Overview
Background
NAME Professor Elizabeth Ellen POWELL
POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital
Email e.powell@uq.edu.au
EDUCATION/TRAINING
Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland
Fellow of the Royal Australasian College of Physicians
Doctor of Philosophy (PhD), The University of Queensland
Fellow of the Royal College of Physicians, London
Fellow, American Association for the Study of Liver Diseases
Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.
Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:
(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.
(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)
(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease
Availability
- Professor Elizabeth Powell is:
- Available for supervision
Fields of research
Research impacts
Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.
Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.
Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.
Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.
International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.
Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.
Works
Search Professor Elizabeth Powell’s works on UQ eSpace
2022
Journal Article
Partnering with support persons and clinicians to improve the health care experiences of patients with cirrhosis
Brown, Catherine, Shahid, Shaouli, Bernardes, Christina M., Toombs, Maree, Clark, Paul J., Powell, Elizabeth E. and Valery, Patricia C. (2022). Partnering with support persons and clinicians to improve the health care experiences of patients with cirrhosis. Journal of Clinical Nursing, 32 (11-12), 2559-2574. doi: 10.1111/jocn.16302
2022
Journal Article
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease
Jouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119
2022
Journal Article
Comment on “Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review”
Valery, Patricia Casarolli and Powell, Elizabeth Ellen (2022). Comment on “Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review”. JHEP Reports, 4 (2) 100393. doi: 10.1016/j.jhepr.2021.100393
2022
Journal Article
Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism
Radford-Smith, Daniel E., Patel, Preya J., Irvine, Katharine M., Russell, Anthony, Siskind, Dan, Anthony, Daniel C., Powell, Elizabeth E. and Probert, Fay (2022). Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS ONE, 17 (1) e0261555, e0261555. doi: 10.1371/journal.pone.0261555
2022
Journal Article
Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease
Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387
2022
Journal Article
An exploration of barriers and facilitators to implementing a nonalcoholic fatty liver disease pathway for people with type 2 diabetes in primary care
Gracen, Lucy, Hayward, Kelly L., Aikebuse, Melanie, Williams, Suzanne, Russell, Anthony, O'Beirne, James, Powell, Elizabeth E. and Valery, Patricia C. (2022). An exploration of barriers and facilitators to implementing a nonalcoholic fatty liver disease pathway for people with type 2 diabetes in primary care. Diabetic Medicine, 39 (6) e14799, e14799. doi: 10.1111/dme.14799
2021
Journal Article
Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study
Johnson, Amy L., Ratnasekera, Isanka U., Irvine, Katharine M., Henderson, Andrew, Powell, Elizabeth E. and Valery, Patricia C. (2021). Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study. BMJ Open Gastroenterology, 8 (1) e000695, e000695. doi: 10.1136/bmjgast-2021-000695
2021
Journal Article
Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease
Irvine, Katharine M., Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Williams, Suzanne, Russell, Anthony and Powell, Elizabeth E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific Reports, 11 (1) 2858, 1-8. doi: 10.1038/s41598-021-82315-z
2021
Journal Article
Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety
Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Li, Catherine, Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2021). Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety. Pharmaceuticals, 14 (12) 1207, 1207. doi: 10.3390/ph14121207
2021
Journal Article
Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests
Johnson, Amy L., Hayward, Kelly L., Patel, Preya, Horsfall, Leigh U., Cheah, Alvin Ee Zhiun, Irvine, Katharine M., Russell, Anthony W., Stuart, Katherine A., Williams, Sue, Hartel, Gunter, Valery, Patricia C. and Powell, Elizabeth E. (2021). Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests. Hepatology Communications, 6 (4), 728-739. doi: 10.1002/hep4.1852
2021
Journal Article
Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care
Hayward, Kelly L., McKillen, Benjamin J., Horsfall, Leigh U., McIvor, Carolyn, Liew, Katerina, Sexton, Jo, Johnson, Amy L., Irvine, Katharine M., Valery, Patricia C., McPhail, Steven M., Britton, Laurence J., Rosenberg, William, Weate, Ingrid, Williams, Sue and Powell, Elizabeth E. (2021). Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care. Internal Medicine Journal, 52 (10) imj.15422, 1749-1758. doi: 10.1111/imj.15422
2021
Journal Article
Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma
Taye, Belaynew W., Clark, Paul J., Hartel, Gunter, Powell, Elizabeth E. and Valery, Patricia C. (2021). Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma. JGH Open, 5 (7) jgh3.12580, 754-762. doi: 10.1002/jgh3.12580
2021
Journal Article
Non-alcoholic fatty liver disease
Powell, Elizabeth E., Wong, Vincent Wai-Sun and Rinella, Mary (2021). Non-alcoholic fatty liver disease. The Lancet, 397 (10290), 2212-2224. doi: 10.1016/S0140-6736(20)32511-3
2021
Journal Article
Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia
Wigg, Alan J., Narayana, Sumudu K., Hartel, Gunter, Medlin, Linda, Pratt, Greg, Powell, Elizabeth E., Clark, Paul, Davies, Jane, Campbell, Kirsty, Toombs, Maree, Larkin, Michael and Valery, Patricia C (2021). Hepatocellular carcinoma amongst Aboriginal and Torres Strait Islander peoples of Australia. EClinicalMedicine, 36 100919, 1-9. doi: 10.1016/j.eclinm.2021.100919
2021
Journal Article
Non-alcoholic fatty liver disease: raising awareness of a looming public health problem
Gracen, Lucy and Powell, Elizabeth E. (2021). Non-alcoholic fatty liver disease: raising awareness of a looming public health problem. The Medical Journal of Australia, 215 (2) mja2.51109, 75-76. doi: 10.5694/mja2.51109
2021
Journal Article
The patient’s perspective in cirrhosis: unmet supportive care needs differ by disease severity, etiology, and age
Valery, Patricia C., Bernardes, Christina M., Mckillen, Benjamin, Amarasena, Samath, Stuart, Katherine A., Hartel, Gunter, Clark, Paul J., Skoien, Richard, Rahman, Tony, Horsfall, Leigh, Hayward, Kelly, Gupta, Rohit, Lee, Andrew, Pillay, Leshni and Powell, Elizabeth E. (2021). The patient’s perspective in cirrhosis: unmet supportive care needs differ by disease severity, etiology, and age. Hepatology Communications, 5 (5), 891-905. doi: 10.1002/hep4.1681
2021
Journal Article
Detecting non-alcoholic fatty liver disease and risk factors in health databases: accuracy and limitations of the ICD-10-AM
Hayward, Kelly Lee, Johnson, Amy L., Horsfall, Leigh U., Moser, Chris, Valery, Patricia C. and Powell, Elizabeth E. (2021). Detecting non-alcoholic fatty liver disease and risk factors in health databases: accuracy and limitations of the ICD-10-AM. BMJ Open Gastroenterology, 8 (1) 000572, e000572. doi: 10.1136/bmjgast-2020-000572
2021
Journal Article
Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis
McPhail, Steven M., Amarasena, Samath, Stuart, Katherine A., Hayward, Kelly, Gupta, Rohit, Brain, David, Hartel, Gunter, Rahman, Tony, Clark, Paul J., Bernardes, Christina M., Skoien, Richard, Mckillen, Benjamin, Lee, Andrew, Pillay, Leshni, Lin, Lei, Khaing, Myat Myat, Horsfall, Leigh, Powell, Elizabeth E. and Valery, Patricia C. (2021). Assessment of health-related quality of life and health utilities in Australian patients with cirrhosis. JGH Open, 5 (1), 133-142. doi: 10.1002/jgh3.12462
2021
Journal Article
Disparities in unmet needs in Indigenous and non-Indigenous Australians with cirrhosis: an exploratory study
Bernardes, Christina M., Clark, Paul J., Brown, Cath, Stuart, Katherine, Pratt, Gregory, Toombs, Maree, Hartel, Gunter, Powell, Elizabeth E. and Valery, Patricia C. (2021). Disparities in unmet needs in Indigenous and non-Indigenous Australians with cirrhosis: an exploratory study. Patient Preference and Adherence, 15, 2649-2658. doi: 10.2147/PPA.S341566
2020
Journal Article
Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis
Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2020). Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis. Internal Medicine Journal, 50 (9), 1142-1146. doi: 10.1111/imj.14986
Funding
Supervision
Availability
- Professor Elizabeth Powell is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
Other advisors: Associate Professor Anthony Russell
Completed supervision
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2019
Doctor Philosophy
Medication-related problems in people with chronic liver disease: the effect of a patient-oriented medication management intervention delivered by a clinical pharmacist
Principal Advisor
Other advisors: Dr Katharine Irvine, Associate Professor Neil Cottrell
-
2015
Doctor Philosophy
Characterisation of Infiltrating Inflammatory Cells in the Development of Liver Injury and Progressive Fibrosis
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Andrew Clouston
-
2004
Doctor Philosophy
THE ROLE OF OBESITY IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC LIVER DISEASES
Principal Advisor
-
2012
Master Philosophy
Characterisation of polarised macrophages and their influence on hepatocyte phenotype and function
Joint Principal Advisor
-
2022
Master Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
Associate Advisor
Other advisors: Dr Katharine Irvine
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2013
Doctor Philosophy
The pathogenesis of non-alcoholic fatty liver disease: From parenchymal injury to portal fibrosis
Associate Advisor
Other advisors: Professor Andrew Clouston
-
2012
Master Philosophy
Does Whole Liver Determination of Liver Steatosis Improve Accuracy?
Associate Advisor
Other advisors: Professor Graham Galloway, Dr Gary Cowin
-
2008
Doctor Philosophy
Investigation of the role of hepatic progenitor cells and the ductular reaction in chronic liver injury in adults, children, and post transplantation
Associate Advisor
-
2008
Doctor Philosophy
The Role of Host Factors in Liver Injury and Non-Response to Antiviral Therapy in Patients With Chronic HCV
Associate Advisor
-
2002
Doctor Philosophy
AN EVALUATION OF STEATOSIS INDUCED FIBROSIS IN CHRONIC HEPATITIS C
Associate Advisor
Media
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