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2025 Journal Article The relationship between CSF1R signaling, monocyte-macrophage differentiation and susceptibility to inflammatory bowel diseaseHume, David A., Summers, Kim M., O’Brien, Claire and Pavli, Paul (2025). The relationship between CSF1R signaling, monocyte-macrophage differentiation and susceptibility to inflammatory bowel disease. Cellular and Molecular Gastroenterology and Hepatology 101510, 101510. doi: 10.1016/j.jcmgh.2025.101510 |
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2025 Journal Article Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutationCarter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525 |
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2025 Journal Article Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamusO'Keeffe, Mary, Booker, Sam A., Walsh, Darren, Li, Mosi, Henley, Chloe, de Oliveira, Laura Simoes, Liu, Mingshan, Wang, Xingran, Banqueri, Maria, Ridley, Katherine, Dissanayake, Kosala N., Martinez-Gonzalez, Cristina, Craigie, Kirsty J., Vasoya, Deepali, Leah, Tom, He, Xin, Hume, David A., Duguid, Ian, Nolan, Matthew F., Qiu, Jing, Wyllie, David J. A., Dando, Owen R., Gonzalez-Sulser, Alfredo, Gan, Jian, Pridans, Clare, Kind, Peter C. and Hardingham, Giles E. (2025). Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus. Nature Neuroscience, 28 (2) 550, 268-279. doi: 10.1038/s41593-024-01833-x |
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2025 Journal Article Asymptotic dimension for covers with controlled growthHume, David, Mackay, John M. and Tessera, Romain (2025). Asymptotic dimension for covers with controlled growth. Journal of the London Mathematical Society, 111 (1) e70043, 1. doi: 10.1112/jlms.70043 |
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2024 Journal Article The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathologyStables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743. doi: 10.1016/j.nbd.2024.106743 |
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2024 Journal Article Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survivalDang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018 |
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2024 Conference Publication An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and InflammationHuang, Stephen, Patkar, Omkar, Schulze, Sarah, Carter-Cusack, Dylan, Ranpura, Ginell, Maxwell, Emma, Keshvari, Sahar, Millard, Susan, Cowin, Gary, Kurniawan, Nyoman, Pettit, Allison, Irvine, Katharine M. and Hume, David A. (2024). An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation. 66th ASH Annual Meeting, San Diego, CA, United States, 7-10 December 2024. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2024-208881 |
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2024 Conference Publication Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the RatCarter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert, Morgan, Paul, Bush, Stephen, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-202662 |
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2024 Conference Publication Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in HaematopoiesisJacquelin, Sebastien, Maxwell, Emma, Flegg, Cameron, Liu, Yajun, Taylor, Isis, Ranpura, Ginell, Nooru-Mohamed, Fathima, Sokolowski, Kamil A., Adamson, Anthony, Irvine, Katharine M. and Hume, David A. (2024). Characterization of a Colony Stimulating Factor Receptor (CSF1R) Upstream Regulatory Element in Haematopoiesis. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-204496 |
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2024 Conference Publication Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout RatsRoberts, Megan, Carter-Cusack, Dylan, Huang, Stephen, Maxwell, Emma, Summers, Kim Z., Irvine, Katharine M. and Hume, David A. (2024). Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats. 66th ASH Annual Meeting, San Diego, CA United States, 7-10 December 2024. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2024-194571 |
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2024 Journal Article Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situPetit, Maxime, Weber-Delacroix, Eleonore, Lanthiez, Francois, Barthelemy, Sandrine, Guillou, Noelline, Firpion, Marina, Bonduelle, Olivia, Hume, David A., Combadiere, Christophe and Boissonnas, Alexandre (2024). Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ. Cell Reports, 43 (10) 114847. doi: 10.1016/j.celrep.2024.114847 |
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2024 Conference Publication Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cellsDang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Asplett, Kiran, Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells. AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy, Boston, MA, United States, 18-21 October 2024. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm24-a001 |
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2024 Journal Article Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasisThierry, Guilhem R., Baudon, Elisa M., Bijnen, Mitchell, Bellomo, Alicia, Lagueyrie, Marine, Mondor, Isabelle, Simonnet, Louise, Carrette, Florent, Fenouil, Romain, Keshvari, Sahar, Hume, David A., Dombrowicz, David and Bajenoff, Marc (2024). Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity, 57 (9), 2108-2121.e6. doi: 10.1016/j.immuni.2024.07.005 |
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2024 Journal Article Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathyChadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh, Carlen-Jones, William, Gandhi, Sunil, Bu, Guojun, Hume, David A., Pridans, Clare, Wszolek, Zbigniew K., Spitale, Robert C., Davtyan, Hayk and Blurton-Jones, Mathew (2024). Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy. Neuron, 112 (16), 2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023 |
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2024 Other Outputs Csf1rko Rat Transcriptomic Atlas and Supplementary TablesCarter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas and Supplementary Tables. The University of Queensland. (Dataset) doi: 10.48610/6d347aa |
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2024 Other Outputs Csf1rko Rat Transcriptomic AtlasCarter-Cusack, Dylan, Hume, David, Summers, Kim and Irvine, Katharine (2024). Csf1rko Rat Transcriptomic Atlas. The University of Queensland. (Dataset) doi: 10.48610/5b57a22 |
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2024 Journal Article Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transferBatoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077 |
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2024 Journal Article The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel diseaseO’Brien, Claire L., Summers, Kim M., Martin, Natalia M., Carter-Cusack, Dylan, Yang, Yuanhao, Barua, Rasel, Dixit, Ojas V. A., Hume, David A. and Pavli, Paul (2024). The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease. Human Genetics, 143 (3), 233-261. doi: 10.1007/s00439-024-02642-9 |
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2024 Journal Article Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolismKeshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023 |
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2024 Book Chapter Genetic and immunohistochemistry tools to visualize rat macrophages in situHuang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6 |
