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Professor Elizabeth Powell
Professor

Elizabeth Powell

Email: 
Phone: 
+61 7 344 38015

Overview

Background

NAME Professor Elizabeth Ellen POWELL

POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital

Email e.powell@uq.edu.au

EDUCATION/TRAINING

Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland

Fellow of the Royal Australasian College of Physicians

Doctor of Philosophy (PhD), The University of Queensland

Fellow of the Royal College of Physicians, London

Fellow, American Association for the Study of Liver Diseases

Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.

Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:

(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.

(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)

(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease

Availability

Professor Elizabeth Powell is:
Available for supervision

Fields of research

Research impacts

Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.

Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.

Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.

Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.

International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.

Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.

Works

Search Professor Elizabeth Powell’s works on UQ eSpace

292 works between 1984 and 2024

41 - 60 of 292 works

2022

Journal Article

Partnering with support persons and clinicians to improve the health care experiences of patients with cirrhosis

Brown, Catherine, Shahid, Shaouli, Bernardes, Christina M., Toombs, Maree, Clark, Paul J., Powell, Elizabeth E. and Valery, Patricia C. (2022). Partnering with support persons and clinicians to improve the health care experiences of patients with cirrhosis. Journal of Clinical Nursing, 32 (11-12), 2559-2574. doi: 10.1111/jocn.16302

Partnering with support persons and clinicians to improve the health care experiences of patients with cirrhosis

2022

Journal Article

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Jouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

2022

Journal Article

Comment on “Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review”

Valery, Patricia Casarolli and Powell, Elizabeth Ellen (2022). Comment on “Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review”. JHEP Reports, 4 (2) 100393. doi: 10.1016/j.jhepr.2021.100393

Comment on “Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review”

2022

Journal Article

Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism

Radford-Smith, Daniel E., Patel, Preya J., Irvine, Katharine M., Russell, Anthony, Siskind, Dan, Anthony, Daniel C., Powell, Elizabeth E. and Probert, Fay (2022). Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS ONE, 17 (1) e0261555, e0261555. doi: 10.1371/journal.pone.0261555

Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism

2022

Journal Article

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

2022

Journal Article

An exploration of barriers and facilitators to implementing a nonalcoholic fatty liver disease pathway for people with type 2 diabetes in primary care

Gracen, Lucy, Hayward, Kelly L., Aikebuse, Melanie, Williams, Suzanne, Russell, Anthony, O'Beirne, James, Powell, Elizabeth E. and Valery, Patricia C. (2022). An exploration of barriers and facilitators to implementing a nonalcoholic fatty liver disease pathway for people with type 2 diabetes in primary care. Diabetic Medicine, 39 (6) e14799, e14799. doi: 10.1111/dme.14799

An exploration of barriers and facilitators to implementing a nonalcoholic fatty liver disease pathway for people with type 2 diabetes in primary care

2021

Journal Article

Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study

Johnson, Amy L., Ratnasekera, Isanka U., Irvine, Katharine M., Henderson, Andrew, Powell, Elizabeth E. and Valery, Patricia C. (2021). Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study. BMJ Open Gastroenterology, 8 (1) e000695, e000695. doi: 10.1136/bmjgast-2021-000695

Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study

2021

Journal Article

Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease

Irvine, Katharine M., Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Williams, Suzanne, Russell, Anthony and Powell, Elizabeth E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific Reports, 11 (1) 2858, 1-8. doi: 10.1038/s41598-021-82315-z

Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease

2021

Journal Article

Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety

Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Li, Catherine, Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2021). Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety. Pharmaceuticals, 14 (12) 1207, 1207. doi: 10.3390/ph14121207

Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety

2021

Journal Article

Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests

Johnson, Amy L., Hayward, Kelly L., Patel, Preya, Horsfall, Leigh U., Cheah, Alvin Ee Zhiun, Irvine, Katharine M., Russell, Anthony W., Stuart, Katherine A., Williams, Sue, Hartel, Gunter, Valery, Patricia C. and Powell, Elizabeth E. (2021). Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests. Hepatology Communications, 6 (4), 728-739. doi: 10.1002/hep4.1852

Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests

2021

Journal Article

Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care

Hayward, Kelly L., McKillen, Benjamin J., Horsfall, Leigh U., McIvor, Carolyn, Liew, Katerina, Sexton, Jo, Johnson, Amy L., Irvine, Katharine M., Valery, Patricia C., McPhail, Steven M., Britton, Laurence J., Rosenberg, William, Weate, Ingrid, Williams, Sue and Powell, Elizabeth E. (2021). Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care. Internal Medicine Journal, 52 (10) imj.15422, 1749-1758. doi: 10.1111/imj.15422

Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care

2021

Journal Article

Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma

Taye, Belaynew W., Clark, Paul J., Hartel, Gunter, Powell, Elizabeth E. and Valery, Patricia C. (2021). Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma. JGH Open, 5 (7) jgh3.12580, 754-762. doi: 10.1002/jgh3.12580

Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma

2021

Journal Article

Non-alcoholic fatty liver disease

Powell, Elizabeth E., Wong, Vincent Wai-Sun and Rinella, Mary (2021). Non-alcoholic fatty liver disease. The Lancet, 397 (10290), 2212-2224. doi: 10.1016/S0140-6736(20)32511-3

Non-alcoholic fatty liver disease

2021

Journal Article

Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia

Wigg, Alan J., Narayana, Sumudu K., Hartel, Gunter, Medlin, Linda, Pratt, Greg, Powell, Elizabeth E., Clark, Paul, Davies, Jane, Campbell, Kirsty, Toombs, Maree, Larkin, Michael and Valery, Patricia C (2021). Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia. EClinicalMedicine, 36 100919, 1-9. doi: 10.1016/j.eclinm.2021.100919

Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia

2021

Journal Article

Non-alcoholic fatty liver disease: raising awareness of a looming public health problem

Gracen, Lucy and Powell, Elizabeth E. (2021). Non-alcoholic fatty liver disease: raising awareness of a looming public health problem. The Medical Journal of Australia, 215 (2) mja2.51109, 75-76. doi: 10.5694/mja2.51109

Non-alcoholic fatty liver disease: raising awareness of a looming public health problem

2021

Journal Article

The patient’s perspective in cirrhosis: unmet supportive care needs differ by disease severity, etiology, and age

Valery, Patricia C., Bernardes, Christina M., Mckillen, Benjamin, Amarasena, Samath, Stuart, Katherine A., Hartel, Gunter, Clark, Paul J., Skoien, Richard, Rahman, Tony, Horsfall, Leigh, Hayward, Kelly, Gupta, Rohit, Lee, Andrew, Pillay, Leshni and Powell, Elizabeth E. (2021). The patient’s perspective in cirrhosis: unmet supportive care needs differ by disease severity, etiology, and age. Hepatology Communications, 5 (5), 891-905. doi: 10.1002/hep4.1681

The patient’s perspective in cirrhosis: unmet supportive care needs differ by disease severity, etiology, and age

2021

Journal Article

Detecting non-alcoholic fatty liver disease and risk factors in health databases: accuracy and limitations of the ICD-10-AM

Hayward, Kelly Lee, Johnson, Amy L., Horsfall, Leigh U., Moser, Chris, Valery, Patricia C. and Powell, Elizabeth E. (2021). Detecting non-alcoholic fatty liver disease and risk factors in health databases: accuracy and limitations of the ICD-10-AM. BMJ Open Gastroenterology, 8 (1) 000572, e000572. doi: 10.1136/bmjgast-2020-000572

Detecting non-alcoholic fatty liver disease and risk factors in health databases: accuracy and limitations of the ICD-10-AM

2021

Journal Article

Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis

McPhail, Steven M., Amarasena, Samath, Stuart, Katherine A., Hayward, Kelly, Gupta, Rohit, Brain, David, Hartel, Gunter, Rahman, Tony, Clark, Paul J., Bernardes, Christina M., Skoien, Richard, Mckillen, Benjamin, Lee, Andrew, Pillay, Leshni, Lin, Lei, Khaing, Myat Myat, Horsfall, Leigh, Powell, Elizabeth E. and Valery, Patricia C. (2021). Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis. JGH Open, 5 (1), 133-142. doi: 10.1002/jgh3.12462

Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis

2021

Journal Article

Disparities in unmet needs in Indigenous and non-Indigenous Australians with cirrhosis: an exploratory study

Bernardes, Christina M., Clark, Paul J., Brown, Cath, Stuart, Katherine, Pratt, Gregory, Toombs, Maree, Hartel, Gunter, Powell, Elizabeth E. and Valery, Patricia C. (2021). Disparities in unmet needs in Indigenous and non-Indigenous Australians with cirrhosis: an exploratory study. Patient Preference and Adherence, 15, 2649-2658. doi: 10.2147/PPA.S341566

Disparities in unmet needs in Indigenous and non-Indigenous Australians with cirrhosis: an exploratory study

2020

Journal Article

Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis

Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2020). Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis. Internal Medicine Journal, 50 (9), 1142-1146. doi: 10.1111/imj.14986

Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis

Funding

Past funding

  • 2019 - 2020
    ELF Study (Siemens - Unrestricted Education Grant)
    Siemens Healthcare Pty Ltd
    Open grant
  • 2017 - 2020
    HLA-G/H2-Bl is Critical for Regulating Inflammation in the Liver
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    MERTK receptor tyrosine kinase: A novel therapeutic target for liver fibrosis (NHMRC Project Grant administered by the University of Sydney)
    University of Sydney
    Open grant
  • 2015 - 2017
    Non-invasive assessment of Hepatic Steatosis (Fibrosis) by Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)
    CSIRO
    Open grant
  • 2015 - 2017
    Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
    Siemens Ltd
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    High throughput gene expression of patient samples via the Nanostring nCounter system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    Targeting the Wnt Pathway: Implication for Chronic Liver disease
    PA Research Foundation
    Open grant
  • 2013 - 2015
    Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
    NHMRC Project Grant
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Monocytes/macrophages in chronic liver diseases: cross-talk with hepatocytes and nonparenchymal cells and role in progressive liver injury
    NHMRC Project Grant
    Open grant
  • 2011 - 2015
    NHMRC Practitioner Fellowship: The role of obesity, insulin resistance and fatty liver (steatosis) in human disease and strategies to monitor and improve patient outcomes
    NHMRC Practitioner Fellowship
    Open grant
  • 2009 - 2012
    Mayne Bequest Fund Research Support Award: Investigation of mechanisms contributing to disease progression and response to treatment in chronic liver diseases
    Mayne Bequest Fund
    Open grant
  • 2008 - 2010
    Role of obesity in impaired treatment response in chronic hepatitis C: mechanisms and therapeutic strategies
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Hepatocyte replicative arrest, hepatic progenitor cells and the ductular reaction in hepatic fibrogenesis
    NHMRC Project Grant
    Open grant
  • 2007
    Non-invasive assessment of hepatic steatosis by magnetic resonance imaging (MRI and spectroscopy (MRS)
    PA Research Foundation
    Open grant
  • 2006
    Effect of weight loss on SOC-3 expression and response to antiviral therapy in patients with chronic hepatitis C
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2006 - 2010
    NHMRC Practitioner Fellowship
    NHMRC Practitioner Fellowship
    Open grant
  • 2006 - 2008
    UQ Postdoctoral Fellowship 2006 - Scott Ward - HS Faculty contribution
    Mayne Bequest Fund
    Open grant
  • 2005
    The effect of obesity on liver function in children who are long term liver transplant recipients
    Royal Children's Hospital Foundation
    Open grant
  • 2005 - 2007
    The role of steatosis in promoting cellular injury and fibrogenesis in human liver disease
    NHMRC Project Grant
    Open grant
  • 2004 - 2006
    Role of magnetic resonance imaging in monitoring hepatic steatosis and visceral adiposity during treatment.
    Wesley Merdical Research
    Open grant
  • 2004 - 2005
    Genetic factors and hepatitis C - role in predicting disease progression
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2004 - 2005
    The Effect Of Alcohol On Hepatitis C-Induced Liver Disease
    Australian Brewers' Foundation
    Open grant
  • 2003 - 2004
    PAHF block funding
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant

Supervision

Availability

Professor Elizabeth Powell is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)

    Principal Advisor

    Other advisors: Associate Professor Anthony Russell

Completed supervision

Media

Enquiries

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