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2024

Journal Article

Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial

Walsham, James, Hammond, Naomi, Blumenthal, Antje, Cohen, Jeremy, Myburgh, John, Finfer, Simon, Evans, David, Peake, Sandra, Kruger, Peter, McCullough, James, Johnk, Loki, Ghelani, Dhaval, Billot, Laurent, Shan, Sana, Meyer, Jason, Rajbhandari, Dorrilyn, Koch, Carolyn, Bellomo, Rinaldo, Burrell, Louise M., Young, Morag, Roberts, Michael, Mackenzie, Lorraine, Medley, Gregory, Dalton, Joshua and Venkatesh, Balasubramanian (2024). Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial. Intensive Care Medicine, 50 (12), 2050-2060. doi: 10.1007/s00134-024-07616-z

Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial

2024

Journal Article

Myddosomes in Toll-like receptor signaling-one to bind and rule them all

Mathmann, Carmen D., Schultz, Thomas E., Cadena, Leslie C. Dominguez and Blumenthal, Antje (2024). Myddosomes in Toll-like receptor signaling-one to bind and rule them all. Immunology and Cell Biology, 102 (9), 752-756. doi: 10.1111/imcb.12816

Myddosomes in Toll-like receptor signaling-one to bind and rule them all

2024

Journal Article

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

Schlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

2024

Journal Article

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

2023

Journal Article

Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis

Rollo, Rachel F., Mori, Giorgia, Hill, Timothy A., Hillemann, Doris, Niemann, Stefan, Homolka, Susanne, Fairlie, David P. and Blumenthal, Antje (2023). Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis. Microbiology Spectrum, 11 (4). doi: 10.1128/spectrum.00465-23

Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis

2023

Conference Publication

1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling

Sim, S., Kaur, S., Styke, C., Millard, S., Blumenthal, A., Pettit, A. and Khosrotehrani, K. (2023). 1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1528

1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling

2023

Conference Publication

Spatiotemporal regulation of rp105 subcellular localization shapes endosomal TLR4 signaling

Mathmann, Carmen, Schultz, Thomas, Ongtengco, Cherica Felize J., Dalton, Emma, Domínguez Cadena, Leslie C., Zamoshnikova, Alina, Stow, Jennifer L. and Blumenthal, Antje (2023). Spatiotemporal regulation of rp105 subcellular localization shapes endosomal TLR4 signaling. IMMUNOLOGY 2023 Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.160.06

Spatiotemporal regulation of rp105 subcellular localization shapes endosomal TLR4 signaling

2023

Journal Article

Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial

Mattke, Adrian, Johnson, Kerry, Gibbons, Kristen, Long, Debbie, Robertson, Jeremy, Venugopal, Prem, Blumenthal, Antje, Schibler, Andreas and Schlapbach, Luregn (2023). Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial. JMIR Research Protocols, 12 e43760, 1-10. doi: 10.2196/43760

Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial

2023

Journal Article

Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes

Enosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan and Man, Si Ming (2023). Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes. The EMBO Journal, 42 (6) e112558, e112558. doi: 10.15252/embj.2022112558

Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes

2022

Journal Article

Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis

Donovan, Meg L., Bielefeldt‐Ohmann, Helle, Rollo, Rachel F., McPherson, Stephen, Schultz, Thomas E., Mori, Giorgia, Kling, Jessica C. and Blumenthal, Antje (2022). Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis. Immunology, 169 (1), 13-26. doi: 10.1111/imm.13606

Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis

2022

Journal Article

Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration

Sim, Seen Ling, Blumenthal, Antje, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration. Frontiers in Endocrinology, 13 957833, 957833. doi: 10.3389/fendo.2022.957833

Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration

2022

Journal Article

The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms

Ramnath, Divya, Das Gupta, Kaustav, Wang, Yizhuo, Abrol, Rishika, Curson, James E. B., Lim, Junxian, Reid, Robert C., Mansell, Ashley, Blumenthal, Antje, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2022). The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111 (2), 327-336. doi: 10.1002/jlb.2mr1021-260r

The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms

2022

Journal Article

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

Wilson, Alicia S., Randall, Katrina L., Pettitt, Jessica A., Ellyard, Julia I., Blumenthal, Antje, Enders, Anselm, Quah, Benjamin J., Bopp, Tobias, Parish, Christopher R. and Brüstle, Anne (2022). Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2. Nature Communications, 13 (1) 528, 528. doi: 10.1038/s41467-022-28172-4

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

2022

Journal Article

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

2021

Journal Article

Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective

Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823

Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective

2021

Journal Article

The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock

Cohen, Jeremy, Blumenthal, Antje, Cuellar-Partida, Gabriel, Evans, David M., Finfer, Simon, Li, Qiang, Ljungberg, Johanna, Myburgh, John, Peach, Elizabeth, Powell, Joseph, Rajbhandari, Dorrilyn, Rhodes, Andrew, Senabouth, Anne and Venkatesh, Balasubramanian (2021). The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock. Intensive Care Medicine, 47 (9), 974-983. doi: 10.1007/s00134-021-06464-5

The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock

2021

Journal Article

Microbiome-immune interactions in tuberculosis

Mori, Giorgia, Morrison, Mark and Blumenthal, Antje (2021). Microbiome-immune interactions in tuberculosis. PLoS Pathogens, 17 (4) e1009377, e1009377. doi: 10.1371/journal.ppat.1009377

Microbiome-immune interactions in tuberculosis

2021

Journal Article

Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

Gibbons, Kristen S., Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, Schlapbach, Luregn J., Johnson, Kerry, Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d’Udekem, Yves, Alphonso, Nelson, Winlaw, David, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick, Schibler, Andreas, Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, Paediatric Intensive Care Unit, Queensland Children’s Hospital, Children’s Health Queensland, Brisbane, Queensland, Australia, Department of Intensive Care Medicine and Neonatology, and Children’s Research Center, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland, Cardiac Surgical Unit, Royal Children’s Hospital, Melbourne, Victoria, Australia, Faculty of Medicine, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia, Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, Paediatric Intensive Care Unit, Queensland Children’s Hospital, Children’s Health Queensland, Brisbane, Queensland, Australia, Paediatric Intensive Care Unit, Starship Children’s Hospital, Auckland, New Zealand ... Paediatric Intensive Care Unit, Queensland Children’s Hospital, Children’s Health Queensland, Brisbane, Queensland, Australia (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58. doi: 10.51893/2021.1.oa4

Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

2021

Journal Article

Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

Gibbons, Kristen S., Schlapbach, Luregn J., Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d'Udekem, Yves, Alphonso, Nelson, Winlaw, David, Johnson, Kerry, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick and Schibler, Andreas (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58.

Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

2021

Journal Article

Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients (Oncogene, (2020), 39, 35, (5756-5767), 10.1038/s41388-020-01394-w)

Burgess, M., Chen, Y. C.E., Mapp, S., Blumenthal, A., Mollee, P., Gill, D. and Saunders, N. A. (2021). Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients (Oncogene, (2020), 39, 35, (5756-5767), 10.1038/s41388-020-01394-w). Oncogene, 40 (6), 1203-1203. doi: 10.1038/s41388-020-01619-y

Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients (Oncogene, (2020), 39, 35, (5756-5767), 10.1038/s41388-020-01394-w)