Overview
Background
The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.
David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute
Availability
- Professor David Hume is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), Australian National University
- Doctor of Philosophy, Australian National University
Research interests
-
Macrophages Biology
Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."
Works
Search Professor David Hume’s works on UQ eSpace
2024
Other Outputs
Csf1rko Rat Transcriptomic Atlas and Supplementary Tables
Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas and Supplementary Tables. The University of Queensland. (Dataset) doi: 10.48610/6d347aa
2024
Other Outputs
Csf1rko Rat Transcriptomic Atlas
Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas. The University of Queensland. (Dataset) doi: 10.48610/5b57a22
2024
Journal Article
Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis
Thierry, Guilhem R., Baudon, Elisa M., Bijnen, Mitchell, Bellomo, Alicia, Lagueyrie, Marine, Mondor, Isabelle, Simonnet, Louise, Carrette, Florent, Fenouil, Romain, Keshvari, Sahar, Hume, David A., Dombrowicz, David and Bajenoff, Marc (2024). Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity, 57 (9), 2108-2121.e6. doi: 10.1016/j.immuni.2024.07.005
2024
Journal Article
Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy
Chadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh, Carlen-Jones, William, Gandhi, Sunil, Bu, Guojun, Hume, David A., Pridans, Clare, Wszolek, Zbigniew K., Spitale, Robert C., Davtyan, Hayk and Blurton-Jones, Mathew (2024). Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Neuron, 112 (16), 2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023
2024
Journal Article
Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer
Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M, Ho, Eileen, Caruso, Melanie, Patkar, Omkar L, Sehgal, Anuj, Millard, Susan M, Hume, David A and Pettit, Allison R (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077
2024
Journal Article
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023
2024
Book Chapter
Genetic and immunohistochemistry tools to visualize rat macrophages in situ
Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6
2024
Journal Article
The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
O’Brien, Claire L., Summers, Kim M., Martin, Natalia M., Carter-Cusack, Dylan, Yang, Yuanhao, Barua, Rasel, Dixit, Ojas V. A., Hume, David A. and Pavli, Paul (2024). The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease. Human Genetics, 143 (3), 233-261. doi: 10.1007/s00439-024-02642-9
2023
Conference Publication
Age related neuropathology in a novel mouse model of Adult‐onset leukoencephalopathy
Shabestari, Sepideh Kiani, Radhakrishnan, Hamsi, Rothermich, Winston Chang, Capocchi, Joia Kai, Jullienne, Amandine, Nguyen, Jasmine, Tran, Kayla Nhi, Pascual, Jesse R., Martini, Alessandra Cadete, Head, Elizabeth, Hume, David A, Pridans, Clare, Obenaus, Andre, Stark, Craig E.L., Davtyan, Hayk and Blurton‐Jones, Mathew (2023). Age related neuropathology in a novel mouse model of Adult‐onset leukoencephalopathy. Alzheimer’s Association International Conference AAIC 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.070996
2023
Journal Article
A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages
Waddell, Lindsey A., Wu, Zhiguang, Sauter, Kristin A., Hope, Jayne C. and Hume, David A. (2023). A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages. Veterinary Immunology and Immunopathology, 266 110681, 110681. doi: 10.1016/j.vetimm.2023.110681
2023
Journal Article
Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development
Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052
2023
Journal Article
Macrophage heterogeneity in the single cell era: facts and artefacts
Hume, David A., Millard, Susan M. and Pettit, Allison R. (2023). Macrophage heterogeneity in the single cell era: facts and artefacts. Blood Journal, 142 (16), 1339-1347. doi: 10.1182/blood.2023020597
2023
Conference Publication
Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease
Whiley, P., Summers, K., Pavli, P., Hume, D. and O'Brien, C. (2023). Transcriptomic signatures of antibacterial responses in the earliest lesions of Crohn's disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2023, Brisbane, QLD Australia, 2—5 September 2023. Richmond, VIC Australia: John Wiley and Sons.
2023
Journal Article
Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis
Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312
2023
Journal Article
Rare genetic variants underlie outlying levels of DNA methylation and gene-expression
Chundru, V. Kartik, Marioni, Riccardo E., Pendergast, James G. D., Lin, Tian, Beveridge, Allan J., Martin, Nicholas G, Montgomery, Grant W., Hume, David A., Deary, Ian J., Visscher, Peter M., Wray, Naomi R. and McRae, Allan F. (2023). Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Human Molecular Genetics, 32 (11), 1912-1921. doi: 10.1093/hmg/ddad028
2023
Journal Article
Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?
Hume, David A. (2023). Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?. European Journal of Immunology, 53 (6) 2250242, e2250242. doi: 10.1002/eji.202250242
2023
Journal Article
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Grootveld, Abigail K., Kyaw, Wunna, Panova, Veera, Lau, Angelica W.Y., Ashwin, Emily, Seuzaret, Guillaume, Dhenni, Rama, Bhattacharyya, Nayan Deger, Khoo, Weng Hua, Biro, Maté, Mitra, Tanmay, Meyer-Hermann, Michael, Bertolino, Patrick, Tanaka, Masato, Hume, David A., Croucher, Peter I., Brink, Robert, Nguyen, Akira, Bannard, Oliver and Phan, Tri Giang (2023). Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell, 186 (6), 1144-1161. doi: 10.1016/j.cell.2023.02.004
2023
Conference Publication
Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer
Batoon, Lena, Keshvari, Sahar, Irvine, Katharine, Caruso, Melanie, Patkar, Omkar, Sehgal, Anuj, Millard, Susan, Hume, David and Pettit, Allison (2023). Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer. 2022 Annual Meeting of the American Society for Bone and Mineral Research, Austin, TX, United States, 9-12 September 2022. Hoboken, NJ, United States: Wiley-Blackwell.
2023
Journal Article
Fibrillin-1 and asprosin, novel players in metabolic syndrome
Summers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979
2023
Journal Article
Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)
Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784
Funding
Current funding
Past funding
Supervision
Availability
- Professor David Hume is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
The role of macrophages in postnatal development
This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.
Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701
Supervision history
Current supervision
-
Doctor Philosophy
Erythroid iron metabolism and its effect on systemic iron homeostasis
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Transcriptional regulation of the mouse Csf1r locus
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Regulation and function of CSF1R-dependent tissue macrophage populations.
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Regulation of Resident Tissue Macrophage Development and Function
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
-
Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor Antje Blumenthal, Dr Katharine Irvine
-
Doctor Philosophy
Preclinical modelling of central nervous system complications and toxicities of cellular and immunotherapies for cancer treatment
Associate Advisor
-
Doctor Philosophy
Pathogen Promoters of Squamous Epithelial Cancer
Associate Advisor
Other advisors: Associate Professor Graham Leggatt, Associate Professor Andrew Brooks, Dr Janin Chandra, Professor Ian Frazer
Completed supervision
-
2024
Doctor Philosophy
Macrophage colony-stimulating factor in the treatment of non-alcoholic fatty liver disease
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
-
2023
Doctor Philosophy
Characterisation of a novel mouse model with a disease-causing Colony Stimulating Factor 1 Receptor mutation
Principal Advisor
Other advisors: Dr Katharine Irvine
-
2023
Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
-
2009
Doctor Philosophy
Regulation and Function of Schlafen in Macrophage Biology
Principal Advisor
Other advisors: Professor Matt Sweet
-
2007
Doctor Philosophy
THE STRUCTURAL BASIS FOR INTERACTION BETWEEN COLONY- STIMULATING FACTOR-1 AND ITS RECEPTOR, CSF-1R
Principal Advisor
Other advisors: Associate Professor Mark Smythe, Professor Bostjan Kobe, Dr Ian Ross
-
2007
Doctor Philosophy
TRANSCRIPTIONAL REGULATION OF THE c-fms PROMOTER BY THE ETS FAMILY OF TRANSCRIPTION FACTORS
Principal Advisor
Other advisors: Professor Kate Stacey
-
2006
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF MACROPHAGE-SPECIFIC TRANSCRIPTS
Principal Advisor
-
2005
Doctor Philosophy
MECHANISMS OF INTERFERON-GAMMA PRIMING OF MACROPHAGE ACTIVATION BY CpG DNA
Principal Advisor
-
2004
Master Science
Study of gene expression profile of osteoclasts
Principal Advisor
-
2004
Doctor Philosophy
THE EXPRESSIONS AND FUNCTIONS OF G3BPs IN MACROPHAGES
Principal Advisor
-
2004
Doctor Philosophy
TRANSCRIPTIONAL ANALYSIS OF MACROPHAGE SIGNALLING IN RESPONSE TO LIPOPOLYSACCHARIDE
Principal Advisor
Other advisors: Professor Brandon Wainwright
-
2003
Doctor Philosophy
THE FUNCTION AND REGULATION OF TARTRATE-RESISTANT ACID PHOSPHATASE (TRAP)
Principal Advisor
-
2003
Doctor Philosophy
Transcriptional regulation of c-fms gene expression
Principal Advisor
-
2003
Doctor Philosophy
MECHANISMS OF ACTION OF BACTERIAL DNA ON MACROPHAGE ACTIVATION
Principal Advisor
Other advisors: Professor Kate Stacey
-
2021
Master Philosophy
Developing a Novel Immune Cell Therapy for Glioblastoma: A Novel Monocyte-based Cell-therapy for the Treatment of Glioblastoma
Associate Advisor
-
2012
Doctor Philosophy
Characterisation of Myeloid Cells in the Peritoneal Foreign Body Response: Evidence for Phenotypic Plasticity
Associate Advisor
Other advisors: Associate Professor Barbara Rolfe
-
2010
Doctor Philosophy
Osteal macrophages (osteomacs) are pivotal for intramembranous bone formation in vivo: Osteomacs facilitate osteoblast maintenance in vivo and enhance osteoblast-mediated bone deposition in a murine model of bone healing
Associate Advisor
Other advisors: Professor Allison Pettit
-
2009
Doctor Philosophy
Role of macrophages, residing on the bone surface, in bone remodelling and repair
Associate Advisor
Other advisors: Professor Allison Pettit
-
2009
Doctor Philosophy
Short Sequence Tags Reveal Global Transcription Of Repetitive Elements In Mammalian Genomes
Associate Advisor
-
2009
Doctor Philosophy
Cellular activation and death in response to cytoplasmic DNA
Associate Advisor
Other advisors: Professor Kate Stacey
-
2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE ROLE OF PROTEIN TYROSINE PHOSPHATASE CD148 IN MACROPHAGES
Associate Advisor
-
2006
Doctor Philosophy
THE ROLE OF MICROPHTHALMIA TRANSCRIPTION FACTOR (MITF) IN OSTEOCLAST GENE REGULATION
Associate Advisor
-
2006
Doctor Philosophy
MOLECULAR AND FUNCTIONAL CHARACTERISATION OF POTENTIAL MURINE RENAL STEM CELLS
Associate Advisor
-
2006
Doctor Philosophy
THE IMPORTANCE OF EPIGENETICS IN MAMMALS
Associate Advisor
Other advisors: Professor Bernard Carroll
-
-
2005
Doctor Philosophy
SHADES OF DOMAINS: BIOINFORMATIC IDENTIFICATION OF PROTEIN DOMAIN SUBTYPES AND CORRELATION WITH FUNCTIONAL SPECIFICITY
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
-
2005
Doctor Philosophy
CELLULAR RESPONSES TO IMMUNOSTIMULATORY DNA
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Kate Stacey
Media
Enquiries
For media enquiries about Professor David Hume's areas of expertise, story ideas and help finding experts, contact our Media team: