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2025

Journal Article

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

2024

Journal Article

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

Stables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

2024

Journal Article

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

2024

Conference Publication

Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat

Carter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert, Morgan, Paul, Bush, Stephen, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-202662

Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat

2024

Conference Publication

Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis

Jacquelin, Sebastien, Maxwell, Emma, Flegg, Cameron, Liu, Yajun, Taylor, Isis, Ranpura, Ginell, Nooru-Mohamed, Fathima, Sokolowski, Kamil A., Adamson, Anthony, Irvine, Katharine M. and Hume, David A. (2024). Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-204496

Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis

2024

Conference Publication

Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats

Roberts, Megan, Carter-Cusack, Dylan, Huang, Stephen, Maxwell, Emma, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-194571

Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats

2024

Conference Publication

An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation

Huang, Stephen, Patkar, Omkar, Schulze, Sarah, Carter-Cusack, Dylan, Ranpura, Ginell, Maxwell, Emma, Keshvari, Sahar, Millard, Susan, Cowin, Gary, Kurniawan, Nyoman, Pettit, Allison, Irvine, Katharine M. and Hume, David A. (2024). An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation. 66th ASH Annual Meeting, San Diego, CA, United States, 7-10 December 2024. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2024-208881

An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation

2024

Journal Article

Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages<i> in</i><i> situ</i>

Petit, Maxime, Weber-Delacroix, Eleonore, Lanthiez, Francois, Barthelemy, Sandrine, Guillou, Noelline, Firpion, Marina, Bonduelle, Olivia, Hume, David A., Combadiere, Christophe and Boissonnas, Alexandre (2024). Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ. Cell Reports, 43 (10) 114847, 114847. doi: 10.1016/j.celrep.2024.114847

Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages<i> in</i><i> situ</i>

2024

Conference Publication

Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells

Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Asplett, Kiran, Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells. AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy, Boston, MA, United States, 18-21 October 2024. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm24-a001

Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells

2024

Other Outputs

Csf1rko Rat Transcriptomic Atlas and Supplementary Tables

Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas and Supplementary Tables. The University of Queensland. (Dataset) doi: 10.48610/6d347aa

Csf1rko Rat Transcriptomic Atlas and Supplementary Tables

2024

Other Outputs

Csf1rko Rat Transcriptomic Atlas

Carter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas. The University of Queensland. (Dataset) doi: 10.48610/5b57a22

Csf1rko Rat Transcriptomic Atlas

2024

Journal Article

Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis

Thierry, Guilhem R., Baudon, Elisa M., Bijnen, Mitchell, Bellomo, Alicia, Lagueyrie, Marine, Mondor, Isabelle, Simonnet, Louise, Carrette, Florent, Fenouil, Romain, Keshvari, Sahar, Hume, David A., Dombrowicz, David and Bajenoff, Marc (2024). Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity, 57 (9), 2108-2121.e6. doi: 10.1016/j.immuni.2024.07.005

Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis

2024

Journal Article

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

Chadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh, Carlen-Jones, William, Gandhi, Sunil, Bu, Guojun, Hume, David A., Pridans, Clare, Wszolek, Zbigniew K., Spitale, Robert C., Davtyan, Hayk and Blurton-Jones, Mathew (2024). Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Neuron, 112 (16), 2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023

Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

2024

Journal Article

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

2024

Journal Article

The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease

O’Brien, Claire L., Summers, Kim M., Martin, Natalia M., Carter-Cusack, Dylan, Yang, Yuanhao, Barua, Rasel, Dixit, Ojas V. A., Hume, David A. and Pavli, Paul (2024). The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease. Human Genetics, 143 (3), 233-261. doi: 10.1007/s00439-024-02642-9

The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease

2024

Journal Article

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

2024

Book Chapter

Genetic and immunohistochemistry tools to visualize rat macrophages in situ

Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6

Genetic and immunohistochemistry tools to visualize rat macrophages in situ

2023

Conference Publication

Age related neuropathology in a novel mouse model of Adult‐onset leukoencephalopathy

Shabestari, Sepideh Kiani, Radhakrishnan, Hamsi, Rothermich, Winston Chang, Capocchi, Joia Kai, Jullienne, Amandine, Nguyen, Jasmine, Tran, Kayla Nhi, Pascual, Jesse R., Martini, Alessandra Cadete, Head, Elizabeth, Hume, David A, Pridans, Clare, Obenaus, Andre, Stark, Craig E.L., Davtyan, Hayk and Blurton‐Jones, Mathew (2023). Age related neuropathology in a novel mouse model of Adult‐onset leukoencephalopathy. Alzheimer’s Association International Conference AAIC 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.070996

Age related neuropathology in a novel mouse model of Adult‐onset leukoencephalopathy

2023

Journal Article

A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages

Waddell, Lindsey A., Wu, Zhiguang, Sauter, Kristin A., Hope, Jayne C. and Hume, David A. (2023). A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages. Veterinary Immunology and Immunopathology, 266 110681, 1-5. doi: 10.1016/j.vetimm.2023.110681

A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages

2023

Journal Article

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development