Overview
Availability
- Dr Katharine Irvine is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Law, University of New South Wales
- Bachelor (Honours) of Science (Advanced), University of New South Wales
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Katharine Irvine’s works on UQ eSpace
2025
Journal Article
Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation
Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525
2024
Journal Article
The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology
Stables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743
2024
Journal Article
High FIB4 is associated with increased risk of cirrhosis decompensation and liver-related mortality in at-risk patients with MASLD
Powell, Elizabeth E., Hartel, Gunter, Irvine, Katharine M., O’Beirne, James, Bhasker, Vikas and Valery, Patricia C. (2024). High FIB4 is associated with increased risk of cirrhosis decompensation and liver-related mortality in at-risk patients with MASLD. Gastro Hep Advances 100607, 100607. doi: 10.1016/j.gastha.2024.100607
2024
Conference Publication
Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat
Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert, Morgan, Paul, Bush, Stephen, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-202662
2024
Conference Publication
Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis
Jacquelin, Sebastien, Maxwell, Emma, Flegg, Cameron, Liu, Yajun, Taylor, Isis, Ranpura, Ginell, Nooru-Mohamed, Fathima, Sokolowski, Kamil A., Adamson, Anthony, Irvine, Katharine M. and Hume, David A. (2024). Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-204496
2024
Conference Publication
Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats
Roberts, Megan, Carter-Cusack, Dylan, Huang, Stephen, Maxwell, Emma, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-194571
2024
Conference Publication
An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation
Huang, Stephen, Patkar, Omkar, Schulze, Sarah, Carter-Cusack, Dylan, Ranpura, Ginell, Maxwell, Emma, Keshvari, Sahar, Millard, Susan, Cowin, Gary, Kurniawan, Nyoman, Pettit, Allison, Irvine, Katharine M. and Hume, David A. (2024). An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation. 66th ASH Annual Meeting, San Diego, CA, United States, 7-10 December 2024. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2024-208881
2024
Journal Article
Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver disease
Gracen, Lucy, Hartel, Gunter, Irvine, Katharine M., Aikebuse, Melanie, Valery, Patricia C. and Powell, Elizabeth E. (2024). Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver disease. Clinical Gastroenterology and Hepatology. doi: 10.1016/j.cgh.2024.09.014
2024
Journal Article
An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations
Gracen, Lucy, Aikebuse, Melanie, Sarraf, Babak, McPhail, Steven, Russell, Anthony, O’Beirne, James, Irvine, Katharine, Williams, Suzanne, Valery, Patricia and Powell, Elizabeth (2024). An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations. Patient Preference and Adherence, Volume 18, 1845-1855. doi: 10.2147/ppa.s468705
2024
Conference Publication
A community-based MASLD care pathway for people with type 2 diabetes: barriers and considerations
Aikebuse, Melanie, Gracen, Lucy, Sarraf, Babak, Mcphail, Steven, Russell, Anthony, O'Beirne, James, Irvine, Katharine, Williams, Suzanne, Valery, Patricia and Powell, Elizabeth (2024). A community-based MASLD care pathway for people with type 2 diabetes: barriers and considerations. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.
2024
Other Outputs
Csf1rko Rat Transcriptomic Atlas and Supplementary Tables
Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas and Supplementary Tables. The University of Queensland. (Dataset) doi: 10.48610/6d347aa
2024
Other Outputs
Csf1rko Rat Transcriptomic Atlas
Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas. The University of Queensland. (Dataset) doi: 10.48610/5b57a22
2024
Journal Article
Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer
Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077
2024
Journal Article
Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023
2024
Journal Article
A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria
Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4
2024
Other Outputs
Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.
Katharine Irvine (2024). Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.. The University of Queensland. (Dataset) doi: 10.48610/ef2c29e
2024
Book Chapter
Genetic and immunohistochemistry tools to visualize rat macrophages in situ
Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6
2023
Journal Article
Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development
Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052
2023
Journal Article
Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists
Gracen, Lucy, Muthukumara, Withma, Aikebuse, Melanie, Russell, Anthony, O'Beirne, James, Irvine, Katharine M., Williams, Suzanne, Puri, Gaurav, Valery, Patricia C., Hayward, Kelly L. and Powell, Elizabeth E. (2023). Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists. Annals of Hepatology, 28 (6) 101142, 101142. doi: 10.1016/j.aohep.2023.101142
2023
Journal Article
Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis
Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312
Funding
Current funding
Supervision
Availability
- Dr Katharine Irvine is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Regulation of Resident Tissue Macrophage Development and Function
Principal Advisor
Other advisors: Professor David Hume, Dr Sahar Keshvari
-
Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Principal Advisor
Other advisors: Professor David Hume, Professor Antje Blumenthal
-
Doctor Philosophy
Deconvoluting Tissue Resident Macrophage Biology
Associate Advisor
Other advisors: Dr Susan Millard, Professor Allison Pettit
-
Doctor Philosophy
Erythroid iron metabolism and its effect on systemic iron homeostasis
Associate Advisor
Other advisors: Professor David Hume
-
Doctor Philosophy
The role of oxidised cholesterols in chronic and infectious diseases: Potential for novel therapeutic interventions
Associate Advisor
Other advisors: Professor Kirsty Short, Honorary Professor Katharina Ronacher
-
Doctor Philosophy
Regulation and function of CSF1R-dependent tissue macrophage populations.
Associate Advisor
Other advisors: Professor David Hume
-
Doctor Philosophy
Investigation of Matrix Regulation of Wound Repair
Associate Advisor
Other advisors: Dr Amanda Kijas, Professor Alan Rowan
-
Doctor Philosophy
Phenotypic impacts of hypomorphic mutations in the mouse Csf1r locus
Associate Advisor
Other advisors: Professor David Hume
-
Doctor Philosophy
Transcriptional regulation of the mouse Csf1r locus
Associate Advisor
Other advisors: Professor David Hume
Completed supervision
-
2022
Master Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
Principal Advisor
Other advisors: Professor Elizabeth Powell
-
2024
Doctor Philosophy
Macrophage colony-stimulating factor in the treatment of non-alcoholic fatty liver disease
Associate Advisor
Other advisors: Dr Sahar Keshvari, Professor David Hume
-
2023
Doctor Philosophy
Characterisation of a novel mouse model with a disease-causing Colony Stimulating Factor 1 Receptor mutation
Associate Advisor
Other advisors: Professor David Hume
-
2023
Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
Associate Advisor
Other advisors: Dr Sahar Keshvari, Professor David Hume
-
2019
Doctor Philosophy
Medication-related problems in people with chronic liver disease: the effect of a patient-oriented medication management intervention delivered by a clinical pharmacist
Associate Advisor
Other advisors: Associate Professor William Cottrell, Professor Elizabeth Powell
-
2015
Doctor Philosophy
Characterisation of Infiltrating Inflammatory Cells in the Development of Liver Injury and Progressive Fibrosis
Associate Advisor
Other advisors: Professor Andrew Clouston, Professor Elizabeth Powell
-
2015
Doctor Philosophy
Cytokines and STAT3 signalling in autoimmune diseases
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2013
Doctor Philosophy
Regulation of TLR4 signalling in macrophages by histone deacetylases
Associate Advisor
Other advisors: Professor Matt Sweet
Media
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