
Overview
Background
Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.
Availability
- Professor Antje Blumenthal is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Basic and Applied Immunology, University of Lübeck
Research interests
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Tuberculosis
- immune response - pathogenesis - novel anti-TB drugs
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Innate Immunity
molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence
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Macrophage biology
infection and inflammation related macrophage functions
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Inflammation
molecular regulation of inflammatory responses
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Sepsis
immune responses and biomarker discovery
Works
Search Professor Antje Blumenthal’s works on UQ eSpace
2021
Journal Article
Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial
Gibbons, Kristen S., Schlapbach, Luregn J., Johnson, Kerry, Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d’Udekem, Yves, Alphonso, Nelson, Winlaw, David, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick and Schibler, Andreas (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58. doi: 10.51893/2021.1.oa4
2021
Journal Article
Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial
Gibbons, Kristen S., Schlapbach, Luregn J., Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d'Udekem, Yves, Alphonso, Nelson, Winlaw, David, Johnson, Kerry, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick and Schibler, Andreas (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58.
2021
Journal Article
Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients (Oncogene, (2020), 39, 35, (5756-5767), 10.1038/s41388-020-01394-w)
Burgess, M., Chen, Y. C.E., Mapp, S., Blumenthal, A., Mollee, P., Gill, D. and Saunders, N. A. (2021). Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients (Oncogene, (2020), 39, 35, (5756-5767), 10.1038/s41388-020-01394-w). Oncogene, 40 (6), 1203-1203. doi: 10.1038/s41388-020-01619-y
2021
Journal Article
SIRPα suppresses response to therapeutic antibodies by nurse like cells from chronic lymphocytic leukemia patients
Chen, Yu-Chen Enya, Burgess, Melinda, Mapp, Sally, Mollee, Peter, Gill, Devinder, Blumenthal, Antje and Saunders, Nicholas A. (2021). SIRPα suppresses response to therapeutic antibodies by nurse like cells from chronic lymphocytic leukemia patients. Frontiers in Immunology, 11 610523, 1-12. doi: 10.3389/fimmu.2020.610523
2021
Journal Article
Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection
Domínguez Cadena, Leslie C., Schultz, Thomas E., Zamoshnikova, Alina, Donovan, Meg L., Mathmann, Carmen D., Yu, Chien-Hsiung, Mori, Giorgia, Stow, Jennifer L and Blumenthal, Antje (2021). Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection. Immunology and Cell Biology, 99 (10), 1067-1076. doi: 10.1111/imcb.12503
2020
Journal Article
Lincolnenins A–D: isomeric bactericidal bianthracenes from Streptomyces lincolnensis
Mohamed, Osama G., Khalil, Zeinab G., Salim, Angela A., Cui, Hui, Blumenthal, Antje and Capon, Robert J. (2020). Lincolnenins A–D: isomeric bactericidal bianthracenes from Streptomyces lincolnensis. The Journal of Organic Chemistry, 86 (16) acs.joc.0c02492, 11011-11018. doi: 10.1021/acs.joc.0c02492
2020
Journal Article
Septic shock: a genomewide association study and polygenic risk score analysis
D'Urso, Shannon, Rajbhandari, Dorrilyn, Peach, Elizabeth, De Guzman, Erika, Li, Qiang, Medland, Sarah E., Gordon, Scott D., Martin, Nicholas G., Ligthart, Symen, Brown, Matthew A., Powell, Joseph, McArthur, Colin, Rhodes, Andrew, Meyer, Jason, Finfer, Simon, Myburgh, John, Blumenthal, Antje, Cohen, Jeremy, Venkatesh, Balasubramanian, Cuellar-Partida, Gabriel and Evans, David M. (2020). Septic shock: a genomewide association study and polygenic risk score analysis. Twin Research and Human Genetics, 23 (4) PII S1832427420000602, 204-213. doi: 10.1017/thg.2020.60
2020
Journal Article
HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients
Burgess, M., Chen, U. C. E., Mapp, S., Blumenthal, A., Mollee, P., Gill, D. and Saunders, N. A. (2020). HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients. Oncogene, 39 (35), 5756-5767. doi: 10.1038/s41388-020-01394-w
2020
Journal Article
Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages
Kapetanovic, Ronan, Afroz, Syeda Farhana, Ramnath, Divya, Lawrence, Grace M.E.P., Okada, Takashi, Curson, James E.B., Bruin, Jost, Fairlie, David P., Schroder, Kate, St John, Justin C., Blumenthal, Antje and Sweet, Matthew J. (2020). Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology and Cell Biology, 98 (7) imcb.12363, 528-539. doi: 10.1111/imcb.12363
2020
Journal Article
Editorial: Wnt signaling in immune cell regulation during microbial infection and cancer
Blumenthal, Antje, Martin-Orozco, Elena, McBride, Jere W., Carson, Dennis A. and Sen, Malini (2020). Editorial: Wnt signaling in immune cell regulation during microbial infection and cancer. Frontiers in Immunology, 11 1133, 1133. doi: 10.3389/fimmu.2020.01133
2020
Conference Publication
Wntless in myeloid cells drives bleomycin-induced lung pathology
Donovan, C., Kim, R., Gomez, H., Liu, G., Blumenthal, A. and Hansbro, P. (2020). Wntless in myeloid cells drives bleomycin-induced lung pathology. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC Australia, 27-31 March 2020. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777
2020
Journal Article
Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2
Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007
2019
Journal Article
Functions of the WNT signaling network in shaping host responses to infection
Ljungberg, Johanna K., Kling, Jessica C., Tran, Thao Thanh and Blumenthal, Antje (2019). Functions of the WNT signaling network in shaping host responses to infection. Frontiers in Immunology, 10 2521, 2521. doi: 10.3389/fimmu.2019.02521
2019
Journal Article
Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial
Schlapbach, Luregn J., Horton, Stephen Brian, Long, Debbie Amanda, Beca, John, Erickson, Simon, Festa, Marino, d’Udekem, Yves, Alphonso, Nelson, Winlaw, David, Johnson, Kerry, Delzoppo, Carmel, van Loon, Kim, Gannon, B., Fooken, Jonas, Blumenthal, Antje, Young, Paul, Jones, Mark, Butt, Warwick and Schibler, Andreas (2019). Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial. BMJ Open, 9 (8) e026664, e026664. doi: 10.1136/bmjopen-2018-026664
2019
Journal Article
Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular
Khalil, Zeinab G., Hill, Timothy A., De Leon Rodriguez, Luis M., Lohman, Rink-Jan, Hoang, Huy N., Reiling, Norbert, Hillemann, Doris, Brimble, Margaret A., Fairlie, David, Blumenthal, Antje and Capon, Robert J. (2019). Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular. Antimicrobial Agents and Chemotherapy, 63 (3) e01773-18. doi: 10.1128/AAC.01773-18
2019
Journal Article
PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia
Enya Chen, Yu-Chen, Burgess, Melinda, Mapp, Sally, Mollee, Peter, Gill, Devinder, Blumenthal, Antje and Saunders, Nicholas A. (2019). PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia. Leukemia, 34 (2), 451-461. doi: 10.1038/s41375-019-0556-z
2018
Journal Article
Temporal regulation of natural Killer T cell interferon gamma responses by beta-catenin-dependent and -independent Wnt signaling
Kling, Jessica C., Jordan, Margaret A., Pitt, Lauren A., Meiners, Jana, Thanh-Tran, Thao , Tran, Le Son , Nguyen, Tam T. K., Mittal, Deepak, Villani, Rehan, Steptoe, Raymond J., Khosrotehrani, Kiarash, Berzins, Stuart P., Baxter, Alan G., Godfrey, Dale I. and Blumenthal, Antje (2018). Temporal regulation of natural Killer T cell interferon gamma responses by beta-catenin-dependent and -independent Wnt signaling. Frontiers in Immunology, 9 (MAR) 483, 483. doi: 10.3389/fimmu.2018.00483
2018
Journal Article
Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
Chamoun, Michelle N., Blumenthal, Antje, Sullivan, Matthew J., Schembri, Mark A. and Ulett, Glen C. (2018). Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology, 44 (4), 1-22. doi: 10.1080/1040841X.2018.1426556
2018
Journal Article
The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties
Schultz, Thomas E., Wiesmüller, Karl-Heinz, Lucas, Megan, Dobos, Karen M., Baxter, Alan G. and Blumenthal, Antje (2018). The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties. Journal of Leukocyte Biology, 103 (2), 311-319. doi: 10.1002/JLB.2MA0517-190RR
2018
Conference Publication
Activation of Fc Gamma Receptor-Dependent Responses to Therapeutic Antibodies By Nurse like Cells Requires PI3Kdelta
Chen, Yu-Chen Enya, Burgess, Melinda Lea, Blumenthal, Antje, Mapp, Sally, Mollee, Peter, Gill, Devinder and Saunders, Nicholas Andrew (2018). Activation of Fc Gamma Receptor-Dependent Responses to Therapeutic Antibodies By Nurse like Cells Requires PI3Kdelta. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-109719
Funding
Current funding
Past funding
Supervision
Availability
- Professor Antje Blumenthal is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Mapping cellular signalling pathways in mycobacteria-infected macrophages
Principal Advisor
Other advisors: Dr Tom Schultz, Dr Carmen Mathmann
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Doctor Philosophy
Molecular regulators of macrophage functions during Mycobacterium tuberculosis infection
Principal Advisor
Other advisors: Dr Carmen Mathmann
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Doctor Philosophy
Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculosis
Principal Advisor
Other advisors: Associate Professor Timothy Wells
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Doctor Philosophy
Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Tom Schultz
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Doctor Philosophy
Impact of nitric oxide on inflammation and coagulation in patients undergoing extracorporeal membrane oxygenation (ECMO)
Principal Advisor
Other advisors: Dr Craig McBride
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Doctor Philosophy
Microbiome-host-interactions in Mycobacterium tuberculosis infection
Principal Advisor
Other advisors: Professor Mark Morrison
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Doctor Philosophy
The Gut-Lung axis in Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Rachel Thomson
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Doctor Philosophy
Transmission dynamics of multi-drug resistant tuberculosis amongst immune suppressed patients exposed to an infectious case
Associate Advisor
Other advisors: Honorary Professor John Upham, Professor Rachel Thomson
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Master Philosophy
The gut-lung axis in nontuberculous mycobacterial pulmonary disease.
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Rachel Thomson
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Master Philosophy
The gut-lung axis in nontuberculous mycobacterial pulmonary disease.
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Rachel Thomson
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Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor David Hume, Dr Katharine Irvine
Completed supervision
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2024
Doctor Philosophy
Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculo sis
Principal Advisor
Other advisors: Associate Professor Timothy Wells
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2024
Doctor Philosophy
Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Tom Schultz
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2023
Doctor Philosophy
Immune functions of WNT production and signalling in the host response to infection with pathogenic E. coli.
Principal Advisor
Other advisors: Associate Professor Timothy Wells, Dr Janin Chandra
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2023
Doctor Philosophy
Bacteria-induced WNT responses and their role in infection-associated inflammation
Principal Advisor
Other advisors: Associate Professor Jeremy Cohen
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2023
Doctor Philosophy
Innate immune mechanisms that shape inflammatory and antimicrobial responses during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet
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2019
Doctor Philosophy
Investigation of Wnt pathway inhibition on host cell control of Listeria monocytogenes infection
Principal Advisor
Other advisors: Associate Professor Jakob Begun
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2018
Doctor Philosophy
Characterisation of the molecular mechanisms of RP105-dependent macrophage activation
Principal Advisor
Other advisors: Professor Matt Sweet
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2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Principal Advisor
Other advisors: Professor Ian Frazer
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2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Principal Advisor
Other advisors: Professor Ian Frazer
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
Regulation of responses to therapeutic antibodies by macrophages derived from chronic lymphocytic leukaemia patients
Associate Advisor
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2014
Doctor Philosophy
The development of an RNAi therapy against acute respiratory viral infection
Associate Advisor
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2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Associate Advisor
Other advisors: Professor Ian Frazer
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2013
Doctor Philosophy
Dissecting the role of Mincle in the macrophage response to trehalose-6,6'-dimycolate and mycobacteria.
Associate Advisor
Media
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