Overview
Background
Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.
Availability
- Professor Antje Blumenthal is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy of Basic and Applied Immunology, University of Lübeck
Research interests
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Tuberculosis
- immune response - pathogenesis - novel anti-TB drugs
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Innate Immunity
molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence
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Macrophage biology
infection and inflammation related macrophage functions
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Inflammation
molecular regulation of inflammatory responses
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Sepsis
immune responses and biomarker discovery
Works
Search Professor Antje Blumenthal’s works on UQ eSpace
2016
Journal Article
Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity
Cohen, Jeremy, Pretorius, Carel J., Ungerer, Jacobus P. J., Cardinal, John, Blumenthal, Antje, Presneill, Jeff, Gatica-Andrades, Marcela, Jarrett, Paul, Lassig-Smith, Melissa, Stuart, Janine, Dunlop, Rachel, Starr, Therese and Venkatesh, Bala (2016). Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity. Critical Care Medicine, 44 (6), 1034-1041. doi: 10.1097/CCM.0000000000001633
2016
Conference Publication
Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide
Kling, J., Meiners, J. and Blumenthal, A. (2016). Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200
2016
Journal Article
The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression
Ariffin, Juliana K., Kapetanovic, Ronan, Schaale, Kolja, Gatica-Andrades, Marcela, Blumenthal, Antje, Schroder, Kate and Sweet, Matthew J. (2016). The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology, 100 (1), 155-161. doi: 10.1189/jlb.2AB0815-339R
2016
Conference Publication
An inhibitor of Wnt protein production improves host control of Listeria monocytogenes
Tran, T. T., Andrades, M. G., Nguyen, T. T. K., Wyer, O., Kling, J. C., Begun, J. and Blumenthal, A. (2016). An inhibitor of Wnt protein production improves host control of Listeria monocytogenes. ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200
2015
Journal Article
Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis
Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2015). Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 11 (12) e1005336. doi: 10.1371/journal.ppat.1005336
2015
Journal Article
Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury
Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 (19) 19, 19. doi: 10.1186/s13069-015-0036-7
2015
Journal Article
RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection
Yu, Chien-Hsiung, Micaroni, Massimo, Puyskens, Andreas, Schultz, Thomas E., Yeo, Jeremy Changyu, Stanley, Amanda C., Lucas, Megan, Kurihara, Jade, Dobos, Karen M., Stow, Jennifer L. and Blumenthal, Antje (2015). RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection. Journal of Immunology, 195 (8), 3890-3900. doi: 10.4049/jimmunol.1500017
2015
Journal Article
Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.
Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje and Capon, Robert J. (2015). Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.. Journal of Natural Products, 78 (4), 949-952. doi: 10.1021/acs.jnatprod.5b00095
2015
Conference Publication
Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway
Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, 27 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_9
2015
Journal Article
Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation
Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032
2015
Conference Publication
Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation
Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/jgh.13087
2015
Conference Publication
IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway
Ullah, M. A., Revez, J., Loh, Z., Simpson, J., Zhang,, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. A. and Phipps, S. (2015). IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway. Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Barcelona, Spain, 6-10 June 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
2015
Conference Publication
Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury
Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, Nov 13-17, 2015. Hoboken, United States: John Wiley & Sons.
2014
Journal Article
Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014)
Gaur, R. L., Ren, K., Blumenthal, A., Bhamidi, S., Gibbs, S., Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014). Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014). Plos Pathogens, 10 (10). doi: 10.1371/journal.ppat.1004489
2014
Journal Article
Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces
Khalil, Zeinab G., Salim, Angela A., Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2014). Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. Organic Letters, 16 (19), 5120-5123. doi: 10.1021/ol502472c
2014
Journal Article
IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia
Gosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014). IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 (5), 2248-2257. doi: 10.4049/jimmunol.1400216
2014
Journal Article
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis
Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014). LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 10 (9), e1004376.1-e1004376.14. doi: 10.1371/journal.ppat.1004376
2014
Journal Article
Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation
Inder, Kerry L., Ruelcke, Jayde E., Petelin, Lara, Moon, Hyeongsun, Choi, Eunju, Rae, James, Blumenthal, Antje, Hutmacher, Dietmar, Saunders, Nicholas A., Stow, Jennifer L., Parton, Robert G. and Hill, Michelle M. (2014). Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of Extracellular Vesicles, 3 (1) 23784, 23784.1-23784.14. doi: 10.3402/jev.v3.23784
2014
Journal Article
IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin
Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R. and Blumenthal, Antje (2014). IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin. Journal of Investigative Dermatology, 134 (10), 2562-2569. doi: 10.1038/jid.2014.201
2014
Journal Article
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection
Trujillo, Carolina, Blumenthal, Antje, Marrero, Joeli, Rhee, Kyu Y., Schnappinger, Dirk and Ehrt, Sabine (2014). Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. mBio, 5 (2) e00085-14, e00085-14.1-e00085-14.12. doi: 10.1128/mBio.00085-14
Funding
Current funding
Past funding
Supervision
Availability
- Professor Antje Blumenthal is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Mapping cellular signalling pathways in mycobacteria-infected macrophages
Principal Advisor
Other advisors: Dr Tom Schultz, Dr Carmen Mathmann
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Doctor Philosophy
Molecular regulators of macrophage functions during Mycobacterium tuberculosis infection
Principal Advisor
Other advisors: Dr Carmen Mathmann
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Doctor Philosophy
Impact of nitric oxide on inflammation and coagulation in patients undergoing extracorporeal membrane oxygenation (ECMO)
Principal Advisor
Other advisors: Professor Craig McBride
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Doctor Philosophy
The Gut-Lung axis in Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Rachel Thomson
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Doctor Philosophy
Transmission dynamics of multi-drug resistant tuberculosis amongst immune suppressed patients exposed to an infectious case
Associate Advisor
Other advisors: Honorary Professor John Upham, Professor Rachel Thomson
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Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor David Hume, Dr Katharine Irvine
Completed supervision
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2024
Doctor Philosophy
Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculo sis
Principal Advisor
Other advisors: Associate Professor Timothy Wells
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2024
Doctor Philosophy
Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Tom Schultz
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2023
Doctor Philosophy
Immune functions of WNT production and signalling in the host response to infection with pathogenic E. coli.
Principal Advisor
Other advisors: Associate Professor Timothy Wells, Dr Janin Chandra
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2023
Doctor Philosophy
Innate immune mechanisms that shape inflammatory and antimicrobial responses during mycobacterial infection
Principal Advisor
Other advisors: Professor Matt Sweet
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2023
Doctor Philosophy
Bacteria-induced WNT responses and their role in infection-associated inflammation
Principal Advisor
Other advisors: Associate Professor Jeremy Cohen
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2019
Doctor Philosophy
Investigation of Wnt pathway inhibition on host cell control of Listeria monocytogenes infection
Principal Advisor
Other advisors: Associate Professor Jakob Begun
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2018
Doctor Philosophy
Characterisation of the molecular mechanisms of RP105-dependent macrophage activation
Principal Advisor
Other advisors: Professor Matt Sweet
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2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Principal Advisor
Other advisors: Emeritus Professor Ian Frazer
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2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Principal Advisor
Other advisors: Emeritus Professor Ian Frazer
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2023
Doctor Philosophy
Deciphering the Influence of Macrophages on Endothelial Progenitors
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Simranpreet Kaur, Professor Kiarash Khosrotehrani
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2020
Doctor Philosophy
Regulation of responses to therapeutic antibodies by macrophages derived from chronic lymphocytic leukaemia patients
Associate Advisor
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2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Associate Advisor
Other advisors: Emeritus Professor Ian Frazer
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2014
Doctor Philosophy
The development of an RNAi therapy against acute respiratory viral infection
Associate Advisor
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2013
Doctor Philosophy
Dissecting the role of Mincle in the macrophage response to trehalose-6,6'-dimycolate and mycobacteria.
Associate Advisor
Media
Enquiries
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