Associate Professor

Graham Leggatt

Email: 
Phone: 
+61 7 344 34315

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Fields of research

Clinical sciences Immunology Oncology and carcinogenesis

Search Professor Graham Leggatt’s works on UQ eSpace

131 works between 1991 and 2024
All (131) Journal Article (105) Book Chapter (1) Conference Publication (24) Book (1)

41 - 60 of 131 works

2016

Conference Publication

Inhibition of Aurora Kinases is curative for HPV-driven tumours

McMillan, N., Fallaha, S., Martin, D., Leggatt, G. and Gabrielli, B. (2016). Inhibition of Aurora Kinases is curative for HPV-driven tumours. 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 28-31 October 2016. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.IGC.0000503327.50238.5c

Inhibition of Aurora Kinases is curative for HPV-driven tumours

2016

Conference Publication

The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance

Rearden, R., Sah, A., Doff, B., Kobayashi, T., McKee, S., Leggatt, G. and Mattarollo, S. (2016). The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance

2016

Conference Publication

Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin

Leggatt, G., Veitch, M., Sheehan, B., McKee, S., Linedale, R., Jazayeri, S. D. and Mattarollo, S. (2016). Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin

2015

Journal Article

Aurora A is critical for survival in HPV-transformed cervical cancer

Gabrielli, Brian, Bokhari, Fawzi, Ranall, Max V., Oo, Zay Yar, Stevenson, Alexander J., Wang, Weili, Murrell, Melanie, Shaikh, Mushfiq, Fallaha, Sora, Clarke, Daniel, Kelly, Madison, Sedelies, Karin, Christensen, Melinda, McKee, Sara, Leggatt, Graham, Leo, Paul, Skalamera, Dubravka, Soyer, H. Peter, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Aurora A is critical for survival in HPV-transformed cervical cancer. Molecular Cancer Therapeutics, 14 (12), 2753-2761. doi: 10.1158/1535-7163.MCT-15-0506

Aurora A is critical for survival in HPV-transformed cervical cancer

2015

Journal Article

Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis

Abd Warif, Nor Malia, Stoitzner, Patrizia, Leggatt, Graham R., Mattarollo, Stephen R., Frazer, Ian H. and Hibma, Merilyn H. (2015). Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS One, 10 (5) e0127155, e0127155-e0127155. doi: 10.1371/journal.pone.0127155

Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis

2015

Journal Article

Recent progress in vaccination against human papillomavirus-mediated cervical cancer

McKee, Sara J., Bergot, Anne-Sophie and Leggatt, Graham R. (2015). Recent progress in vaccination against human papillomavirus-mediated cervical cancer. Reviews in Medical Virology, 25 (S1), 54-71. doi: 10.1002/rmv.1824

Recent progress in vaccination against human papillomavirus-mediated cervical cancer

2015

Journal Article

NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

Kobayashi, Takumi, Doff, Brianna L., Rearden, Rory C., Leggatt, Graham R. and Mattarollo, Stephen R. (2015). NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Oncoimmunology, 4 (3) e990793, e990793-1-e990793-11. doi: 10.4161/2162402X.2014.990793

NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

2015

Conference Publication

Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Gabrielli, Brian G., Bokhari, Fawzi, Ranall, Max, Oo, Zay Yar, Stevenson, Alex, Wang, Weili, McKee, Sara, Leggatt, Graham, Leo, Paul, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA United States, 18-22 April 2015. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2015-945

Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

2014

Journal Article

HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells

Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10) e1004466, 1-11. doi: 10.1371/journal.ppat.1004466

HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells

2014

Journal Article

Peptide dose and/or structure in vaccines as a determinant of T cell responses

Leggatt, Graham R. (2014). Peptide dose and/or structure in vaccines as a determinant of T cell responses. Vaccines, 2 (3), 537-548. doi: 10.3390/vaccines2030537

Peptide dose and/or structure in vaccines as a determinant of T cell responses

2014

Journal Article

Immunosuppressive roles of natural killer T (NKT) cells in the skin

McKee, Sara J., Mattarollo, Stephen R. and Leggatt, Graham R. (2014). Immunosuppressive roles of natural killer T (NKT) cells in the skin. Journal of Leukocyte Biology, 96 (1), 49-54. doi: 10.1189/jlb.4RU0114-001R

Immunosuppressive roles of natural killer T (NKT) cells in the skin

2014

Journal Article

Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells

Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (6) e101381, e101381. doi: 10.1371/journal.pone.0101381

Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells

2014

Journal Article

The kinematics of cytotoxic lymphocytes influence their ability to kill target cells

Bhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). The kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (5) e95248, e95248.1-e95248.11. doi: 10.1371/journal.pone.0095248

The kinematics of cytotoxic lymphocytes influence their ability to kill target cells

2014

Conference Publication

Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Gabrielli, B., Bokhari, F., Ranall, M., Stevenson, A., Murell, M., Kelly, M., McKee, S., Leggatt, G., Gonda, T. and McMillan, N. (2014). Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, 18-21 November 2014. Abingdon, Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(14)70420-4

Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

2013

Journal Article

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

2013

Journal Article

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes

Choyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R., Liem, Amy, Lambert, Paul F., Frazer, Ian H. and Leggatt, Graham R. (2013). Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes. PLoS One, 8 (2) e57798, e57798.1-e57798.8. doi: 10.1371/journal.pone.0057798

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes

2013

Conference Publication

Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin

Leggatt, Graham, Mattarollo, Stephen, Yong, Michelle, Nissen, Michael and Frazer, Ian (2013). Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin. 100th Annual Meeting of the American Association of Immunologists, Honolulu, Hawaii, 03-07 May 2013. Bethesda, MD United States: American Association of Immunologists.

Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin

2012

Journal Article

A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin

Fiorenza, Salvatore, Kenna, Tony J., Comerford, Iain, McColl, Shaun, Steptoe, Raymond J., Leggatt, Graham R. and Frazer, Ian H. (2012). A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin. Journal of Immunology, 189 (12), 5622-5631. doi: 10.4049/jimmunol.1200709

A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin

2012

Journal Article

Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice

Heng, Tracy S. P., Reiseger, Jessica J., Fletcher, Anne L., Leggatt, Graham R., White, Olivia J., Vlahos, Katerina, Frazer, Ian H., Turner, Stephen J. and Boyd, Richard L. (2012). Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice. PLoS One, 7 (8) e42677, e42677.1-e42677.11. doi: 10.1371/journal.pone.0042677

Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice

2012

Journal Article

gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen

Rahimpour, Azad, Mattarollo, Stephen R., Yong, Michelle, Leggatt, Graham R., Steptoe, Raymond J. and Frazer, Ian H. (2012). gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen. Journal of Investigative Dermatology, 132 (6), 1656-1664. doi: 10.1038/jid.2012.16

gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen

Past funding

  • 2020 - 2022
    Intradermal delivery of therapeutic antibodies in skin cancer
    TdC Pioneering Grant
    Open grant
  • 2017 - 2019
    Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Novel therapeutic targets for HPV-driven cancers (Cancer Council Queensland grant administered by Griffith University
    Griffith University
    Open grant
  • 2014
    Local immune response to perineural squamous cell carcinoma
    PA Research Foundation
    Open grant
  • 2014 - 2017
    Memory CD8 T cell subsets in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2013 - 2014
    The Gavin Chase Research Project Grant
    Cancer Council Queensland
    Open grant
  • 2012 - 2013
    RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2010 - 2012
    Suppressor NKT cell trafficking to epithelial precancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    Histone deacetylase inhibitors can inhibit tumour growth via induction of an anti-tumour immune response
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    The Role of RNA interference in the induction of immune responses
    ARC Linkage Projects
    Open grant
  • 2006 - 2008
    Mechanisms of dendritic cell-induced T-cell tolerance
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    Optimising Immunotherapy in Tumour Antigen Experienced Host
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
    Queensland Cancer Fund
    Open grant
  • 2004 - 2008
    Improving Vaccines Against Viruses And Tumours: Optimising the Cytotoxic T Lymphocyte Response
    Lions Medical Research Foundation
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant _HLTH_CICR_Med SCD
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Treatment Of Virally-Induced Cancers By RNA Interference
    NHMRC Project Grant
    Open grant
  • 2003 - 2004
    Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
    NHMRC Project Grant
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant
  • 2002
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire.
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001
    CTL Avidity As A Determinant Of The Mature, Antigen-Specific Immune Repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001 - 2003
    CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
    NHMRC Project Grant
    Open grant
  • 2000
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    Analysis of functional activation thresholds in peripheral CD8+ T cells
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Clonal selection of CTL avidity in the periphery
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    CTL avidity and cell number as determinants of E7 tumour regression in vivo
    Cancer Bequest Fund
    Open grant
  • 1999 - 2001
    Development of hybrid HPV/HIV VLPs, a novel vaccine to prevent both HIV and HPV infection
    NHMRC Project Grant
    Open grant
  • 1998
    The Role of CTL Avidity and Cytokine Environment in the Control of Papillomavirus Infection and Epithelial Tumours
    Mayne Bequest Fund
    Open grant

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

For media enquiries about Associate Professor Graham Leggatt's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au