Associate Professor

Graham Leggatt

Email: 
Phone: 
+61 7 344 36961

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Fields of research

Clinical sciences Immunology Oncology and carcinogenesis

Search Professor Graham Leggatt’s works on UQ eSpace

128 works between 1991 and 2024
All (128) Journal Article (105) Book Chapter (1) Conference Publication (21) Book (1)

1 - 20 of 128 works

2024

Journal Article

Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity

Wright, Quentin G, Sinha, Debottam, Wells, James W, Frazer, Ian H, Gonzalez Cruz, Jazmina L and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960

Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity

2023

Journal Article

Metabolomics at the tumor microenvironment interface: decoding cellular conversations

Berrell, Naomi, Sadeghirad, Habib, Blick, Tony, Bidgood, Charles, Leggatt, Graham R., O'Byrne, Ken and Kulasinghe, Arutha (2023). Metabolomics at the tumor microenvironment interface: decoding cellular conversations. Medicinal Research Reviews, 44 (3), 1121-1146. doi: 10.1002/med.22010

Metabolomics at the tumor microenvironment interface: decoding cellular conversations

2023

Conference Publication

Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths

Nunes, Caroline Brito, Hwang, Liang-Dar, Wang, Geng, Yengo, Loic, Leggatt, Graham, Moen, Gunn-Helen and Evans, David M. (2023). Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane Australia, Mar 21-25, 2023. HEIDELBERG: SPRINGER HEIDELBERG.

Contributions of Maternal Classical HLA Alleles and Spousal HLA Incompatibility to the Risk of Miscarriages and Stillbirths

2022

Conference Publication

Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo

Wright, Q., Sinha, D., Gonzalez-Cruz, J., Frazer, I. and Leggatt, G. (2022). Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo. ESMO Immuno-Oncology Congress 2022, Geneva, Switzerland, 7-9 December 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.iotech.2022.100289

Targeting of immune regulatory proteins through locoregional delivery of mAbs augments CD8 T cell mediated anti-tumour responses in vivo

2022

Conference Publication

Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity

Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.

Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity

2021

Journal Article

PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy

Wright, Quentin, Gonzalez Cruz, Jazmina L., Wells, James W. and Leggatt, Graham R. (2021). PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy. Cancers, 13 (13) 3310, 3310. doi: 10.3390/cancers13133310

PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy

2021

Journal Article

Evolution of cancer vaccines—challenges, achievements and future directions

Tay, Ban Qi, Wright, Quentin, Ladwa, Rahul, Perry, Christopher, Leggatt, Graham, Simpson, Fiona, Wells, James W., Panizza, Benedict J., Frazer, Ian H. and Cruz, Jazmina L. G. (2021). Evolution of cancer vaccines—challenges, achievements and future directions. Vaccines, 9 (5) 535, 535. doi: 10.3390/vaccines9050535

Evolution of cancer vaccines—challenges, achievements and future directions

2021

Journal Article

Investigating T cell immunity in cancer: achievements and prospects

Zeng, Zhen, Chew, Hui Yi, Cruz, Jazmina G., Leggatt, Graham R. and Wells, James W. (2021). Investigating T cell immunity in cancer: achievements and prospects. International Journal of Molecular Sciences, 22 (6) 2907, 1-17. doi: 10.3390/ijms22062907

Investigating T cell immunity in cancer: achievements and prospects

2020

Journal Article

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment

Kobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee Elyse, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham, Gandhi, Maher K., Hill, Michelle M, Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel and Mattarollo, Stephen R. (2020). Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood, 136 (26), 3004-3017. doi: 10.1182/blood.2020005602

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment

2020

Journal Article

Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium

Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011

Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium

2020

Conference Publication

Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin

Leggatt, Graham R., Salim, Nazhifah and Mattarollo, Stephen (2020). Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.165.27

Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin

2020

Conference Publication

Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis

Wright, Quentin, Minnie, Simone and Leggatt, Graham R. (2020). Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis. Immunology 2020™ Meeting, Honolulu, HI United States, 8 - 12 May 2020. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.204.supp.241.23

Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis

2020

Conference Publication

Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin

Leggatt, Graham R., Salim, Nazhifah and Mattarollo, Stephen (2020). Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin. IMMUNOLOGY2020, Honolulu, HI, United States, 8-12 May, 2020. Rockville, MD, United States: American Association of Immunologists.

Upregulated 4-1BB (CD137) expression on skin T cells from a mouse model of precancerous skin

2020

Journal Article

Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs

Wong, Arthur, Lanyon, Janet M., O'Handley, Ryan, Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2020). Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs. Marine Mammal Science, 36 (1) mms.12629, 180-194. doi: 10.1111/mms.12629

Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs

2020

Conference Publication

Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis

Wright, Quentin, Minnie, Simone and Leggatt, Graham R. (2020). Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis. IMMUNOLOGY2020, Honolulu, HI, United States, 8-12 May 2020. Rockville, MD, United States: American Association of Immunologists.

Intradermal delivery of a combination of immunomodulatory antibodies can promote rejection of hyperplastic skin in a mouse model of actinic keratosis

2019

Journal Article

Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage

Tuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0

Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage

2019

Journal Article

HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development

Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162

HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development

2019

Journal Article

NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion

Lam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650

NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion

2018

Journal Article

Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interaction

Kuo, Paula, Teoh, Siok Min, Tuong, Zewen K., Leggatt, Graham R., Mattarollo, Stephen R. and Frazer, Ian H. (2018). Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interaction. Frontiers in Immunology, 9 2896, 2896. doi: 10.3389/fimmu.2018.02896

Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interaction

2018

Journal Article

The role of CXCR3 and its chemokine ligands in skin disease and cancer

Kuo, Paula T., Zeng, Zhen, Salim, Nazhifah, Mattarollo, Stephen, Wells, James W. and Leggatt, Graham R. (2018). The role of CXCR3 and its chemokine ligands in skin disease and cancer. Frontiers in Medicine, 5 (SEP) 271, 271. doi: 10.3389/fmed.2018.00271

The role of CXCR3 and its chemokine ligands in skin disease and cancer

Past funding

  • 2020 - 2022
    Intradermal delivery of therapeutic antibodies in skin cancer
    TdC Pioneering Grant
    Open grant
  • 2017 - 2019
    Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Novel therapeutic targets for HPV-driven cancers (Cancer Council Queensland grant administered by Griffith University
    Griffith University
    Open grant
  • 2014
    Local immune response to perineural squamous cell carcinoma
    PA Research Foundation
    Open grant
  • 2014 - 2017
    Memory CD8 T cell subsets in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2013 - 2014
    The Gavin Chase Research Project Grant
    Cancer Council Queensland
    Open grant
  • 2012 - 2013
    RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2010 - 2012
    Suppressor NKT cell trafficking to epithelial precancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    Histone deacetylase inhibitors can inhibit tumour growth via induction of an anti-tumour immune response
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    The Role of RNA interference in the induction of immune responses
    ARC Linkage Projects
    Open grant
  • 2006 - 2008
    Mechanisms of dendritic cell-induced T-cell tolerance
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    Optimising Immunotherapy in Tumour Antigen Experienced Host
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
    Queensland Cancer Fund
    Open grant
  • 2004 - 2008
    Improving Vaccines Against Viruses And Tumours: Optimising the Cytotoxic T Lymphocyte Response
    Lions Medical Research Foundation
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant _HLTH_CICR_Med SCD
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Treatment Of Virally-Induced Cancers By RNA Interference
    NHMRC Project Grant
    Open grant
  • 2003 - 2004
    Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
    NHMRC Project Grant
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant
  • 2002
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire.
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001 - 2003
    CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
    NHMRC Project Grant
    Open grant
  • 2001
    CTL Avidity As A Determinant Of The Mature, Antigen-Specific Immune Repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2000
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    Analysis of functional activation thresholds in peripheral CD8+ T cells
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Clonal selection of CTL avidity in the periphery
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    CTL avidity and cell number as determinants of E7 tumour regression in vivo
    Cancer Bequest Fund
    Open grant
  • 1999 - 2001
    Development of hybrid HPV/HIV VLPs, a novel vaccine to prevent both HIV and HPV infection
    NHMRC Project Grant
    Open grant
  • 1998
    The Role of CTL Avidity and Cytokine Environment in the Control of Papillomavirus Infection and Epithelial Tumours
    Mayne Bequest Fund
    Open grant

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

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