Associate Professor

Graham Leggatt

Email: 
Phone: 
+61 7 344 34315

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Fields of research

Clinical sciences Immunology Oncology and carcinogenesis

Search Professor Graham Leggatt’s works on UQ eSpace

128 works between 1991 and 2024
All (128) Journal Article (105) Book Chapter (1) Conference Publication (21) Book (1)

21 - 40 of 128 works

2018

Journal Article

An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes

Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190

An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes

2018

Journal Article

Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia

Kerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R. and Mattarollo, Stephen R. (2018). Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia. OncoImmunology, 7 (10) e1486952, 1-10. doi: 10.1080/2162402x.2018.1486952

Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia

2018

Journal Article

HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin

Kuo, Paula, Tuong, Zewen K, Teoh, Siok Min, Frazer, Ian H, Mattarollo, Stephen and Leggatt, Graham R (2018). HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin. The Journal of investigative dermatology, 138 (6), 1348-1359. doi: 10.1016/j.jid.2017.12.021

HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin

2018

Journal Article

Development of a polyclonal anti-dugong immunoglobulin G (IgG) antibody with evaluation of total plasma IgG in a living dugong (Dugong dugon) population

Wong, Arthur, Lanyon, Janet M., McKee, Sara J., Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2018). Development of a polyclonal anti-dugong immunoglobulin G (IgG) antibody with evaluation of total plasma IgG in a living dugong (Dugong dugon) population. Veterinary Immunology and Immunopathology, 200, 16-25. doi: 10.1016/j.vetimm.2018.04.003

Development of a polyclonal anti-dugong immunoglobulin G (IgG) antibody with evaluation of total plasma IgG in a living dugong (Dugong dugon) population

2018

Journal Article

Comparison of i-STAT® with traditional laboratory analysers in the measurement of blood analytes from field captured dugongs (Dugong dugon)

Wong, Arthur W., Lanyon, Janet M., Sneath, Helen L., Leggatt, Graham R. and Woolford, Lucy (2018). Comparison of i-STAT® with traditional laboratory analysers in the measurement of blood analytes from field captured dugongs (Dugong dugon). Aquatic Mammals, 44 (1), 19-31. doi: 10.1578/AM.44.1.2018.19

Comparison of i-STAT® with traditional laboratory analysers in the measurement of blood analytes from field captured dugongs (Dugong dugon)

2018

Journal Article

B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity

McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599

B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity

2017

Journal Article

Modulation of antigen presenting cell functions during chronic HPV infection

Bashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017). Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4, 58-65. doi: 10.1016/j.pvr.2017.08.002

Modulation of antigen presenting cell functions during chronic HPV infection

2017

Journal Article

Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

Bhat, Purnima, Leggatt, Graham, Waterhouse, Nigel and Frazer, Ian H. (2017). Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death and Disease, 8 (6) e2836, e2836.1-e2836.11. doi: 10.1038/cddis.2017.67

Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

2017

Journal Article

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients

Linedale, Richard, Schmidt, Campbell, King, Brigid T., Ganko, Annabelle G., Simpson, Fiona, Panizza, Benedict J. and Graham R. Leggatt (2017). Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS One, 12 (4) e0175755, e0175755.1-e0175755.13. doi: 10.1371/journal.pone.0175755

Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients

2017

Journal Article

HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts

Jazayeri, Seyed D., Kuo, Paula, Leggatt, Graham R. and Frazer, Ian (2017). HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts. Frontiers in Immunology, 8 (MAY) 524, 524. doi: 10.3389/fimmu.2017.00524

HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts

2017

Journal Article

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

2016

Journal Article

Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling

Rearden, Rory, Sah, Amelia, Doff, Brianna, Kobayashi, Takumi, McKee, Sara J., Leggatt, Graham R. and Mattarollo, Stephen R. (2016). Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling. Immunology and Cell Biology, 94 (6), 554-562. doi: 10.1038/icb.2016.9

Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling

2016

Journal Article

Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

Chawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016). Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 (2), 213-222. doi: 10.1007/s00262-015-1788-z

Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

2016

Conference Publication

Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin

Leggatt, G., Veitch, M., Sheehan, B., McKee, S., Linedale, R., Jazayeri, S. D. and Mattarollo, S. (2016). Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Tissue resident CD103+CD69+ T cells develop rapidly and do not require cognate antigen within the epidermis of a mouse model of precancerous skin

2016

Conference Publication

Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells

Kobayashi, T., Tuong, K., Man, K., Mckee, S., Leggatt, G., Kallies, A. and Mattarollo, S. (2016). Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Altered nutrient levels caused by B cell lymphoma leads to dysfunctional natural killer cells

2016

Conference Publication

Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers

Mattarollo, Stephen, Leggatt, Graham, Wells, James, Lambert, Paul and Frazer, Ian H. (2016). Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers. International Cancer Immunotherapy Conference: Translating Science into Survival, New York, United States, September 16-19, 2015. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.CRICIMTEATIAACR15-A064

Modeling checkpoint blockade inhibitor resistant immunoregulation induced by squamous epithelial cancers

2016

Conference Publication

Immunotherapy for persisting viral infection and associated cancer

Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Immunotherapy for persisting viral infection and associated cancer

2016

Conference Publication

Inhibition of Aurora Kinases is curative for HPV-driven tumours

McMillan, N., Fallaha, S., Martin, D., Leggatt, G. and Gabrielli, B. (2016). Inhibition of Aurora Kinases is curative for HPV-driven tumours. 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 28-31 October 2016. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.IGC.0000503327.50238.5c

Inhibition of Aurora Kinases is curative for HPV-driven tumours

2016

Conference Publication

The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance

Rearden, R., Sah, A., Doff, B., Kobayashi, T., McKee, S., Leggatt, G. and Mattarollo, S. (2016). The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

The implications of vaccination-induced IFN-gamma signalling on the control of B-cell lymphoma and the acquisition of immune resistance

2015

Journal Article

Aurora A is critical for survival in HPV-transformed cervical cancer

Gabrielli, Brian, Bokhari, Fawzi, Ranall, Max V., Oo, Zay Yar, Stevenson, Alexander J., Wang, Weili, Murrell, Melanie, Shaikh, Mushfiq, Fallaha, Sora, Clarke, Daniel, Kelly, Madison, Sedelies, Karin, Christensen, Melinda, McKee, Sara, Leggatt, Graham, Leo, Paul, Skalamera, Dubravka, Soyer, H. Peter, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Aurora A is critical for survival in HPV-transformed cervical cancer. Molecular Cancer Therapeutics, 14 (12), 2753-2761. doi: 10.1158/1535-7163.MCT-15-0506

Aurora A is critical for survival in HPV-transformed cervical cancer

Past funding

  • 2020 - 2022
    Intradermal delivery of therapeutic antibodies in skin cancer
    TdC Pioneering Grant
    Open grant
  • 2017 - 2019
    Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Novel therapeutic targets for HPV-driven cancers (Cancer Council Queensland grant administered by Griffith University
    Griffith University
    Open grant
  • 2014
    Local immune response to perineural squamous cell carcinoma
    PA Research Foundation
    Open grant
  • 2014 - 2017
    Memory CD8 T cell subsets in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2013 - 2014
    The Gavin Chase Research Project Grant
    Cancer Council Queensland
    Open grant
  • 2012 - 2013
    RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2010 - 2012
    Suppressor NKT cell trafficking to epithelial precancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    Histone deacetylase inhibitors can inhibit tumour growth via induction of an anti-tumour immune response
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    The Role of RNA interference in the induction of immune responses
    ARC Linkage Projects
    Open grant
  • 2006 - 2008
    Mechanisms of dendritic cell-induced T-cell tolerance
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    Optimising Immunotherapy in Tumour Antigen Experienced Host
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
    Queensland Cancer Fund
    Open grant
  • 2004 - 2008
    Improving Vaccines Against Viruses And Tumours: Optimising the Cytotoxic T Lymphocyte Response
    Lions Medical Research Foundation
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant _HLTH_CICR_Med SCD
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Treatment Of Virally-Induced Cancers By RNA Interference
    NHMRC Project Grant
    Open grant
  • 2003 - 2004
    Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
    NHMRC Project Grant
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant
  • 2002
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire.
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001
    CTL Avidity As A Determinant Of The Mature, Antigen-Specific Immune Repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001 - 2003
    CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
    NHMRC Project Grant
    Open grant
  • 2000
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    Analysis of functional activation thresholds in peripheral CD8+ T cells
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Clonal selection of CTL avidity in the periphery
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    CTL avidity and cell number as determinants of E7 tumour regression in vivo
    Cancer Bequest Fund
    Open grant
  • 1999 - 2001
    Development of hybrid HPV/HIV VLPs, a novel vaccine to prevent both HIV and HPV infection
    NHMRC Project Grant
    Open grant
  • 1998
    The Role of CTL Avidity and Cytokine Environment in the Control of Papillomavirus Infection and Epithelial Tumours
    Mayne Bequest Fund
    Open grant

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

For media enquiries about Associate Professor Graham Leggatt's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au