Dr

Katharine Irvine

Email: 
Phone: 
+61 7 344 38014

Availability

Dr Katharine Irvine is:
Available for supervision

Fields of research

Biological Sciences Genetics Immunology

Qualifications

  • Bachelor of Law, University of New South Wales
  • Bachelor (Honours) of Science (Advanced), University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Search Professor Katharine Irvine’s works on UQ eSpace

161 works between 2004 and 2025
All (161) Journal Article (116) Book Chapter (3) Conference Publication (37) Other Outputs (5)

21 - 40 of 161 works

2023

Journal Article

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

Thai, Le May, O'Reilly, Liam, Reibe-Pal, Saskia, Sue, Nancy, Holliday, Holly, Small, Lewin, Schmitz-Peiffer, Carsten, Dhenni, Rama, Wang-Wei Tsai, Vicky, Norris, Nicholas, Yau, Belinda, Zhang, Xuan, Lee, Kailun, Yan, Chenxu, Shi, Yan-Chuan, Kebede, Melkam A., Brink, Robert, Cooney, Gregory J., Irvine, Katharine M., Breit, Samuel N., Phan, Tri G., Swarbrick, Alexander and Biden, Trevor J. (2023). β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling. iScience, 26 (4) 106477, 1-23. doi: 10.1016/j.isci.2023.106477

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

2023

Conference Publication

Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine, Caruso, Melanie, Patkar, Omkar, Sehgal, Anuj, Millard, Susan, Hume, David and Pettit, Allison (2023). Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer. 2022 Annual Meeting of the American Society for Bone and Mineral Research, Austin, TX, United States, 9-12 September 2022. Hoboken, NJ, United States: Wiley-Blackwell.

Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer

2023

Journal Article

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)

Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)

2022

Journal Article

Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes

Gracen, Lucy, Hayward, Kelly L., Aikebuse, Melanie, Russell, Anthony, O’Beirne, James, McPhail, Steven, Irvine, Katharine M., Williams, Suzanne, Valery, Patricia C. and Powell, Elizabeth E. (2022). Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes. BMC Health Services Research, 22 (1) 487, 1-11. doi: 10.1186/s12913-022-07808-7

Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes

2022

Journal Article

CSF1R as a therapeutic target in bone diseases: obvious but not so simple

Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4

CSF1R as a therapeutic target in bone diseases: obvious but not so simple

2022

Journal Article

Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD

Canivet, Clémence M., Costentin, Charlotte, Irvine, Katharina M., Delamarre, Adèle, Lannes, Adrien, Sturm, Nathalie, Oberti, Frederic, Patel, Preya J., Decaens, Thomas, Irles-Depé, Marie, Fouchard, Isabelle, Hermabessière, Paul, Roux, Marine, Barthelon, Justine, Calès, Paul, Powell, Elizabeth E., de Ledinghen, Victor and Boursier, Jérôme (2022). Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD. Hepatology, 77 (3), n/a-n/a. doi: 10.1002/hep.32665

Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD

2022

Conference Publication

Non-alcoholic fatty liver disease and type 2 diabetes: low referral rate of patients at increased risk of progressive liver disease

Gracen, Lucy, Hayward, Kelly, Aikebuse, Melanie, Russell, Anthony, O'Beirne, James, Irvine, Katharine, Williams, Suzanne, Valery, Patricia and Powell, Elizabeth (2022). Non-alcoholic fatty liver disease and type 2 diabetes: low referral rate of patients at increased risk of progressive liver disease. AMSTERDAM: ELSEVIER.

Non-alcoholic fatty liver disease and type 2 diabetes: low referral rate of patients at increased risk of progressive liver disease

2022

Journal Article

Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis

Gracen, Lucy, Hayward, Kelly L., Irvine, Katharine M., Valery, Patricia C. and Powell, Elizabeth E. (2022). Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis. Journal of Hepatology, 77 (4), 1219-1221. doi: 10.1016/j.jhep.2022.06.016

Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis

2022

Journal Article

Epidemiology of ascites fluid infections in patients with cirrhosis in Queensland, Australia from 2008 to 2017: a population-based study

Ratnasekera, Isanka U., Johnson, Amy, Powell, Elizabeth E., Henderson, Andrew, Irvine, Katharine M. and Valery, Patricia C. (2022). Epidemiology of ascites fluid infections in patients with cirrhosis in Queensland, Australia from 2008 to 2017: a population-based study. Medicine, 101 (20) 00010, e29217. doi: 10.1097/MD.0000000000029217

Epidemiology of ascites fluid infections in patients with cirrhosis in Queensland, Australia from 2008 to 2017: a population-based study

2022

Journal Article

Patient‐oriented medication education intervention has long‐term benefits for people with decompensated cirrhosis

Hayward, Kelly L., Bansal, Vikas, Valery, Patricia C., Irvine, Katharine M., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2022). Patient‐oriented medication education intervention has long‐term benefits for people with decompensated cirrhosis. Hepatology Communications, 6 (11), 3281-3282. doi: 10.1002/hep4.1999

Patient‐oriented medication education intervention has long‐term benefits for people with decompensated cirrhosis

2022

Journal Article

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

2022

Journal Article

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

2022

Journal Article

Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism

Radford-Smith, Daniel E., Patel, Preya J., Irvine, Katharine M., Russell, Anthony, Siskind, Dan, Anthony, Daniel C., Powell, Elizabeth E. and Probert, Fay (2022). Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS ONE, 17 (1) e0261555, e0261555. doi: 10.1371/journal.pone.0261555

Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism

2022

Journal Article

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele WL., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra and MacDonald, Kelli PA. (2022). ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. JHEP Reports, 4 (1) 100386, 1-14. doi: 10.1016/j.jhepr.2021.100386

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

2022

Journal Article

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

2021

Journal Article

Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study

Johnson, Amy L., Ratnasekera, Isanka U., Irvine, Katharine M., Henderson, Andrew, Powell, Elizabeth E. and Valery, Patricia C. (2021). Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study. BMJ Open Gastroenterology, 8 (1) e000695, e000695. doi: 10.1136/bmjgast-2021-000695

Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study

2021

Journal Article

A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z

A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

2021

Journal Article

Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease

Irvine, Katharine M., Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Williams, Suzanne, Russell, Anthony and Powell, Elizabeth E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific Reports, 11 (1) 2858, 1-8. doi: 10.1038/s41598-021-82315-z

Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease

2021

Journal Article

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

2021

Journal Article

Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety

Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Li, Catherine, Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2021). Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety. Pharmaceuticals, 14 (12) 1207, 1207. doi: 10.3390/ph14121207

Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety

Current funding

  • 2025
    Hepatic delivery of Colony Stimulating Factor 1mRNA to promote liver repair
    Gastroenterological Society of Australia
    Open grant
  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant

Past funding

  • 2022 - 2024
    Macrophage-driven lipid metabolism in health and disease - mechanisms and therapeutic opportunities
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    CD14 inhibition in a Liver Inflammation mouse model
    Innovation Connections
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
    Siemens Ltd
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    Human liver progenitor cell characterisation, isolation and manipulation
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2013 - 2015
    Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    ALF Pauline Hall Research Fellowship: The role of macrophage in chronic liver disease progression
    Australian Liver Foundation
    Open grant
  • 2010 - 2012
    Pathological changes associated with chronic RelB activiation in T1D
    Juvenile Diabetes Research Foundation
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant

Availability

Dr Katharine Irvine is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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