Professor Antje Blumenthal
Professor

Antje Blumenthal

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Phone: 
+61 7 344 36984

Background

Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.

Availability

Professor Antje Blumenthal is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biomedical and Clinical Sciences Clinical sciences Immunology Infectious diseases Innate immunity Medical microbiology Signal transduction

Qualifications

  • Doctor of Philosophy of Basic and Applied Immunology, University of Lübeck

Research interests

  • Tuberculosis

    - immune response - pathogenesis - novel anti-TB drugs

  • Innate Immunity

    molecular and cellular mechanisms of pathogen recognition, host cell activation and anti-microbial defence

  • Macrophage biology

    infection and inflammation related macrophage functions

  • Inflammation

    molecular regulation of inflammatory responses

  • Sepsis

    immune responses and biomarker discovery

Search Professor Antje Blumenthal’s works on UQ eSpace

92 works between 2000 and 2025
All (92) Journal Article (78) Conference Publication (13) Other Outputs (1)

81 - 92 of 92 works

2009

Journal Article

Tuberculosis and host metabolism: ancient associations, fresh insights

Blumenthal, Antje, Isovski, Flonza and Rhee, Kyu Y. (2009). Tuberculosis and host metabolism: ancient associations, fresh insights. Translational Research, 154 (1), 7-14. doi: 10.1016/j.trsl.2009.04.004

Tuberculosis and host metabolism: ancient associations, fresh insights

2009

Journal Article

RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins

Blumenthal, A., Kobayashi, Toshihiko, Pierini, Lynda M., Banaei, Niaz, Ernst, Joel D., Miyake, Kensuke and Ehrt, Sabine (2009). RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins. Cell Host and Microbe, 5 (1), 35-46. doi: 10.1016/j.chom.2008.12.002

RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins

2006

Journal Article

The wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

Blumenthal, Antje, Ehlers, Stefan, Lauber, Jörg, Buer, Jan, Lange, Christoph, Goldmann, Torsten, Heine, Holger, Brandt, Ernst and Reiling, Norbert (2006). The wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood, 108 (3), 965-973. doi: 10.1182/blood-2005-12-5046

The wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

2005

Journal Article

Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alpha beta receptor and STAT1

Shi, Shuangping, Blumenthal, Antje, Hickey, Christopher M., Gandotra, Sheetal, Levy, David and Ehrt, Sabine (2005). Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alpha beta receptor and STAT1. Journal of Immunology, 175 (5), 3318-3328. doi: 10.4049/jimmunol.175.5.3318

Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alpha beta receptor and STAT1

2005

Journal Article

Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics

Blumenthal, Antje, Lauber, Jorg, Hoffmann, Reinhard, Ernst, Martin, Keller, Christine, Buer, Jan, Ehlers, Stefan and Reiling, Norbert (2005). Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics. Infection and Immunity, 73 (6), 3330-3341. doi: 10.1128/IAI.73.6.3330-3341.2005

Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics

2004

Journal Article

Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells

Mohamed, S. A., Wesch, D., Blumenthal, A., Bruse, P., Windler, K., Ernst, M., Kabelitz, D., Oehmichen, M. and Meissner, C. (2004). Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells. Experimental Gerontology, 39 (2), 181-188. doi: 10.1016/j.exger.2003.10.011

Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells

2004

Journal Article

Resistance and susceptibility to tuberculosis analysed at the transcriptome level: Lessons from mouse macrophages

Keller, Christopher, Lauber, Joerg, Blumenthal, Antje, Buer, Jan and Ehlers, Stefan (2004). Resistance and susceptibility to tuberculosis analysed at the transcriptome level: Lessons from mouse macrophages. Tuberculosis, 84 (3-4), 144-158. doi: 10.1016/j.tube.2003.12.003

Resistance and susceptibility to tuberculosis analysed at the transcriptome level: Lessons from mouse macrophages

2003

Journal Article

Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 and characterization of its chemical and biological properties

Gronow, Sabine, Noah, Christian, Blumenthal, Antje, Lindner, Buko and Brade, Helmut (2003). Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 and characterization of its chemical and biological properties. Journal of Biological Chemistry, 278 (3), 1647-1655. doi: 10.1074/jbc.M206942200

Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 and characterization of its chemical and biological properties

2002

Journal Article

Control of mycobacterial replication in human macrophages: Roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways

Blumenthal, Antje, Ehlers, Stefan, Ernst, Martin, Flad, Hans-Dieter and Reiling, Norbert (2002). Control of mycobacterial replication in human macrophages: Roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways. Infection and Immunity, 70 (9), 4961-4967. doi: 10.1128/IAI.70.9.4961-4967.2002

Control of mycobacterial replication in human macrophages: Roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways

2001

Journal Article

Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity

Reiling, N., Blumenthal, A., Flad, H. D., Ernst, M. and Ehlers, S. (2001). Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. Journal of Immunology, 167 (6), 3339-3345. doi: 10.4049/jimmunol.167.6.3339

Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity

2000

Conference Publication

Infection of human monocyte-derived macrophages with Mycobacterium avium: MAP kinase activation is inversely correlated to bacterial survival in vitro

Blumenthal, A., Ehlers, S., Ernst, M., Flad, H.-D. and Reiling, N. (2000). Infection of human monocyte-derived macrophages with Mycobacterium avium: MAP kinase activation is inversely correlated to bacterial survival in vitro. Joint Annual Meeting of the German and Dutch Societies of Immunology, Duseldorf, Germany, 29 November - 02 December 2000. Jena, Germany: Urban und Fischer Verlag.

Infection of human monocyte-derived macrophages with Mycobacterium avium: MAP kinase activation is inversely correlated to bacterial survival in vitro

2000

Conference Publication

Mycobacteria-induced TNF and IL-10 formation by human macrophages: the role of MAP kinases

Reiling, N., Blumenthal, A., Flad, H.-D., Ernst, M. and Ehlers, S. (2000). Mycobacteria-induced TNF and IL-10 formation by human macrophages: the role of MAP kinases. Joint Annual Meeting of the German and Dutch Societies of Immunology, Duseldorf, Germany, 29 November - 02 December 2000. Jena, Germany: Urban und Fischer Verlag.

Mycobacteria-induced TNF and IL-10 formation by human macrophages: the role of MAP kinases

Current funding

  • 2025 - 2028
    Preclinical validation of anti-tubercular conjugated oligoelectrolytes
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2026
    Improving tuberculosis diagnosis and care through functional immune screening
    TRI Leading Innovations through New Collaborations Scheme
    Open grant
  • 2024 - 2027
    Molecular drivers of metabolic reprogramming in Mycobacterium tuberculosis infection
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2026
    New Frontiers in Innate Immunity
    ARC Future Fellowships
    Open grant
  • 2022 - 2025
    Defining host immune and microbial determinants of disease trajectory in mycobacterial infection
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2025
    Host Gene Expression Signatures to Diagnose Sepsis in Children
    MRFF Genomics Health Futures Mission, Project Grant administered by AusIndustry
    Open grant

Past funding

  • 2022 - 2023
    Molecular regulators of inflammation
    The American Association of Immunologists Careers in Immunology Fellowship
    Open grant
  • 2022 - 2024
    Can blood RNA signatures improve the diagnosis of latent tuberculosis in solid organ transplant recipients? (2022 MSHRSS Co-funded Collaboration Grant led by MSH)
    Metro South Hospital and Health Service
    Open grant
  • 2021
    Controlling the enemy within: What makes macrophages restrict or promote Mycobacterium tuberculosis growth in vivo
    GeoMx Whole Transcriptome Atlas Neuroscience Grant
    Open grant
  • 2021 - 2024
    Diagnostic utility of tests of latent tuberculosis in immune compromised contacts exposed to multi-drug resistant tuberculosis (2021 Metro South SERTA Novice Researcher Grant administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Enhancing host defence to combat bacterial infections (2020 Georgina Sweet Award)
    Georgina Sweet Award for Women in Quantitative Biomedical Science
    Open grant
  • 2020 - 2023
    Molecular regulators of inflammation during Gram-negative bacterial infection
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2022
    Nitric Oxide to improve recovery and survival in neonates and children on Extracorporeal Life Support - a pilot randomized controlled trial (the NECTAR trial)
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2022
    Vascular responsiveness in septic shock (NHMRC Project Grant led by UNSW)
    University of New South Wales
    Open grant
  • 2018 - 2020
    RAPIDS TRIAL: Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis
    Gold Coast Hospital and Health Services
    Open grant
  • 2018 - 2023
    Preclinical Validation of a Novel Drug Lead to Treat Tuberculosis
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2018 - 2020
    Enhancing host defence mechanisms in severe bacterial infections
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Nitric Oxide on Cardio Pulmonary Bypass in Congenital Heart Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    Reducing morbidity and mortality in infants and children after cardiopulmonary bypass - a multicenter randomized controlled trial
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    Innate immune signalling in Mycobacterium tuberculosis infection
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Developing new antibiotics to treat tuberculosis
    Australian Tropical Medicine Commercialisation Programme
    Open grant
  • 2016 - 2019
    Cellular regulation of receptor signalling and cytokine responses
    NHMRC Project Grant
    Open grant
  • 2016
    Establishing a gnotobiotic germ-free mouse facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    The Australian human microbiota project-microbe isolation facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2017
    Towards biomarkers for patient stratification in sepsis
    TRI Spore Grants
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    Multiplex High Throughput Bio-plex Protein Assay Platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    Targeting the Wnt Pathway: Implication for Chronic Liver disease
    PA Research Foundation
    Open grant
  • 2013 - 2014
    ResTeach 2013 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2013 - 2016
    RP105 is a new innate immune receptor for Mycobacterium tuberculosis
    NHMRC Project Grant
    Open grant
  • 2011 - 2012
    Immune modulation by Wnt/B-Catenin signalling during bacterial infection
    UQ Early Career Researcher
    Open grant
  • 2011
    Laser Scanner for Biomolecular Imaging
    NHMRC Equipment Grant
    Open grant

Availability

Professor Antje Blumenthal is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Investigating molecular mechanisms of RP105-dependent macrophage activation during mycobacterial infection

    Principal Advisor

    Other advisors: Professor Matt Sweet, Dr Tom Schultz

  • Doctor Philosophy

    Impact of nitric oxide on inflammation and coagulation in patients undergoing extracorporeal membrane oxygenation (ECMO)

    Principal Advisor

    Other advisors: Dr Craig McBride

  • Doctor Philosophy

    Microbiome-host-interactions in Mycobacterium tuberculosis infection

    Principal Advisor

    Other advisors: Professor Mark Morrison

  • Doctor Philosophy

    Mapping cellular signalling pathways in mycobacteria-infected macrophages

    Principal Advisor

    Other advisors: Dr Tom Schultz, Dr Carmen Mathmann

  • Doctor Philosophy

    Molecular regulators of macrophage functions during Mycobacterium tuberculosis infection

    Principal Advisor

    Other advisors: Dr Carmen Mathmann

  • Doctor Philosophy

    Characterisation of the anti-mycobacterial activity of wollamide cyclic hexapeptides against Mycobacterium tuberculosis

    Principal Advisor

    Other advisors: Associate Professor Timothy Wells

  • Doctor Philosophy

    Transmission dynamics of multi-drug resistant tuberculosis amongst immune suppressed patients exposed to an infectious case

    Associate Advisor

    Other advisors: Honorary Professor John Upham, Professor Rachel Thomson

  • Master Philosophy

    The gut-lung axis in nontuberculous mycobacterial pulmonary disease.

    Associate Advisor

    Other advisors: Professor Mark Morrison, Professor Rachel Thomson

  • Master Philosophy

    The gut-lung axis in nontuberculous mycobacterial pulmonary disease.

    Associate Advisor

    Other advisors: Professor Mark Morrison, Professor Rachel Thomson

  • Doctor Philosophy

    Functions of CSF1R signalling in inflammation.

    Associate Advisor

    Other advisors: Professor David Hume, Dr Katharine Irvine

Completed supervision

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