Suppressor NKT cell trafficking to epithelial precancer (2010-2012)
Abstract
The clinical use of the body's immune system to attack existing cancers has met with limited success. Cancer often avoids the immune response by setting up a suppressive environment locally at the tumour. Our study addresses one component of this local environment which involves recruitment of a special subset of suppressive white blood cells - NKT cells. We will establish if drugs can block their recruitment and prevent progression of the cancer.