Professor Antje Blumenthal
Professor

Antje Blumenthal

Email: 
Phone: 
+61 7 344 36984

Background

Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.

Availability

Professor Antje Blumenthal is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Immunology Infectious diseases Innate immunity Medical microbiology Signal transduction

Qualifications

  • Doctor of Philosophy of Basic and Applied Immunology, University of Lübeck

Research interests

  • Tuberculosis

    - immune response - pathogenesis - novel anti-TB drugs

  • Innate Immunity

    molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence

  • Macrophage biology

    infection and inflammation related macrophage functions

  • Inflammation

    molecular regulation of inflammatory responses

  • Sepsis

    immune responses and biomarker discovery

Search Professor Antje Blumenthal’s works on UQ eSpace

92 works between 2000 and 2025
All (92) Journal Article (78) Conference Publication (13) Other Outputs (1)

41 - 60 of 92 works

2017

Journal Article

Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494

Khalil, Zeinab G., Salim, Angela A., Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2017). Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494. The Journal of Antibiotics, 70 (12), 1097-1103. doi: 10.1038/ja.2017.119

Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494

2017

Journal Article

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112

FANTOM5 CAGE profiles of human and mouse samples

2017

Journal Article

The duality of macrophage function in Chronic Lymphocytic Leukaemia

Chen, Y. C. E., Mapp, S., Blumenthal, A., Burgess, M. L., Mazzieri, R., Mattarollo, S., Mollee, P., Gill, D. and Saunders, N. A. (2017). The duality of macrophage function in Chronic Lymphocytic Leukaemia. Biochimica et Biophysica Acta (BBA) Reviews on Cancer, 1868 (1), 176-182. doi: 10.1016/j.bbcan.2017.03.006

The duality of macrophage function in Chronic Lymphocytic Leukaemia

2017

Journal Article

WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice

Gatica-Andrades, Marcela, Vagenas, Dimitrios, Kling, Jessica, Nguyen, Tam T. K., Benham, Helen, Thomas, Ranjeny, Korner, Heinrich, Venkatesh, Bala, Cohen, Jeremy and Blumenthal, Antje (2017). WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice. Blood Advances, 1 (16), 1274-1286. doi: 10.1182/bloodadvances.2017006163

WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice

2017

Journal Article

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole K., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017). CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 (3), 837-844. doi: 10.1189/jlb.1AB0217-065R

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

2017

Journal Article

Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes

Kling, Jessica C. and Blumenthal, Antje (2017). Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes. Journal of Leukocyte Biology, 101 (4), 827-840. doi: 10.1189/jlb.1MR0616-272R

Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes

2017

Journal Article

Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors

Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J. and Stow, Jennifer L. (2017). Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors. Journal of Biological Chemistry, 292 (11), 4411-4422. doi: 10.1074/jbc.M116.766337

Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors

2017

Journal Article

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6

Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R. and Stacey, Katryn J. (2017). Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95 (5), 491-495. doi: 10.1038/icb.2017.5

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6

2017

Journal Article

The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications

Schultz, Thomas E. and Blumenthal, Antje (2017). The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications. Journal of Leukocyte Biology, 101 (1), 183-192. doi: 10.1189/jlb.2VMR1215-582R

The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications

2016

Journal Article

Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity

Cohen, Jeremy, Pretorius, Carel J., Ungerer, Jacobus P. J., Cardinal, John, Blumenthal, Antje, Presneill, Jeff, Gatica-Andrades, Marcela, Jarrett, Paul, Lassig-Smith, Melissa, Stuart, Janine, Dunlop, Rachel, Starr, Therese and Venkatesh, Bala (2016). Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity. Critical Care Medicine, 44 (6), 1034-1041. doi: 10.1097/CCM.0000000000001633

Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity

2016

Conference Publication

Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide

Kling, J., Meiners, J. and Blumenthal, A. (2016). Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide

2016

Journal Article

The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression

Ariffin, Juliana K., Kapetanovic, Ronan, Schaale, Kolja, Gatica-Andrades, Marcela, Blumenthal, Antje, Schroder, Kate and Sweet, Matthew J. (2016). The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology, 100 (1), 155-161. doi: 10.1189/jlb.2AB0815-339R

The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression

2016

Conference Publication

An inhibitor of Wnt protein production improves host control of Listeria monocytogenes

Tran, T. T., Andrades, M. G., Nguyen, T. T. K., Wyer, O., Kling, J. C., Begun, J. and Blumenthal, A. (2016). An inhibitor of Wnt protein production improves host control of Listeria monocytogenes. ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200

An inhibitor of Wnt protein production improves host control of Listeria monocytogenes

2015

Journal Article

Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis

Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2015). Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 11 (12) e1005336. doi: 10.1371/journal.ppat.1005336

Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis

2015

Journal Article

Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 (19) 19, 19. doi: 10.1186/s13069-015-0036-7

Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

2015

Journal Article

RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection

Yu, Chien-Hsiung, Micaroni, Massimo, Puyskens, Andreas, Schultz, Thomas E., Yeo, Jeremy Changyu, Stanley, Amanda C., Lucas, Megan, Kurihara, Jade, Dobos, Karen M., Stow, Jennifer L. and Blumenthal, Antje (2015). RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection. Journal of Immunology, 195 (8), 3890-3900. doi: 10.4049/jimmunol.1500017

RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection

2015

Journal Article

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje and Capon, Robert J. (2015). Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.. Journal of Natural Products, 78 (4), 949-952. doi: 10.1021/acs.jnatprod.5b00095

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

2015

Conference Publication

Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway

Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, 27 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_9

Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway

2015

Journal Article

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

2015

Conference Publication

Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation

Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/jgh.13087

Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation

Current funding

  • 2025 - 2028
    Preclinical validation of anti-tubercular conjugated oligoelectrolytes
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2026
    Improving tuberculosis diagnosis and care through functional immune screening
    TRI Leading Innovations through New Collaborations Scheme
    Open grant
  • 2024 - 2027
    Molecular drivers of metabolic reprogramming in Mycobacterium tuberculosis infection
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2026
    New Frontiers in Innate Immunity
    ARC Future Fellowships
    Open grant
  • 2022 - 2025
    Defining host immune and microbial determinants of disease trajectory in mycobacterial infection
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2025
    Host Gene Expression Signatures to Diagnose Sepsis in Children
    MRFF Genomics Health Futures Mission, Project Grant administered by AusIndustry
    Open grant

Past funding

  • 2022 - 2023
    Molecular regulators of inflammation
    The American Association of Immunologists Careers in Immunology Fellowship
    Open grant
  • 2022 - 2024
    Can blood RNA signatures improve the diagnosis of latent tuberculosis in solid organ transplant recipients? (2022 MSHRSS Co-funded Collaboration Grant led by MSH)
    Metro South Hospital and Health Service
    Open grant
  • 2021
    Controlling the enemy within: What makes macrophages restrict or promote Mycobacterium tuberculosis growth in vivo
    GeoMx Whole Transcriptome Atlas Neuroscience Grant
    Open grant
  • 2021 - 2024
    Diagnostic utility of tests of latent tuberculosis in immune compromised contacts exposed to multi-drug resistant tuberculosis (2021 Metro South SERTA Novice Researcher Grant administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Enhancing host defence to combat bacterial infections (2020 Georgina Sweet Award)
    Georgina Sweet Award for Women in Quantitative Biomedical Science
    Open grant
  • 2020 - 2023
    Molecular regulators of inflammation during Gram-negative bacterial infection
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2022
    Nitric Oxide to improve recovery and survival in neonates and children on Extracorporeal Life Support - a pilot randomized controlled trial (the NECTAR trial)
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    Vascular responsiveness in septic shock (NHMRC Project Grant led by UNSW)
    University of New South Wales
    Open grant
  • 2018 - 2020
    RAPIDS TRIAL: Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis
    Gold Coast Hospital and Health Services
    Open grant
  • 2018 - 2023
    Preclinical Validation of a Novel Drug Lead to Treat Tuberculosis
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2018 - 2020
    Enhancing host defence mechanisms in severe bacterial infections
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Nitric Oxide on Cardio Pulmonary Bypass in Congenital Heart Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Reducing morbidity and mortality in infants and children after cardiopulmonary bypass - a multicenter randomized controlled trial
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    Innate immune signalling in Mycobacterium tuberculosis infection
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Developing new antibiotics to treat tuberculosis
    Australian Tropical Medicine Commercialisation Programme
    Open grant
  • 2016 - 2019
    Cellular regulation of receptor signalling and cytokine responses
    NHMRC Project Grant
    Open grant
  • 2016
    Establishing a gnotobiotic germ-free mouse facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    The Australian human microbiota project-microbe isolation facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2017
    Towards biomarkers for patient stratification in sepsis
    TRI Spore Grants
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    Multiplex High Throughput Bio-plex Protein Assay Platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    Targeting the Wnt Pathway: Implication for Chronic Liver disease
    PA Research Foundation
    Open grant
  • 2013 - 2014
    ResTeach 2013 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2013 - 2016
    RP105 is a new innate immune receptor for Mycobacterium tuberculosis
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Immune modulation by Wnt/B-Catenin signalling during bacterial infection
    UQ Early Career Researcher
    Open grant
  • 2011
    Laser Scanner for Biomolecular Imaging
    NHMRC Equipment Grant
    Open grant

Availability

Professor Antje Blumenthal is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection

    Principal Advisor

    Other advisors: Professor Matt Sweet, Dr Tom Schultz

  • Doctor Philosophy

    Impact of nitric oxide on inflammation and coagulation in patients undergoing extracorporeal membrane oxygenation (ECMO)

    Principal Advisor

    Other advisors: Dr Craig McBride

  • Doctor Philosophy

    Microbiome-host-interactions in Mycobacterium tuberculosis infection

    Principal Advisor

    Other advisors: Professor Mark Morrison

  • Doctor Philosophy

    Mapping cellular signalling pathways in mycobacteria-infected macrophages

    Principal Advisor

    Other advisors: Dr Tom Schultz, Dr Carmen Mathmann

  • Doctor Philosophy

    Molecular regulators of macrophage functions during Mycobacterium tuberculosis infection

    Principal Advisor

    Other advisors: Dr Carmen Mathmann

  • Doctor Philosophy

    Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculosis

    Principal Advisor

    Other advisors: Associate Professor Timothy Wells

  • Doctor Philosophy

    Transmission dynamics of multi-drug resistant tuberculosis amongst immune suppressed patients exposed to an infectious case

    Associate Advisor

    Other advisors: Honorary Professor John Upham, Professor Rachel Thomson

  • Master Philosophy

    The gut-lung axis in nontuberculous mycobacterial pulmonary disease.

    Associate Advisor

    Other advisors: Professor Mark Morrison, Professor Rachel Thomson

  • Master Philosophy

    The gut-lung axis in nontuberculous mycobacterial pulmonary disease.

    Associate Advisor

    Other advisors: Professor Mark Morrison, Professor Rachel Thomson

  • Doctor Philosophy

    Functions of CSF1R signalling in inflammation.

    Associate Advisor

    Other advisors: Professor David Hume, Dr Katharine Irvine

Completed supervision

Enquiries

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