Overview
Background
Professor Layton is a national leader in innovative ophthalmology, with expertise in macular disease, lens surgery and minimally invasive glaucoma interventions. He completed ophthalmology training in Queensland, Oxford and London, subspecialty training in retinal disease at the Royal Brisbane Hospital and holds a PhD in diabetic retinopathy from Oxford University. Professor Layton is a Rhodes Scholar and founding director of the LVF Ophthalmology Research Centre in Brisbane, Australia. He is also CEO of Ocugene, a Queensland based biotech start-up which is commercialising his gene therapy technology targeting macular degeneration, uveitis and choroidal melanoma. Professor Layton is the listed inventor of multiple ophthalmic patent applications currently under review in the USA, the EU, Japan, Israel, Australia and Singapore. He has published extensively in the international literature and his work has been recognised by awards from international eye research organisations.
Availability
- Associate Professor Chris Layton is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, Queensland University of Technology
- Bachelor of Medicine Surgery, The University of Queensland
- Doctor of Philosophy, University of Oxford
- Royal Australian and New Zealand College of Ophthalmologists, Royal Australian and New Zealand College of Ophthalmologists
Research interests
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Ophthalmology
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Gene therapy
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Intraocular drug delivery and targeting
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Medical retina disease
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Retinal angiogenesis
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Diabetic Retinopathy
Research impacts
The LVF Ophthalmology Research Centre is a prominent ophthalmologist led research unit in Queensland. The unit’s research focus is on optimising next generation targeted therapeutics for the intravitreal treatment of currently blinding or fatal medical retinal conditions. Our world class infrastructure includes modern, extensively equipped PC2 laboratories and access to on site flow cytometry; confocal, multiphoton and 3D scanning super resolution microscopy; microPET imaging and mass spectrometry. The unit has developed a complete bench to bedside development pipeline through our clinical research infrastructure, from high technology discovery work of targeted therapeutics in cell culture systems to unit sponsored clinical trials. Academic training is a specialty of the unit and forms the ideal foundation for a career as a visual scientist, neuroscientist or academic ophthalmologist. Alternatively, experiences in the unit can be tailored to impart a high level of ophthalmic knowledge prior to undertaking the RANZCO ophthalmology training program or equivalency examinations. Supervision is supportive and directed towards the career goals of the Centre's members, not the advancement of the Centre itself.
Works
Search Professor Chris Layton’s works on UQ eSpace
2018
Journal Article
Current evidence for the prevention of endophthalmitis in anti-VEGF intravitreal injections
Lau, P. ET., Jenkins, K. S. and Layton, C. J. (2018). Current evidence for the prevention of endophthalmitis in anti-VEGF intravitreal injections. Journal of Ophthalmology, 2018 (1) 8567912, 1-8. doi: 10.1155/2018/8567912
2018
Journal Article
miRNA122a regulation of gene therapy vectors targeting hepatocellular cancer stem cells
Dhungel, Bijay, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018). miRNA122a regulation of gene therapy vectors targeting hepatocellular cancer stem cells. OncoTarget, 9 (34), 23577-23588. doi: 10.18632/oncotarget.25280
2018
Journal Article
Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma
Dhungel, Bijay, Andrzejewski, Slawomir, Jayachandran, Aparna, Shrestha, Ritu, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018). Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma. Molecular Therapy, 25 (2), 115-128. doi: 10.1038/s41434-018-0002-2
2018
Conference Publication
Evaluation of tumor specific promoters for transcriptional targeting of hepatocellular carcinoma
Dhungel, Bijay, Jayachandran, Aparna, Layton, Christopher J. and Steel, Jason C. (2018). Evaluation of tumor specific promoters for transcriptional targeting of hepatocellular carcinoma. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney Australia, May 24-26, 2017. Hoboken, NJ United States: Wiley.
2017
Conference Publication
Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma
Goh, A., Ramlogan-Steel, C., Jayachandran, A., Steel, J. and Layton, C. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. 2017 European Association for Vision and Eye Research Conference, Nice, France, 27 - 30 September 2017. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-3768.2017.02787
2017
Conference Publication
Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma
Goh, A., Ramlogan-Steel, C., Jayachandran, A., Steel, J. and Layton, C. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. 2017 European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-3768.2017.02787
2017
Conference Publication
The 8-fold quadrant dissection method for ex vivo human interventional retinal experimentation
Murali, A., Ramlogan-Steel, C., Andrzejewski, S., Dhungel, B., Steel, J. and Layton, C. (2017). The 8-fold quadrant dissection method for ex vivo human interventional retinal experimentation. 2017 European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-3768.2017.01558
2017
Journal Article
A novel ABCA4 mutation associated with a late-onset Stargardt disease phenotype: a hypomorphic allele?
Kaway, Cindy S., Adams, Madeleine K. M., Jenkins, Kevin Sean and Layton, Christopher J. (2017). A novel ABCA4 mutation associated with a late-onset Stargardt disease phenotype: a hypomorphic allele?. Case Reports in Ophthalmology, 8 (1), 180-184. doi: 10.1159/000464129
2017
Journal Article
Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma
Dhungel, Bijay, Jayachandran, Aparna, Layton, Christopher J. and Steel, Jason C. (2017). Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma. Drug Delivery, 24 (1), 289-299. doi: 10.1080/10717544.2016.1247926
2017
Conference Publication
Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium
Layton, C. J., Dhungel, B. , Andrzejewski, S. , Jayachandran, A. , Murali, A. and Steel, J. S. (2017). Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2017.02683
2017
Conference Publication
Evaluation of the Glypican-3 Promoter for Transcriptional Targeting of Hepatocellular Carcinoma
Dhungel, Bijay, Jayachandran, Aparna, Shrestha, Ritu, Ramlogan-Steel, Charmaine, Layton, Christopher J. and Steel, Jason C. (2017). Evaluation of the Glypican-3 Promoter for Transcriptional Targeting of Hepatocellular Carcinoma. 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington DC United States, 10-13 May 2017. CAMBRIDGE: Cell Press.
2017
Conference Publication
Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma
Goh, A. , Ramlogan‐Steel, C. , Jayachandran, A., Steel, J. and Layton, C. J. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2017.02787
2017
Conference Publication
Ophthalmoscopic and video OCT methods to detect spontaneous venous pulsation in individuals with apparently normal intracranial pressure: the rebirth of the SVP?
Jenkins, K. S., Adams, M. K. M. and Layton, C. J. (2017). Ophthalmoscopic and video OCT methods to detect spontaneous venous pulsation in individuals with apparently normal intracranial pressure: the rebirth of the SVP?. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2017.01516
2017
Journal Article
External ophthalmomyiasis caused by oestrus ovis
Jenkins, K. Sean and Layton, Christopher J. (2017). External ophthalmomyiasis caused by oestrus ovis. Clinical and Experimental Ophthalmology, 46 (3), 300-301. doi: 10.1111/ceo.13033
2017
Conference Publication
The 8‐fold quadrant dissection method for ex vivo human interventional retinal experimentation
Murali, A., Ramlogan‐Steel, C., Andrzejewski, S., Dhungel, B., Steel, J. and Layton, C. J. (2017). The 8‐fold quadrant dissection method for ex vivo human interventional retinal experimentation. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell . doi: 10.1111/j.1755-3768.2017.01558
2016
Journal Article
Therapeutic targeting of diabetic retinal neuropathy as a strategy in preventing diabetic retinopathy
de Moraes, Gabriela and Layton, Christopher J. (2016). Therapeutic targeting of diabetic retinal neuropathy as a strategy in preventing diabetic retinopathy. Clinical and Experimental Ophthalmology, 44 (9), 838-852. doi: 10.1111/ceo.12795
2016
Journal Article
An eye for art? A challenge of ophthalmic body modification
Jenkins, Kevin Sean and Layton, Christopher J. (2016). An eye for art? A challenge of ophthalmic body modification. Clinical and Experimental Ophthalmology, 44 (8), 741-741. doi: 10.1111/ceo.12758
2016
Conference Publication
Effects of erythropoietin on glucose induced exacerbation of hypoxic damage in cultured photoreceptor-like cells
Layton, Christopher J., Kawai, Cindy S., de Moraes, Gabriela, Jenkins, Kevin and Goh, Amanda Y. (2016). Effects of erythropoietin on glucose induced exacerbation of hypoxic damage in cultured photoreceptor-like cells. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA United States, 1-5 May 2016. Rockville, MD United States: Association for Research in Vision and Ophthalmology.
2016
Conference Publication
Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy
Jenkins, K. S., Rowan, A. and Layton, C. J. (2016). Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy. 2016 European Association for Vision and Eye Research Conference, Nice, France, 5-8 October 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2016.0565
2016
Journal Article
Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design
Lim, Paul C. C. and Layton, Christopher J. (2016). Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design. Clinical and Experimental Ophthalmology, 44 (5), 410-421. doi: 10.1111/ceo.12671
Funding
Past funding
Supervision
Availability
- Associate Professor Chris Layton is:
- Available for supervision
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Available projects
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1. Penetrative intraviteal anti-angiogenic gene therapy approaches for sub-RPE choroidal neovascularisation in exudative macular degeneration
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2. Intravitreal modulated immunotherapy for severe choroidal inflammation
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3. Penetrative intravitreal cancer gene therapy for the treatment of uveal melanoma
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4. EPO as a neuroprotective agent in human diabetic retinal neuropathy associated with nephropathy
Requires AHPRA registration and a clinical degree
Supervision history
Current supervision
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Doctor Philosophy
Penetrative intraviteal gene therapy approaches to macular degeneration
Principal Advisor
Completed supervision
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2021
Doctor Philosophy
Aspects of posterior segment therapeutic targeting in retinal diseases
Principal Advisor
Other advisors: Associate Professor Peter Moyle
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2018
Doctor Philosophy
Targeting Hepatocellular Carcinoma with genetically modified Adeno Associated Viruses
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
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