Overview
Background
The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.
David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute
Availability
- Professor David Hume is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), Australian National University
- Doctor of Philosophy, Australian National University
Research interests
-
Macrophages Biology
Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."
Works
Search Professor David Hume’s works on UQ eSpace
2022
Journal Article
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)
Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y
2022
Conference Publication
Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity
Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.
2022
Journal Article
Microglia states and nomenclature: A field at its crossroads
Paolicelli, Rosa C., Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C., Butovsky, Oleg, Carson, Monica J., Castellano, Bernardo, Colonna, Marco, Cowley, Sally A., Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L., de Strooper, Bart, Denes, Adam ... Wyss-Coray, Tony (2022). Microglia states and nomenclature: A field at its crossroads. Neuron, 110 (21), 3458-3483. doi: 10.1016/j.neuron.2022.10.020
2022
Journal Article
CSF1R as a therapeutic target in bone diseases: obvious but not so simple
Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4
2022
Journal Article
Poincaré profiles of Lie groups and a coarse geometric dichotomy
Hume, David, Mackay, John M. and Tessera, Romain (2022). Poincaré profiles of Lie groups and a coarse geometric dichotomy. Geometric and Functional Analysis, 32 (5), 1063-1133. doi: 10.1007/s00039-022-00617-4
2022
Journal Article
Graphia: a platform for the graph-based visualisation and analysis of high dimensional data
Freeman, Tom C., Horsewell, Sebastian, Patir, Anirudh, Harling-Lee, Josh, Regan, Tim, Shih, Barbara B., Prendergast, James, Hume, David A. and Angus, Tim (2022). Graphia: a platform for the graph-based visualisation and analysis of high dimensional data. PLOS Computational Biology, 18 (7) e1010310, 1-17. doi: 10.1371/journal.pcbi.1010310
2022
Journal Article
Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells
Hume, David A., Offermanns, Stefan and Bonnavion, Remy (2022). Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity, 55 (7), 1139-1140. doi: 10.1016/j.immuni.2022.06.010
2022
Journal Article
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
Kiani Shabestari, Sepideh, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Chang Rothermich, Winston, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek and Blurton-Jones, Mathew (2022). Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Cell Reports, 39 (11) 110961, 1-30. doi: 10.1016/j.celrep.2022.110961
2022
Journal Article
Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer
Laviron, Marie, Petit, Maxime, Weber-Delacroix, Eléonore, Combes, Alexis J., Arkal, Arjun Rao, Barthélémy, Sandrine, Courau, Tristan, Hume, David A., Combadière, Christophe, Krummel, Matthew F. and Boissonnas, Alexandre (2022). Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer. Cell Reports, 39 (8) 110865, 1-20. doi: 10.1016/j.celrep.2022.110865
2022
Journal Article
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling
Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237
2022
Journal Article
Generation and network analysis of an RNA-seq transcriptional atlas for the rat
Summers, Kim M., Bush, Stephen J., Wu, Chunlei and Hume, David A. (2022). Generation and network analysis of an RNA-seq transcriptional atlas for the rat. NAR Genomics and Bioinformatics, 4 (1) lqac017, lqac017. doi: 10.1093/nargab/lqac017
2022
Journal Article
Use of quantitative real‐time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection
Lisowski, Zofia M., Lefevre, Lucas, Mair, Tim S., Clark, Emily L., Hudson, Neil P. H., Hume, David A. and Pirie, R. Scott (2022). Use of quantitative real‐time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection. Equine Veterinary Journal, 54 (1), 52-62. doi: 10.1111/evj.13429
2022
Journal Article
Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells
Hume, David A. (2022). Letter to the editor: Questioning the existence of Aif1+, Csf1r+ mesenchymal stem cells. Hepatology, 78 (2), n/a-n/a. doi: 10.1002/hep.32809
2022
Journal Article
Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease
Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387
2022
Journal Article
Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain
Bradford, Barry M., McGuire, Lynne I., Hume, David A., Pridans, Clare and Mabbott, Neil A. (2022). Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain. GLIA, 70 (11), 2169-2187. doi: 10.1002/glia.24244
2022
Conference Publication
Appearances Can Be Deceiving: Macrophage Fragmentation Confounds Ex Vivo Haematopoietic Tissue Analysis
Pettit, Allison R., Batoon, Lena, Heng, Ostyn, Hume, David, Irvine, Kate, Kaur, Simranpreet, Levesque, Jean-Pierre, Magor, Graham, Millard, Susan, Noll, Jacqueline, Perkins, Andrew, Raggatt, Liza, Sandrock, Cheyenne, Sehgal, Anuj, Sester, David, Opperman, Khatora Shanae, Summers, Kim, Wu, Andy and Zannettino, Andrew (2022). Appearances Can Be Deceiving: Macrophage Fragmentation Confounds Ex Vivo Haematopoietic Tissue Analysis. 51st Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Edinburgh, United Kingdom, 1-4 September 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.exphem.2022.07.018
2021
Journal Article
Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter
Psifidi, Androniki, Kranis, Andreas, Rothwell, Lisa M., Bremner, Abi, Russell, Kay, Robledo, Diego, Bush, Stephen J., Fife, Mark, Hocking, Paul M., Banos, Georgios, Hume, David A., Kaufman, Jim, Bailey, Richard A., Avendano, Santiago, Watson, Kellie A., Kaiser, Pete and Stevens, Mark. P. (2021). Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter. Scientific Reports, 11 (1) 1623. doi: 10.1038/s41598-020-79005-7
2021
Journal Article
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2021). Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nature Communications, 12 (1) 3297. doi: 10.1038/s41467-021-23143-7
2021
Journal Article
A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity
Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z
2021
Journal Article
Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues
Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058
Funding
Current funding
Past funding
Supervision
Availability
- Professor David Hume is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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The role of macrophages in postnatal development
This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.
Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701
Supervision history
Current supervision
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Doctor Philosophy
Transcriptional regulation of the mouse Csf1r locus
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Regulation and function of CSF1R-dependent tissue macrophage populations.
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Regulation of Resident Tissue Macrophage Development and Function
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
-
Doctor Philosophy
Erythroid iron metabolism and its effect on systemic iron homeostasis
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Pathogen Promoters of Squamous Epithelial Cancer
Associate Advisor
Other advisors: Associate Professor Graham Leggatt, Associate Professor Andrew Brooks, Dr Janin Chandra, Professor Ian Frazer
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Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor Antje Blumenthal, Dr Katharine Irvine
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Doctor Philosophy
Preclinical modelling of central nervous system complications and toxicities of cellular and immunotherapies for cancer treatment
Associate Advisor
Completed supervision
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2024
Doctor Philosophy
Macrophage colony-stimulating factor in the treatment of non-alcoholic fatty liver disease
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
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2023
Doctor Philosophy
Characterisation of a novel mouse model with a disease-causing Colony Stimulating Factor 1 Receptor mutation
Principal Advisor
Other advisors: Dr Katharine Irvine
-
2023
Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
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2009
Doctor Philosophy
Regulation and Function of Schlafen in Macrophage Biology
Principal Advisor
Other advisors: Professor Matt Sweet
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2007
Doctor Philosophy
THE STRUCTURAL BASIS FOR INTERACTION BETWEEN COLONY- STIMULATING FACTOR-1 AND ITS RECEPTOR, CSF-1R
Principal Advisor
Other advisors: Associate Professor Mark Smythe, Professor Bostjan Kobe, Dr Ian Ross
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2007
Doctor Philosophy
TRANSCRIPTIONAL REGULATION OF THE c-fms PROMOTER BY THE ETS FAMILY OF TRANSCRIPTION FACTORS
Principal Advisor
Other advisors: Professor Kate Stacey
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2006
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF MACROPHAGE-SPECIFIC TRANSCRIPTS
Principal Advisor
-
2005
Doctor Philosophy
MECHANISMS OF INTERFERON-GAMMA PRIMING OF MACROPHAGE ACTIVATION BY CpG DNA
Principal Advisor
-
2004
Master Science
Study of gene expression profile of osteoclasts
Principal Advisor
-
2004
Doctor Philosophy
THE EXPRESSIONS AND FUNCTIONS OF G3BPs IN MACROPHAGES
Principal Advisor
-
2004
Doctor Philosophy
TRANSCRIPTIONAL ANALYSIS OF MACROPHAGE SIGNALLING IN RESPONSE TO LIPOPOLYSACCHARIDE
Principal Advisor
Other advisors: Professor Brandon Wainwright
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2003
Doctor Philosophy
THE FUNCTION AND REGULATION OF TARTRATE-RESISTANT ACID PHOSPHATASE (TRAP)
Principal Advisor
-
2003
Doctor Philosophy
Transcriptional regulation of c-fms gene expression
Principal Advisor
-
2003
Doctor Philosophy
MECHANISMS OF ACTION OF BACTERIAL DNA ON MACROPHAGE ACTIVATION
Principal Advisor
Other advisors: Professor Kate Stacey
-
2021
Master Philosophy
Developing a Novel Immune Cell Therapy for Glioblastoma: A Novel Monocyte-based Cell-therapy for the Treatment of Glioblastoma
Associate Advisor
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2012
Doctor Philosophy
Characterisation of Myeloid Cells in the Peritoneal Foreign Body Response: Evidence for Phenotypic Plasticity
Associate Advisor
Other advisors: Associate Professor Barbara Rolfe
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2010
Doctor Philosophy
Osteal macrophages (osteomacs) are pivotal for intramembranous bone formation in vivo: Osteomacs facilitate osteoblast maintenance in vivo and enhance osteoblast-mediated bone deposition in a murine model of bone healing
Associate Advisor
Other advisors: Professor Allison Pettit
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2009
Doctor Philosophy
Role of macrophages, residing on the bone surface, in bone remodelling and repair
Associate Advisor
Other advisors: Professor Allison Pettit
-
2009
Doctor Philosophy
Short Sequence Tags Reveal Global Transcription Of Repetitive Elements In Mammalian Genomes
Associate Advisor
-
2009
Doctor Philosophy
Cellular activation and death in response to cytoplasmic DNA
Associate Advisor
Other advisors: Professor Kate Stacey
-
2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE ROLE OF PROTEIN TYROSINE PHOSPHATASE CD148 IN MACROPHAGES
Associate Advisor
-
2006
Doctor Philosophy
THE ROLE OF MICROPHTHALMIA TRANSCRIPTION FACTOR (MITF) IN OSTEOCLAST GENE REGULATION
Associate Advisor
-
2006
Doctor Philosophy
MOLECULAR AND FUNCTIONAL CHARACTERISATION OF POTENTIAL MURINE RENAL STEM CELLS
Associate Advisor
-
2006
Doctor Philosophy
THE IMPORTANCE OF EPIGENETICS IN MAMMALS
Associate Advisor
Other advisors: Professor Bernard Carroll
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-
2005
Doctor Philosophy
SHADES OF DOMAINS: BIOINFORMATIC IDENTIFICATION OF PROTEIN DOMAIN SUBTYPES AND CORRELATION WITH FUNCTIONAL SPECIFICITY
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
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2005
Doctor Philosophy
CELLULAR RESPONSES TO IMMUNOSTIMULATORY DNA
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Kate Stacey
Media
Enquiries
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