Overview
Background
Professor Layton is a national leader in innovative ophthalmology, with expertise in macular disease, lens surgery and minimally invasive glaucoma interventions. He completed ophthalmology training in Queensland, Oxford and London, subspecialty training in retinal disease at the Royal Brisbane Hospital and holds a PhD in diabetic retinopathy from Oxford University. Professor Layton is a Rhodes Scholar and founding director of the LVF Ophthalmology Research Centre in Brisbane, Australia. He is also CEO of Ocugene, a Queensland based biotech start-up which is commercialising his gene therapy technology targeting macular degeneration, uveitis and choroidal melanoma. Professor Layton is the listed inventor of multiple ophthalmic patent applications currently under review in the USA, the EU, Japan, Israel, Australia and Singapore. He has published extensively in the international literature and his work has been recognised by awards from international eye research organisations.
Availability
- Associate Professor Chris Layton is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, Queensland University of Technology
- Bachelor of Medicine Surgery, The University of Queensland
- Doctor of Philosophy, University of Oxford
- Royal Australian and New Zealand College of Ophthalmologists, Royal Australian and New Zealand College of Ophthalmologists
Research interests
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Ophthalmology
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Gene therapy
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Intraocular drug delivery and targeting
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Medical retina disease
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Retinal angiogenesis
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Diabetic Retinopathy
Research impacts
The LVF Ophthalmology Research Centre is a prominent ophthalmologist led research unit in Queensland. The unit’s research focus is on optimising next generation targeted therapeutics for the intravitreal treatment of currently blinding or fatal medical retinal conditions. Our world class infrastructure includes modern, extensively equipped PC2 laboratories and access to on site flow cytometry; confocal, multiphoton and 3D scanning super resolution microscopy; microPET imaging and mass spectrometry. The unit has developed a complete bench to bedside development pipeline through our clinical research infrastructure, from high technology discovery work of targeted therapeutics in cell culture systems to unit sponsored clinical trials. Academic training is a specialty of the unit and forms the ideal foundation for a career as a visual scientist, neuroscientist or academic ophthalmologist. Alternatively, experiences in the unit can be tailored to impart a high level of ophthalmic knowledge prior to undertaking the RANZCO ophthalmology training program or equivalency examinations. Supervision is supportive and directed towards the career goals of the Centre's members, not the advancement of the Centre itself.
Works
Search Professor Chris Layton’s works on UQ eSpace
Featured
2015
Journal Article
Familial disorders of the optic disc: presentation of a mother and daughter and review of the literature
Hsu, Chia Lee and Layton, Christopher J. (2015). Familial disorders of the optic disc: presentation of a mother and daughter and review of the literature. Case Reports in Ophthalmology, 6 (2), 251-259. doi: 10.1159/000437381
Featured
2014
Journal Article
Factors associated with significant ocular injury in conservatively treated orbital fractures
Layton, Christopher J. (2014). Factors associated with significant ocular injury in conservatively treated orbital fractures. Journal of Ophthalmology, 2014 412397, 412397.1-412397.6. doi: 10.1155/2014/412397
Featured
2004
Journal Article
Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat
Layton, Christopher J., Chidlow, Glyn, Casson, Robert J., Wood, John P. M., Graham, Mark and Osborne, Neville N. (2004). Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat. Investigative Ophthalmology and Visual Science, 46 (8), 2878-2885. doi: 10.1167/iovs.04-1458
2024
Journal Article
AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?
Castro, Brenda, Steel, Jason C. and Layton, Christopher J. (2024). AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?. Expert Reviews in Molecular Medicine, 26 e9, 1-15. doi: 10.1017/erm.2024.4
2023
Journal Article
AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapies
Castro, Brenda F. M., Steel, Jason C. and Layton, Christopher J. (2023). AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapies. BioDrugs, 38 (1), 73-93. doi: 10.1007/s40259-023-00629-y
2022
Journal Article
Attitudes of eye health practitioners towards diagnostic tests and therapies for dry eye disease in Australasia
Li, Ye, Smith, Robert G., Steel, Jason C. and Layton, Christopher J. (2022). Attitudes of eye health practitioners towards diagnostic tests and therapies for dry eye disease in Australasia. Contact Lens and Anterior Eye, 45 (6) 101724, 1-6. doi: 10.1016/j.clae.2022.101724
2021
Journal Article
Differences in uveal melanoma age-standardized incidence rates in two eastern states of Australia are driven by differences in rurality and ultraviolet radiation
Chalada, Melissa, Ramlogan-steel, Charmaine A., Dhungel, Bijay P., Goh, Amanda Y., Gardiner, Samuel, Layton, Christopher J. and Steel, Jason C. (2021). Differences in uveal melanoma age-standardized incidence rates in two eastern states of Australia are driven by differences in rurality and ultraviolet radiation. Cancers, 13 (23) 5894, 5894. doi: 10.3390/cancers13235894
2021
Other Outputs
Expression vector and method
Layton, Christopher and Steel, Jason (2021). Expression vector and method. US Patent App. 16/963,880.
2021
Journal Article
Neutralisation of adeno-associated virus transduction by human vitreous humour
Andrzejewski, Sławomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason C. and Layton, Christopher J. (2021). Neutralisation of adeno-associated virus transduction by human vitreous humour. Gene Therapy, 28 (5), 242-255. doi: 10.1038/s41434-020-0162-8
2021
Journal Article
The impact of ultraviolet radiation on the aetiology and development of uveal melanoma
Chalada, Melissa, Ramlogan-Steel, Charmaine A., Dhungel, Bijay P., Layton, Christopher J. and Steel, Jason C. (2021). The impact of ultraviolet radiation on the aetiology and development of uveal melanoma. Cancers, 13 (7) 1700, 1700. doi: 10.3390/cancers13071700
2020
Journal Article
Time‐to‐event survival statistics in ophthalmology: methodological research
Layton, Christopher J. and Layton, Danielle M. (2020). Time‐to‐event survival statistics in ophthalmology: methodological research. Clinical and Experimental Ophthalmology, 48 (9) ceo.13848, 1136-1145. doi: 10.1111/ceo.13848
2020
Journal Article
Characterisation and validation of the 8-fold quadrant dissected human retinal explant culture model for pre-clinical toxicology investigation
Murali, Aparna, Ramlogan-Steel, Charmaine A., Steel, Jason C. and Layton, Christopher J. (2020). Characterisation and validation of the 8-fold quadrant dissected human retinal explant culture model for pre-clinical toxicology investigation. Toxicology in Vitro, 63 104716, 1-10. doi: 10.1016/j.tiv.2019.104716
2020
Journal Article
Presence and prevalence of uv related genetic mutations in uveal melanoma: similarities with cutaneous melanoma
Goh, A. Y., Ramlogan-Steel, C. A., Jenkins, K. S., Steel, J. C. and Layton, C. J. (2020). Presence and prevalence of uv related genetic mutations in uveal melanoma: similarities with cutaneous melanoma. Neoplasma, 67 (5), 958-971. doi: 10.4149/neo_2020_190815N768
2020
Conference Publication
Recombinant Adeno-Associated Virus Vector Tropism in Human Retina
Andrzejewski, Slawomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason and Layton, Christopher J. (2020). Recombinant Adeno-Associated Virus Vector Tropism in Human Retina. In: 23rd Annual Meeting of the American Society for Gene and Cell Therapy, Electr Network, (254-254). 12-15 May 2020.
2019
Journal Article
Gene therapy and the adeno associated virus in the treatment of genetic and acquired ophthalmic diseases in humans: trials, future directions and safety considerations
Ramlogan-Steel, Charmaine A., Murali, Aparna, Andrzejewski, Slawomir, Dhungel, Bijay, Steel, Jason C. and Layton, Christopher J. (2019). Gene therapy and the adeno associated virus in the treatment of genetic and acquired ophthalmic diseases in humans: trials, future directions and safety considerations. Clinical & Experimental Ophthalmology, 47 (4), 521-536. doi: 10.1111/ceo.13416
2019
Journal Article
Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus
Andrzejewski, Slawomir, Murali, Aparna, Ramlogan-Steel, Charmaine, Edwards, Katie P., Efron, Nathan, Steel, Jason C. and Layton, Christopher J. (2019). Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus. Gene Therapy, 26 (6), 250-263. doi: 10.1038/s41434-019-0076-5
2019
Conference Publication
Effect of human vitreous humour components and neutralising antibodies on transduction activity of recombinant AAV2, AAV5, AAV6 and AAV8
Andrzejewski, S., Moyle, P., Stringer, B., Steel, J. and Layton, C. J. (2019). Effect of human vitreous humour components and neutralising antibodies on transduction activity of recombinant AAV2, AAV5, AAV6 and AAV8. Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Sheffield, United Kingdom , 19-21 June 2019. New Rochelle, NY, United States: Mary Ann Liebert.
2018
Journal Article
Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy
Jenkins, K. Sean, Steel, Jason C. and Layton, Christopher J. (2018). Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy. Journal of Ophthalmology, 2018 8479850, 1-9. doi: 10.1155/2018/8479850
2018
Journal Article
microRNA199a based post-transcriptional detargeting of gene vectors for Hepatocellular Carcinoma
Dhungel, Bijay, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018). microRNA199a based post-transcriptional detargeting of gene vectors for Hepatocellular Carcinoma. Molecular Therapy - Nucleic Acids, 13, 78-88. doi: 10.1016/j.omtn.2018.08.016
2018
Journal Article
Retinal explant culture: a platform to investigate human neuro-retina
Murali, Aparna, Ramlogan-Steel, Charmaine A., Andrzejewski, Slawomir, Steel, Jason C. and Layton, Christopher J. (2018). Retinal explant culture: a platform to investigate human neuro-retina. Clinical & Experimental Ophthalmology, 47 (2) ceo.13434, 274-285. doi: 10.1111/ceo.13434
Funding
Past funding
Supervision
Availability
- Associate Professor Chris Layton is:
- Available for supervision
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Available projects
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1. Penetrative intraviteal anti-angiogenic gene therapy approaches for sub-RPE choroidal neovascularisation in exudative macular degeneration
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2. Intravitreal modulated immunotherapy for severe choroidal inflammation
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3. Penetrative intravitreal cancer gene therapy for the treatment of uveal melanoma
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4. EPO as a neuroprotective agent in human diabetic retinal neuropathy associated with nephropathy
Requires AHPRA registration and a clinical degree
Supervision history
Current supervision
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Doctor Philosophy
Penetrative intraviteal gene therapy approaches to macular degeneration
Principal Advisor
Completed supervision
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2021
Doctor Philosophy
Aspects of posterior segment therapeutic targeting in retinal diseases
Principal Advisor
Other advisors: Associate Professor Peter Moyle
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2018
Doctor Philosophy
Targeting Hepatocellular Carcinoma with genetically modified Adeno Associated Viruses
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
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