Professor Antje Blumenthal
Professor

Antje Blumenthal

Email: 
Phone: 
+61 7 344 36984

Background

Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.

Availability

Professor Antje Blumenthal is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Immunology Infectious diseases Innate immunity Medical microbiology Signal transduction

Qualifications

  • Doctor of Philosophy of Basic and Applied Immunology, University of Lübeck

Research interests

  • Tuberculosis

    - immune response - pathogenesis - novel anti-TB drugs

  • Innate Immunity

    molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence

  • Macrophage biology

    infection and inflammation related macrophage functions

  • Inflammation

    molecular regulation of inflammatory responses

  • Sepsis

    immune responses and biomarker discovery

Search Professor Antje Blumenthal’s works on UQ eSpace

92 works between 2000 and 2025
All (92) Journal Article (78) Conference Publication (13) Other Outputs (1)

61 - 80 of 92 works

2015

Conference Publication

IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway

Ullah, M. A., Revez, J., Loh, Z., Simpson, J., Zhang,, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. A. and Phipps, S. (2015). IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway. Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Barcelona, Spain, 6-10 June 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway

2015

Conference Publication

Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, Nov 13-17, 2015. Hoboken, United States: John Wiley & Sons.

Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury

2014

Journal Article

Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014)

Gaur, R. L., Ren, K., Blumenthal, A., Bhamidi, S., Gibbs, S., Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014). Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014). Plos Pathogens, 10 (10). doi: 10.1371/journal.ppat.1004489

Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014)

2014

Journal Article

Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces

Khalil, Zeinab G., Salim, Angela A., Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2014). Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. Organic Letters, 16 (19), 5120-5123. doi: 10.1021/ol502472c

Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces

2014

Journal Article

IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia

Gosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014). IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 (5), 2248-2257. doi: 10.4049/jimmunol.1400216

IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia

2014

Journal Article

LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis

Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014). LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 10 (9), e1004376.1-e1004376.14. doi: 10.1371/journal.ppat.1004376

LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis

2014

Journal Article

Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

Inder, Kerry L., Ruelcke, Jayde E., Petelin, Lara, Moon, Hyeongsun, Choi, Eunju, Rae, James, Blumenthal, Antje, Hutmacher, Dietmar, Saunders, Nicholas A., Stow, Jennifer L., Parton, Robert G. and Hill, Michelle M. (2014). Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of Extracellular Vesicles, 3 (1) 23784, 23784.1-23784.14. doi: 10.3402/jev.v3.23784

Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

2014

Journal Article

IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin

Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R. and Blumenthal, Antje (2014). IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin. Journal of Investigative Dermatology, 134 (10), 2562-2569. doi: 10.1038/jid.2014.201

IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin

2014

Journal Article

Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection

Trujillo, Carolina, Blumenthal, Antje, Marrero, Joeli, Rhee, Kyu Y., Schnappinger, Dirk and Ehrt, Sabine (2014). Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. mBio, 5 (2) e00085-14, e00085-14.1-e00085-14.12. doi: 10.1128/mBio.00085-14

Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection

2014

Journal Article

Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Raju, Ritesh, Khalil, Zeinab G., Piggott, Andrew M., Blumenthal, Antje, Gardiner, Donald L., Skinner-Adams, Tina S. and Capon, Robert J. (2014). Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244). Organic Letters, 16 (6), 1716-1719. doi: 10.1021/ol5003913

Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

2014

Journal Article

A promoter-level mammalian expression atlas

Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab ... Hayashizaki, Yoshihide (2014). A promoter-level mammalian expression atlas. Nature, 507 (7493), 462-470. doi: 10.1038/nature13182

A promoter-level mammalian expression atlas

2014

Conference Publication

Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo

Gatica-Andrades, M. D., Nguyen, T. T. K., Schultz, T. E., Wyer, O. J. K., Melo-Bolivar, J., Walker, M. J., Frazer, I. H., Barnett, T. C. and Blumenthal, A. (2014). Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo. British Society for Immunology Annual Congress 2014, Brighton, United Kingdom, 1-4 December 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12406

Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo

2014

Journal Article

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4

Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4

2013

Journal Article

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

2013

Journal Article

Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA

McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje and McMillan, Nigel A. J. (2013). Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Molecular Therapy - Nucleic Acid, 2 (1) e96, e96. doi: 10.1038/mtna.2013.22

Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA

2012

Journal Article

Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer

Skalamera, Dubravka, Dahmer, Mareike, Purdon, Amy S., Wilson, Benjamin M., Ranall, Max V., Blumenthal, Antje, Gabrielli, Brian and Gonda, Thomas J. (2012). Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer. PloS One, 7 (12) e51733, e51733.1-e51733.15. doi: 10.1371/journal.pone.0051733

Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer

2012

Journal Article

M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection

Blumenthal, Antje, Nagalingam, Gayathri, Huch, Jennifer H., Walker, Lara, Guillemin, Gilles J., Smythe, George A., Ehrt, Sabine, Britton, Warwick J. and Saunders, Bernadette M. (2012). M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PloS One, 7 (5) e37314, e37314.1-e37314.11. doi: 10.1371/journal.pone.0037314

M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection

2011

Journal Article

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

Park, Sae Woong, Klotzsche, Marcus, Wilson, Daniel J., Boshoff, Helena I., Eoh, Hyungjin, Manjunatha, Ujjini, Blumenthal, Antje, Rhee, Kyu, Barry III, Clifton E., Aldrich, Courtney C., Ehrt, Sabine and Schnappinger, Dirk (2011). Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathogens, 7 (9) e1002264, e1002264.1-e1002264.10. doi: 10.1371/journal.ppat.1002264

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression

2010

Journal Article

Simultaneous analysis of multiple mycobacterium tuberculosis knockdown mutants in vitro and in vivo

Blumenthal, Antje, Trujillo, Carolina, Ehrt, Sabine and Schnappinger, Dirk (2010). Simultaneous analysis of multiple mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS One, 5 (12) e15667, e15667-1-e15667-12. doi: 10.1371/journal.pone.0015667

Simultaneous analysis of multiple mycobacterium tuberculosis knockdown mutants in vitro and in vivo

2010

Journal Article

Induction of ER stress in macrophages of tuberculosis granulomas

Seimon, Tracie A., Kim, Mi-Jeong, Blumenthal, Antje, Koo, Jovanka, Ehrt, Sabine, Wainwright, Helen, Bekker, Linda-Gail, Kaplan, Gilla, Nathan, Carl, Tabas, Ira and Russell, David G. (2010). Induction of ER stress in macrophages of tuberculosis granulomas. PLoS One, 5 (9) e12772, e12772.1-e12772.12. doi: 10.1371/journal.pone.0012772

Induction of ER stress in macrophages of tuberculosis granulomas

Current funding

  • 2025 - 2028
    Preclinical validation of anti-tubercular conjugated oligoelectrolytes
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2026
    Improving tuberculosis diagnosis and care through functional immune screening
    TRI Leading Innovations through New Collaborations Scheme
    Open grant
  • 2024 - 2027
    Molecular drivers of metabolic reprogramming in Mycobacterium tuberculosis infection
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2026
    New Frontiers in Innate Immunity
    ARC Future Fellowships
    Open grant
  • 2022 - 2025
    Defining host immune and microbial determinants of disease trajectory in mycobacterial infection
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2025
    Host Gene Expression Signatures to Diagnose Sepsis in Children
    MRFF Genomics Health Futures Mission, Project Grant administered by AusIndustry
    Open grant

Past funding

  • 2022 - 2023
    Molecular regulators of inflammation
    The American Association of Immunologists Careers in Immunology Fellowship
    Open grant
  • 2022 - 2024
    Can blood RNA signatures improve the diagnosis of latent tuberculosis in solid organ transplant recipients? (2022 MSHRSS Co-funded Collaboration Grant led by MSH)
    Metro South Hospital and Health Service
    Open grant
  • 2021
    Controlling the enemy within: What makes macrophages restrict or promote Mycobacterium tuberculosis growth in vivo
    GeoMx Whole Transcriptome Atlas Neuroscience Grant
    Open grant
  • 2021 - 2024
    Diagnostic utility of tests of latent tuberculosis in immune compromised contacts exposed to multi-drug resistant tuberculosis (2021 Metro South SERTA Novice Researcher Grant administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Enhancing host defence to combat bacterial infections (2020 Georgina Sweet Award)
    Georgina Sweet Award for Women in Quantitative Biomedical Science
    Open grant
  • 2020 - 2023
    Molecular regulators of inflammation during Gram-negative bacterial infection
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2022
    Nitric Oxide to improve recovery and survival in neonates and children on Extracorporeal Life Support - a pilot randomized controlled trial (the NECTAR trial)
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    Vascular responsiveness in septic shock (NHMRC Project Grant led by UNSW)
    University of New South Wales
    Open grant
  • 2018 - 2020
    RAPIDS TRIAL: Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis
    Gold Coast Hospital and Health Services
    Open grant
  • 2018 - 2023
    Preclinical Validation of a Novel Drug Lead to Treat Tuberculosis
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2018 - 2020
    Enhancing host defence mechanisms in severe bacterial infections
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Nitric Oxide on Cardio Pulmonary Bypass in Congenital Heart Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Reducing morbidity and mortality in infants and children after cardiopulmonary bypass - a multicenter randomized controlled trial
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    Innate immune signalling in Mycobacterium tuberculosis infection
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Developing new antibiotics to treat tuberculosis
    Australian Tropical Medicine Commercialisation Programme
    Open grant
  • 2016 - 2019
    Cellular regulation of receptor signalling and cytokine responses
    NHMRC Project Grant
    Open grant
  • 2016
    Establishing a gnotobiotic germ-free mouse facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    The Australian human microbiota project-microbe isolation facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2017
    Towards biomarkers for patient stratification in sepsis
    TRI Spore Grants
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    Multiplex High Throughput Bio-plex Protein Assay Platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    Targeting the Wnt Pathway: Implication for Chronic Liver disease
    PA Research Foundation
    Open grant
  • 2013 - 2014
    ResTeach 2013 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2013 - 2016
    RP105 is a new innate immune receptor for Mycobacterium tuberculosis
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Immune modulation by Wnt/B-Catenin signalling during bacterial infection
    UQ Early Career Researcher
    Open grant
  • 2011
    Laser Scanner for Biomolecular Imaging
    NHMRC Equipment Grant
    Open grant

Availability

Professor Antje Blumenthal is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Mapping cellular signalling pathways in mycobacteria-infected macrophages

    Principal Advisor

    Other advisors: Dr Tom Schultz, Dr Carmen Mathmann

  • Doctor Philosophy

    Molecular regulators of macrophage functions during Mycobacterium tuberculosis infection

    Principal Advisor

    Other advisors: Dr Carmen Mathmann

  • Doctor Philosophy

    Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculosis

    Principal Advisor

    Other advisors: Associate Professor Timothy Wells

  • Doctor Philosophy

    Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection

    Principal Advisor

    Other advisors: Professor Matt Sweet, Dr Tom Schultz

  • Doctor Philosophy

    Impact of nitric oxide on inflammation and coagulation in patients undergoing extracorporeal membrane oxygenation (ECMO)

    Principal Advisor

    Other advisors: Dr Craig McBride

  • Doctor Philosophy

    Microbiome-host-interactions in Mycobacterium tuberculosis infection

    Principal Advisor

    Other advisors: Professor Mark Morrison

  • Doctor Philosophy

    Transmission dynamics of multi-drug resistant tuberculosis amongst immune suppressed patients exposed to an infectious case

    Associate Advisor

    Other advisors: Honorary Professor John Upham, Professor Rachel Thomson

  • Master Philosophy

    The gut-lung axis in nontuberculous mycobacterial pulmonary disease.

    Associate Advisor

    Other advisors: Professor Mark Morrison, Professor Rachel Thomson

  • Master Philosophy

    The gut-lung axis in nontuberculous mycobacterial pulmonary disease.

    Associate Advisor

    Other advisors: Professor Mark Morrison, Professor Rachel Thomson

  • Doctor Philosophy

    Functions of CSF1R signalling in inflammation.

    Associate Advisor

    Other advisors: Professor David Hume, Dr Katharine Irvine

Completed supervision

Enquiries

Contact Professor Antje Blumenthal directly for media enquiries about their areas of expertise.

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au