
Overview
Background
Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.
Availability
- Professor Antje Blumenthal is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Basic and Applied Immunology, University of Lübeck
Research interests
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Tuberculosis
- immune response - pathogenesis - novel anti-TB drugs
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Innate Immunity
molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence
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Macrophage biology
infection and inflammation related macrophage functions
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Inflammation
molecular regulation of inflammatory responses
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Sepsis
immune responses and biomarker discovery
Works
Search Professor Antje Blumenthal’s works on UQ eSpace
2025
Journal Article
No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis
Blumenthal, Antje and Domínguez Cadena, Leslie C. (2025). No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Journal of Experimental Medicine, 222 (3) e20242285, 1-3. doi: 10.1084/jem.20242285
2024
Journal Article
Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial
Walsham, James, Hammond, Naomi, Blumenthal, Antje, Cohen, Jeremy, Myburgh, John, Finfer, Simon, Evans, David, Peake, Sandra, Kruger, Peter, McCullough, James, Johnk, Loki, Ghelani, Dhaval, Billot, Laurent, Shan, Sana, Meyer, Jason, Rajbhandari, Dorrilyn, Koch, Carolyn, Bellomo, Rinaldo, Burrell, Louise M., Young, Morag, Roberts, Michael, Mackenzie, Lorraine, Medley, Gregory, Dalton, Joshua and Venkatesh, Balasubramanian (2024). Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial. Intensive Care Medicine, 50 (12), 2050-2060. doi: 10.1007/s00134-024-07616-z
2024
Journal Article
Myddosomes in Toll-like receptor signaling-one to bind and rule them all
Mathmann, Carmen D., Schultz, Thomas E., Cadena, Leslie C. Dominguez and Blumenthal, Antje (2024). Myddosomes in Toll-like receptor signaling-one to bind and rule them all. Immunology and Cell Biology, 102 (9), 752-756. doi: 10.1111/imcb.12816
2024
Journal Article
Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study
Schlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8
2024
Journal Article
Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis
Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768
2023
Journal Article
Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis
Rollo, Rachel F., Mori, Giorgia, Hill, Timothy A., Hillemann, Doris, Niemann, Stefan, Homolka, Susanne, Fairlie, David P. and Blumenthal, Antje (2023). Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis. Microbiology Spectrum, 11 (4). doi: 10.1128/spectrum.00465-23
2023
Conference Publication
1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling
Sim, S., Kaur, S., Styke, C., Millard, S., Blumenthal, A., Pettit, A. and Khosrotehrani, K. (2023). 1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1528
2023
Conference Publication
Spatiotemporal regulation of rp105 subcellular localization shapes endosomal TLR4 signaling
Mathmann, Carmen, Schultz, Thomas, Ongtengco, Cherica Felize J., Dalton, Emma, Domínguez Cadena, Leslie C., Zamoshnikova, Alina, Stow, Jennifer L. and Blumenthal, Antje (2023). Spatiotemporal regulation of rp105 subcellular localization shapes endosomal TLR4 signaling. IMMUNOLOGY 2023 Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.160.06
2023
Journal Article
Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial
Mattke, Adrian, Johnson, Kerry, Gibbons, Kristen, Long, Debbie, Robertson, Jeremy, Venugopal, Prem, Blumenthal, Antje, Schibler, Andreas and Schlapbach, Luregn (2023). Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial. JMIR Research Protocols, 12 e43760, 1-10. doi: 10.2196/43760
2023
Journal Article
Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes
Enosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan and Man, Si Ming (2023). Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes. The EMBO Journal, 42 (6) e112558, e112558. doi: 10.15252/embj.2022112558
2022
Journal Article
Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis
Donovan, Meg L., Bielefeldt‐Ohmann, Helle, Rollo, Rachel F., McPherson, Stephen, Schultz, Thomas E., Mori, Giorgia, Kling, Jessica C. and Blumenthal, Antje (2022). Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis. Immunology, 169 (1), 13-26. doi: 10.1111/imm.13606
2022
Journal Article
Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration
Sim, Seen Ling, Blumenthal, Antje, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration. Frontiers in Endocrinology, 13 957833, 957833. doi: 10.3389/fendo.2022.957833
2022
Journal Article
The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms
Ramnath, Divya, Das Gupta, Kaustav, Wang, Yizhuo, Abrol, Rishika, Curson, James E. B., Lim, Junxian, Reid, Robert C., Mansell, Ashley, Blumenthal, Antje, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2022). The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111 (2), 327-336. doi: 10.1002/jlb.2mr1021-260r
2022
Journal Article
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2
Wilson, Alicia S., Randall, Katrina L., Pettitt, Jessica A., Ellyard, Julia I., Blumenthal, Antje, Enders, Anselm, Quah, Benjamin J., Bopp, Tobias, Parish, Christopher R. and Brüstle, Anne (2022). Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2. Nature Communications, 13 (1) 528, 528. doi: 10.1038/s41467-022-28172-4
2022
Journal Article
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
2021
Journal Article
Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective
Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823
2021
Journal Article
The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock
Cohen, Jeremy, Blumenthal, Antje, Cuellar-Partida, Gabriel, Evans, David M., Finfer, Simon, Li, Qiang, Ljungberg, Johanna, Myburgh, John, Peach, Elizabeth, Powell, Joseph, Rajbhandari, Dorrilyn, Rhodes, Andrew, Senabouth, Anne and Venkatesh, Balasubramanian (2021). The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock. Intensive Care Medicine, 47 (9), 974-983. doi: 10.1007/s00134-021-06464-5
2021
Journal Article
Microbiome-immune interactions in tuberculosis
Mori, Giorgia, Morrison, Mark and Blumenthal, Antje (2021). Microbiome-immune interactions in tuberculosis. PLoS Pathogens, 17 (4) e1009377, e1009377. doi: 10.1371/journal.ppat.1009377
2021
Other Outputs
Pre-diabetes increases tuberculosis disease severity, while high body fat without impaired glucose tolerance is protective
Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-diabetes increases tuberculosis disease severity, while high body fat without impaired glucose tolerance is protective. doi: 10.1101/2021.04.06.438735
2021
Journal Article
Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial
Gibbons, Kristen S., Schlapbach, Luregn J., Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d'Udekem, Yves, Alphonso, Nelson, Winlaw, David, Johnson, Kerry, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick and Schibler, Andreas (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Antje Blumenthal is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculosis
Principal Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Tom Schultz
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Doctor Philosophy
Impact of nitric oxide on inflammation and coagulation in patients undergoing extracorporeal membrane oxygenation (ECMO)
Principal Advisor
Other advisors: Dr Craig McBride
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Doctor Philosophy
Microbiome-host-interactions in Mycobacterium tuberculosis infection
Principal Advisor
Other advisors: Professor Mark Morrison
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Doctor Philosophy
Mapping cellular signalling pathways in mycobacteria-infected macrophages
Principal Advisor
Other advisors: Dr Tom Schultz, Dr Carmen Mathmann
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Doctor Philosophy
Molecular regulators of macrophage functions during Mycobacterium tuberculosis infection
Principal Advisor
Other advisors: Dr Carmen Mathmann
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Master Philosophy
The gut-lung axis in nontuberculous mycobacterial pulmonary disease.
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Rachel Thomson
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Master Philosophy
The gut-lung axis in nontuberculous mycobacterial pulmonary disease.
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Rachel Thomson
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Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor David Hume, Dr Katharine Irvine
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Doctor Philosophy
Transmission dynamics of multi-drug resistant tuberculosis amongst immune suppressed patients exposed to an infectious case
Associate Advisor
Other advisors: Honorary Professor John Upham, Professor Rachel Thomson
Completed supervision
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2024
Doctor Philosophy
Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculo sis
Principal Advisor
Other advisors: Associate Professor Timothy Wells
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2024
Doctor Philosophy
Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Tom Schultz
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2023
Doctor Philosophy
Immune functions of WNT production and signalling in the host response to infection with pathogenic E. coli.
Principal Advisor
Other advisors: Associate Professor Timothy Wells, Dr Janin Chandra
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2023
Doctor Philosophy
Bacteria-induced WNT responses and their role in infection-associated inflammation
Principal Advisor
Other advisors: Associate Professor Jeremy Cohen
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2023
Doctor Philosophy
Innate immune mechanisms that shape inflammatory and antimicrobial responses during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet
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2019
Doctor Philosophy
Investigation of Wnt pathway inhibition on host cell control of Listeria monocytogenes infection
Principal Advisor
Other advisors: Associate Professor Jakob Begun
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2018
Doctor Philosophy
Characterisation of the molecular mechanisms of RP105-dependent macrophage activation
Principal Advisor
Other advisors: Professor Matt Sweet
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2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Principal Advisor
Other advisors: Professor Ian Frazer
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2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Principal Advisor
Other advisors: Professor Ian Frazer
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
Regulation of responses to therapeutic antibodies by macrophages derived from chronic lymphocytic leukaemia patients
Associate Advisor
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2014
Doctor Philosophy
The development of an RNAi therapy against acute respiratory viral infection
Associate Advisor
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2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Associate Advisor
Other advisors: Professor Ian Frazer
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2013
Doctor Philosophy
Dissecting the role of Mincle in the macrophage response to trehalose-6,6'-dimycolate and mycobacteria.
Associate Advisor
Media
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