Overview
Background
NAME Professor Elizabeth Ellen POWELL
POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital
Email e.powell@uq.edu.au
EDUCATION/TRAINING
Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland
Fellow of the Royal Australasian College of Physicians
Doctor of Philosophy (PhD), The University of Queensland
Fellow of the Royal College of Physicians, London
Fellow, American Association for the Study of Liver Diseases
Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.
Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:
(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.
(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)
(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease
Availability
- Professor Elizabeth Powell is:
- Available for supervision
Fields of research
Research impacts
Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.
Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.
Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.
Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.
International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.
Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.
Works
Search Professor Elizabeth Powell’s works on UQ eSpace
Featured
2018
Journal Article
A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care
Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Bernard, Anne, Brown, Nigel Neil, Lampe, Guy, Buck, Lyndall, Saad, Nivene, Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Rosenberg, William and Powell, Elizabeth Ellen (2018). A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care. Hepatology Communications, 2 (8), 893-905. doi: 10.1002/hep4.1208
Featured
2018
Journal Article
Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes
Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14) ARTN e120274. doi: 10.1172/jci.insight.120274
Featured
2018
Journal Article
Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis
Patel, Preya J., Banh, Xuan, Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew, Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C., Williams, Suzanne and Powell, Elizabeth E (2018). Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis. Internal Medicine Journal, 48 (2), 144-151. doi: 10.1111/imj.13667
Featured
2018
Journal Article
Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis
Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018). Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78, 80-94. doi: 10.1016/j.metabol.2017.09.002
Featured
2017
Journal Article
Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease
Patel, Preya J., Smith, David, Connor, Jason P., Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew D., Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C. and Powell, Elizabeth E. (2017). Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology and Hepatology, 2017 7927685, 7927685-8. doi: 10.1155/2017/7927685
Featured
2017
Journal Article
Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis
Hayward, Kelly L., Valery, Patricia C., Martin, Jennifer H., Karmakar, Antara, Patel, Preya J., Horsfall, Leigh U., Tallis, Caroline J., Stuart, Katherine A., Wright, Penny L., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Cottrell, W. Neil (2017). Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World Journal of Gastroenterology, 23 (40), 7321-7331. doi: 10.3748/wjg.v23.i40.7321
Featured
2017
Journal Article
Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management
Hayward, Kelly L., Horsfall, Leigh U., Ruffin, Brittany J., Cottrell, W. Neil, Chachay, Veronique S., Irvine, Katharine M., Martin, Jennifer H., Powell, Elizabeth E. and Valery, Patricia C. (2017). Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Internal Medicine Journal, 47 (8), 952-955. doi: 10.1111/imj.13505
Featured
2017
Journal Article
Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management
Patel, Preya Janubhai, Hayward, Kelly Lee, Rudra, Rathiga, Horsfall, Leigh Ula, Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Clouston, Andrew Donald, Stuart, Katherine Anne, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Russell, Anthony William and Powell, Elizabeth Ellen (2017). Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management. Medicine, 96 (26) e6761, e6761. doi: 10.1097/MD.0000000000006761
Featured
2017
Journal Article
Identifying areas of need relative to liver disease: geographic clustering within a health service district
El-Atem, Nathan, Irvine, Katharine M., Valery, Patricia C., Wojcik, Kyle, Horsfall, Leigh, Johnson, Tracey, Janda, Monika, McPhail, Steven M. and Powell, Elizabeth E. (2017). Identifying areas of need relative to liver disease: geographic clustering within a health service district. Australian Health Review, 41 (4), 407-418. doi: 10.1071/AH15225
2024
Journal Article
An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations
Gracen, Lucy, Aikebuse, Melanie, Sarraf, Babak, McPhail, Steven, Russell, Anthony, O’Beirne, James, Irvine, Katharine, Williams, Suzanne, Valery, Patricia and Powell, Elizabeth (2024). An Australian Community-Based Metabolic Dysfunction-Associated Steatotic Liver Disease Care Pathway for People with Type 2 Diabetes: Barriers and Considerations. Patient Preference and Adherence, Volume 18, 1845-1855. doi: 10.2147/ppa.s468705
2024
Journal Article
Australians with metabolic dysfunction‐associated steatotic liver disease have a twofold increase in the incidence of cancer
Powell, Elizabeth E, Roche, Shruti, Sarraf, Babak, Hartel, Gunter, Skoien, Richard, Leggett, Barbara, O'Beirne, James and Valery, Patricia C (2024). Australians with metabolic dysfunction‐associated steatotic liver disease have a twofold increase in the incidence of cancer. JGH Open, 8 (7) e70000, e70000. doi: 10.1002/jgh3.70000
2024
Journal Article
Rising hospital admissions for alcohol-related cirrhosis and the impact of sex and comorbidity – a data linkage study
Sarraf, B., Skoien, R., Hartel, G., O'Beirne, J., Clark, P.J., Collins, L., Leggett, B., Powell, E.E. and Valery, P.C. (2024). Rising hospital admissions for alcohol-related cirrhosis and the impact of sex and comorbidity – a data linkage study. Public Health, 232, 178-187. doi: 10.1016/j.puhe.2024.04.030
2024
Conference Publication
qBallooning: AI-based ballooned hepatocyte detection and quantification by second harmonic generation/two photon excitation microscopy
Kleiner, David E., Clouston, Andrew D., Goodman, Zachary, Guy, Cynthia D., Brunt, Elizabeth M., Lackner, Carolin, Tiniakos, Dina G., Wee, Aileen, Yeh, Matthew, Leow, Wei Qiang, Chng, Elaine, Ren, Yayun, Goh, George Boon Bee, Powell, Elizabeth E., Rinella, Mary E., Sanyal, Arun J, Neuschwander-Tetri, Brent A., Younossi, Zobair, Charlton, Michael, Ratziu, Vlad, Harrison, Stephen A., Tai, Dean and Anstee, Quentin M. (2024). qBallooning: AI-based ballooned hepatocyte detection and quantification by second harmonic generation/two photon excitation microscopy. EASL Congress 2024, Milan, Italy, 5-8 June 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0168-8278(24)01444-2
2024
Journal Article
High prevalence of diabetes among young First Nations Peoples with metabolic dysfunction-associated steatotic liver disease: a population-based study in Australia
Valery, Patricia C., Roche, Shruti, Brown, Catherine, O’Beirne, James, Hartel, Gunter, Leggett, Barbara, Skoien, Richard and Powell, Elizabeth E. (2024). High prevalence of diabetes among young First Nations Peoples with metabolic dysfunction-associated steatotic liver disease: a population-based study in Australia. International Journal for Equity in Health, 23 (1) 84, 84. doi: 10.1186/s12939-024-02153-z
2024
Journal Article
A discrete choice experiment to elicit preferences for a chronic disease screening programme in Queensland, Australia
Senanayake, S., Barnett, A., Brain, D., Allen, M., Powell, E.E., O'Beirne, J., Valery, P., Hickman, I.J. and Kularatna, S. (2024). A discrete choice experiment to elicit preferences for a chronic disease screening programme in Queensland, Australia. Public Health, 228, 105-111. doi: 10.1016/j.puhe.2024.01.007
2024
Journal Article
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
Rinella, Mary E., Lazarus, Jeffrey V., Ratziu, Vlad, Francque, Sven M., Sanyal, Arun J., Kanwal, Fasiha, Romero, Diana, Abdelmalek, Manal F., Anstee, Quentin M., Arab, Juan Pablo, Arrese, Marco, Bataller, Ramon, Beuers, Ulrich, Boursier, Jerome, Bugianesi, Elisabetta, Byrne, Christopher D., Narro, Graciela E. Castro, Chowdhury, Abhijit, Cortez-Pinto, Helena, Cryer, Donna R., Cusi, Kenneth, El-Kassas, Mohamed, Klein, Samuel, Eskridge, Wayne, Fan, Jiangao, Gawrieh, Samer, Guy, Cynthia D., Harrison, Stephen A., Kim, Seung Up ... Newsome, Philip N. (2024). A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Annals of Hepatology, 29 (1) 101133. doi: 10.1016/j.aohep.2023.101133
2023
Journal Article
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
Rinella, Mary E., Lazarus, Jeffrey V., Ratziu, Vlad, Francque, Sven M., Sanyal, Arun J., Kanwal, Fasiha, Romero, Diana, Abdelmalek, Manal F., Anstee, Quentin M., Pablo Arab, Juan, Arrese, Marco, Bataller, Ramon, Beuers, Ulrich, Boursier, Jerome, Bugianesi, Elisabetta, Byrne, Christopher D., Castro Narro, Graciela E., Chowdhury, Abhijit, Cortez-Pinto, Helena, Cryer, Donna R., Cusi, Kenneth, El-Kassas, Mohamed, Klein, Samuel, Eskridge, Wayne, Fan, Jiangao, Gawrieh, Samer, Guy, Cynthia D., Harrison, Stephen A., Kim, Seung Up ... Newsome, Philip N. (2023). A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology, 78 (6), 1966-1986. doi: 10.1097/HEP.0000000000000520
2023
Journal Article
Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists
Gracen, Lucy, Muthukumara, Withma, Aikebuse, Melanie, Russell, Anthony, O'Beirne, James, Irvine, Katharine M., Williams, Suzanne, Puri, Gaurav, Valery, Patricia C., Hayward, Kelly L. and Powell, Elizabeth E. (2023). Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists. Annals of Hepatology, 28 (6) 101142, 101142. doi: 10.1016/j.aohep.2023.101142
2023
Journal Article
Gene variants implicated in steatotic liver disease: opportunities for diagnostics and therapeutics
Huang, Gary, Wallace, Daniel F., Powell, Elizabeth E., Rahman, Tony, Clark, Paul J. and Subramaniam, V. Nathan (2023). Gene variants implicated in steatotic liver disease: opportunities for diagnostics and therapeutics. Biomedicines, 11 (10) 2809, 1-15. doi: 10.3390/biomedicines11102809
2023
Journal Article
Changing prevalence of medication use in people with cirrhosis: a retrospective cohort study using pharmaceutical benefits scheme data
Hayward, Kelly L., Weersink, Rianne A., Bernardes, Christina M., McIvor, Carolyn, Rahman, Tony, Skoien, Richard, Clark, Paul J., Stuart, Katherine A., Hartel, Gunter, Valery, Patricia C. and Powell, Elizabeth E. (2023). Changing prevalence of medication use in people with cirrhosis: a retrospective cohort study using pharmaceutical benefits scheme data. Drugs - Real World Outcomes, 10 (4), 605-618. doi: 10.1007/s40801-023-00390-2
Funding
Supervision
Availability
- Professor Elizabeth Powell is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
Other advisors: Associate Professor Anthony Russell
Completed supervision
-
2019
Doctor Philosophy
Medication-related problems in people with chronic liver disease: the effect of a patient-oriented medication management intervention delivered by a clinical pharmacist
Principal Advisor
Other advisors: Dr Katharine Irvine, Associate Professor Neil Cottrell
-
2015
Doctor Philosophy
Characterisation of Infiltrating Inflammatory Cells in the Development of Liver Injury and Progressive Fibrosis
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Andrew Clouston
-
2004
Doctor Philosophy
THE ROLE OF OBESITY IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC LIVER DISEASES
Principal Advisor
-
2012
Master Philosophy
Characterisation of polarised macrophages and their influence on hepatocyte phenotype and function
Joint Principal Advisor
-
2022
Master Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
Associate Advisor
Other advisors: Dr Katharine Irvine
-
2013
Doctor Philosophy
The pathogenesis of non-alcoholic fatty liver disease: From parenchymal injury to portal fibrosis
Associate Advisor
Other advisors: Professor Andrew Clouston
-
2012
Master Philosophy
Does Whole Liver Determination of Liver Steatosis Improve Accuracy?
Associate Advisor
Other advisors: Professor Graham Galloway, Dr Gary Cowin
-
2008
Doctor Philosophy
Investigation of the role of hepatic progenitor cells and the ductular reaction in chronic liver injury in adults, children, and post transplantation
Associate Advisor
-
2008
Doctor Philosophy
The Role of Host Factors in Liver Injury and Non-Response to Antiviral Therapy in Patients With Chronic HCV
Associate Advisor
-
2002
Doctor Philosophy
AN EVALUATION OF STEATOSIS INDUCED FIBROSIS IN CHRONIC HEPATITIS C
Associate Advisor
Media
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