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2025

Journal Article

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

2025

Journal Article

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

O'Keeffe, Mary, Booker, Sam A., Walsh, Darren, Li, Mosi, Henley, Chloe, de Oliveira, Laura Simoes, Liu, Mingshan, Wang, Xingran, Banqueri, Maria, Ridley, Katherine, Dissanayake, Kosala N., Martinez-Gonzalez, Cristina, Craigie, Kirsty J., Vasoya, Deepali, Leah, Tom, He, Xin, Hume, David A., Duguid, Ian, Nolan, Matthew F., Qiu, Jing, Wyllie, David J. A., Dando, Owen R., Gonzalez-Sulser, Alfredo, Gan, Jian, Pridans, Clare, Kind, Peter C. and Hardingham, Giles E. (2025). Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus. Nature Neuroscience, 28 (2) 550, 268-279. doi: 10.1038/s41593-024-01833-x

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

2025

Journal Article

Asymptotic dimension for covers with controlled growth

Hume, David, Mackay, John M. and Tessera, Romain (2025). Asymptotic dimension for covers with controlled growth. Journal of the London Mathematical Society, 111 (1) e70043. doi: 10.1112/jlms.70043

Asymptotic dimension for covers with controlled growth

2024

Journal Article

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

Stables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

2024

Journal Article

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

2024

Journal Article

Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages<i> in</i><i> situ</i>

Petit, Maxime, Weber-Delacroix, Eleonore, Lanthiez, Francois, Barthelemy, Sandrine, Guillou, Noelline, Firpion, Marina, Bonduelle, Olivia, Hume, David A., Combadiere, Christophe and Boissonnas, Alexandre (2024). Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ. Cell Reports, 43 (10) 114847, 114847. doi: 10.1016/j.celrep.2024.114847

Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages<i> in</i><i> situ</i>

2024

Journal Article

Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis

Thierry, Guilhem R., Baudon, Elisa M., Bijnen, Mitchell, Bellomo, Alicia, Lagueyrie, Marine, Mondor, Isabelle, Simonnet, Louise, Carrette, Florent, Fenouil, Romain, Keshvari, Sahar, Hume, David A., Dombrowicz, David and Bajenoff, Marc (2024). Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity, 57 (9), 2108-2121.e6. doi: 10.1016/j.immuni.2024.07.005

Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis

2024

Journal Article

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

Chadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh, Carlen-Jones, William, Gandhi, Sunil, Bu, Guojun, Hume, David A., Pridans, Clare, Wszolek, Zbigniew K., Spitale, Robert C., Davtyan, Hayk and Blurton-Jones, Mathew (2024). Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Neuron, 112 (16), 2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

2024

Journal Article

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

2024

Journal Article

The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease

O’Brien, Claire L., Summers, Kim M., Martin, Natalia M., Carter-Cusack, Dylan, Yang, Yuanhao, Barua, Rasel, Dixit, Ojas V. A., Hume, David A. and Pavli, Paul (2024). The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease. Human Genetics, 143 (3), 233-261. doi: 10.1007/s00439-024-02642-9

The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease

2024

Journal Article

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

2023

Journal Article

A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages

Waddell, Lindsey A., Wu, Zhiguang, Sauter, Kristin A., Hope, Jayne C. and Hume, David A. (2023). A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages. Veterinary Immunology and Immunopathology, 266 110681, 1-5. doi: 10.1016/j.vetimm.2023.110681

A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages

2023

Journal Article

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

2023

Journal Article

Macrophage heterogeneity in the single cell era: facts and artefacts

Hume, David A., Millard, Susan M. and Pettit, Allison R. (2023). Macrophage heterogeneity in the single cell era: facts and artefacts. Blood Journal, 142 (16), 1339-1347. doi: 10.1182/blood.2023020597

Macrophage heterogeneity in the single cell era: facts and artefacts

2023

Journal Article

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

2023

Journal Article

Rare genetic variants underlie outlying levels of DNA methylation and gene-expression

Chundru, V. Kartik, Marioni, Riccardo E., Pendergast, James G. D., Lin, Tian, Beveridge, Allan J., Martin, Nicholas G, Montgomery, Grant W., Hume, David A., Deary, Ian J., Visscher, Peter M., Wray, Naomi R. and McRae, Allan F. (2023). Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Human Molecular Genetics, 32 (11), 1912-1921. doi: 10.1093/hmg/ddad028

Rare genetic variants underlie outlying levels of DNA methylation and gene-expression

2023

Journal Article

Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?

Hume, David A. (2023). Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?. European Journal of Immunology, 53 (6) 2250242, e2250242. doi: 10.1002/eji.202250242

Fate‐mapping studies in inbred mice: a model for understanding macrophage development and homeostasis?

2023

Journal Article

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

Grootveld, Abigail K., Kyaw, Wunna, Panova, Veera, Lau, Angelica W.Y., Ashwin, Emily, Seuzaret, Guillaume, Dhenni, Rama, Bhattacharyya, Nayan Deger, Khoo, Weng Hua, Biro, Maté, Mitra, Tanmay, Meyer-Hermann, Michael, Bertolino, Patrick, Tanaka, Masato, Hume, David A., Croucher, Peter I., Brink, Robert, Nguyen, Akira, Bannard, Oliver and Phan, Tri Giang (2023). Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell, 186 (6), 1144-1161. doi: 10.1016/j.cell.2023.02.004

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

2023

Journal Article

Fibrillin-1 and asprosin, novel players in metabolic syndrome

Summers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979

Fibrillin-1 and asprosin, novel players in metabolic syndrome

2023

Journal Article

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)

Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)