecular mechanisms of epithelial and immune cell communication in skin homeostasis and immunity.
- Elucidating signalling pathways and cytokines/chemokine interactions to develop novel drug targets and strategies to treat skin diseases such as Psoriasis, Hidradenitis Suppurative, Atopic Dermatitis.
Availability
- Dr Snehlata Kumari is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor, Patna University
- Masters (Coursework), University of Pune
- Doctoral (Research) of Biological Sciences, University of Cologne
Research interests
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Skin Inflammation and Immunity
Identifying new regulatory check points to help prevent skin inflammation
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Skin Cancer
Development of novel therapeutics for melanoma and non-melanoma cancer
Works
Search Professor Snehlata Kumari’s works on UQ eSpace
2014
Journal Article
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
Kumari, Snehlata, Redouane, Younes, Lopez-Mosqueda, Jaime, Shiraishi, Ryoko, Romanowska, Malgorzata, Lutzmayer, Stefan, Kuiper, Jan, Martinez, Conception, Dikic, Ivan, Pasparakis, Manolis and Ikeda, Fumiyo (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife, 3 e03422. doi: 10.7554/eLife.03422
2014
Journal Article
Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin
Kumari, Snehlata, Herzberg, Benjamin, Pofahl, Ruth, Krieg, Thomas and Haase, Ingo (2014). Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin. Journal of Investigative Dermatology, 134 (10), 2541-2550. doi: 10.1038/jid.2014.193
2014
Journal Article
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, Marius, Vlantis, Katerina, Kumari, Snehlata, Polykratis, Apostolos, Kim, Chun, Wachsmuth, Laurens, Eftychi, Christina, Lin, Juan, Corona, Teresa, Hermance, Nicole, Zelic, Matija, Kirsch, Petra, Basic, Marijana, Bleich, Andre, Kelliher, Michelle and Pasparakis, Manolis (2014). RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature, 513 (7516), 90-94. doi: 10.1038/nature13608
2014
Conference Publication
Altered tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice
Kumari, S., Bonnet, M., Witte, E., Wolk, K., Kollias, G., Sabat, R., Pasparakis, M. and Haase, I. (2014). Altered tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. 41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Cologne Germany, Mar 13-15, 2014. HOBOKEN: WILEY-BLACKWELL.
2013
Journal Article
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice
Kumari, Snehlata, Bonnet, Marion C., Ulvmar, Maria H., Wolk, Kerstin, Karagianni, Niki, Witte, Ellen, Uthoff-Hachenberg, Claudia, Renauld, Jean-Christophe, Kollias, George, Toftgard, Rune, Sabat, Robert, Pasparakis, Manolis and Haase, Ingo (2013). Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity, 39 (5), 899-911. doi: 10.1016/j.immuni.2013.10.009
2013
Conference Publication
Epidermal RelA specifically restricts contact allergen induced inflammation and apoptosis in skin
Kumari, S., Krieg, T. and Haase, J. (2013). Epidermal RelA specifically restricts contact allergen induced inflammation and apoptosis in skin. International Investigative Dermatology Meeting, Edinburgh Scotland, May 08-11, 2013. NEW YORK: NATURE PUBLISHING GROUP.
2012
Conference Publication
Epidermal control of psoriasis like skin inflammation by a TNF-alpha and IL-24 dependent mechanism
Kumari, S., Pasparakis, M., Sabat, R. and Haase, I. (2012). Epidermal control of psoriasis like skin inflammation by a TNF-alpha and IL-24 dependent mechanism. 75th Annual Meeting of the Society-for-Investigative-Dermatology, Raleigh Nc, May 09-12, 2012. NEW YORK: NATURE PUBLISHING GROUP.
2011
Conference Publication
Control of psoriasis-like skin inflammation by epidermal keratinocytes through a tumour necrosis factor-alpha- and interleukin-24-dependent mechanism
Kumari, S. and Haase, I. (2011). Control of psoriasis-like skin inflammation by epidermal keratinocytes through a tumour necrosis factor-alpha- and interleukin-24-dependent mechanism. 6th International Congress of Psoriasis - from Gene to Clinic, London England, Dec 01-03, 2011. MALDEN: WILEY-BLACKWELL.
2011
Conference Publication
Epidermal control of psoriasis like skin inflammation by a TNF-a and IL-24 dependent mechanism
Kumari, Snehlata and Haase, Ingo (2011). Epidermal control of psoriasis like skin inflammation by a TNF-a and IL-24 dependent mechanism. 41st Annual Meeting of the European-Society-for-Dermatological-Research, Barcelona Spain, Sep 07-10, 2011. NEW YORK: NATURE PUBLISHING GROUP.
2010
Conference Publication
Systemic recruitment of myeloid cells upon deletion of IKK2 from epidermal keratinocytes
Kumari, Snehlata, Pasparakis, Manolis and Haase, Ingo (2010). Systemic recruitment of myeloid cells upon deletion of IKK2 from epidermal keratinocytes. 40th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR 2010), Helsinki Finland, Sep 08-11, 2010. NEW YORK: NATURE PUBLISHING GROUP.
Funding
Past funding
Supervision
Availability
- Dr Snehlata Kumari is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Principal Advisor
Other advisors: Professor Gabrielle Belz, Professor Kiarash Khosrotehrani
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Doctor Philosophy
Understanding the immunomodulatory mechanisms regulating inflammation
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Associate Professor James Wells
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Principal Advisor
Other advisors: Professor Fiona Simpson, Professor Kiarash Khosrotehrani
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Doctor Philosophy
Precision diagnostics for early melanoma detection
Associate Advisor
Other advisors: Dr Quan Nguyen, Professor Peter Soyer, Associate Professor Mitchell Stark
Media
Enquiries
Contact Dr Snehlata Kumari directly for media enquiries about:
- Atopic Dermatitis
- Cytokines
- Hidradenitis Suppurativa
- Inflammation
- Inflammatory Skin Diseases
- Psoriasis
- Signalling
- Skin Inflammation
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