Overview
Background
Dr Snehlata Kumari is a group leader and the head of the Skin Inflammation and Immunity Laboratory at the Frazer Institute, University of Queensland, in Brisbane, Australia. Her international career and academic training spanned Germany, India, and Australia. She is a board member of the Australasian Society for Dermatology Research (ASDR) and a councillor on the International Psoriasis Council.
She has discovered novel signalling mechanisms that regulate the balance between homeostasis and inflammation in the skin. These findings highlight new mechanisms by which inflammatory diseases are initiated and propagated via NF-κB, TNF, IL-20 family cytokines, and necroptotic and apoptotic signalling pathways. Her research work has been published in top-tier journals, including Nature (3x), Nature Communications, Cell Metabolism, and Immunity.
Her scientific contributions have received international recognitions and honours, including the German National Academy of Sciences, the German Research Foundation (DFG), the European Society for Dermatological Research, the Japanese Society for Investigative Dermatology, and the Young Women Investigators Award from the International Cytokine and Interferon Society.
Overall aims and research focus
- Immunomodulatory mechanisms regulating inflammation and immunity.
- Cellular and cell-soluble factor interactions in inflammatory diseases, including Psoriasis, Hidradenitis Suppurative, and Atopic Dermatitis.
Availability
- Dr Snehlata Kumari is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor, Patna University
- Masters (Coursework), University of Pune
- Doctoral (Research) of Biological Sciences, University of Cologne
Research interests
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Inflammation and Immunity
Identifying new regulatory check points to help prevent skin inflammation
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Skin cancer
Development of novel therapeutics for melanoma and non-melanoma cancer
Works
Search Professor Snehlata Kumari’s works on UQ eSpace
2018
Conference Publication
IKK/NF-kB signaling in keratinocytes controls TNF-dependent necroptosis- and apoptosis-mediated skin inflammation
Kumari, S., Van, T. and Pasparakis, M. (2018). IKK/NF-kB signaling in keratinocytes controls TNF-dependent necroptosis- and apoptosis-mediated skin inflammation. International Investigative Dermatology (IID) Meeting, Orlando Fl, May 16-19, 2018. NEW YORK: ELSEVIER SCIENCE INC.
2017
Journal Article
The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation
Kondylis, Vangelis, Kumari, Snehlata, Vlantis, Katerina and Pasparakis, Manolis (2017). The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunological Reviews, 277 (1), 113-127. doi: 10.1111/imr.12550
2017
Book Chapter
Epithelial cell death and inflammation in skin
Kumari, Snehlata and Pasparakis, Manolis (2017). Epithelial cell death and inflammation in skin. Apoptotic and non-apoptotic cell death. (pp. 77-93) edited by Shigekazu Nagata and Hiroyasu Nakano. Cham, Switzerland: Springer. doi: 10.1007/82_2015_466
2016
Journal Article
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
Lin, Juan, Kumari, Snehlata, Kim, Chun, Van, Trieu-My, Wachsmuth, Laurens, Polykratis, Apostolos and Pasparakis, Manolis (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540 (7631), 124-128. doi: 10.1038/nature20558
2016
Conference Publication
Role of RIP kinase signalling in the development of skin inflammation in mice with keratinocyte-specific IKK deficiency
Kumari, S., Van, T. and Pasparakis, M. (2016). Role of RIP kinase signalling in the development of skin inflammation in mice with keratinocyte-specific IKK deficiency. Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Munich Germany, Sep 07-10, 2016. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.jid.2016.06.354
2014
Journal Article
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
Kumari, Snehlata, Redouane, Younes, Lopez-Mosqueda, Jaime, Shiraishi, Ryoko, Romanowska, Malgorzata, Lutzmayer, Stefan, Kuiper, Jan, Martinez, Conception, Dikic, Ivan, Pasparakis, Manolis and Ikeda, Fumiyo (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife, 3 e03422. doi: 10.7554/eLife.03422
2014
Journal Article
Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin
Kumari, Snehlata, Herzberg, Benjamin, Pofahl, Ruth, Krieg, Thomas and Haase, Ingo (2014). Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin. Journal of Investigative Dermatology, 134 (10), 2541-2550. doi: 10.1038/jid.2014.193
2014
Journal Article
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, Marius, Vlantis, Katerina, Kumari, Snehlata, Polykratis, Apostolos, Kim, Chun, Wachsmuth, Laurens, Eftychi, Christina, Lin, Juan, Corona, Teresa, Hermance, Nicole, Zelic, Matija, Kirsch, Petra, Basic, Marijana, Bleich, Andre, Kelliher, Michelle and Pasparakis, Manolis (2014). RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature, 513 (7516), 90-94. doi: 10.1038/nature13608
2014
Conference Publication
Altered tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice
Kumari, S., Bonnet, M., Witte, E., Wolk, K., Kollias, G., Sabat, R., Pasparakis, M. and Haase, I. (2014). Altered tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. 41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Cologne Germany, Mar 13-15, 2014. HOBOKEN: WILEY-BLACKWELL.
2013
Journal Article
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice
Kumari, Snehlata, Bonnet, Marion C., Ulvmar, Maria H., Wolk, Kerstin, Karagianni, Niki, Witte, Ellen, Uthoff-Hachenberg, Claudia, Renauld, Jean-Christophe, Kollias, George, Toftgard, Rune, Sabat, Robert, Pasparakis, Manolis and Haase, Ingo (2013). Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity, 39 (5), 899-911. doi: 10.1016/j.immuni.2013.10.009
2013
Conference Publication
Epidermal RelA specifically restricts contact allergen induced inflammation and apoptosis in skin
Kumari, S., Krieg, T. and Haase, J. (2013). Epidermal RelA specifically restricts contact allergen induced inflammation and apoptosis in skin. International Investigative Dermatology Meeting, Edinburgh Scotland, May 08-11, 2013. NEW YORK: NATURE PUBLISHING GROUP.
2012
Conference Publication
Epidermal control of psoriasis like skin inflammation by a TNF-alpha and IL-24 dependent mechanism
Kumari, S., Pasparakis, M., Sabat, R. and Haase, I. (2012). Epidermal control of psoriasis like skin inflammation by a TNF-alpha and IL-24 dependent mechanism. 75th Annual Meeting of the Society-for-Investigative-Dermatology, Raleigh Nc, May 09-12, 2012. NEW YORK: NATURE PUBLISHING GROUP.
2011
Conference Publication
Control of psoriasis-like skin inflammation by epidermal keratinocytes through a tumour necrosis factor-alpha- and interleukin-24-dependent mechanism
Kumari, S. and Haase, I. (2011). Control of psoriasis-like skin inflammation by epidermal keratinocytes through a tumour necrosis factor-alpha- and interleukin-24-dependent mechanism. 6th International Congress of Psoriasis - from Gene to Clinic, London England, Dec 01-03, 2011. MALDEN: WILEY-BLACKWELL.
2011
Conference Publication
Epidermal control of psoriasis like skin inflammation by a TNF-a and IL-24 dependent mechanism
Kumari, Snehlata and Haase, Ingo (2011). Epidermal control of psoriasis like skin inflammation by a TNF-a and IL-24 dependent mechanism. 41st Annual Meeting of the European-Society-for-Dermatological-Research, Barcelona Spain, Sep 07-10, 2011. NEW YORK: NATURE PUBLISHING GROUP.
2010
Conference Publication
Systemic recruitment of myeloid cells upon deletion of IKK2 from epidermal keratinocytes
Kumari, Snehlata, Pasparakis, Manolis and Haase, Ingo (2010). Systemic recruitment of myeloid cells upon deletion of IKK2 from epidermal keratinocytes. 40th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR 2010), Helsinki Finland, Sep 08-11, 2010. NEW YORK: NATURE PUBLISHING GROUP.
Funding
Past funding
Supervision
Availability
- Dr Snehlata Kumari is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Understanding immune diversity in skin inflammation
Principal Advisor
Other advisors: Professor Gabrielle Belz, Professor Kiarash Khosrotehrani
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Doctor Philosophy
Characterizing the role of ion channel kinase in skin homeostasis
Principal Advisor
Other advisors: Professor Fiona Simpson, Professor Kiarash Khosrotehrani
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Doctor Philosophy
The Immunomodulatory Role of Damage-Associated Molecular Patterns in Inflammatory Skin Conditions
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Associate Professor James Wells
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Doctor Philosophy
Precision diagnostics for early melanoma detection
Associate Advisor
Other advisors: Dr Quan Nguyen, Professor Peter Soyer, Associate Professor Mitchell Stark
Media
Enquiries
Contact Dr Snehlata Kumari directly for media enquiries about:
- Atopic Dermatitis
- Cytokines
- Hidradenitis Suppurativa
- Inflammation
- Inflammatory Skin Diseases
- Psoriasis
- Signalling
- Skin Inflammation
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