Associate Professor

Graham Leggatt

Email: 
Phone: 
+61 7 344 34315

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Fields of research

Clinical sciences Immunology Oncology and carcinogenesis

Search Professor Graham Leggatt’s works on UQ eSpace

131 works between 1991 and 2024
All (131) Book (1) Journal Article (105) Conference Publication (24) Book Chapter (1)

61 - 80 of 131 works

2013

Journal Article

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

2013

Journal Article

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes

Choyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R., Liem, Amy, Lambert, Paul F., Frazer, Ian H. and Leggatt, Graham R. (2013). Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes. PLoS One, 8 (2) e57798, e57798.1-e57798.8. doi: 10.1371/journal.pone.0057798

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes

2013

Conference Publication

Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin

Leggatt, Graham, Mattarollo, Stephen, Yong, Michelle, Nissen, Michael and Frazer, Ian (2013). Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin. 100th Annual Meeting of the American Association of Immunologists, Honolulu, Hawaii, 03-07 May 2013. Bethesda, MD United States: American Association of Immunologists.

Systemic lymphopenia results in loss of suppressive lymphocytes from precancerous skin

2012

Journal Article

A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin

Fiorenza, Salvatore, Kenna, Tony J., Comerford, Iain, McColl, Shaun, Steptoe, Raymond J., Leggatt, Graham R. and Frazer, Ian H. (2012). A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin. Journal of Immunology, 189 (12), 5622-5631. doi: 10.4049/jimmunol.1200709

A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin

2012

Journal Article

Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice

Heng, Tracy S. P., Reiseger, Jessica J., Fletcher, Anne L., Leggatt, Graham R., White, Olivia J., Vlahos, Katerina, Frazer, Ian H., Turner, Stephen J. and Boyd, Richard L. (2012). Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice. PLoS One, 7 (8) e42677, e42677.1-e42677.11. doi: 10.1371/journal.pone.0042677

Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice

2012

Journal Article

gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen

Rahimpour, Azad, Mattarollo, Stephen R., Yong, Michelle, Leggatt, Graham R., Steptoe, Raymond J. and Frazer, Ian H. (2012). gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen. Journal of Investigative Dermatology, 132 (6), 1656-1664. doi: 10.1038/jid.2012.16

gamma delta T cells augment rejection of skin grafts by enhancing cross-priming of CD8 T cells to skin-derived antigen

2012

Journal Article

Histone deacetylase inhibitors in the generation of the anti-tumour immune response

Leggatt, Graham R. and Gabrielli, Brian (2012). Histone deacetylase inhibitors in the generation of the anti-tumour immune response. Immunology and Cell Biology, 90 (1), 33-38. doi: 10.1038/icb.2011.94

Histone deacetylase inhibitors in the generation of the anti-tumour immune response

2012

Journal Article

Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives

Saunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012). Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 (8), 675-684. doi: 10.1002/emmm.201101131

Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives

2011

Journal Article

NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins

Mattarollo, Stephen R., Yong, Michelle, Gosmann, Christina, Choyce, Allison, Chan, Dora, Leggatt, Graham R. and Frazer, Ian H. (2011). NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins. Journal of Immunology, 187 (4), 1601-1608. doi: 10.4049/jimmunol.1100756

NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins

2011

Journal Article

Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis

Zhou, Fang, Leggatt, Graham R. and Frazer, Ian H. (2011). Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis. The Federation of European Biochemical Societies (FEBS) Journal, 278 (6), 955-963. doi: 10.1111/j.1742-4658.2011.08011.x

Human papillomavirus 16 E7 protein inhibits interferon-gamma-mediated enhancement of keratinocyte antigen processing and T-cell lysis

2011

Journal Article

Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy

Bhat, Purnima, Mattarollo, Stephen R., Gosmann, Christina, Frazer, Ian H. and Leggatt, Graham R. (2011). Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy. Immunological Reviews, 239 (1), 85-98. doi: 10.1111/j.1600-065X.2010.00966.x

Regulation of immune responses to HPVinfection and during HPV-directed immunotherapy

2010

Journal Article

IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes

Hadis, Usriansyah, Leggatt, Graham R., Thomas, Ranjeny, Frazer, Ian H. and Kovacs, Eva M. (2010). IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes. Experimental Dermatology, 19 (8), 723-729. doi: 10.1111/j.1600-0625.2010.01092.x

IL-1 signalling determines the fate of skin grafts expressing non-self protein in keratinocytes

2010

Journal Article

Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes

Broom, Jennifer K., Lew, Andrew M., Azukizawa, Hiroaki, Kenna, Tony J., Leggatt, Graham R. and Frazer, Ian H. (2010). Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes. Journal of Investigative Dermatology, 130 (6), 1581-1589. doi: 10.1038/jid.2010.17

Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes

2010

Journal Article

Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen

Mattarollo, Stephen R., Yong, Michelle, Tan, Lieven, Frazer, Ian H. and Leggatt, Graham R. (2010). Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. Journal of Immunology, 184 (10), 5663-5669. doi: 10.4049/jimmunol.0903730

Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen

2010

Journal Article

Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production

Mattarollo, Stephen R., Rahimpour, Azad, Choyce, Allison, Godfrey, Dale I., Leggatt, Graham R. and Frazer, Ian H. (2010). Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production. Journal of Immunology, 184 (3), 1242-1250. doi: 10.4049/jimmunol.0902191

Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production

2009

Journal Article

Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis

Zhou, F, Frazer, IH and Leggatt, GR (2009). Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis. EXPERIMENTAL DERMATOLOGY, 18 (12), 1053-1059. doi: 10.1111/j.1600-0625.2009.00907.x

Keratinocytes efficiently process endogenous antigens for cytotoxic T-cell mediated lysis

2009

Journal Article

Enhanced tumor growth in the NaS1 sulfate transporter null mouse

Dawson, P A, Choyce, A, Chuang, C, Whitelock, J, Markovich, D and Leggatt, GR (2009). Enhanced tumor growth in the NaS1 sulfate transporter null mouse. Cancer Science, 101 (2), 369-373. doi: 10.1111/j.1349-7006.2009.01399.x

Enhanced tumor growth in the NaS1 sulfate transporter null mouse

2009

Journal Article

IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host

Liu, Xiao Song, Leerberg, Joanne, MacDonald, Kelli, Leggatt, Graham and Frazer, Ian (2009). IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. The Jounral of Immunology, 183 (1), 51-58. doi: 10.4049/jimmunol.0802047

IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host

2009

Journal Article

Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses

Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham, Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert and McMillan, Nigel (2009). Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 106 (20), 8314-8319. doi: 10.1073/pnas.0812085106

Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses

2009

Journal Article

Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4(+)CD25(+) T cells

Narayan, S., Choyce, A., Linedale, R., Saunders, N. A., Dahler, A., Chan, E., Fernando, G. J., Frazer, I. H. and Leggatt, G. R. (2009). Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4(+)CD25(+) T cells. European Journal of Immunology, 39 (2), 481-490. doi: 10.1002/eji.200838527

Epithelial expression of human papillomavirus type 16 E7 protein results in peripheral CD8 T-cell suppression mediated by CD4(+)CD25(+) T cells

Past funding

  • 2020 - 2022
    Intradermal delivery of therapeutic antibodies in skin cancer
    TdC Pioneering Grant
    Open grant
  • 2017 - 2019
    Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Novel therapeutic targets for HPV-driven cancers (Cancer Council Queensland grant administered by Griffith University
    Griffith University
    Open grant
  • 2014
    Local immune response to perineural squamous cell carcinoma
    PA Research Foundation
    Open grant
  • 2014 - 2017
    Memory CD8 T cell subsets in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2013 - 2014
    The Gavin Chase Research Project Grant
    Cancer Council Queensland
    Open grant
  • 2012 - 2013
    RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2010 - 2012
    Suppressor NKT cell trafficking to epithelial precancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    Histone deacetylase inhibitors can inhibit tumour growth via induction of an anti-tumour immune response
    Cancer Council Queensland
    Open grant
  • 2008
    Studying the function of antigen experienced CD4+GITR+T cells
    PA Research Foundation
    Open grant
  • 2008 - 2009
    The Role of RNA interference in the induction of immune responses
    ARC Linkage Projects
    Open grant
  • 2007 - 2009
    Hyposulfataemia and tumour cell growth
    Queensland Cancer Fund
    Open grant
  • 2006 - 2008
    Mechanisms of dendritic cell-induced T-cell tolerance
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    Optimising Immunotherapy in Tumour Antigen Experienced Host
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
    Queensland Cancer Fund
    Open grant
  • 2004 - 2008
    Improving Vaccines Against Viruses And Tumours: Optimising the Cytotoxic T Lymphocyte Response
    Lions Medical Research Foundation
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant _HLTH_CICR_Med SCD
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Treatment Of Virally-Induced Cancers By RNA Interference
    NHMRC Project Grant
    Open grant
  • 2003 - 2004
    Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
    NHMRC Project Grant
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant
  • 2002
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire.
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001 - 2003
    CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
    NHMRC Project Grant
    Open grant
  • 2001
    CTL Avidity As A Determinant Of The Mature, Antigen-Specific Immune Repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2000
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    Analysis of functional activation thresholds in peripheral CD8+ T cells
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Clonal selection of CTL avidity in the periphery
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    CTL avidity and cell number as determinants of E7 tumour regression in vivo
    Cancer Bequest Fund
    Open grant
  • 1999 - 2001
    Development of hybrid HPV/HIV VLPs, a novel vaccine to prevent both HIV and HPV infection
    NHMRC Project Grant
    Open grant
  • 1998 - 1999
    CTL Acquisition of Avidity and Function is Determined by Cytokine Environment and Antigen
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1998
    The Role of CTL Avidity and Cytokine Environment in the Control of Papillomavirus Infection and Epithelial Tumours
    Mayne Bequest Fund
    Open grant

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

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