Associate Professor

Graham Leggatt

Email: 
Phone: 
+61 7 344 34315

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Fields of research

Clinical sciences Immunology Oncology and carcinogenesis

Search Professor Graham Leggatt’s works on UQ eSpace

131 works between 1991 and 2024
All (131) Book (1) Journal Article (105) Conference Publication (24) Book Chapter (1)

41 - 60 of 131 works

2017

Journal Article

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

2016

Journal Article

Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling

Rearden, Rory, Sah, Amelia, Doff, Brianna, Kobayashi, Takumi, McKee, Sara J., Leggatt, Graham R. and Mattarollo, Stephen R. (2016). Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling. Immunology and Cell Biology, 94 (6), 554-562. doi: 10.1038/icb.2016.9

Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling

2016

Journal Article

Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

Chawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016). Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 (2), 213-222. doi: 10.1007/s00262-015-1788-z

Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

2016

Conference Publication

The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance

Rearden, R., Sah, A., Doff, B., Kobayashi, T., McKee, S., Leggatt, G. and Mattarollo, S. (2016). The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance

2016

Conference Publication

Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin

Leggatt, G., Veitch, M., Sheehan, B., McKee, S., Linedale, R., Jazayeri, S. D. and Mattarollo, S. (2016). Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin

2016

Conference Publication

Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells

Kobayashi, T., Tuong, K., Man, K., Mckee, S., Leggatt, G., Kallies, A. and Mattarollo, S. (2016). Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells

2016

Conference Publication

Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers

Mattarollo, Stephen, Leggatt, Graham, Wells, James, Lambert, Paul and Frazer, Ian H. (2016). Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers. International Cancer Immunotherapy Conference: Translating Science into Survival, New York, United States, September 16-19, 2015. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.CRICIMTEATIAACR15-A064

Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers

2016

Conference Publication

Immunotherapy for persisting viral infection and associated cancer

Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Immunotherapy for persisting viral infection and associated cancer

2016

Conference Publication

Inhibition of Aurora Kinases is curative for HPV-driven tumours

McMillan, N., Fallaha, S., Martin, D., Leggatt, G. and Gabrielli, B. (2016). Inhibition of Aurora Kinases is curative for HPV-driven tumours. 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 28-31 October 2016. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.IGC.0000503327.50238.5c

Inhibition of Aurora Kinases is curative for HPV-driven tumours

2015

Journal Article

Aurora A is critical for survival in HPV-transformed cervical cancer

Gabrielli, Brian, Bokhari, Fawzi, Ranall, Max V., Oo, Zay Yar, Stevenson, Alexander J., Wang, Weili, Murrell, Melanie, Shaikh, Mushfiq, Fallaha, Sora, Clarke, Daniel, Kelly, Madison, Sedelies, Karin, Christensen, Melinda, McKee, Sara, Leggatt, Graham, Leo, Paul, Skalamera, Dubravka, Soyer, H. Peter, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Aurora A is critical for survival in HPV-transformed cervical cancer. Molecular Cancer Therapeutics, 14 (12), 2753-2761. doi: 10.1158/1535-7163.MCT-15-0506

Aurora A is critical for survival in HPV-transformed cervical cancer

2015

Journal Article

Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis

Abd Warif, Nor Malia, Stoitzner, Patrizia, Leggatt, Graham R., Mattarollo, Stephen R., Frazer, Ian H. and Hibma, Merilyn H. (2015). Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS One, 10 (5) e0127155, e0127155-e0127155. doi: 10.1371/journal.pone.0127155

Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis

2015

Journal Article

Recent progress in vaccination against human papillomavirus-mediated cervical cancer

McKee, Sara J., Bergot, Anne-Sophie and Leggatt, Graham R. (2015). Recent progress in vaccination against human papillomavirus-mediated cervical cancer. Reviews in Medical Virology, 25 (S1), 54-71. doi: 10.1002/rmv.1824

Recent progress in vaccination against human papillomavirus-mediated cervical cancer

2015

Journal Article

NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

Kobayashi, Takumi, Doff, Brianna L., Rearden, Rory C., Leggatt, Graham R. and Mattarollo, Stephen R. (2015). NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Oncoimmunology, 4 (3) e990793, e990793-1-e990793-11. doi: 10.4161/2162402X.2014.990793

NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

2015

Conference Publication

Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Gabrielli, Brian G., Bokhari, Fawzi, Ranall, Max, Oo, Zay Yar, Stevenson, Alex, Wang, Weili, McKee, Sara, Leggatt, Graham, Leo, Paul, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA United States, 18-22 April 2015. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2015-945

Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

2014

Journal Article

HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells

Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10) e1004466, 1-11. doi: 10.1371/journal.ppat.1004466

HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells

2014

Journal Article

Peptide dose and/or structure in vaccines as a determinant of T cell responses

Leggatt, Graham R. (2014). Peptide dose and/or structure in vaccines as a determinant of T cell responses. Vaccines, 2 (3), 537-548. doi: 10.3390/vaccines2030537

Peptide dose and/or structure in vaccines as a determinant of T cell responses

2014

Journal Article

Immunosuppressive roles of natural killer T (NKT) cells in the skin

McKee, Sara J., Mattarollo, Stephen R. and Leggatt, Graham R. (2014). Immunosuppressive roles of natural killer T (NKT) cells in the skin. Journal of Leukocyte Biology, 96 (1), 49-54. doi: 10.1189/jlb.4RU0114-001R

Immunosuppressive roles of natural killer T (NKT) cells in the skin

2014

Journal Article

Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells

Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (6) e101381, e101381. doi: 10.1371/journal.pone.0101381

Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells

2014

Journal Article

The kinematics of cytotoxic lymphocytes influence their ability to kill target cells

Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). The kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (5) e95248, e95248.1-e95248.11. doi: 10.1371/journal.pone.0095248

The kinematics of cytotoxic lymphocytes influence their ability to kill target cells

2014

Conference Publication

Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Gabrielli, B., Bokhari, F., Ranall, M., Stevenson, A., Murell, M., Kelly, M., McKee, S., Leggatt, G., Gonda, T. and McMillan, N. (2014). Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, 18-21 November 2014. Abingdon, Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(14)70420-4

Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Past funding

  • 2020 - 2022
    Intradermal delivery of therapeutic antibodies in skin cancer
    TdC Pioneering Grant
    Open grant
  • 2017 - 2019
    Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Novel therapeutic targets for HPV-driven cancers (Cancer Council Queensland grant administered by Griffith University
    Griffith University
    Open grant
  • 2014
    Local immune response to perineural squamous cell carcinoma
    PA Research Foundation
    Open grant
  • 2014 - 2017
    Memory CD8 T cell subsets in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2013 - 2014
    The Gavin Chase Research Project Grant
    Cancer Council Queensland
    Open grant
  • 2012 - 2013
    RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2010 - 2012
    Suppressor NKT cell trafficking to epithelial precancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    Histone deacetylase inhibitors can inhibit tumour growth via induction of an anti-tumour immune response
    Cancer Council Queensland
    Open grant
  • 2008
    Studying the function of antigen experienced CD4+GITR+T cells
    PA Research Foundation
    Open grant
  • 2008 - 2009
    The Role of RNA interference in the induction of immune responses
    ARC Linkage Projects
    Open grant
  • 2007 - 2009
    Hyposulfataemia and tumour cell growth
    Queensland Cancer Fund
    Open grant
  • 2006 - 2008
    Mechanisms of dendritic cell-induced T-cell tolerance
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    Optimising Immunotherapy in Tumour Antigen Experienced Host
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
    Queensland Cancer Fund
    Open grant
  • 2004 - 2008
    Improving Vaccines Against Viruses And Tumours: Optimising the Cytotoxic T Lymphocyte Response
    Lions Medical Research Foundation
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant _HLTH_CICR_Med SCD
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Treatment Of Virally-Induced Cancers By RNA Interference
    NHMRC Project Grant
    Open grant
  • 2003 - 2004
    Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
    NHMRC Project Grant
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant
  • 2002
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire.
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001
    CTL Avidity As A Determinant Of The Mature, Antigen-Specific Immune Repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001 - 2003
    CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
    NHMRC Project Grant
    Open grant
  • 2000
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    Analysis of functional activation thresholds in peripheral CD8+ T cells
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Clonal selection of CTL avidity in the periphery
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    CTL avidity and cell number as determinants of E7 tumour regression in vivo
    Cancer Bequest Fund
    Open grant
  • 1999 - 2001
    Development of hybrid HPV/HIV VLPs, a novel vaccine to prevent both HIV and HPV infection
    NHMRC Project Grant
    Open grant
  • 1998 - 1999
    CTL Acquisition of Avidity and Function is Determined by Cytokine Environment and Antigen
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998
    The Role of CTL Avidity and Cytokine Environment in the Control of Papillomavirus Infection and Epithelial Tumours
    Mayne Bequest Fund
    Open grant

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

For media enquiries about Associate Professor Graham Leggatt's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au