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2026 Journal Article Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the <i>Csf1r</i> locusLiu, Yajun, Jacquelin, Sebastien, Taylor, Isis, Green, Emma K., Patkar, Omkar L., Keshvari, Sahar, Ranpura, Ginell, O'Brien, Conan J. O., Jessen, Eline, Maxwell, Emma, Allavena, Rachel, Gallerand, Alexandre, Ivanov, Stoyan, Adamson, Antony, Humphreys, Neil E., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2026). Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus. Development, 153 (13) dev.205655. doi: 10.1242/dev.205655 |
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2026 Journal Article Homozygous kinase-dead <i>Csf1r</i> mutation in outbred mice reveals essential and redundant functions of tissue resident macrophagesJacquelin, Sebastien, Maxwell, Emma, Taylor, Isis, Green, Emma, O’Brien, Conan J O, Jessen, Eline E, Ranpura, Ginell, Guo, Jintao, Nooru-Mohamed, Fathima, Liu, Yajun, Keshvari, Sahar, Huang, Stephen, Cooper, Emily, Lane, Steven W, Flegg, Cameron, Kasherman, Maria A, Sokolowski, Kamil, Pettit, Allison R, Hume, David A and Irvine, Katharine M (2026). Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages. Journal of Leukocyte Biology, 118 (6) qiag074. doi: 10.1093/jleuko/qiag074 |
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2026 Journal Article Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesityWang, Yizhuo, Ramnath, Divya, Das Gupta, Kaustav, Prakrithi, P., Bisht, Kavita, Miller, Gregory C., Xiong, Zherui, Wan, Yujun, Tejo, Ellen N., Curson, James E. B., Abrol, Rishika, Keshvari, Sahar, Gunther, Kimberley S., Atkinson, Jordan D., Loh, Zhixuan, Engel, Jessica A., Engwerda, Christian R., Burgener, Sabrina Sofia, Schroder, Kate, Fairlie, David P., Clouston, Andrew D., Powell, Elizabeth E., Irvine, Katharine M., Sullivan, Mitchell A., Lévesque, Jean‐Pierre, Nguyen, Quan, Sweet, Matthew J. and Karunakaran, Denuja (2026). Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity. Clinical and Translational Immunology, 15 (6) e70100, 1-20. doi: 10.1002/cti2.70100 |
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2026 Conference Publication Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera, Isanka, Phan, Min-Duy, Nguyen, Nhu, Jessen, Eline, Keshvari, Sahar, Ong, Yvette, Kidd, Timothy, Hancock, Steven, Hume, David, Powell, Elizabeth, Sweet, Matthew, Schembri, Mark and Irvine, Katharine (2026). Ascites bactericidal capacity in patients with decompensated cirrhosis. 61st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Vienna Austria, Sep 15-19, 2025. AMSTERDAM: ELSEVIER. |
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2026 Journal Article Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera I, Isanka U., Phan M-D, Min-Duy, Nhu, Nguyen T.K., Jessen, Eline E., Keshvari, Sahar, Ong, Yvette, Kidd, Timothy J., Hancock, Steven J., Morris, Samuel A.S., Sester, David P., Hume, David A., Powell, Elizabeth E., Sweet, Matthew J., Schembri, Mark A. and Irvine, Katharine M. (2026). Ascites bactericidal capacity in patients with decompensated cirrhosis. Cellular and Molecular Gastroenterology and Hepatology, 20 (9) 101812, 101812. doi: 10.1016/j.jcmgh.2026.101812 |
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2026 Journal Article FRI-403 Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera, Isanka, Phan, Min-Duy, Nguyen, Nhu, Jessen, Eline, Keshvari, Sahar, Ong, Yvette, Kidd, Timothy, Hancock, Steven, Hume, David, Powell, Elizabeth, Sweet, Matthew, Schembri, Mark and Irvine, Katharine (2026). FRI-403 Ascites bactericidal capacity in patients with decompensated cirrhosis. Journal of Hepatology, 84, S170-S171. doi: 10.1016/s0168-8278(26)00664-1 |
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2026 Journal Article Spleen size may also be an important prognostic indicator of liver-related outcomes in metabolic-dysfunction-associated steatotic liver disease patients without clinically significant portal hypertensionChang, David R., Hartel, Gunter, Nguyen, Thy, McLean, Kate, Stuart, Katherine A., Valery, Patricia C., Irvine, Katharine, Powell, Elizabeth E. and Chouhan, Manil D. (2026). Spleen size may also be an important prognostic indicator of liver-related outcomes in metabolic-dysfunction-associated steatotic liver disease patients without clinically significant portal hypertension. Journal of Clinical and Experimental Hepatology, 16 (3) 103522, 1-3. doi: 10.1016/j.jceh.2026.103522 |
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2026 Conference Publication Macrophage colony stimulating factor (CSF1) induces a proregenerative response in human liver during normothermic machine perfusionKeshvari, Sahar, Schulze, Sarah, Carter-Cusack, Dylan, Butler, Nick and Irvine, Katharine (2026). Macrophage colony stimulating factor (CSF1) induces a proregenerative response in human liver during normothermic machine perfusion. Congress of the European-Association-for-the-Study-of-the-Liver Congress (EASL), Barcelona Spain, May 27-30, 2026. AMSTERDAM: ELSEVIER. |
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2026 Conference Publication Macrophage colony stimulating factor (CSF1) induces a proregenerative response in human liver during normothermic machine perfusionKeshvari, Sahar, Schulze, Sarah, Carter-Cusack, Dylan, Butler, Nick and Irvine, Katharine (2026). Macrophage colony stimulating factor (CSF1) induces a proregenerative response in human liver during normothermic machine perfusion. EASL Congress 2026, Barcelona, Spain, 27-30 May 2026. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0168-8278(26)01267-5 |
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2026 Journal Article Reflex Testing for Hepatitis D Infection: A Unique Opportunity to Reduce Hepatitis D-Related Chronic Liver Disease Deaths in AustraliaHowell, Jessica, Andersson, Lauren, Levy, Miriam T., O'Beirne, James, Adams, Leon, Irvine, Katharine, Majumdar, Avik, Ahlenstiel, Golo, Jackson, Kathy, Hajkowicz, Krispin, Doyle, Joseph, Davies, Jane, Cherian, Sarah, Dimech, Wayne and Thompson, Alexander J. (2026). Reflex Testing for Hepatitis D Infection: A Unique Opportunity to Reduce Hepatitis D-Related Chronic Liver Disease Deaths in Australia. Medical Journal of Australia, 224 (4) e70170. doi: 10.5694/mja2.70170 |
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2026 Journal Article A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cellsMaxwell, Emma, Taylor, Isis, Flegg, Cameron, Liu, Yajun, Ranpura, Ginell, Nooru-Mohamed, Fathima, Green, Emma K., Huang, Stephen, Guo, Jintao, Teakle, Ngari, Sokolowski, Kamil A., Irvine, Katharine M., Hume, David A. and Jacquelin, Sebastien (2026). A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells. Journal of Leukocyte Biology, 118 (2) qiag004, 1-14. doi: 10.1093/jleuko/qiag004 |
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2026 Journal Article Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescenceVu, Hani, Sun, Yuliangzi, Xiong, Zherui, Tan, Xiao, Radford-Smith, Daniel, Causer, Andrew, Dickens, Alex M., Hyötyläinen, Tuulia, Evstafev, Ilia, Oresic, Matej, Nefzger, Christian, O’Sullivan, Eoin D., Watt, Matthew J., Ramm, Grant A., Clouston, Andrew, Irvine, Katharine, Nguyen, Quan H. and Powell, Elizabeth E. (2026). Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence. JHEP Reports, 8 (2) 101657, 1-12. doi: 10.1016/j.jhepr.2025.101657 |
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2025 Journal Article Acute and resolving inflammation differentially regulates beta cell function in mice via interactions between peritoneal and islet-associated macrophagesO'reilly, Liam, Thai, Le May, Sue, Nancy, Dhenni, Rama, Castro-Martinez, Ariel, Munoz, Marcia, Rogers, Michael J., Phan, Tri G., Schmitz-Peiffer, Carsten, Irvine, Katharine M. and Biden, Trevor J. (2025). Acute and resolving inflammation differentially regulates beta cell function in mice via interactions between peritoneal and islet-associated macrophages. Diabetologia, 69 (5), 1249-1264. doi: 10.1007/s00125-025-06638-6 |
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2025 Conference Publication Blood cell homeostasis is maintained in the absence of resident mononuclear phagocytes in fetal liver and bone marrow in CSF1R knockout ratsRoberts, Megan L., Carter-Cusack, Dylan, Huang, Stephen, Maxwell, Emma C., Summers, Kim M. and Irvine, Katharine M. (2025). Blood cell homeostasis is maintained in the absence of resident mononuclear phagocytes in fetal liver and bone marrow in CSF1R knockout rats. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Hoboken, NJ United States: John Wiley & Sons. |
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2025 Journal Article MASLD fibrosis stage F3 is morphologically and transcriptomically diverse: implications for assessing therapeutic responseLi, Chaoyi, Nguyen, Quan H., Irvine, Katharine, Powell, Elizabeth E. and Clouston, Andrew (2025). MASLD fibrosis stage F3 is morphologically and transcriptomically diverse: implications for assessing therapeutic response. Journal of Hepatology, 84 (4), e135-e137. doi: 10.1016/j.jhep.2025.11.006 |
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2025 Other Outputs Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic ReprogrammingVu, Hani, Sun, Yuliangzi, Xiong, Zherui, Tan, Xiao, Irvine, Katharine, Nguyen, Quan H. and Powell, Elizabeth E. (2025). Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming. The University of Queensland. (Dataset) doi: 10.48610/e95155f |
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2025 Journal Article Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammationHuang, Stephen, Patkar, Omkar L., Schulze, Sarah, Carter-Cusack, Dylan, Millard, Susan, Ranpura, Ginell, Green, Emma K., Maxwell, Emma, Kanesarajah, Jeeva, Cowin, Gary, Stimson, Damion, Kurniawan, Nyoman D, Keshvari, Sahar, Allavena, Rachel, Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2025). Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation. Life Science Alliance, 8 (10) e202503435, e202503435. doi: 10.26508/lsa.202503435 |
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2025 Journal Article Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in ratsSchulze, Sarah, Keshvari, Sahar, Miller, Gregory C., Bridle, Kim R., Hume, David A. and Irvine, Katharine M. (2025). Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats. World Journal of Gastroenterology, 31 (24) 108234, 1-18. doi: 10.3748/wjg.v31.i24.108234 |
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2025 Journal Article Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammationHuang, Stephen, Patkar, Omkar L., Schulze, Sarah, Carter-Cusack, Dylan, Millard, Susan, Ranpura, Ginell, Green, Emma K., Maxwell, Emma, Kanesarajah, Jeeva, Cowin, Gary, Stimson, Damion, Kurniawan, Nyoman D., Keshvari, Sahar, Allavena, Rachel, Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2025). Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation. Life Science Alliance, 8 (9) e202503264, e202503264. doi: 10.26508/lsa.202503264 |
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2025 Journal Article Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver diseaseGracen, Lucy, Hartel, Gunter, Irvine, Katharine M., Aikebuse, Melanie, Valery, Patricia C. and Powell, Elizabeth E. (2025). Factors to consider in the selection of non-invasive fibrosis tests for metabolic dysfunction-associated steatotic liver disease. Clinical Gastroenterology and Hepatology, 23 (5), 874-876. doi: 10.1016/j.cgh.2024.09.014 |
