Overview
Availability
- Associate Professor Graham Leggatt is:
- Not available for supervision
Fields of research
Works
Search Professor Graham Leggatt’s works on UQ eSpace
2024
Journal Article
Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival
Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018
2024
Conference Publication
Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells
Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Asplett, Kiran, Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells. AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy, Boston, MA, United States, 18-21 October 2024. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm24-a001
2024
Journal Article
Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity
Wright, Quentin G., Sinha, Debottam, Wells, James W., Frazer, Ian H., Gonzalez Cruz, Jazmina L. and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960. doi: 10.1136/jitc-2023-007960
2023
Journal Article
Metabolomics at the tumor microenvironment interface: decoding cellular conversations
Berrell, Naomi, Sadeghirad, Habib, Blick, Tony, Bidgood, Charles, Leggatt, Graham R., O'Byrne, Ken and Kulasinghe, Arutha (2023). Metabolomics at the tumor microenvironment interface: decoding cellular conversations. Medicinal Research Reviews, 44 (3), 1121-1146. doi: 10.1002/med.22010
2023
Conference Publication
Contributions of maternal classical HLA alleles and KIR genes to the risk of miscarriages and stillbirths
Nunes, Caroline Brito, Decina, Caitlin, Hwang, Liang-Dar, Wang, Geng, Leggatt, Graham, Moen, Gunn-Helen and Evans, David (2023). Contributions of maternal classical HLA alleles and KIR genes to the risk of miscarriages and stillbirths. International Statistical Genetics Workshop, Boulder, CO United States, 5 - 11 March 2023.
2023
Conference Publication
Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths
Nunes, Caroline Brito, Hwang, Liang-Dar, Wang, Geng, Yengo, Loic, Leggatt, Graham, Moen, Gunn-Helen and Evans, David M. (2023). Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane Australia, Mar 21-25, 2023. HEIDELBERG: SPRINGER HEIDELBERG.
2022
Conference Publication
Contributions of maternal classical HLA alleles to the risk of miscarriages and stillbirths
Brito Nunes, Caroline, Hwang, Liang-Dar, Wang, Geng, Leggatt, Graham, Moen, Gunn-Helen and Evans, David (2022). Contributions of maternal classical HLA alleles to the risk of miscarriages and stillbirths. Queensland Perinatal Consortium (QPaCt), Brisbane, QLD Australia, 15 December 2022.
2022
Conference Publication
Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity
Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.
2022
Conference Publication
Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo
Wright, Q., Sinha, D., Gonzalez-Cruz, J., Frazer, I. and Leggatt, G. (2022). Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo. ESMO Immuno-Oncology Congress 2022, Geneva, Switzerland, 7-9 December 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.iotech.2022.100289
2021
Journal Article
PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy
Wright, Quentin, Gonzalez Cruz, Jazmina L., Wells, James W. and Leggatt, Graham R. (2021). PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy. Cancers, 13 (13) 3310, 3310. doi: 10.3390/cancers13133310
2021
Journal Article
Evolution of cancer vaccines—challenges, achievements and future directions
Tay, Ban Qi, Wright, Quentin, Ladwa, Rahul, Perry, Christopher, Leggatt, Graham, Simpson, Fiona, Wells, James W., Panizza, Benedict J., Frazer, Ian H. and Cruz, Jazmina L. G. (2021). Evolution of cancer vaccines—challenges, achievements and future directions. Vaccines, 9 (5) 535, 535. doi: 10.3390/vaccines9050535
2021
Journal Article
Investigating T cell immunity in cancer: achievements and prospects
Zeng, Zhen, Chew, Hui Yi, Cruz, Jazmina G., Leggatt, Graham R. and Wells, James W. (2021). Investigating T cell immunity in cancer: achievements and prospects. International Journal of Molecular Sciences, 22 (6) 2907, 1-17. doi: 10.3390/ijms22062907
2020
Journal Article
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment
Kobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee Elyse, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham, Gandhi, Maher K., Hill, Michelle M, Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel and Mattarollo, Stephen R. (2020). Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood, 136 (26), 3004-3017. doi: 10.1182/blood.2020005602
2020
Journal Article
Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium
Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011
2020
Conference Publication
Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin
Leggatt, Graham R., Salim, Nazhifah and Mattarollo, Stephen (2020). Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.165.27
2020
Conference Publication
Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis
Wright, Quentin, Minnie, Simone and Leggatt, Graham R. (2020). Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.241.23
2020
Conference Publication
Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin
Leggatt, Graham R., Salim, Nazhifah and Mattarollo, Stephen (2020). Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin. IMMUNOLOGY2020, Honolulu, HI, United States, 8-12 May, 2020. Rockville, MD, United States: American Association of Immunologists.
2020
Journal Article
Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs
Wong, Arthur, Lanyon, Janet M., O'Handley, Ryan, Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2020). Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs. Marine Mammal Science, 36 (1) mms.12629, 180-194. doi: 10.1111/mms.12629
2020
Conference Publication
Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis
Wright, Quentin, Minnie, Simone and Leggatt, Graham R. (2020). Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis. IMMUNOLOGY2020, Honolulu, HI, United States, 8-12 May 2020. Rockville, MD, United States: American Association of Immunologists.
2019
Journal Article
HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development
Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162
Funding
Past funding
Supervision
Availability
- Associate Professor Graham Leggatt is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Associate Advisor
Other advisors: Professor David Hume, Dr Janin Chandra, Professor Ian Frazer
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Associate Advisor
Other advisors: Professor David Hume, Dr Janin Chandra, Professor Ian Frazer
-
Doctor Philosophy
Understanding the immunomodulatory mechanisms regulating inflammation
Associate Advisor
Other advisors: Associate Professor James Wells, Dr Snehlata Kumari
Completed supervision
-
2023
Doctor Philosophy
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
Principal Advisor
Other advisors: Professor Ian Frazer, Dr Jazmina Gonzalez Cruz
-
2011
Doctor Philosophy
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
Principal Advisor
Other advisors: Professor Ian Frazer
-
Doctor Philosophy
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
Principal Advisor
Other advisors: Professor Ian Frazer
-
2020
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
Associate Advisor
Other advisors: Dr Janin Chandra, Professor Ian Frazer
-
2019
Doctor Philosophy
Harnessing the immunomodulatory effects of NKT cells for cancer immunotherapy using a Clec9a-targeted nanoemulsion delivery system
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2018
Doctor Philosophy
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
Associate Advisor
Other advisors: Professor Ian Frazer
-
2018
Doctor Philosophy
Targeting Hepatocellular Carcinoma with genetically modified Adeno Associated Viruses
Associate Advisor
Other advisors: Associate Professor Chris Layton
-
2016
Doctor Philosophy
Health surveillance of a subtropical wild dugong population: development and application of tools for assessment of clinical health and immunology
Associate Advisor
Other advisors: Dr Janet Lanyon
-
2013
Doctor Philosophy
Genetic variation in IL23R and its role in ankylosing spondylitis
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2013
Master Philosophy
B cell lymphoma evades the immune system by inactivating lymphoma-specific T cells.
Associate Advisor
-
2011
Doctor Philosophy
RNAi against Virally-Induced Disease
Associate Advisor
Other advisors: Dr Wenyi Gu
-
2010
Doctor Philosophy
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
Associate Advisor
Other advisors: Professor Ian Frazer
-
2010
Doctor Philosophy
Role of dendritic epidermal T cells in skin graft rejection
Associate Advisor
Other advisors: Professor Ian Frazer
-
2009
Doctor Philosophy
Human Papillomavirus 16 E7 Inhibits the ability of IFN-γ in Enhancement of MHC Class I Antigen Presentation and CTL Lysis by Affecting IRF-1 Expression in Keratinocytes
Associate Advisor
Other advisors: Professor Ian Frazer
-
2003
Doctor Philosophy
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
Associate Advisor
Other advisors: Professor Ian Frazer
-
2002
Doctor Philosophy
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
Associate Advisor
Other advisors: Professor Ian Frazer
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