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2025 Journal Article Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammationHuang, Stephen, Patkar, Omkar L., Schulze, Sarah, Carter-Cusack, Dylan, Millard, Susan, Ranpura, Ginell, Green, Emma K., Maxwell, Emma, Kanesarajah, Jeeva, Cowin, Gary, Stimson, Damion, Kurniawan, Nyoman D, Keshvari, Sahar, Allavena, Rachel, Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2025). Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation. Life Science Alliance, 8 (10) e202503435, e202503435. doi: 10.26508/lsa.202503435 |
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2025 Journal Article Life without microgliaHume, David A. (2025). Life without microglia. Trends in Neurosciences, 48 (8), 560-569. doi: 10.1016/j.tins.2025.06.006 |
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2025 Journal Article Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in ratsSchulze, Sarah, Keshvari, Sahar, Miller, Gregory C., Bridle, Kim R., Hume, David A. and Irvine, Katharine M. (2025). Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats. World Journal of Gastroenterology, 31 (24) 108234, 1-18. doi: 10.3748/wjg.v31.i24.108234 |
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2025 Journal Article Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammationHuang, Stephen, Patkar, Omkar L., Schulze, Sarah, Carter-Cusack, Dylan, Millard, Susan, Ranpura, Ginell, Green, Emma K., Maxwell, Emma, Kanesarajah, Jeeva, Cowin, Gary, Stimson, Damion, Kurniawan, Nyoman D., Keshvari, Sahar, Allavena, Rachel, Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2025). Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation. Life Science Alliance, 8 (9) e202503264. doi: 10.26508/lsa.202503264 |
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2025 Journal Article The Involvement of IL-34 in Inflammatory and Malignant Skin DiseasesDang, Thi Viet Trinh, Mehdi, Ahmed M., Kumari, Snehlata, Khosrotehrani, Kiarash, Frazer, Ian H., Hume, David A. and Chandra, Janin (2025). The Involvement of IL-34 in Inflammatory and Malignant Skin Diseases. Journal of Investigative Dermatology, 1-13. doi: 10.1016/j.jid.2025.05.003 |
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2025 Journal Article Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factorWhiley, Phillip J., Dixit, Ojas V. A., Das Gupta, Mukta, Patel, Hardip, Zhao, Guoyan, Connor, Susan J., Summers, Kim M., Hume, David A., Pavli, Paul and O'Brien, Claire L. (2025). Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor. Immunology and Cell Biology, 103 (5), 473-484. doi: 10.1111/imcb.70031 |
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2025 Journal Article The relationship between CSF1R signaling, monocyte-macrophage differentiation and susceptibility to inflammatory bowel diseaseHume, David A., Summers, Kim M., O’Brien, Claire and Pavli, Paul (2025). The relationship between CSF1R signaling, monocyte-macrophage differentiation and susceptibility to inflammatory bowel disease. Cellular and Molecular Gastroenterology and Hepatology, 19 (8) 101510, 101510. doi: 10.1016/j.jcmgh.2025.101510 |
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2025 Journal Article Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamusO'Keeffe, Mary, Booker, Sam A., Walsh, Darren, Li, Mosi, Henley, Chloe, de Oliveira, Laura Simoes, Liu, Mingshan, Wang, Xingran, Banqueri, Maria, Ridley, Katherine, Dissanayake, Kosala N., Martinez-Gonzalez, Cristina, Craigie, Kirsty J., Vasoya, Deepali, Leah, Tom, He, Xin, Hume, David A., Duguid, Ian, Nolan, Matthew F., Qiu, Jing, Wyllie, David J. A., Dando, Owen R., Gonzalez-Sulser, Alfredo, Gan, Jian, Pridans, Clare, Kind, Peter C. and Hardingham, Giles E. (2025). Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus. Nature Neuroscience, 28 (2) 550, 268-279. doi: 10.1038/s41593-024-01833-x |
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2025 Journal Article Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutationCarter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525 |
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2025 Journal Article Asymptotic dimension for covers with controlled growthHume, David, Mackay, John M. and Tessera, Romain (2025). Asymptotic dimension for covers with controlled growth. Journal of the London Mathematical Society, 111 (1) e70043, 1. doi: 10.1112/jlms.70043 |
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2024 Journal Article The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathologyStables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743 |
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2024 Journal Article Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survivalDang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018 |
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2024 Journal Article Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situPetit, Maxime, Weber-Delacroix, Eleonore, Lanthiez, Francois, Barthelemy, Sandrine, Guillou, Noelline, Firpion, Marina, Bonduelle, Olivia, Hume, David A., Combadiere, Christophe and Boissonnas, Alexandre (2024). Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ. Cell Reports, 43 (10) 114847, 114847. doi: 10.1016/j.celrep.2024.114847 |
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2024 Journal Article Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasisThierry, Guilhem R., Baudon, Elisa M., Bijnen, Mitchell, Bellomo, Alicia, Lagueyrie, Marine, Mondor, Isabelle, Simonnet, Louise, Carrette, Florent, Fenouil, Romain, Keshvari, Sahar, Hume, David A., Dombrowicz, David and Bajenoff, Marc (2024). Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity, 57 (9), 2108-2121.e6. doi: 10.1016/j.immuni.2024.07.005 |
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2024 Journal Article Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathyChadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh, Carlen-Jones, William, Gandhi, Sunil, Bu, Guojun, Hume, David A., Pridans, Clare, Wszolek, Zbigniew K., Spitale, Robert C., Davtyan, Hayk and Blurton-Jones, Mathew (2024). Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Neuron, 112 (16), 2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023 |
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2024 Journal Article Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transferBatoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077 |
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2024 Journal Article The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel diseaseO’Brien, Claire L., Summers, Kim M., Martin, Natalia M., Carter-Cusack, Dylan, Yang, Yuanhao, Barua, Rasel, Dixit, Ojas V. A., Hume, David A. and Pavli, Paul (2024). The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease. Human Genetics, 143 (3), 233-261. doi: 10.1007/s00439-024-02642-9 |
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2024 Journal Article Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolismKeshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023 |
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2023 Journal Article A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophagesWaddell, Lindsey A., Wu, Zhiguang, Sauter, Kristin A., Hope, Jayne C. and Hume, David A. (2023). A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages. Veterinary Immunology and Immunopathology, 266 110681, 1-5. doi: 10.1016/j.vetimm.2023.110681 |
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2023 Journal Article Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo developmentHume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052 |
