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Dr

Katharine Irvine

Email: 
Phone: 
+61 7 344 38014

Overview

Availability

Dr Katharine Irvine is:
Available for supervision

Qualifications

  • Bachelor of Law, University of New South Wales
  • Bachelor (Honours) of Science (Advanced), University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Katharine Irvine’s works on UQ eSpace

159 works between 2004 and 2025

1 - 20 of 159 works

2025

Journal Article

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

2024

Journal Article

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

Stables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

2024

Journal Article

High FIB4 is associated with increased risk of cirrhosis decompensation and liver-related mortality in at-risk patients with MASLD

Powell, Elizabeth E., Hartel, Gunter, Irvine, Katharine M., O’Beirne, James, Bhasker, Vikas and Valery, Patricia C. (2024). High FIB4 is associated with increased risk of cirrhosis decompensation and liver-related mortality in at-risk patients with MASLD. Gastro Hep Advances 100607, 100607. doi: 10.1016/j.gastha.2024.100607

High FIB4 is associated with increased risk of cirrhosis decompensation and liver-related mortality in at-risk patients with MASLD

2024

Conference Publication

Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat

Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert, Morgan, Paul, Bush, Stephen, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-202662

Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat

2024

Conference Publication

Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis

Jacquelin, Sebastien, Maxwell, Emma, Flegg, Cameron, Liu, Yajun, Taylor, Isis, Ranpura, Ginell, Nooru-Mohamed, Fathima, Sokolowski, Kamil A., Adamson, Anthony, Irvine, Katharine M. and Hume, David A. (2024). Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-204496

Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis

2024

Conference Publication

Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats

Roberts, Megan, Carter-Cusack, Dylan, Huang, Stephen, Maxwell, Emma, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-194571

Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats

2024

Conference Publication

An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation

Huang, Stephen, Patkar, Omkar, Schulze, Sarah, Carter-Cusack, Dylan, Ranpura, Ginell, Maxwell, Emma, Keshvari, Sahar, Millard, Susan, Cowin, Gary, Kurniawan, Nyoman, Pettit, Allison, Irvine, Katharine M. and Hume, David A. (2024). An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation. 66th ASH Annual Meeting, San Diego, CA, United States, 7-10 December 2024. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2024-208881

An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation

2024

Journal Article

Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver disease

Gracen, Lucy, Hartel, Gunter, Irvine, Katharine M., Aikebuse, Melanie, Valery, Patricia C. and Powell, Elizabeth E. (2024). Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver disease. Clinical Gastroenterology and Hepatology. doi: 10.1016/j.cgh.2024.09.014

Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver disease

2024

Journal Article

An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations

Gracen, Lucy, Aikebuse, Melanie, Sarraf, Babak, McPhail, Steven, Russell, Anthony, O’Beirne, James, Irvine, Katharine, Williams, Suzanne, Valery, Patricia and Powell, Elizabeth (2024). An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations. Patient Preference and Adherence, Volume 18, 1845-1855. doi: 10.2147/ppa.s468705

An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations

2024

Conference Publication

A community-based MASLD care pathway for people with type 2 diabetes: barriers and considerations

Aikebuse, Melanie, Gracen, Lucy, Sarraf, Babak, Mcphail, Steven, Russell, Anthony, O'Beirne, James, Irvine, Katharine, Williams, Suzanne, Valery, Patricia and Powell, Elizabeth (2024). A community-based MASLD care pathway for people with type 2 diabetes: barriers and considerations. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

A community-based MASLD care pathway for people with type 2 diabetes: barriers and considerations

2024

Other Outputs

Csf1rko Rat Transcriptomic Atlas and Supplementary Tables

Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas and Supplementary Tables. The University of Queensland. (Dataset) doi: 10.48610/6d347aa

Csf1rko Rat Transcriptomic Atlas and Supplementary Tables

2024

Other Outputs

Csf1rko Rat Transcriptomic Atlas

Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas. The University of Queensland. (Dataset) doi: 10.48610/5b57a22

Csf1rko Rat Transcriptomic Atlas

2024

Journal Article

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

2024

Journal Article

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

2024

Journal Article

A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4

A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

2024

Other Outputs

Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.

Katharine Irvine (2024). Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.. The University of Queensland. (Dataset) doi: 10.48610/ef2c29e

Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.

2024

Book Chapter

Genetic and immunohistochemistry tools to visualize rat macrophages in situ

Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6

Genetic and immunohistochemistry tools to visualize rat macrophages in situ

2023

Journal Article

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

2023

Journal Article

Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists

Gracen, Lucy, Muthukumara, Withma, Aikebuse, Melanie, Russell, Anthony, O'Beirne, James, Irvine, Katharine M., Williams, Suzanne, Puri, Gaurav, Valery, Patricia C., Hayward, Kelly L. and Powell, Elizabeth E. (2023). Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists. Annals of Hepatology, 28 (6) 101142, 101142. doi: 10.1016/j.aohep.2023.101142

Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists

2023

Journal Article

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

Funding

Current funding

  • 2025
    Hepatic delivery of Colony Stimulating Factor 1mRNA to promote liver repair
    Gastroenterological Society of Australia
    Open grant
  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant

Past funding

  • 2022 - 2024
    Macrophage-driven lipid metabolism in health and disease - mechanisms and therapeutic opportunities
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    CD14 inhibition in a Liver Inflammation mouse model
    Innovation Connections
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
    Siemens Ltd
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    Human liver progenitor cell characterisation, isolation and manipulation
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2013 - 2015
    Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    ALF Pauline Hall Research Fellowship: The role of macrophage in chronic liver disease progression
    Australian Liver Foundation
    Open grant
  • 2010 - 2012
    Pathological changes associated with chronic RelB activiation in T1D
    Juvenile Diabetes Research Foundation
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant

Supervision

Availability

Dr Katharine Irvine is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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